{"id":"https://openalex.org/W4313244376","doi":"https://doi.org/10.3390/pharmaceutics15010075","title":"Isavuconazole Pharmacokinetics and Pharmacodynamics in Children","display_name":"Isavuconazole Pharmacokinetics and Pharmacodynamics in Children","publication_year":2022,"publication_date":"2022-12-26","ids":{"openalex":"https://openalex.org/W4313244376","doi":"https://doi.org/10.3390/pharmaceutics15010075","pmid":"https://pubmed.ncbi.nlm.nih.gov/36678704","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9865364"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics15010075","doi":"https://doi.org/10.3390/pharmaceutics15010075","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15010075","pdf_url":"https://www.mdpi.com/1999-4923/15/1/75/pdf?version=1672053937","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/15/1/75/pdf?version=1672053937","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061598824","display_name":"Hirsh Elhence","orcid":"https://orcid.org/0000-0002-9151-0553","observed_orcids":["https://orcid.org/0000-0002-9151-0553"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hirsh Elhence","raw_affiliation_strings":["Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA"],"raw_orcid":"https://orcid.org/0000-0002-9151-0553","affiliations":[{"raw_affiliation_string":"Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043886334","display_name":"Kanokporn Mongkolrattanothai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanokporn Mongkolrattanothai","raw_affiliation_strings":["Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074033112","display_name":"Sindhu Mohandas","orcid":"https://orcid.org/0000-0002-8397-6249","observed_orcids":["https://orcid.org/0000-0002-8397-6249"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sindhu Mohandas","raw_affiliation_strings":["Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026635936","display_name":"Michael Noel Neely","orcid":"https://orcid.org/0000-0002-1675-8276","observed_orcids":["https://orcid.org/0000-0002-1675-8276"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael N. Neely","raw_affiliation_strings":["Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA","Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA"],"raw_orcid":"https://orcid.org/0000-0002-1675-8276","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026635936"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.0983,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79101244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.19140000641345978,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isavuconazole","display_name":"isavuconazole","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9570000171661377},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.7680000066757202},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.718999981880188},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.48899999260902405},{"id":"https://openalex.org/keywords/auc-estimation","display_name":"AUC estimation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.5709999799728394},{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":0.7160000205039978},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.925000011920929},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.779308557510376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7562099099159241},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6598365902900696},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6045168042182922},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.5288276076316833},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4610321819782257},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.44250452518463135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4119744300842285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39066290855407715},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.09410625696182251},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics15010075","doi":"https://doi.org/10.3390/pharmaceutics15010075","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15010075","pdf_url":"https://www.mdpi.com/1999-4923/15/1/75/pdf?version=1672053937","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9865364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9865364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:36678704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36678704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a85b1af7cb68401d9864ecde058aa54c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a85b1af7cb68401d9864ecde058aa54c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 15, Iss 1, p 75 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics15010075","doi":"https://doi.org/10.3390/pharmaceutics15010075","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15010075","pdf_url":"https://www.mdpi.com/1999-4923/15/1/75/pdf?version=1672053937","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313244376.pdf","grobid_xml":"https://content.openalex.org/works/W4313244376.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1999521622","https://openalex.org/W2010066166","https://openalex.org/W2016379438","https://openalex.org/W2021298363","https://openalex.org/W2057605178","https://openalex.org/W2102904779","https://openalex.org/W2148605276","https://openalex.org/W2155299664","https://openalex.org/W2157308892","https://openalex.org/W2166734004","https://openalex.org/W2189861011","https://openalex.org/W2751649240","https://openalex.org/W2754519822","https://openalex.org/W2774974184","https://openalex.org/W2779362765","https://openalex.org/W2889930082","https://openalex.org/W2990821920","https://openalex.org/W3100311432","https://openalex.org/W3129166109","https://openalex.org/W3165720081","https://openalex.org/W4206420615","https://openalex.org/W4283721701"],"related_works":["https://openalex.org/W7125132893","https://openalex.org/W7131266930","https://openalex.org/W4389029403","https://openalex.org/W4404345016","https://openalex.org/W4200077799","https://openalex.org/W4220780027","https://openalex.org/W4415405318","https://openalex.org/W7154027064","https://openalex.org/W4407426839","https://openalex.org/W7212144944"],"abstract_inverted_index":{"Isavuconazole":[0],"is":[1],"a":[2,13,38,184,190,194,199],"broad-spectrum":[3],"azole":[4],"anti-fungal":[5],"not":[6],"yet":[7],"approved":[8],"in":[9,25,99,107],"children.":[10],"We":[11,36],"conducted":[12],"retrospective,":[14],"single-center":[15],"review":[16],"of":[17,117,138],"isavuconazole":[18,97],"use":[19],"and":[20,33,55,61,70,82,91,109,111,150,196],"routine":[21],"therapeutic":[22],"drug":[23],"monitoring":[24],"pediatric":[26],"patients,":[27,46],"extracting":[28],"demographic,":[29],"dosing,":[30],"concentration,":[31,186],"mortality":[32,136],"hepatoxicity":[34],"data.":[35],"constructed":[37],"nonparametric":[39],"population":[40],"model":[41],"using":[42],"Pmetrics.":[43],"Of":[44],"26":[45],"19":[47],"(73%)":[48],"were":[49,57,102],"male.":[50],"The":[51,94],"mean":[52],"(SD)":[53],"age":[54],"weight":[56],"12.7":[58],"(5.5)":[59],"years":[60],"50.9":[62],"(26.8)":[63],"kg.":[64],"Eighty":[65],"percent":[66],"received":[67],"between":[68],"9.7":[69],"10.6":[71],"mg/kg":[72],"per":[73],"dose.":[74],"Ten":[75],"(38%)":[76],"subjects":[77],"had":[78,85],"proven":[79],"fungal":[80],"disease":[81],"eight":[83],"(31%)":[84],"probable":[86],"disease,":[87],"mostly":[88],"with":[89,113,143,153,166,173,189],"Candida":[90],"Aspergillus":[92],"spp.":[93],"predicted":[95],"steady-state":[96,144],"concentrations":[98,155],"our":[100],"patients":[101],"similar":[103],"to":[104],"previous":[105],"reports":[106],"children":[108],"adults,":[110],"simulations":[112],"the":[114,179],"proposed":[115],"dosing":[116],"10":[118,176],"mg/kg/dose":[119],"every":[120],"8":[121],"h":[122,177],"for":[123],"2":[124],"days":[125],"followed":[126],"by":[127],"once":[128],"daily":[129,145],"maintenance":[130,181],"matched":[131],"effective":[132],"adult":[133],"exposures.":[134],"Attributable":[135],"(5":[137],"11":[139],"deaths)":[140],"was":[141],"associated":[142],"AUC":[146,169],"<":[147],"60":[148],"mg\u2217h/L":[149],"higher":[151],"AST/ALT":[152],"trough":[154,162,185,197],">":[156],"5":[157],"mg/L.":[158],"Neither":[159],"dose":[160,182],"nor":[161],"alone":[163],"correlated":[164],"well":[165],"AUC,":[167],"but":[168],"can":[170],"be":[171],"estimated":[172],"one":[174],"sample":[175],"after":[178],"first":[180],"or":[183,193],"if":[187],"combined":[188],"Bayesian":[191,200],"approach":[192],"peak":[195],"without":[198],"approach.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-01-06T00:00:00"}