{"id":"https://openalex.org/W4312998196","doi":"https://doi.org/10.2298/sarh220308113i","title":"Real-world data of cardiotoxicity during long-term therapy with trastuzumab in human epidermal growth factor receptor-2-positive metastatic breast cancer","display_name":"Real-world data of cardiotoxicity during long-term therapy with trastuzumab in human epidermal growth factor receptor-2-positive metastatic breast cancer","publication_year":2022,"publication_date":"2022-12-16","ids":{"openalex":"https://openalex.org/W4312998196","doi":"https://doi.org/10.2298/sarh220308113i"},"language":"en","primary_location":{"id":"doi:10.2298/sarh220308113i","doi":"https://doi.org/10.2298/sarh220308113i","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh220308113i","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81792200113I","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81792200113I","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018237103","display_name":"Marina Iljovska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Marina Iljovska","raw_affiliation_strings":["University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104078165","display_name":"Emilija Lazareva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Emilija Lazareva","raw_affiliation_strings":["University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009853299","display_name":"Snezhana Smichkoska","orcid":"https://orcid.org/0000-0002-2228-170X","observed_orcids":["https://orcid.org/0000-0002-2228-170X"]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Snezhana Smichkoska","raw_affiliation_strings":["University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039657897","display_name":"Violeta Klisarovska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Violeta Klisarovska","raw_affiliation_strings":["Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of Gynecologic Oncology and Brachytherapy, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of Gynecologic Oncology and Brachytherapy, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083582365","display_name":"Igor Stojkovski","orcid":"https://orcid.org/0000-0002-5770-2578","observed_orcids":["https://orcid.org/0000-0002-5770-2578"]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Igor Stojkovski","raw_affiliation_strings":["Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of CNS, Bone Tumors and Skin Cancer, Skopje, North Macedonia;","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of CNS, Bone Tumors and Skin Cancer, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080762102","display_name":"Gordana Petkovska","orcid":"https://orcid.org/0009-0002-1129-0237","observed_orcids":["https://orcid.org/0009-0002-1129-0237"]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Gordana Petkovska","raw_affiliation_strings":["University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Radiotherapy and Oncology, Department of Breast and Thorax Malignancies, Skopje, North Macedonia + Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087148612","display_name":"Nenad Mitreski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267927","display_name":"University Clinic for Radiotherapy and Oncology","ror":"https://ror.org/052m9k994","country_code":"MK","type":"education","lineage":["https://openalex.org/I4405267927"]},{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":true,"raw_author_name":"Nenad Mitreski","raw_affiliation_strings":["Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of Gastrointestinal Malignancies, Skopje, North Macedonia","Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia + University Clinic for Radiotherapy and Oncology, Department of Gastrointestinal Malignancies, Skopje, North Macedonia","institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"]},{"raw_affiliation_string":"Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia;","institution_ids":["https://openalex.org/I76245029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087148612"],"corresponding_institution_ids":["https://openalex.org/I4405267927","https://openalex.org/I76245029"],"apc_list":null,"apc_paid":null,"fwci":0.1749,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42489339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"151","issue":"1-2","first_page":"26","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.7310000061988831},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.996999979019165},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.7699999809265137},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9527606964111328},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9330447912216187},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.791053056716919},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7244466543197632},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.7020355463027954},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6871973872184753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6366778612136841},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