{"id":"https://openalex.org/W4312377539","doi":"https://doi.org/10.1039/d2md00243d","title":"Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1 H -pyrrol-3-yl)- N -methylmethanamines as SERT inhibitors with potential antidepressant action","display_name":"Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1 H -pyrrol-3-yl)- N -methylmethanamines as SERT inhibitors with potential antidepressant action","publication_year":2022,"publication_date":"2022-10-29","ids":{"openalex":"https://openalex.org/W4312377539","doi":"https://doi.org/10.1039/d2md00243d","pmid":"https://pubmed.ncbi.nlm.nih.gov/36846366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9945855"},"language":"en","primary_location":{"id":"doi:10.1039/d2md00243d","doi":"https://doi.org/10.1039/d2md00243d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2md00243d","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9945855/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041940529","display_name":"Anjani Umarani Wunnava","orcid":"https://orcid.org/0000-0001-5310-2842","observed_orcids":["https://orcid.org/0000-0001-5310-2842"]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjani Uma Rani Wunnava","raw_affiliation_strings":["Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India"],"raw_orcid":"https://orcid.org/0000-0001-5310-2842","affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054914192","display_name":"Sony Priya Kurati","orcid":"https://orcid.org/0000-0003-0716-1619","observed_orcids":["https://orcid.org/0000-0003-0716-1619"]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sony Priya Kurati","raw_affiliation_strings":["Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India"],"raw_orcid":"https://orcid.org/0000-0003-0716-1619","affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kilari Eswar Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kilari Eswar Kumar","raw_affiliation_strings":["Pharmacology Department, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007326162","display_name":"Murali Krishna Kumar Muthyala","orcid":"https://orcid.org/0000-0002-4766-7836","observed_orcids":["https://orcid.org/0000-0002-4766-7836"]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Murali Krishna Kumar Muthyala","raw_affiliation_strings":["Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Research Lab, Andhra University College of Pharmaceutical Science, Andhra University, Visakhapatnam, India","institution_ids":["https://openalex.org/I100887729"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007326162"],"corresponding_institution_ids":["https://openalex.org/I100887729"],"apc_list":null,"apc_paid":null,"fwci":0.2585,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.45547968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"2","first_page":"393","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12562","display_name":"Synthesis and Characterization of Pyrroles","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter-inhibitors","display_name":"serotonin transporter inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/depression-model","display_name":"depression model","score":0.6420000195503235},{"id":"https://openalex.org/keywords/pyrrolidine-derivatives","display_name":"pyrrolidine derivatives","score":0.6230000257492065},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.8562279939651489},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6819636821746826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6804347634315491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5786988139152527},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.5587276816368103},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5558997988700867},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.5029720664024353},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.43172502517700195},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4272562265396118},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4127589762210846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25862592458724976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18321183323860168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15912359952926636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13390448689460754},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09514451026916504},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d2md00243d","doi":"https://doi.org/10.1039/d2md00243d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2md00243d","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:36846366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36846366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9945855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9945855/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9945855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9945855/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Med Chem","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4853127059","display_name":null,"funder_award_id":"DST/WOS-A/CS/116/2017","funder_id":"https://openalex.org/F4320334773","funder_display_name":"Science for Equity, Empowerment and Development Division"}],"funders":[{"id":"https://openalex.org/F4320334773","display_name":"Science for Equity, Empowerment and Development Division","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1205728809","https://openalex.org/W1963981929","https://openalex.org/W1964160578","https://openalex.org/W1973386992","https://openalex.org/W1983773897","https://openalex.org/W1987491785","https://openalex.org/W1995574940","https://openalex.org/W2005594217","https://openalex.org/W2012764667","https://openalex.org/W2013598219","https://openalex.org/W2024861481","https://openalex.org/W2027065525","https://openalex.org/W2037111632","https://openalex.org/W2043335534","https://openalex.org/W2051987027","https://openalex.org/W2061767371","https://openalex.org/W2064655929","https://openalex.org/W2067510367","https://openalex.org/W2068586063","https://openalex.org/W2071411334","https://openalex.org/W2073658789","https://openalex.org/W2077250079","https://openalex.org/W2079961396","https://openalex.org/W2080093346","https://openalex.org/W2081618527","https://openalex.org/W2086624144","https://openalex.org/W2087744801","https://openalex.org/W2090470620","https://openalex.org/W2124549431","https://openalex.org/W2128201662","https://openalex.org/W2134967712","https://openalex.org/W2155508038","https://openalex.org/W2157558738","https://openalex.org/W2159762027","https://openalex.org/W2172163321","https://openalex.org/W2293744162","https://openalex.org/W2297026543","https://openalex.org/W2410560657","https://openalex.org/W2413621212","https://openalex.org/W2413948147","https://openalex.org/W2468352036","https://openalex.org/W2765322245","https://openalex.org/W2765702580","https://openalex.org/W2898292990","https://openalex.org/W2949580964","https://openalex.org/W3008209007","https://openalex.org/W3047537776","https://openalex.org/W3130507619","https://openalex.org/W4252438761"],"related_works":["https://openalex.org/W2975243046","https://openalex.org/W4416998911","https://openalex.org/W4300963551","https://openalex.org/W3172810056","https://openalex.org/W7199300487","https://openalex.org/W1919615929","https://openalex.org/W2142514218","https://openalex.org/W3082764919","https://openalex.org/W3161692348","https://openalex.org/W2043436518"],"abstract_inverted_index":{"antidepressant":[0],"activity":[1],"using":[2],"the":[3,22,25,32,53],"unpredictable":[4],"chronic":[5],"mild":[6],"stress":[7],"(UCMS)":[8],"protocol":[9],"to":[10,46],"induce":[11],"depression":[12],"in":[13],"mice.":[14],"The":[15],"effect":[16],"of":[17,24,55],"BM212":[18],"and":[19,29],"SA-5":[20,36],"on":[21,52],"behaviour":[23,54],"animals":[26],"was":[27,44],"assessed":[28],"compared":[30],"against":[31],"standard":[33],"drug":[34],"sertraline.":[35],"at":[37],"20":[38],"mg":[39],"per":[40],"kg":[41],"body":[42],"weight":[43],"found":[45],"have":[47],"a":[48],"statistically":[49],"significant":[50],"impact":[51],"depressed":[56],"animals.":[57]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-04T00:00:00"}
