{"id":"https://openalex.org/W4312747745","doi":"https://doi.org/10.33549/physiolres.930432","title":"Human ATP-binding cassette (ABC) transporters and lipoprotein metabolism.","display_name":"Human ATP-binding cassette (ABC) transporters and lipoprotein metabolism.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W4312747745","doi":"https://doi.org/10.33549/physiolres.930432","mag":"2182243624","pmid":"https://pubmed.ncbi.nlm.nih.gov/15209530"},"language":"en","primary_location":{"id":"doi:10.33549/physiolres.930432","doi":"https://doi.org/10.33549/physiolres.930432","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.930432","pdf_url":"https://doi.org/10.33549/physiolres.930432","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.33549/physiolres.930432","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071884101","display_name":"Jana Stefkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J \u0160tefkov\u00e1","raw_affiliation_strings":["Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021269981","display_name":"R. Poledne","orcid":"https://orcid.org/0000-0003-2453-6611","observed_orcids":["https://orcid.org/0000-0003-2453-6611"]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"R Poledne","raw_affiliation_strings":["Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091695483","display_name":"Jaroslav Alois Hubacek","orcid":"https://orcid.org/0000-0001-6537-1353","observed_orcids":["https://orcid.org/0000-0001-6537-1353"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"JA Hub\u00e1\u010dek","raw_affiliation_strings":["Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic","Institute of Physiology , Academy of Sciences of the Czech Republic , Prague , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Center for Experimental Cardiovascular Research, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]},{"raw_affiliation_string":"Institute of Physiology , Academy of Sciences of the Czech Republic , Prague , Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":800,"currency":"EUR","value_usd":862},"apc_paid":{"value":800,"currency":"EUR","value_usd":862},"fwci":6.4169,"has_fulltext":true,"cited_by_count":173,"citation_normalized_percentile":{"value":0.98560115,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"53","issue":"3","first_page":"235","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.375,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.9150000214576721},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/abcg5","display_name":"ABCG5","score":0.8500000238418579},{"id":"https://openalex.org/keywords/abcg8","display_name":"ABCG8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tangier-disease","display_name":"Tangier disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sitosterolemia","display_name":"sitosterolemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.6639999747276306},{"id":"https://openalex.org/keywords/genetic-disorders","display_name":"genetic disorders","score":0.46000000834465027},{"id":"https://openalex.org/keywords/hdl-deficiency","display_name":"HDL deficiency","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.9250507354736328},{"id":"https://openalex.org/C2779982054","wikidata":"https://www.wikidata.org/wiki/Q1442621","display_name":"Tangier disease","level":5,"score":0.8840683698654175},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.774786114692688},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6448755264282227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5759968161582947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5476977229118347},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4330018162727356},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2930038571357727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21806466579437256}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.33549/physiolres.930432","doi":"https://doi.org/10.33549/physiolres.930432","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.930432","pdf_url":"https://doi.org/10.33549/physiolres.930432","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},{"id":"pmid:15209530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15209530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological research","raw_type":"Journal Article"},{"id":"mag:2182243624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15209530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.33549/physiolres.930432","doi":"https://doi.org/10.33549/physiolres.930432","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.930432","pdf_url":"https://doi.org/10.33549/physiolres.930432","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312747745.pdf","grobid_xml":"https://content.openalex.org/works/W4312747745.