{"id":"https://openalex.org/W4313309042","doi":"https://doi.org/10.4049/jimmunol.112.6.2135","title":"Interaction of C-Reactive Protein Complexes with the Complement System","display_name":"Interaction of C-Reactive Protein Complexes with the Complement System","publication_year":1974,"publication_date":"1974-06-01","ids":{"openalex":"https://openalex.org/W4313309042","doi":"https://doi.org/10.4049/jimmunol.112.6.2135","mag":"1910264735","pmid":"https://pubmed.ncbi.nlm.nih.gov/4151108"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.112.6.2135","doi":"https://doi.org/10.4049/jimmunol.112.6.2135","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.112.6.2135","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111971409","display_name":"Melvin H. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin H Kaplan","raw_affiliation_strings":["Department of Medicine, Case Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital , Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Case Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital , Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108495906","display_name":"John E. Volanakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E Volanakis","raw_affiliation_strings":["Department of Medicine, Case Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital , Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Case Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital , Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.1984,"has_fulltext":false,"cited_by_count":606,"citation_normalized_percentile":{"value":0.97269097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"112","issue":"6","first_page":"2135","last_page":"2147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.30570000410079956,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/complement-consumption","display_name":"complement consumption","score":0.7620000243186951},{"id":"https://openalex.org/keywords/pneumococcal-c-polysaccharide","display_name":"pneumococcal C-polysaccharide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.8069999814033508},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.6790000200271606},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.871999979019165},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.5419999957084656},{"id":"https://openalex.org/keywords/lecithin","display_name":"lecithin","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C152669594","wikidata":"https://www.wikidata.org/wiki/Q904197","display_name":"Complement fixation test","level":4,"score":0.7777254581451416},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6112321615219116},{"id":"https://openalex.org/C133229898","wikidata":"https://www.wikidata.org/wiki/Q7239484","display_name":"Precipitin","level":3,"score":0.5588913559913635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5435370206832886},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.528201162815094},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.5064531564712524},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.49398189783096313},{"id":"https://openalex.org/C196955773","wikidata":"https://www.wikidata.org/wiki/Q256632","display_name":"Immunodiffusion","level":3,"score":0.4437510669231415},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.4241310656070709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36056357622146606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2744455933570862},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27244383096694946},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.19179067015647888}],"mesh":[{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003168","descriptor_name":"Complement Fixation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.112.6.2135","doi":"https://doi.org/10.4049/jimmunol.112.6.2135","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.112.6.2135","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:4151108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4151108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1910264735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4151108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1910264735","https://openalex.org/W7098013837","https://openalex.org/W7095704103","https://openalex.org/W1963341217","https://openalex.org/W2329109548","https://openalex.org/W1628741361","https://openalex.org/W1672081243","https://openalex.org/W2155140643","https://openalex.org/W1572246200","https://openalex.org/W2414679224"],"abstract_inverted_index":{"Abstract":[0],"The":[1,275],"reaction":[2,35,58,214],"of":[3,18,27,45,49,52,59,67,72,76,89,93,97,106,124,137,155,185,193,208,215,226,267,270,277,298],"C-reactive":[4],"protein":[5],"(CRP)-positive":[6],"sera":[7,61,102,120,130,143,217],"and":[8,21,82,84,142,163,198,203,220,231,258,282],"crystalline":[9,115],"CRP":[10,37,98,127,188,256,278,299],"with":[11,31,62,114,139,146,190,218,221],"pneumococcal":[12,147],"C-polysaccharide":[13,219],"at":[14,176],"equivalence":[15],"induced":[16],"consumption":[17,44,71,88,123,165,252],"human":[19,119],"complement":[20,46,53,107,125,164,201,251,288],"C3":[22],"conversion":[23],"in":[24,56,64,99,240,292,300],"the":[25,57,65,94,110,160,182,194,209,248,263,268,287,295,301],"absence":[26,66],"detectable":[28,68,238],"antibody.":[29],"Sera":[30],"negative":[32],"or":[33,42,74,237,273],"trace":[34,154],"for":[36,228,279],"most":[38],"often":[39],"gave":[40],"no":[41],"minimal":[43,95,111],"on":[47],"addition":[48],"C-polysaccharide.":[50,158],"Analysis":[51],"components":[54],"consumed":[55],"CRP-positive":[60,216],"C-polysaccharide,":[63],"antibody,":[69],"demonstrated":[70,223],"80%":[73],"more":[75],"total":[77],"hemolytic":[78],"complement,":[79],"C1,":[80],"C4,":[81],"C2,":[83],"42":[85],"to":[86,134,150,157,255,285,294],"66%":[87],"C3-9.":[90],"Quantitative":[91],"estimates":[92],"amount":[96],"acute":[100],"phase":[101],"which":[103],"permitted":[104,122,247],"fixation":[105,202],"closely":[108],"approximated":[109],"value":[112],"obtained":[113,212],"CRP.":[116],"All":[117],"normal":[118],"tested":[121],"by":[126,170,179,200,204,213],"complexes,":[128],"including":[129],"from":[131],"infants":[132],"5":[133],"7":[135],"months":[136],"age":[138],"physiologic":[140],"hypogammaglobulinemia":[141],"previously":[144],"absorbed":[145],"cell":[148],"walls":[149],"remove":[151],"any":[152],"presumptive":[153],"antibody":[156,186,272],"Both":[159],"CRP-C-polysaccharide":[161],"precipitation":[162,227],"reactions":[166],"were":[167,174,235],"100%":[168],"inhibited":[169,178],"phosphoryl":[171,191],"choline":[172,192,195,280],"but":[173],"not":[175],"all":[177],"N-acetyl":[180],"galactosamine,":[181],"major":[183],"determinant":[184],"specificity.":[187],"reacted":[189],"phosphatides,":[196],"lecithin":[197,222],"sphingomyelin,":[199],"flocculation.":[205],"Immunodiffusion":[206],"analysis":[207],"washed":[210],"complexes":[211,257],"strong":[224],"lines":[225],"CRP,":[229],"C1q,":[230],"C3,":[232],"whereas":[233],"immunoglobulins":[234],"absent":[236],"only":[239],"faint":[241],"traces.":[242],"These":[243],"combined":[244],"data":[245],"have":[246],"conclusion":[249],"that":[250,259],"was":[253],"attributable":[254],"it":[260],"proceeded":[261],"via":[262],"classical":[264],"pathway":[265],"independent":[266],"presence":[269],"specific":[271],"immunoglobulin.":[274],"specificity":[276],"phosphatides":[281],"its":[283],"capacity":[284],"activate":[286],"system":[289],"are":[290],"considered":[291],"relation":[293],"possible":[296],"functions":[297],"inflammatory":[302],"process.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-06T00:00:00"}