{"id":"https://openalex.org/W4313309243","doi":"https://doi.org/10.4049/jimmunol.110.6.1623","title":"Guinea Pig Lymphotoxin (LT)","display_name":"Guinea Pig Lymphotoxin (LT)","publication_year":1973,"publication_date":"1973-06-01","ids":{"openalex":"https://openalex.org/W4313309243","doi":"https://doi.org/10.4049/jimmunol.110.6.1623"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.110.6.1623","doi":"https://doi.org/10.4049/jimmunol.110.6.1623","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.110.6.1623","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072133376","display_name":"Steven A. Rosenberg","orcid":"https://orcid.org/0000-0002-8939-8910","observed_orcids":["https://orcid.org/0000-0002-8939-8910"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A Rosenberg","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020767104","display_name":"Margaret Henrichon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Henrichon","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001347659","display_name":"John A Coyne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A Coyne","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113576149","display_name":"John R. David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R David","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital , Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Department of Medicine, Harvard Medical School, and the Robert B. Brigham Hospital, Boston, Massachusetts 02120","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Robert B. Brigham Hospital From the , and the , Boston, Massachusetts 02120","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.8579,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72480343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"6","first_page":"1623","last_page":"1629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-necrosis-factor-beta","display_name":"lymphotoxin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lymphocyte-migration-inhibition","display_name":"lymphocyte migration inhibition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.4909999966621399},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5199999809265137},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.35499998927116394},{"id":"https://openalex.org/keywords/embryonic-fibroblasts","display_name":"embryonic fibroblasts","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C61879462","wikidata":"https://www.wikidata.org/wiki/Q24774130","display_name":"Lymphotoxin","level":3,"score":0.9647713899612427},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.8444200754165649},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.8048965930938721},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5432267785072327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5148023962974548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47544050216674805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33797064423561096},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3244745135307312},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29650723934173584},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.1414097547531128},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1310197114944458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09709405899047852}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.110.6.1623","doi":"https://doi.org/10.4049/jimmunol.110.6.1623","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.110.6.1623","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1678889663","https://openalex.org/W1524612529","https://openalex.org/W1502681603","https://openalex.org/W1647443488","https://openalex.org/W2070711586","https://openalex.org/W1553879259","https://openalex.org/W2323937698","https://openalex.org/W1486139555","https://openalex.org/W1515146327","https://openalex.org/W4313310175"],"abstract_inverted_index":{"Abstract":[0],"Lymphotoxin":[1],"(LT)":[2],"was":[3,22,26,67,71],"found":[4],"to":[5,91],"be":[6],"present":[7,38],"in":[8,17,39],"the":[9,36,40,62],"same":[10],"supernatants":[11],"as":[12],"antigen-stimulated":[13],"guinea":[14,85],"pig":[15,86],"lymphocytes":[16],"which":[18],"migration-inhibitory":[19,60],"factor":[20],"(MIF)":[21],"found.":[23],"LT":[24,65,70],"activity":[25],"determined":[27],"by":[28,48,55],"staining":[29],"target":[30,57,78],"cells":[31,37],"with":[32],"trypan":[33],"blue,":[34],"counting":[35],"media":[41],"and":[42,51],"determining":[43],"their":[44],"viability,":[45],"direct":[46],"observation":[47],"time-lapse":[49],"cinematography":[50],"measuring":[52],"protein":[53],"synthesis":[54],"surviving":[56],"cells.":[58],"Like":[59],"factor,":[61],"induction":[63],"of":[64,76,84],"release":[66],"antigen":[68],"specific.":[69],"effective":[72],"on":[73],"a":[74],"number":[75],"different":[77],"cell":[79],"lines;":[80],"however,":[81],"young":[82],"cultures":[83],"embryo":[87],"fibroblasts":[88],"were":[89],"resistant":[90],"it.":[92]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-01-06T00:00:00"}