{"id":"https://openalex.org/W4313208366","doi":"https://doi.org/10.55730/1300-0152.2626","title":"The investigation of diverse physiological and therapeutic impact of cellular-based products derived from human cumulus cells","display_name":"The investigation of diverse physiological and therapeutic impact of cellular-based products derived from human cumulus cells","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4313208366","doi":"https://doi.org/10.55730/1300-0152.2626","pmid":"https://pubmed.ncbi.nlm.nih.gov/37529007","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10388000"},"language":"en","primary_location":{"id":"doi:10.55730/1300-0152.2626","doi":"https://doi.org/10.55730/1300-0152.2626","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0152.2626","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=2626&context=biology","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=2626&context=biology","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017489936","display_name":"Derya Buruk\u00e7u","orcid":"https://orcid.org/0000-0002-5178-0620","observed_orcids":["https://orcid.org/0000-0002-5178-0620"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"DERYA BURUK\u00c7U","raw_affiliation_strings":["Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, \u0130stanbul, Turkey","of Genetics and , of Engineering , Yeditepe University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]},{"raw_affiliation_string":"of Genetics and , of Engineering , Yeditepe University , ,","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027591630","display_name":"SEMA YILMAZ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"SEMA YILMAZ","raw_affiliation_strings":["Department of Internal Medical Sciences and - Child Health and Diseases, U\u015fak University, U\u015fak, Turkey","of Sciences and - and , , , of in vitro , and , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medical Sciences and - Child Health and Diseases, U\u015fak University, U\u015fak, Turkey","institution_ids":["https://openalex.org/I204585392"]},{"raw_affiliation_string":"of Sciences and - and , , , of in vitro , and , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027362269","display_name":"Oya Alag\u00f6z","orcid":"https://orcid.org/0000-0003-4160-0961","observed_orcids":["https://orcid.org/0000-0003-4160-0961"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]},{"id":"https://openalex.org/I4210150802","display_name":"Yeditepe University Hospital","ror":"https://ror.org/05vzbfc95","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210150802"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"OYA ALAG\u00d6Z","raw_affiliation_strings":["Department of in vitro Diagnostic, Yeditepe University Medical School and Yeditepe University Hospital, \u0130stanbul, Turkey","of Genetics and , of Engineering , Yeditepe University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of in vitro Diagnostic, Yeditepe University Medical School and Yeditepe University Hospital, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489","https://openalex.org/I4210150802"]},{"raw_affiliation_string":"of Genetics and , of Engineering , Yeditepe University , ,","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022536911","display_name":"Cumhur Kaan Yalt\u0131r\u0131k","orcid":"https://orcid.org/0000-0002-4312-5685","observed_orcids":["https://orcid.org/0000-0002-4312-5685"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]},{"id":"https://openalex.org/I4210110321","display_name":"\u00dcmraniye E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/023wdy559","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210110321"]},{"id":"https://openalex.org/I4210150802","display_name":"Yeditepe University Hospital","ror":"https://ror.org/05vzbfc95","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210150802"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"CUMHUR KAAN YALTIRIK","raw_affiliation_strings":["Department of Neurosurgery, Yeditepe University Medical School and Yeditepe University Hospital, \u0130stanbul, Turkey","Department of Neurosurgery, \u00dcmraniye Training and Research Hospital, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yeditepe University Medical School and Yeditepe University Hospital, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489","https://openalex.org/I4210150802"]},{"raw_affiliation_string":"Department of Neurosurgery, \u00dcmraniye Training and Research Hospital, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4210110321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035316807","display_name":"NEC\u0130P ERKUT ATTAR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"NEC\u0130P ERKUT ATTAR","raw_affiliation_strings":["of Genetics and , of Engineering , Yeditepe University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"of Genetics and , of Engineering , Yeditepe University , ,","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F\u0130KRETT\u0130N \u015eAH\u0130N","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"F\u0130KRETT\u0130N \u015eAH\u0130N","raw_affiliation_strings":["Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039241787","display_name":"Esra Aydemir","orcid":"https://orcid.org/0000-0002-6965-2838","observed_orcids":["https://orcid.org/0000-0002-6965-2838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ESRA AYDEM\u0130R \u00c7OBAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"5","first_page":"400","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.824999988079071},{"id":"https://openalex.org/keywords/nucleus-pulposus-cells","display_name":"nucleus pulposus cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":1.0},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.42100000381469727},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8007674813270569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6692174673080444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6305116415023804},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6130326986312866},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.4962020516395569},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4440733790397644},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4357556700706482},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2447834312915802},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1851935088634491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1761707067489624},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13021746277809143},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11558982729911804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09104770421981812}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.55730/1300-0152.2626","doi":"https://doi.org/10.55730/1300-0152.2626","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0152.2626","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=2626&context=biology","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10388000","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10388000","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10388000/pdf/turkjbiol-46-5-400.