{"id":"https://openalex.org/W4312428241","doi":"https://doi.org/10.1189/jlb.71.6.957","title":"Selective up-regulation of phospholipase C-\u03b22 during granulocytic differentiation of normal and leukemic hematopoietic progenitors","display_name":"Selective up-regulation of phospholipase C-\u03b22 during granulocytic differentiation of normal and leukemic hematopoietic progenitors","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W4312428241","doi":"https://doi.org/10.1189/jlb.71.6.957","mag":"2185122408","pmid":"https://pubmed.ncbi.nlm.nih.gov/12050180"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.71.6.957","doi":"https://doi.org/10.1189/jlb.71.6.957","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.71.6.957","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069715759","display_name":"Valeria Bertagnolo","orcid":"https://orcid.org/0000-0002-4742-2302","observed_orcids":["https://orcid.org/0000-0002-4742-2302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria Bertagnolo","raw_affiliation_strings":["Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088919162","display_name":"Marco Marchisio","orcid":"https://orcid.org/0000-0003-3058-3422","observed_orcids":["https://orcid.org/0000-0003-3058-3422"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Marco Marchisio","raw_affiliation_strings":["Department of Biomorphology, University \u201cG.D'Annunzio\u201d , Chieti, Italy","Department of Pathology, Uniformed Services University of the Health Sciences , Bethesda, Maryland","Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomorphology, University \u201cG.D'Annunzio\u201d , Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences , Bethesda, Maryland","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005222266","display_name":"Sabina Pierpaoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabina Pierpaoli","raw_affiliation_strings":["Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049011266","display_name":"Maria Luisa Colamussi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Luisa Colamussi","raw_affiliation_strings":["Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042510782","display_name":"Federica Brugnoli","orcid":"https://orcid.org/0000-0001-6658-9629","observed_orcids":["https://orcid.org/0000-0001-6658-9629","https://orcid.org/0000-0002-6934-9396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federica Brugnoli","raw_affiliation_strings":["Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028913158","display_name":"Giuseppe Visani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Visani","raw_affiliation_strings":["L.A. Seragnoli Institute of Haematology, University of Bologna , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L.A. Seragnoli Institute of Haematology, University of Bologna , Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043662372","display_name":"Giorgio Zauli","orcid":"https://orcid.org/0000-0002-3750-8698","observed_orcids":["https://orcid.org/0000-0002-3750-8698"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Zauli","raw_affiliation_strings":["Department of Normal Human Morphology, University of Trieste , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Normal Human Morphology, University of Trieste , Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028358932","display_name":"Silvano Capitani","orcid":"https://orcid.org/0000-0003-2795-6814","observed_orcids":["https://orcid.org/0000-0003-2795-6814"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvano Capitani","raw_affiliation_strings":["MIUR ICSI (Interdisciplinary Center for the Study of Inflammation), University of Ferrara , Italy","Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIUR ICSI (Interdisciplinary Center for the Study of Inflammation), University of Ferrara , Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology , Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028358932"],"corresponding_institution_ids":["https://openalex.org/I201324441"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.2871,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.45989394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"71","issue":"6","first_page":"957","last_page":"965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-c-beta2","display_name":"PLC\u03b22","score":0.9639999866485596},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nb4-cells","display_name":"NB4 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neutrophil-maturation","display_name":"neutrophil maturation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/leukemic-blasts","display_name":"leukemic blasts","score":0.5529999732971191},{"id":"https://openalex.org/keywords/differentiation-markers","display_name":"differentiation