{"id":"https://openalex.org/W4313244652","doi":"https://doi.org/10.3390/life13010058","title":"Mealworm Ethanol Extract Enhances Myogenic Differentiation and Alleviates Dexamethasone-Induced Muscle Atrophy in C2C12 Cells","display_name":"Mealworm Ethanol Extract Enhances Myogenic Differentiation and Alleviates Dexamethasone-Induced Muscle Atrophy in C2C12 Cells","publication_year":2022,"publication_date":"2022-12-24","ids":{"openalex":"https://openalex.org/W4313244652","doi":"https://doi.org/10.3390/life13010058","pmid":"https://pubmed.ncbi.nlm.nih.gov/36676007","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9862036"},"language":"en","primary_location":{"id":"doi:10.3390/life13010058","doi":"https://doi.org/10.3390/life13010058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life13010058","pdf_url":"https://www.mdpi.com/2075-1729/13/1/58/pdf?version=1673346141","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-1729/13/1/58/pdf?version=1673346141","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005717177","display_name":"Ra\u2010Yeong Choi","orcid":"https://orcid.org/0000-0002-7313-0901","observed_orcids":["https://orcid.org/0000-0002-7313-0901"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ra-Yeong Choi","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074911656","display_name":"Bong Sun Kim","orcid":"https://orcid.org/0000-0001-7676-6238","observed_orcids":["https://orcid.org/0000-0001-7676-6238"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bong Sun Kim","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066213907","display_name":"Eu-Jin Ban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eu-Jin Ban","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029489184","display_name":"Minchul Seo","orcid":"https://orcid.org/0000-0001-9430-4870","observed_orcids":["https://orcid.org/0000-0001-9430-4870"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minchul Seo","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9430-4870","affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103240916","display_name":"Joon Ha Lee","orcid":"https://orcid.org/0000-0002-1477-7000","observed_orcids":["https://orcid.org/0000-0002-1477-7000"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joon Ha Lee","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1477-7000","affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102860518","display_name":"In-Woo Kim","orcid":"https://orcid.org/0009-0003-6261-6601","observed_orcids":["https://orcid.org/0009-0003-6261-6601"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"In-Woo Kim","raw_affiliation_strings":["Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea","institution_ids":["https://openalex.org/I2800443534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102860518"],"corresponding_institution_ids":["https://openalex.org/I2800443534"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":0.5111,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.51584379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"1","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenebrio-molitor","display_name":"Tenebrio molitor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dexamethasone-induced-muscle-atrophy","display_name":"dexamethasone-induced muscle atrophy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/murf1","display_name":"MuRF1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.7590000033378601},{"id":"https://openalex.org/keywords/myogenic-regulatory-factors","display_name":"myogenic regulatory factors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.7289999723434448},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.4659999907016754},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.4740000069141388},{"id":"https://openalex.org/keywords/glucocorticoid-induced-myopathy","display_name":"glucocorticoid-induced myopathy","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778106681","wikidata":"https://www.wikidata.org/wiki/Q416095","display_name":"MyoD","level":4,"score":0.7649291753768921},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.7324213981628418},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.6899194717407227},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.6501451730728149},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6323994398117065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6281741857528687},{"id":"https://openalex.org/C168003608","wikidata":"https://www.wikidata.org/wiki/Q21101484","display_name":"FOXO3","level":4,"score":0.617222011089325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5917114615440369},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5567420125007629},{"id":"https://openalex.org/C2780508455","wikidata":"https://www.wikidata.org/wiki/Q6947923","display_name":"Myogenic regulatory