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Biol","raw_type":"Text"},{"id":"pmid:37529007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37529007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of biology = Turk biyoloji dergisi","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55730/1300-0152.2626","doi":"https://doi.org/10.55730/1300-0152.2626","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0152.2626","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=2626&context=biology","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330712","display_name":"Yeditepe \u00dcniversitesi","ror":"https://ror.org/025mx2575"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313208366.pdf","grobid_xml":"https://content.openalex.org/works/W4313208366.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1483531844","https://openalex.org/W1583321654","https://openalex.org/W1606979075","https://openalex.org/W1809721560","https://openalex.org/W1964925190","https://openalex.org/W1965752048","https://openalex.org/W1967358869","https://openalex.org/W1969154370","https://openalex.org/W2025371271","https://openalex.org/W2027668519","https://openalex.org/W2031057328","https://openalex.org/W2037745991","https://openalex.org/W2053175780","https://openalex.org/W2060268289","https://openalex.org/W2068969716","https://openalex.org/W2103202233","https://openalex.org/W2109997796","https://openalex.org/W2123381052","https://openalex.org/W2138473567","https://openalex.org/W2142935918","https://openalex.org/W2146344380","https://openalex.org/W2153323265","https://openalex.org/W2232301144","https://openalex.org/W2269652733","https://openalex.org/W2320308628","https://openalex.org/W2325219057","https://openalex.org/W2328868894","https://openalex.org/W2401533062","https://openalex.org/W2405677626","https://openalex.org/W2411126648","https://openalex.org/W2492412236","https://openalex.org/W2581349431","https://openalex.org/W2590272855","https://openalex.org/W2598203207","https://openalex.org/W2605679498","https://openalex.org/W2609586609","https://openalex.org/W2793729526","https://openalex.org/W2794290318","https://openalex.org/W2805516250","https://openalex.org/W2902282736","https://openalex.org/W2907523928","https://openalex.org/W2943215794","https://openalex.org/W2945792041","https://openalex.org/W2973285604","https://openalex.org/W3003950199","https://openalex.org/W3027203647","https://openalex.org/W3041917813","https://openalex.org/W3096394403","https://openalex.org/W3134655784","https://openalex.org/W4211010047"],"related_works":["https://openalex.org/W2052050956","https://openalex.org/W3033817267","https://openalex.org/W1559953871","https://openalex.org/W2153955125","https://openalex.org/W1889147326","https://openalex.org/W2990037441","https://openalex.org/W2140254621","https://openalex.org/W3163807666","https://openalex.org/W2280739577","https://openalex.org/W7100293609"],"abstract_inverted_index":{"Particular":[0],"somatic":[1],"cells,":[2],"namely":[3],"cumulus":[4,33,83,159],"cells":[5,67],"(CCs)":[6],"that":[7,158,194],"support":[8],"the":[9,17,22,25,39,55,63,75,80,108,146,163,189],"oocyte":[10,23],"maturation,":[11],"fertility,":[12],"and":[13,19,90,119,123,133,138,153,165,174],"viability":[14],"by":[15,129],"providing":[16],"nutrients":[18],"energy":[20],"to":[21,37,62,144,188],"envelop":[24],"mammalian":[26],"oocyte.":[27],"In":[28,95],"this":[29],"study,":[30],"discarded":[31],"human":[32,64],"tissues":[34],"were":[35,60,70,127,142],"used":[36,198],"reveal":[38],"value":[40],"of":[41,58,74,77,82,101,121,148,167],"hyaluronic":[42],"acid-rich":[43],"CCs":[44],"on":[45,87,150],"several":[46],"cellular":[47],"events,":[48],"including":[49],"differentiation.":[50],"Conditioned":[51],"media,":[52],"recovered":[53],"from":[54],"primary":[56],"culture":[57],"CCs,":[59],"introduced":[61],"nucleus":[65],"pulposus":[66],"(hNPCs)":[68],"which":[69],"functionally":[71],"distorted":[72],"because":[73],"loss":[76],"chondrogenecity.":[78],"Enlightening":[79],"impact":[81],"conditioned":[84],"media":[85,161],"(CCM)":[86],"wound":[88,151,177],"healing":[89,152],"angiogenesis":[91,173],"was":[92,115,179],"also":[93],"investigated.":[94],"line":[96],"with":[97,105],"these":[98],"goals,":[99],"differentiation":[100,113],"hNPCs":[102],"into":[103],"chondrocytes":[104],"CCM":[106,149,186,195],"as":[107],"basal":[109],"medium":[110],"containing":[111],"traditional":[112],"agents":[114],"induced":[116],"upon":[117],"isolation":[118],"characterization":[120],"hCCs":[122],"hNPCs.":[124,168],"The":[125],"effects":[126],"detected":[128,180],"differentiation-specific":[130],"cell":[131],"stains":[132],"gene":[134],"expression":[135],"analyses.":[136],"Scratch":[137],"tube":[139],"formation":[140],"assays":[141],"performed":[143],"detect":[145],"effect":[147],"angiogenesis.":[154],"Our":[155],"results":[156],"showed":[157],"cell-conditioned":[160],"promoted":[162],"chondrogenesis":[164],"osteogenesis":[166],"A":[169],"significant":[170],"increase":[171],"in":[172,182,185,199],"ability":[175],"for":[176],"closure":[178],"only":[181],"groups":[183],"cultured":[184],"compared":[187],"control.":[190],"These":[191],"findings":[192],"demonstrated":[193],"might":[196],"be":[197],"therapeutics.":[200]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-01-06T00:00:00"}
