{"id":"https://openalex.org/W4312901199","doi":"https://doi.org/10.54307/nwmj.2022.63835","title":"Cytotoxic effects of calcitriol on osteosarcoma cells","display_name":"Cytotoxic effects of calcitriol on osteosarcoma cells","publication_year":2022,"publication_date":"2022-10-02","ids":{"openalex":"https://openalex.org/W4312901199","doi":"https://doi.org/10.54307/nwmj.2022.63835"},"language":"en","primary_location":{"id":"doi:10.54307/nwmj.2022.63835","doi":"https://doi.org/10.54307/nwmj.2022.63835","is_oa":true,"landing_page_url":"https://doi.org/10.54307/nwmj.2022.63835","pdf_url":"https://nwmedj.org/article/download/37/37","source":{"id":"https://openalex.org/S4387286917","display_name":"Northwestern Medical Journal","issn_l":"2979-9538","issn":["2979-9538"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northwestern Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://nwmedj.org/article/download/37/37","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071280773","display_name":"H\u00fcmeyra \u00c7elik","orcid":"https://orcid.org/0000-0002-3394-2438","observed_orcids":["https://orcid.org/0000-0002-3394-2438"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fcmeyra \u00c7elik","raw_affiliation_strings":["Bolu Abant Izzet Baysal University, Department of Physiology, Bolu, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3394-2438","affiliations":[{"raw_affiliation_string":"Bolu Abant Izzet Baysal University, Department of Physiology, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020870876","display_name":"Ayhan \u00c7etinkaya","orcid":"https://orcid.org/0000-0002-8212-7149","observed_orcids":["https://orcid.org/0000-0002-8212-7149"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ayhan \u00c7etinkaya","raw_affiliation_strings":["Bolu Abant Izzet Baysal University, Department of Physiology, Bolu, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8212-7149","affiliations":[{"raw_affiliation_string":"Bolu Abant Izzet Baysal University, Department of Physiology, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]},{"author_position":"last","author":{"id":null,"display_name":"\u0130lhan \u00c7elik","orcid":"https://orcid.org/0000-0003-3709-2511","observed_orcids":["https://orcid.org/0000-0003-3709-2511"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130lhan \u00c7elik","raw_affiliation_strings":["Bolu Abant Izzet Baysal University, Department of Orthopedics and Traumatology, Bolu, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-3709-2511","affiliations":[{"raw_affiliation_string":"Bolu Abant Izzet Baysal University, Department of Orthopedics and Traumatology, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76973811"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":"163","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.7639999985694885},{"id":"https://openalex.org/keywords/vitamin-d-analogs","display_name":"vitamin D analogs","score":0.6489999890327454},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.8994567394256592},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.629314661026001},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.585176408290863},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5709675550460815},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5239341855049133},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4834178686141968},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.47298917174339294},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4175404906272888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41539159417152405},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3935709595680237},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39033830165863037},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3783886730670929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36664843559265137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3277361989021301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32699108123779297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30618780851364136},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.2132219672203064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15458989143371582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.54307/nwmj.2022.63835","doi":"https://doi.org/10.54307/nwmj.2022.63835","is_oa":true,"landing_page_url":"https://doi.org/10.54307/nwmj.2022.63835","pdf_url":"https://nwmedj.org/article/download/37/37","source":{"id":"https://openalex.org/S4387286917","display_name":"Northwestern