factors","level":5,"score":0.5422372221946716},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5348607301712036},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5059365630149841},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.44854727387428284},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4468202292919159},{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.4357706904411316},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4271092116832733},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.42085176706314087},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.33726024627685547},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.31927579641342163},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2827586829662323},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22290891408920288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12460213899612427}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/life13010058","doi":"https://doi.org/10.3390/life13010058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life13010058","pdf_url":"https://www.mdpi.com/2075-1729/13/1/58/pdf?version=1673346141","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},{"id":"pmid:36676007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36676007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9862036","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9862036/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:456f55b1a26e4b46bb5eeae73716c022","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/456f55b1a26e4b46bb5eeae73716c022","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, Vol 13, Iss 1, p 58 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/life13010058","doi":"https://doi.org/10.3390/life13010058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life13010058","pdf_url":"https://www.mdpi.com/2075-1729/13/1/58/pdf?version=1673346141","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6116049213","display_name":null,"funder_award_id":"PJ01591201","funder_id":"https://openalex.org/F4320322035","funder_display_name":"Rural Development Administration"}],"funders":[{"id":"https://openalex.org/F4320322035","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313244652.pdf","grobid_xml":"https://content.openalex.org/works/W4313244652.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W154426487","https://openalex.org/W1966114596","https://openalex.org/W1966697534","https://openalex.org/W1969655939","https://openalex.org/W1987426784","https://openalex.org/W1998867833","https://openalex.org/W1999765859","https://openalex.org/W2002226709","https://openalex.org/W2033797333","https://openalex.org/W2061929833","https://openalex.org/W2063443396","https://openalex.org/W2087223804","https://openalex.org/W2087898570","https://openalex.org/W2104473184","https://openalex.org/W2121628947","https://openalex.org/W2146415848","https://openalex.org/W2167033587","https://openalex.org/W2171071516","https://openalex.org/W2171237698","https://openalex.org/W2757965705","https://openalex.org/W2908388245","https://openalex.org/W2966616897","https://openalex.org/W3032128425","https://openalex.org/W3138477242","https://openalex.org/W3205394071","https://openalex.org/W3206878581","https://openalex.org/W3210703732","https://openalex.org/W3213416179","https://openalex.org/W6606259754"],"related_works":["https://openalex.org/W4401509763","https://openalex.org/W7169877603","https://openalex.org/W4399896860","https://openalex.org/W4410334236","https://openalex.org/W7196929057","https://openalex.org/W4381233951","https://openalex.org/W4408726305","https://openalex.org/W4408991177","https://openalex.org/W3122732949","https://openalex.org/W4403299094"],"abstract_inverted_index":{"Aging,":[0],"and":[1,37,64,76,130,151,171,198],"other":[2],"disease-related":[3],"muscle":[4,18,60,114,125,175,180,196],"disorders":[5],"are":[6,133],"serious":[7],"health":[8],"problems.":[9],"Dexamethasone":[10],"(DEX),":[11],"a":[12,190],"synthetic":[13],"glucocorticoid,":[14],"can":[15,161,172,188],"trigger":[16],"skeletal":[17,139],"atrophy.":[19,40,199],"This":[20],"study":[21],"examined":[22],"the":[23,47,56,82,88,91,103,112,120,144,167],"effects":[24],"of":[25,59,93,106,123,146],"mealworm":[26],"(Tenebrio":[27],"molitor":[28],"larva)":[29],"ethanol":[30],"extract":[31],"(TME)":[32],"on":[33],"C2C12":[34,116],"myoblast":[35],"differentiation":[36,48,95],"DEX-induced":[38,113,174],"myotube":[39,43,163],"TME":[41,52,79,118,142,160,187],"induced":[42],"formation":[44],"compared":[45,86],"to":[46,87],"medium":[49],"(DM)":[50],"group.":[51],"also":[53,101],"significantly":[54],"increased":[55,81],"mRNA":[57],"expression":[58,92,122],"creatine":[61],"kinase":[62,153],"(CKm)":[63],"myogenic":[65,73,94],"regulatory":[66],"factors":[67],"(MRFs),":[68],"such":[69],"as":[70],"myogenin":[71],"(MyoG),":[72],"factor":[74],"(Myf)5,":[75],"MRF4":[77],"(Myf6).":[78],"dramatically":[80],"muscle-specific":[83],"protein,":[84],"MyoG,":[85],"control,":[89],"whereas":[90],"1":[96],"(MyoD)":[97],"remained":[98],"unchanged.":[99],"It":[100],"activated":[102],"mammalian":[104],"target":[105],"rapamycin":[107],"(mTOR)":[108],"signaling":[109,169],"pathway.":[110],"In":[111],"atrophy":[115,176],"model,":[117],"reduced":[119],"gene":[121],"atrogin-1,":[124],"RING":[126],"finger":[127],"protein-1":[128],"(MuRF-1),":[129],"myostatin,":[131],"which":[132],"involved":[134],"in":[135,138],"protein":[136,152],"degradation":[137],"muscles.":[140],"Furthermore,":[141],"elevated":[143],"phosphorylation":[145],"forkhead":[147],"box":[148],"O3":[149],"(FoxO3\u03b1)":[150],"B":[154],"(Akt).":[155],"These":[156],"findings":[157],"suggest":[158],"that":[159],"enhance":[162],"hypertrophy":[164],"by":[165,177,183],"regulating":[166],"mTOR":[168],"pathway,":[170],"rescue":[173],"alleviating":[178],"atrophic":[179],"markers":[181],"mediated":[182],"Akt":[184],"activation.":[185],"Thus,":[186],"be":[189],"potential":[191],"therapeutic":[192],"agent":[193],"for":[194],"treating":[195],"weakness":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-06T00:00:00"}