5455356240272522},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.48609209060668945},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.482822984457016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43746837973594666},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35903400182724},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33691030740737915},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.13668319582939148}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2298/sarh220308113i","doi":"https://doi.org/10.2298/sarh220308113i","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh220308113i","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81792200113I","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:53c39b1de24145babc702452f5b6ee82","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/53c39b1de24145babc702452f5b6ee82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 1-2, Pp 26-31 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2298/sarh220308113i","doi":"https://doi.org/10.2298/sarh220308113i","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh220308113i","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81792200113I","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312998196.pdf","grobid_xml":"https://content.openalex.org/works/W4312998196.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1966021078","https://openalex.org/W1969345980","https://openalex.org/W2000598990","https://openalex.org/W2130900820","https://openalex.org/W2133939298","https://openalex.org/W2145298865","https://openalex.org/W2158158704","https://openalex.org/W2243356516","https://openalex.org/W2322068229","https://openalex.org/W2800400752","https://openalex.org/W2913899849","https://openalex.org/W2996630100","https://openalex.org/W2999536665","https://openalex.org/W3012380787","https://openalex.org/W3045656459","https://openalex.org/W3083694235","https://openalex.org/W3128646645","https://openalex.org/W3138977263","https://openalex.org/W3165720345","https://openalex.org/W3203425221","https://openalex.org/W4205365281","https://openalex.org/W4206757514"],"related_works":["https://openalex.org/W4385476398","https://openalex.org/W2907853190","https://openalex.org/W2038163957","https://openalex.org/W4416615742","https://openalex.org/W2677987541","https://openalex.org/W2099545363","https://openalex.org/W3003660073","https://openalex.org/W3032103578","https://openalex.org/W2558952163","https://openalex.org/W3118577092"],"abstract_inverted_index":{"Introduction/Objective.":[0],"This":[1],"study":[2],"aims":[3],"to":[4],"investigate":[5],"the":[6,50,53,59,68,71,83,101,104,108,122,164,188,192,198,203,213],"cardiotoxicity":[7],"of":[8,23,39,49,58,62,75,110,131,159,194,205,216,227],"long-term":[9,36,228],"therapy":[10,64,133,230],"with":[11,15,26,80,197],"trastuzumab":[12,37,81,123,132,229],"in":[13,67,82,103,163,231],"patients":[14,25,34,51,121,237],"HER-2-positive":[16,28],"metastatic":[17,27,84,234],"breast":[18,29,235],"cancer.":[19],"Methods.":[20],"A":[21],"total":[22],"48":[24],"cancer":[30,236],"were":[31,52,144],"analyzed.":[32],"The":[33,46,128,140,156,221],"received":[35],"(time":[38],"application":[40,61],"was":[41,88,125,135],"longer":[42],"than":[43],"20":[44],"months).":[45],"analyzed":[47],"characteristics":[48],"following:":[54],"age,":[55],"initial":[56],"stage":[57],"disease,":[60],"anti-HER-2":[63,206],"and":[65,73,106,151],"anthracyclines":[66],"adjuvant":[69],"setting,":[70],"number":[72],"type":[74],"applied":[76],"systemic":[77],"therapies":[78],"concomitant":[79],"setting.":[85],"Cardiac":[86],"toxicity":[87],"assessed":[89],"using":[90,178],"left":[91],"ventricular":[92],"ejection":[93],"fraction":[94],"(LVEF)":[95],"values":[96,143,158,186,201],"at":[97,100,107,187,202],"three":[98,165],"time-points:":[99],"beginning,":[102],"middle,":[105],"end":[109,189,193],"treatment":[111,124,207],"period":[112],"for":[113],"each":[114],"patient":[115],"separately.":[116],"Results.":[117],"In":[118],"17":[119],"(35.4%)":[120],"temporary":[126],"discontinued.":[127],"average":[129],"time":[130],"interval":[134],"52.2":[136],"?":[137,146,149,153,218],"23.5":[138],"months.":[139],"mean":[141,157,184,199],"LVEF":[142,160,185,200,217],"66.73":[145],"7.02%,":[147],"64.62":[148],"5.7%,":[150],"63.44":[152],"6.1%,":[154],"respectively.":[155],"differed":[161],"significantly":[162,182],"observed":[166],"time-points":[167],"(F":[168],"=":[169,172,209],"4.9":[170],"p":[171],"0.009).":[173],"Post":[174],"hoc":[175],"pairwise":[176],"comparison,":[177],"Bonferroni":[179],"correction,":[180],"confirmed":[181],"lower":[183],"point":[190],"(at":[191],"treatment)":[195],"compared":[196],"beginning":[204],"(p":[208],"0.019),":[210],"but":[211],"within":[212],"reference":[214],"range":[215],"50%.":[219],"Conclusion.":[220],"data":[222],"confirm":[223],"good":[224],"safety":[225],"profile":[226],"HER-2":[232],"positive":[233],"considering":[238],"cardiotoxicity.":[239]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-01-05T00:00:00"}