Medical Journal","issn_l":"2979-9538","issn":["2979-9538"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northwestern Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3545e365ef234c978026ebd269f9d51f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3545e365ef234c978026ebd269f9d51f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Northwestern Medical Journal, Vol 2, Iss 3 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.54307/nwmj.2022.63835","doi":"https://doi.org/10.54307/nwmj.2022.63835","is_oa":true,"landing_page_url":"https://doi.org/10.54307/nwmj.2022.63835","pdf_url":"https://nwmedj.org/article/download/37/37","source":{"id":"https://openalex.org/S4387286917","display_name":"Northwestern Medical Journal","issn_l":"2979-9538","issn":["2979-9538"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northwestern Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312901199.pdf","grobid_xml":"https://content.openalex.org/works/W4312901199.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1814922229","https://openalex.org/W2011528548","https://openalex.org/W2020994990","https://openalex.org/W2024389772","https://openalex.org/W2026781999","https://openalex.org/W2051351379","https://openalex.org/W2056866215","https://openalex.org/W2106402853","https://openalex.org/W2120446217","https://openalex.org/W2136399690","https://openalex.org/W2150530981","https://openalex.org/W2513951655","https://openalex.org/W2796593272","https://openalex.org/W2802593900","https://openalex.org/W2898684784","https://openalex.org/W2937546955","https://openalex.org/W2946828871","https://openalex.org/W3084283392","https://openalex.org/W3107471288","https://openalex.org/W3170090128","https://openalex.org/W3211512462","https://openalex.org/W4283582970"],"related_works":["https://openalex.org/W795673820","https://openalex.org/W1586408895","https://openalex.org/W2720197837","https://openalex.org/W4393313255","https://openalex.org/W2397547070","https://openalex.org/W3080877836","https://openalex.org/W3165126305","https://openalex.org/W1858522507","https://openalex.org/W4378882536","https://openalex.org/W2155501835"],"abstract_inverted_index":{"Aim:":[0],"It":[1],"was":[2,69,81,118],"aimed":[3],"to":[4,71,120,126,158],"examine":[5],"the":[6,16,42,72,127,135],"effect":[7,86,97],"of":[8,67,98,138],"calcitriol":[9,68,99],"which":[10],"has":[11],"known":[12],"anticancer":[13],"activities,":[14],"on":[15],"osteosarcoma":[17],"cell":[18],"line":[19],"SAOS-2":[20,23],"cells":[21,24,43,56,73,106],"[1,25(OH)2D3].Methods:":[22],"were":[25,44,49,57,91,107],"grown":[26],"in":[27,29,33,104,114,146,152],"culture":[28,31],"conventional":[30],"flasks":[32],"DMEM":[34],"medium":[35],"at":[36,101],"37\u00b0C":[37],"and":[38,62,87,149,160],"5%":[39],"CO2.":[40],"When":[41],"70-80%":[45],"confluent,":[46],"morphological":[47],"changes":[48],"examined":[50],"under":[51],"an":[52],"inverted":[53],"microscope.":[54],"The":[55,96],"passaged":[58],"into":[59],"96":[60],"microplates,":[61],"after":[63],"passage,":[64],"different":[65,102],"concentrations":[66,103],"applied":[70,100],"(0.1;":[74],"0.5;":[75],"1;":[76],"5;":[77],"10;":[78],"25":[79,111],"nM/ml)":[80],"done.":[82],"After":[83],"administration,":[84],"cytotoxic":[85],"proliferation":[88,90,117],"rates/cell":[89],"analyzed":[92],"by":[93],"MTT":[94],"method.Results:":[95],"cultured":[105],"0.1,":[108],"1,":[109],"10,":[110],"nM/ml":[112],"doses,":[113],"these":[115],"groups":[116],"found":[119],"be":[121,143],"statistically":[122],"significantly":[123],"reduced":[124],"compared":[125],"control":[128],"group":[129],"(p\u22640.05).Conclusion:":[130],"Our":[131],"data":[132],"imply":[133],"that":[134],"antiproliferative":[136],"effects":[137],"vitamin":[139],"D":[140],"applications":[141],"can":[142],"benefited":[144],"from":[145],"exosomal,":[147],"combined":[148],"supportive":[150],"treatments":[151],"osteosarcoma.":[153],"Further":[154],"trials":[155],"are":[156],"warranted":[157],"confirm":[159],"validate":[161],"our":[162],"findings.":[163]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-05T00:00:00"}
