{"id":"https://openalex.org/W4312920134","doi":"https://doi.org/10.1189/jlb.72.5.995","title":"IL-12-dependent nuclear factor-\u03baB activation leads to de novo synthesis and release of IL-8 and TNF-\u03b1 in human neutrophils","display_name":"IL-12-dependent nuclear factor-\u03baB activation leads to de novo synthesis and release of IL-8 and TNF-\u03b1 in human neutrophils","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W4312920134","doi":"https://doi.org/10.1189/jlb.72.5.995","mag":"2185588490","pmid":"https://pubmed.ncbi.nlm.nih.gov/12429722"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.72.5.995","doi":"https://doi.org/10.1189/jlb.72.5.995","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.72.5.995","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004492595","display_name":"Futwan A Al-Mohanna","orcid":"https://orcid.org/0000-0001-5931-0837","observed_orcids":["https://orcid.org/0000-0001-5931-0837"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Futwan Al-Mohanna","raw_affiliation_strings":["Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040854252","display_name":"Soad M. Saleh","orcid":"https://orcid.org/0009-0008-3368-3465","observed_orcids":["https://orcid.org/0009-0008-3368-3465"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Soad Saleh","raw_affiliation_strings":["Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108388100","display_name":"Ranjit S. Parhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ranjit S Parhar","raw_affiliation_strings":["Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052375316","display_name":"Kate S. Collison","orcid":"https://orcid.org/0000-0002-0691-6859","observed_orcids":["https://orcid.org/0000-0002-0691-6859"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Kate Collison","raw_affiliation_strings":["Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004492595"],"corresponding_institution_ids":["https://openalex.org/I2800965796"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.7378,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.69302186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"72","issue":"5","first_page":"995","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.1500999927520752,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9679999947547913},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8349999785423279},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7179999947547913},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bapta-am","display_name":"BAPTA-AM","score":0.847000002861023},{"id":"https://openalex.org/keywords/calcium-chelation","display_name":"calcium chelation","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6428284645080566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6250874996185303},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.521324098110199},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5192306637763977},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4908474087715149},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.43815895915031433},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41555023193359375},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4111136496067047},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40513312816619873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38851335644721985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3507251739501953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2288309931755066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1861417293548584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08020952343940735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1189/jlb.72.5.995","doi":"https://doi.org/10.1189/jlb.72.5.995","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.72.5.995","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:12429722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12429722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"mag:2185588490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12429722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W146127512","https://openalex.org/W207029473","https://openalex.org/W1482532981","https://openalex.org/W1543425313","https://openalex.org/W1559441662","https://openalex.org/W1590514634","https://openalex.org/W1821778272","https://openalex.org/W1825540737","https://openalex.org/W1965679299","https://openalex.org/W1970140843","https://openalex.org/W1975466690","https://openalex.org/W1976802937","https://openalex.org/W1979514172","https://openalex.org/W1981448275","https://openalex.org/W1985456177","https://openalex.org/W1995700626","https://openalex.org/W2003824193","https://openalex.org/W2004998168","https://openalex.org/W2006014863","https://openalex.org/W2007037974","https://openalex.org/W2023668184","https://openalex.org/W2026694052","https://openalex.org/W2027260180","https://openalex.org/W2027569621","https://openalex.org/W2029513848","https://openalex.org/W2030592815","https://openalex.org/W2035671081","https://openalex.org/W2042166751","https://openalex.org/W2057093252","https://openalex.org/W2058516438","https://openalex.org/W2060768566","https://openalex.org/W2061988659","https://openalex.org/W2066868766","https://openalex.org/W2069372382","https://openalex.org/W2069496628","https://openalex.org/W2070853191","https://openalex.org/W2081483716","https://openalex.org/W2086309499","https://openalex.org/W2094646101","https://openalex.org/W2096996062","https://openalex.org/W2101093438","https://openalex.org/W2102156468","https://openalex.org/W2104439753","https://openalex.org/W2104899797","https://openalex.org/W2108473659","https://openalex.org/W2158361318","https://openalex.org/W2161485037","https://openalex.org/W2188769257","https://openalex.org/W2293864489","https://openalex.org/W2419090891","https://openalex.org/W4234332479","https://openalex.org/W4313377034","https://openalex.org/W6823113895"],"related_works":["https://openalex.org/W2185588490","https://openalex.org/W2158361318","https://openalex.org/W1908743184","https://openalex.org/W2415041345","https://openalex.org/W2149700993","https://openalex.org/W2095370288","https://openalex.org/W1909047751","https://openalex.org/W4313381075","https://openalex.org/W2088953386","https://openalex.org/W2014770545"],"abstract_inverted_index":{"The":[0],"cytokine":[1],"interleukin":[2],"(IL)-12":[3],"plays":[4],"a":[5,24,87,120,128,141],"bridging":[6],"role":[7,130],"between":[8,144],"innate":[9],"and":[10,50,60,75,109,113,122,139,148,153],"adaptive":[11],"immunity.":[12],"Here,":[13],"we":[14],"demonstrate":[15,127],"that":[16,84],"treatment":[17],"of":[18,38,53,66,111,136,151],"neutrophils":[19,138],"with":[20,47],"IL-12":[21,85,103,132],"leads":[22],"to":[23],"transient":[25,147],"increase":[26,89],"in":[27,63,90,119,133],"intracellular-free":[28],"calcium":[29,69],"[Ca(+)(+)](i)":[30,146],"levels,":[31,93],"which":[32,94],"is":[33,45,61],"necessary":[34],"for":[35,131],"the":[36,48,54,64,67,76,98,105,134,149],"production":[37,44,78,110],"reactive":[39],"oxygen":[40],"metabolites":[41],"(ROM).":[42],"This":[43],"associated":[46],"activation":[49,135],"nuclear":[51,57],"translocation":[52],"transcription":[55],"factor":[56,58,116],"(NF)-kappaB":[59],"inhibited":[62],"presence":[65],"intracellular":[68],"chelator":[70],"1,2-bis(O-amminophenoxy)":[71],"ethane-N,N-N',N'-tetraacetic":[72],"acid-acetoxymethyl":[73],"ester":[74],"ROM":[77],"inhibitor":[79],"diphenyl":[80],"iodonium.":[81],"We":[82],"show":[83],"causes":[86],"significant":[88],"total":[91],"mRNA":[92],"appear":[95],"dependent":[96],"on":[97],"generated":[99],"ROM.":[100],"In":[101],"addition":[102],"induces":[104],"de":[106],"novo":[107],"synthesis":[108],"IL-8":[112,152],"tumor":[114],"necrosis":[115],"alpha":[117],"(TNF-alpha)":[118],"calcium-":[121],"ROM-dependent":[123,142],"manner.":[124],"Our":[125],"data":[126],"direct":[129],"human":[137],"suggest":[140],"interplay":[143],"IL-12-induced":[145],"release":[150],"TNF-alpha":[154],"through":[155],"NF-kappaB":[156],"activation.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-01-05T00:00:00"}