{"id":"https://openalex.org/W4313283149","doi":"https://doi.org/10.1101/2022.12.29.522204","title":"A high-throughput machine vision-based univariate scale for pain and analgesia in mice","display_name":"A high-throughput machine vision-based univariate scale for pain and analgesia in mice","publication_year":2022,"publication_date":"2022-12-29","ids":{"openalex":"https://openalex.org/W4313283149","doi":"https://doi.org/10.1101/2022.12.29.522204"},"language":"en","primary_location":{"id":"doi:10.1101/2022.12.29.522204","doi":"https://doi.org/10.1101/2022.12.29.522204","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522204","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/03/2022.12.29.522204.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/03/2022.12.29.522204.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048377134","display_name":"Gautam S. Sabnis","orcid":"https://orcid.org/0000-0002-9985-7463","observed_orcids":["https://orcid.org/0000-0002-9985-7463"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gautam S. Sabnis","raw_affiliation_strings":["The Jackson Laboratory","The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010535372","display_name":"Leinani E. Hession","orcid":"https://orcid.org/0000-0002-2257-801X","observed_orcids":["https://orcid.org/0000-0002-2257-801X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leinani E. Hession","raw_affiliation_strings":["The Jackson Laboratory","The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609"],"raw_orcid":"https://orcid.org/0000-0002-2257-801X","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077701918","display_name":"Kyungin Kim","orcid":"https://orcid.org/0000-0002-8098-8295","observed_orcids":["https://orcid.org/0000-0002-8098-8295"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyungin Kim","raw_affiliation_strings":["The Jackson Laboratory","The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022916895","display_name":"Jacob A. Beierle","orcid":"https://orcid.org/0000-0001-6517-7614","observed_orcids":["https://orcid.org/0000-0001-6517-7614"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob A. Beierle","raw_affiliation_strings":["The Jackson Laboratory","The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609"],"raw_orcid":"https://orcid.org/0000-0001-6517-7614","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100357359","display_name":"Vivek Kumar","orcid":"https://orcid.org/0000-0001-6643-7465","observed_orcids":["https://orcid.org/0000-0001-6643-7465"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivek Kumar","raw_affiliation_strings":["The Jackson Laboratory","The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609"],"raw_orcid":"https://orcid.org/0000-0001-6643-7465","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100357359"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.10660000145435333,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pain-assessment","display_name":"pain assessment","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/machine-vision","display_name":"machine vision","score":0.7570000290870667},{"id":"https://openalex.org/keywords/formalin-injection","display_name":"formalin injection","score":0.6809999942779541},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nociceptive-behavior","display_name":"nociceptive behavior","score":0.8259999752044678},{"id":"https://openalex.org/keywords/morphine-antinociception","display_name":"morphine antinociception","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mouse-strains","display_name":"mouse strains","score":0.6819999814033508},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.7677825093269348},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6391995549201965},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.6074625849723816},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5809437036514282},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.5305517315864563},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.48614808917045593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48538124561309814},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.46998870372772217},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43380647897720337},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3998061418533325},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3656269907951355},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3254140019416809},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30453693866729736},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.25823739171028137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25785067677497864},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.20176759362220764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12586358189582825},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.12.29.522204","doi":"https://doi.org/10.1101/2022.12.29.522204","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522204","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/03/2022.12.29.522204.