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W183828014","https://openalex.org/W326686267","https://openalex.org/W1483242733","https://openalex.org/W1565854032","https://openalex.org/W1580565903","https://openalex.org/W1591670239","https://openalex.org/W1607399348","https://openalex.org/W1737345100","https://openalex.org/W1751757376","https://openalex.org/W1829281532","https://openalex.org/W1860908381","https://openalex.org/W1908881400","https://openalex.org/W1956702905","https://openalex.org/W1971274721","https://openalex.org/W1986381180","https://openalex.org/W1989188411","https://openalex.org/W1991544676","https://openalex.org/W1993447679","https://openalex.org/W2000173643","https://openalex.org/W2010623159","https://openalex.org/W2011755553","https://openalex.org/W2011867546","https://openalex.org/W2018910159","https://openalex.org/W2020930773","https://openalex.org/W2028533496","https://openalex.org/W2030988632","https://openalex.org/W2036021040","https://openalex.org/W2037074028","https://openalex.org/W2037103758","https://openalex.org/W2037167329","https://openalex.org/W2045042938","https://openalex.org/W2046583732","https://openalex.org/W2046797281","https://openalex.org/W2051463254","https://openalex.org/W2055522214","https://openalex.org/W2065263199","https://openalex.org/W2069540409","https://openalex.org/W2071006116","https://openalex.org/W2075087933","https://openalex.org/W2085295869","https://openalex.org/W2090064498","https://openalex.org/W2097878215","https://openalex.org/W2098498572","https://openalex.org/W2108293406","https://openalex.org/W2110670175","https://openalex.org/W2110790042","https://openalex.org/W2119468178","https://openalex.org/W2136615212","https://openalex.org/W2141220818","https://openalex.org/W2142024216","https://openalex.org/W2144693938","https://openalex.org/W2146281408","https://openalex.org/W2158031669","https://openalex.org/W2162097287","https://openalex.org/W2189600589","https://openalex.org/W2252872720","https://openalex.org/W2317841552","https://openalex.org/W2332525086"],"related_works":["https://openalex.org/W2182243624","https://openalex.org/W2161926177","https://openalex.org/W2169687779","https://openalex.org/W1908587496","https://openalex.org/W1965380608","https://openalex.org/W7097181977","https://openalex.org/W1694784217","https://openalex.org/W2138657570","https://openalex.org/W2107919309","https://openalex.org/W7100380902"],"abstract_inverted_index":{"The":[0,35,80,165],"ATP-binding":[1],"cassette":[2],"(ABC)":[3],"superfamily":[4],"of":[5,12,21,43,48,65,85,96,144,158],"active":[6],"transporters":[7,37,98],"involves":[8],"a":[9,19,41,77,139],"large":[10],"number":[11],"functionally":[13],"diverse":[14],"transmembrane":[15,87],"proteins.":[16,34],"They":[17],"transport":[18,70],"variety":[20,42],"substrates":[22,44],"including":[23],"amino":[24],"acids,":[25],"lipids,":[26],"inorganic":[27],"ions,":[28],"peptides,":[29],"saccharides,":[30],"metals,":[31],"drugs,":[32],"and":[33,46,89,130,155,169],"ABC":[36,82],"not":[38],"only":[39],"move":[40],"into":[45],"out":[47],"the":[49,63,71,74,148],"cell,":[50],"but":[51],"also":[52,54],"are":[53,136],"involved":[55],"in":[56,94,112,120,147],"intracellular":[57],"compartmental":[58],"transport.":[59],"Energy":[60],"derived":[61],"from":[62],"hydrolysis":[64],"ATP":[66],"is":[67],"used":[68],"to":[69],"substrate":[72],"across":[73],"membrane":[75],"against":[76],"concentration":[78],"gradient.":[79],"typical":[81],"transporter":[83],"consists":[84],"two":[86,90],"domains":[88],"nucleotide-binding":[91],"domains.":[92],"Defects":[93],"14":[95],"these":[97],"cause":[99,122,160],"13":[100],"genetic":[101],"diseases":[102],"(cystic":[103],"fibrosis,":[104],"Stargardt":[105],"disease,":[106,109],"adrenoleukodystrophy,":[107],"Tangier":[108,128],"etc.).":[110],"Mutations":[111,119],"three":[113],"genes":[114],"affect":[115],"lipid":[116],"levels":[117],"expressively.":[118],"ABCA1":[121],"severe":[123,140],"HDL":[124],"deficiency":[125,141],"syndromes":[126],"called":[127],"disease":[129],"familial":[131],"high-density":[132,145],"lipoprotein":[133,146],"deficiency,":[134],"which":[135,159],"characterized":[137],"by":[138],"or":[142],"absence":[143],"plasma.":[149],"Two":[150],"other":[151],"ABCG":[152],"transporters,":[153],"ABCG5":[154],"ABCG8,":[156],"mutations":[157],"sitosterolemia,":[161],"have":[162],"been":[163],"identified.":[164],"affected":[166],"individuals":[167],"absorb":[168],"retain":[170],"plant":[171],"sterols,":[172],"as":[173,175],"well":[174],"shellfish":[176],"sterols.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-05T00:00:00"}