markers","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7588539123535156},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7392272353172302},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6903207898139954},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.6882928609848022},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6360667943954468},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.627609372138977},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6133953332901001},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6004300117492676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.523554265499115},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5200238227844238},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4910757541656494},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.48138001561164856},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47432467341423035},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47380250692367554},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4560317099094391},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4182668626308441},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3637998700141907},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.31743085384368896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29640519618988037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17618617415428162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05277082324028015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004963","descriptor_name":"Estrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1189/jlb.71.6.957","doi":"https://doi.org/10.1189/jlb.71.6.957","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.71.6.957","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:12050180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12050180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.560.4230","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.560.4230","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jleukbio.org/content/71/6/957.full.pdf","raw_type":"text"},{"id":"pmh:oai:sfera.unife.it:11392/1199494","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/1199494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2185122408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12050180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324162","display_name":"Universit\u00e0 degli Studi di Ferrara","ror":"https://ror.org/041zkgm14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W6670230","https://openalex.org/W74606824","https://openalex.org/W188006079","https://openalex.org/W237249694","https://openalex.org/W1553544241","https://openalex.org/W1555554937","https://openalex.org/W1588479784","https://openalex.org/W1589900156","https://openalex.org/W1958742527","https://openalex.org/W1981182586","https://openalex.org/W1982712788","https://openalex.org/W1990680410","https://openalex.org/W2019724092","https://openalex.org/W2039491348","https://openalex.org/W2040356862","https://openalex.org/W2049074441","https://openalex.org/W2050901966","https://openalex.org/W2053305914","https://openalex.org/W2055916570","https://openalex.org/W2085096659","https://openalex.org/W2090747098","https://openalex.org/W2090912148","https://openalex.org/W2128627515","https://openalex.org/W2134362985","https://openalex.org/W2141083396","https://openalex.org/W2147505659","https://openalex.org/W2153363951","https://openalex.org/W2201431517","https://openalex.org/W2229138542","https://openalex.org/W2318214416","https://openalex.org/W2329801673","https://openalex.org/W2410508926","https://openalex.org/W6635107235","https://openalex.org/W6679123884","https://openalex.org/W6682659693"],"related_works":["https://openalex.org/W2185122408","https://openalex.org/W2108225058","https://openalex.org/W2019724092","https://openalex.org/W2145104359","https://openalex.org/W1995961863","https://openalex.org/W7097818722","https://openalex.org/W2160102679","https://openalex.org/W2599211421","https://openalex.org/W2443203724","https://openalex.org/W1999953753"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3,26,106],"have":[4],"investigated":[5],"the":[6,12,28,38,112,118,124,136,172],"expression":[7,116,133],"of":[8,14,17,40,47,57,93,114,120,127,131,140,158,161,178],"phospholipase":[9],"C-beta2":[10],"during":[11],"course":[13],"granulocytic":[15,83,138],"differentiation":[16,139],"normal":[18,142,162],"and":[19,117,155,163],"malignant":[20,164],"progenitors.":[21,144,166],"As":[22],"a":[23,32,45,65,108,153],"model":[24,36],"system,":[25],"used":[27],"NB4":[29,76],"cell":[30],"line,":[31],"reliable":[33,156],"in":[34,64,74,173],"vitro":[35],"for":[37],"study":[39],"acute":[41,48],"promyelocytic":[42],"leukemia":[43,50],"(APL),":[44],"variety":[46],"myeloid":[49,165],"(AML)":[51],"that":[52,70,150],"responds":[53],"to":[54,100,123,176],"pharmacological":[55],"doses":[56],"all":[58],"trans-retinoic":[59],"acid":[60],"(ATRA)":[61],"by":[62,96,102],"differentiating":[63],"neutrophil-like":[66],"manner.":[67],"We":[68],"found":[69],"PLC-beta2,":[71],"virtually":[72],"absent":[73],"untreated":[75],"cells,":[77],"was":[78],"strongly":[79],"up-regulated":[80],"after":[81],"ATRA-induced":[82],"differentiation.":[84],"Remarkably,":[85],"using":[86],"primary":[87],"blasts":[88,122],"purified":[89],"from":[90],"bone":[91],"marrow":[92],"patients":[94],"affected":[95],"APL":[97,121,179],"successfully":[98],"induced":[99],"remission":[101],"treatment":[103],"with":[104],"ATRA,":[105],"showed":[107],"striking":[109],"correlation":[110],"between":[111],"amount":[113],"PLC-beta2":[115,132,151,168],"responsiveness":[119,175],"differentiative":[125],"activity":[126],"ATRA.":[128],"An":[129],"increase":[130],"also":[134],"characterized":[135],"cytokine-induced":[137],"CD34+":[141],"hematopoietic":[143],"Taken":[145],"together,":[146],"these":[147],"data":[148],"show":[149],"represents":[152],"sensitive":[154],"marker":[157],"neutrophil":[159],"maturation":[160],"Moreover,":[167],"levels":[169],"can":[170],"predict":[171],"vivo":[174],"ATRA":[177],"patients.":[180]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-04T00:00:00"}