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.12.29.522204","doi":"https://doi.org/10.1101/2022.12.29.522204","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522204","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/03/2022.12.29.522204.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G386266877","display_name":null,"funder_award_id":"DA041668","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6149589070","display_name":null,"funder_award_id":"DA048634","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313283149.pdf","grobid_xml":"https://content.openalex.org/works/W4313283149.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W127203346","https://openalex.org/W1939173654","https://openalex.org/W1977591411","https://openalex.org/W1979134363","https://openalex.org/W1987184368","https://openalex.org/W2001933690","https://openalex.org/W2005733093","https://openalex.org/W2023402503","https://openalex.org/W2024836296","https://openalex.org/W2027880398","https://openalex.org/W2033438673","https://openalex.org/W2035958703","https://openalex.org/W2037058589","https://openalex.org/W2045656233","https://openalex.org/W2047865790","https://openalex.org/W2056787619","https://openalex.org/W2070123858","https://openalex.org/W2072147212","https://openalex.org/W2076983043","https://openalex.org/W2110812658","https://openalex.org/W2121086045","https://openalex.org/W2129728285","https://openalex.org/W2157103853","https://openalex.org/W2166622977","https://openalex.org/W2168132586","https://openalex.org/W2510170606","https://openalex.org/W2553928236","https://openalex.org/W2577537660","https://openalex.org/W2731461838","https://openalex.org/W2753084136","https://openalex.org/W2771017922","https://openalex.org/W2790605163","https://openalex.org/W2808405426","https://openalex.org/W2808862074","https://openalex.org/W2888742196","https://openalex.org/W2910694877","https://openalex.org/W2950439954","https://openalex.org/W2952213141","https://openalex.org/W2966567124","https://openalex.org/W2969706685","https://openalex.org/W2999595408","https://openalex.org/W3006396166","https://openalex.org/W3027482181","https://openalex.org/W3047805832","https://openalex.org/W3087722312","https://openalex.org/W3109858200","https://openalex.org/W3127799913","https://openalex.org/W3135350336","https://openalex.org/W3137049560","https://openalex.org/W3137131833","https://openalex.org/W3158678351","https://openalex.org/W3201435727","https://openalex.org/W3207767877","https://openalex.org/W4206326164","https://openalex.org/W4206651841","https://openalex.org/W4280632321","https://openalex.org/W4292065802"],"related_works":["https://openalex.org/W3087722312","https://openalex.org/W2966567124","https://openalex.org/W3135350336","https://openalex.org/W4280632321","https://openalex.org/W3047805832","https://openalex.org/W6987130372","https://openalex.org/W7214081511","https://openalex.org/W1972821819","https://openalex.org/W2030054923","https://openalex.org/W2068703624"],"abstract_inverted_index":{"1":[0],"Abstract":[1],"Treatment":[2],"of":[3,66,79,98,117,123],"acute":[4],"and":[5,33,51,55,59,69,76,119,126,148,162,177],"chronic":[6],"pain":[7,54,100],"represent":[8],"a":[9,43,90,103,166,182],"widespread":[10],"clinical":[11],"challenge":[12],"with":[13],"poor":[14],"therapeutic":[15],"options.":[16],"While":[17],"rodents":[18],"are":[19],"an":[20,37],"invaluable":[21],"model":[22,97,152],"to":[23,88,173],"study":[24],"pain,":[25],"scoring":[26],"nociceptive":[27,171],"responses":[28,172],"in":[29,121,140,181],"clinically":[30],"relevant":[31],"paradigms":[32],"at":[34],"high-throughput":[35,47],"remains":[36],"unmet":[38],"challenge.":[39],"Therefore,":[40],"there":[41],"is":[42],"need":[44],"for":[45,93,168],"automated,":[46],"methods":[48],"that":[49,107,145],"sensitively":[50],"accurately":[52],"assess":[53],"analgesia.":[56],"Such":[57],"objective":[58],"scalable":[60],"technologies":[61],"will":[62],"enable":[63],"the":[64,74,84,94],"discovery":[65],"novel":[67],"analgesics":[68],"yield":[70],"mechanistic":[71],"insights":[72],"into":[73],"neural":[75],"genetic":[77,175],"mechanisms":[78],"pain.":[80],"Here,":[81],"we":[82],"adopt":[83],"open":[85],"field":[86],"arena":[87],"build":[89],"univariate":[91],"scale":[92],"formalin":[95,124,141],"injection":[96],"inflammatory":[99],"by":[101],"using":[102,129],"machine":[104],"learning":[105],"approach":[106],"incorporates":[108],"82":[109],"behavioral":[110],"features.":[111],"This":[112,151,159],"tool":[113,164],"outperforms":[114],"traditional":[115],"measures":[116],"licking":[118],"shaking":[120],"detection":[122],"dose,":[125],"was":[127],"validated":[128],"4":[130],"diverse":[131],"mouse":[132],"strains.":[133],"We":[134],"also":[135,153],"detected":[136],"previously":[137],"unreported":[138],"differences":[139],"induced":[142,157],"nocifensive":[143],"behaviors":[144],"were":[146],"strain":[147],"sex":[149],"specific.":[150],"reliably":[154],"identifies":[155],"morphine":[156],"antinociception.":[158],"novel,":[160],"sensitive,":[161],"inexpensive":[163],"provides":[165],"method":[167],"quantifying":[169],"voluntary":[170],"facilitate":[174],"mapping":[176],"analgesic":[178],"compound":[179],"screening":[180],"high":[183],"throughput":[184],"manner.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}
