{"id":"https://openalex.org/W4312224809","doi":"https://doi.org/10.21203/rs.3.rs-2279000/v1","title":"Human Glioma Endothelial Cells With Stem cell properties","display_name":"Human Glioma Endothelial Cells With Stem cell properties","publication_year":2022,"publication_date":"2022-12-28","ids":{"openalex":"https://openalex.org/W4312224809","doi":"https://doi.org/10.21203/rs.3.rs-2279000/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2279000/v1","doi":"https://doi.org/10.21203/rs.3.rs-2279000/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2279000/v1","pdf_url":"https://www.researchsquare.com/article/rs-2279000/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2279000/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060111024","display_name":"Aman Sharma","orcid":"https://orcid.org/0000-0003-4166-157X","observed_orcids":["https://orcid.org/0000-0003-4166-157X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aman Sharma","raw_affiliation_strings":["ExoCan Healthcare Technologies Pvt Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ExoCan Healthcare Technologies Pvt Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534016","display_name":"Dattatraya Prakash Muzumdar","orcid":"https://orcid.org/0000-0003-1150-3204","observed_orcids":["https://orcid.org/0000-0003-1150-3204"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dattatraya Muzumdar","raw_affiliation_strings":["Seth G.S. Medical College, KEM Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seth G.S. Medical College, KEM Hospital","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047887305","display_name":"Anjali Shiras","orcid":"https://orcid.org/0000-0002-3173-6956","observed_orcids":["https://orcid.org/0000-0002-3173-6956"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]},{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjali Shiras","raw_affiliation_strings":["National Centre for Cell Science (NCCS), SP Pune University Campus","Medical College, KEM Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science (NCCS), SP Pune University Campus","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"Medical College, KEM Hospital","institution_ids":["https://openalex.org/I193353881"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.46219998598098755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.46219998598098755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.28929999470710754,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.21739999949932098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9150000214576721},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.7730000019073486},{"id":"https://openalex.org/keywords/multilineage-differentiation","display_name":"multilineage differentiation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.765999972820282},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.710098922252655},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.7002884745597839},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6680303812026978},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6502503752708435},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6310262680053711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5682443380355835},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.5164487361907959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4844203293323517},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.482452929019928},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.4414409101009369},{"id":"https://openalex.org/C2779310769","wikidata":"https://www.wikidata.org/wiki/Q6553374","display_name":"Lineage markers","level":4,"score":0.4259253740310669},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.41952648758888245},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3854864835739136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3582429885864258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32220935821533203},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2865128517150879},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.28290069103240967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2678104043006897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16545847058296204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05409294366836548}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2279000/v1","doi":"https://doi.org/10.21203/rs.3.rs-2279000/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2279000/v1","pdf_url":"https://www.researchsquare.com/article/rs-2279000/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2279000/v1","doi":"https://doi.org/10.21203/rs.3.rs-2279000/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2279000/v1","pdf_url":"https://www.researchsquare.com/article/rs-2279000/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312224809.pdf","grobid_xml":"https://content.openalex.org/works/W4312224809.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1968354884","https://openalex.org/W1969421850","https://openalex.org/W1971787155","https://openalex.org/W1987819627","https://openalex.org/W1995168398","https://openalex.org/W1998796283","https://openalex.org/W2011895269","https://openalex.org/W2025232712","https://openalex.org/W2041617965","https://openalex.org/W2063457159","https://openalex.org/W2067565627","https://openalex.org/W2074198697","https://openalex.org/W2096800614","https://openalex.org/W2102488910","https://openalex.org/W2106675906","https://openalex.org/W2112703519","https://openalex.org/W2117013761","https://openalex.org/W2118709967","https://openalex.org/W2122747565","https://openalex.org/W2133436567","https://openalex.org/W2147628739","https://openalex.org/W2149932164","https://openalex.org/W2162868519","https://openalex.org/W2163230397","https://openalex.org/W2294196585","https://openalex.org/W2310609292","https://openalex.org/W2335714162","https://openalex.org/W2389899834","https://openalex.org/W2588061682","https://openalex.org/W2592308949","https://openalex.org/W2996179913","https://openalex.org/W3047781594","https://openalex.org/W3049402876","https://openalex.org/W3137340042","https://openalex.org/W3184165695","https://openalex.org/W3203281004","https://openalex.org/W4248259718"],"related_works":["https://openalex.org/W3032186897","https://openalex.org/W2137281600","https://openalex.org/W1969421850","https://openalex.org/W2029470215","https://openalex.org/W4413400007","https://openalex.org/W6889944258","https://openalex.org/W2112703519","https://openalex.org/W2899590404","https://openalex.org/W2568963205","https://openalex.org/W2730647935"],"abstract_inverted_index":{"Abstract":[0],"Glioblastoma":[1],"(GBM)":[2],"tumor":[3,29,42,135],"relapse":[4],"is":[5,34],"attributed":[6],"to":[7,20],"presence":[8],"of":[9,28,63,129],"therapy":[10],"defying":[11],"Glioma":[12],"stem":[13,54,141,159],"cells":[14,33,155],"(GSCs).":[15],"GSCs":[16],"have":[17],"been":[18],"shown":[19],"trans-differentiate":[21],"into":[22,122],"endothelial-like":[23],"cells.":[24,125],"However,":[25],"the":[26],"influence":[27],"micro-environment":[30,43],"on":[31],"endothelial":[32,47,67,154],"not":[35],"clearly":[36],"understood.":[37],"Here,":[38],"we":[39,59],"investigated":[40],"whether":[41],"conditioning":[44],"can":[45],"alter":[46],"cell":[48,68,142,160],"phenotype":[49],"and":[50,71,90,107,115,146],"endow":[51],"them":[52,73],"with":[53,158],"cell-like":[55],"properties.":[56],"For":[57],"this,":[58],"establishing":[60],"a":[61,109],"battery":[62],"primary":[64],"human":[65,130],"glioma":[66],"cultures":[69],"(hGECs)":[70],"characterized":[72],"for":[74],"purity":[75],"in":[76,78,80,96,108,162],"multiple":[77],"vitro,":[79],"vivo":[81],"assays.":[82],"Our":[83],"data":[84,150],"shows":[85,151],"that":[86,134,152],"hGECs":[87,118],"harbored":[88],"stemness":[89],"multi-lineage":[91],"differentiation":[92,111,121],"potential":[93],"as":[94],"assessed":[95],"serum":[97],"free":[98],"growth":[99],"assay,":[100,103,106],"sphere":[101],"forming":[102],"limiting":[104],"dilution":[105],"serum-induced":[110],"assay":[112],"where":[113],"Nestin":[114,145],"CD31":[116],"co-expressing":[117],"could":[119],"spontaneously":[120],"GFAP":[123],"positive":[124],"Moreover,":[126],"immunohistochemistry":[127],"analysis":[128],"GBM":[131],"tumors":[132],"showed":[133],"vessel":[136],"regions":[137],"expressed":[138],"two":[139],"key":[140],"specific":[143],"markers":[144],"Mushashi.":[147],"Together,":[148],"our":[149],"tumor-specific":[153],"are":[156],"enriched":[157],"properties":[161],"GBM.":[163]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-01-04T00:00:00"}
