{"id":"https://openalex.org/W4312201129","doi":"https://doi.org/10.1038/s41467-022-35691-7","title":"Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages","display_name":"Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages","publication_year":2022,"publication_date":"2022-12-27","ids":{"openalex":"https://openalex.org/W4312201129","doi":"https://doi.org/10.1038/s41467-022-35691-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/36575170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9794824"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-35691-7","doi":"https://doi.org/10.1038/s41467-022-35691-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-35691-7","pdf_url":"https://www.nature.com/articles/s41467-022-35691-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-35691-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100618462","display_name":"Wei Hong Feng","orcid":"https://orcid.org/0000-0002-5605-0811","observed_orcids":["https://orcid.org/0000-0002-5605-0811"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Feng","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":"https://orcid.org/0000-0002-5605-0811","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071186147","display_name":"Abha Singh Bais","orcid":"https://orcid.org/0000-0001-5910-1306","observed_orcids":["https://orcid.org/0000-0001-5910-1306"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abha Bais","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074698598","display_name":"Haoting He","orcid":"https://orcid.org/0009-0007-2031-353X","observed_orcids":["https://orcid.org/0009-0007-2031-353X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoting He","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036898779","display_name":"Cassandra Rios","orcid":"https://orcid.org/0000-0002-9962-2656","observed_orcids":["https://orcid.org/0000-0002-9962-2656"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra Rios","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":"https://orcid.org/0000-0002-9962-2656","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081830070","display_name":"Shan Jiang","orcid":"https://orcid.org/0000-0003-2020-6447","observed_orcids":["https://orcid.org/0000-0003-2020-6447"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Jiang","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000587","display_name":"Juan Xu","orcid":"https://orcid.org/0000-0002-6486-0128","observed_orcids":["https://orcid.org/0000-0002-6486-0128"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Xu","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011945621","display_name":"Cindy A. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Chang","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010346419","display_name":"Dennis Kostka","orcid":"https://orcid.org/0000-0002-1460-5487","observed_orcids":["https://orcid.org/0000-0002-1460-5487"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Kostka","raw_affiliation_strings":["Department of Computational & Systems Biology and Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":"https://orcid.org/0000-0002-1460-5487","affiliations":[{"raw_affiliation_string":"Department of Computational & Systems Biology and Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100406312","display_name":"Guang Li","orcid":"https://orcid.org/0000-0002-8546-2364","observed_orcids":["https://orcid.org/0000-0002-8546-2364"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guang Li","raw_affiliation_strings":["Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA. guangli@pitt.edu","Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA"],"raw_orcid":"https://orcid.org/0000-0002-8546-2364","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA. guangli@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100406312"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":5.2942,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.97731429,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"7960","last_page":"7960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardiac-embryogenesis","display_name":"cardiac embryogenesis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neonatal-heart","display_name":"neonatal heart","score":0.875},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mouse-heart","display_name":"mouse heart","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cardiac-cell-types","display_name":"cardiac cell types","score":0.7820000052452087},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epicardium","display_name":"epicardium","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.8960000276565552},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tbx18","display_name":"Tbx18","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-modules","display_name":"gene modules","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.8428938388824463},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.8134450912475586},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8016707897186279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6900697946548462},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.6854066252708435},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6736237406730652},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5996252298355103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49720051884651184},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48999109864234924},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4700435698032379},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44728368520736694},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44670993089675903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2976136803627014}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-022-35691-7","doi":"https://doi.org/10.1038/s41467-022-35691-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-35691-7","pdf_url":"https://www.nature.com/articles/s41467-022-35691-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:36575170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36575170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9794824","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9794824/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35691-7","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-35691-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a0470a8b66594a5b92b5d2ca0f1c00d6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a0470a8b66594a5b92b5d2ca0f1c00d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)","raw_type":"article"},{"id":"pmh:oai:zenodo.org:7411556","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/7411556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.7411556","doi":"https://doi.org/10.5281/zenodo.7411556","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.7411556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-35691-7","doi":"https://doi.org/10.1038/s41467-022-35691-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-35691-7","pdf_url":"https://www.nature.com/articles/s41467-022-35691-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1122860784","display_name":"Generation of four-chambered hearts through organoid fusions","funder_award_id":"DP2HL163745","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G184012457","display_name":"Cellular and Molecular Mechanisms of Atrial Cardiomyocyte Lineage Commitment ","funder_award_id":"R00HL133472","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5865704070","display_name":null,"funder_award_id":"DP2HL163745","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G666619039","display_name":null,"funder_award_id":"R00HL133472","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7402199","display_name":null,"funder_award_id":"R00HL133472; DP2HL163745","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000141818","display_name":null,"funder_award_id":"R00HL133472 and DP2HL163745","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320320794","display_name":"Canterbury Medical Research Foundation","ror":"https://ror.org/01kr2nz80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312201129.pdf","grobid_xml":"https://content.openalex.org/works/W4312201129.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1947441899","https://openalex.org/W1969038150","https://openalex.org/W1971898007","https://openalex.org/W1988832870","https://openalex.org/W1994117018","https://openalex.org/W1997226890","https://openalex.org/W2012416932","https://openalex.org/W2036097053","https://openalex.org/W2036519740","https://openalex.org/W2045570557","https://openalex.org/W2051076484","https://openalex.org/W2053869099","https://openalex.org/W2059611250","https://openalex.org/W2068391384","https://openalex.org/W2072162746","https://openalex.org/W2075401648","https://openalex.org/W2087818666","https://openalex.org/W2088204183","https://openalex.org/W2089414860","https://openalex.org/W2099788803","https://openalex.org/W2102103202","https://openalex.org/W2105253426","https://openalex.org/W2110275759","https://openalex.org/W2114545874","https://openalex.org/W2120856680","https://openalex.org/W2122001453","https://openalex.org/W2126829269","https://openalex.org/W2132731433","https://openalex.org/W2149551437","https://openalex.org/W2159502734","https://openalex.org/W2168834654","https://openalex.org/W2172166419","https://openalex.org/W2172609591","https://openalex.org/W2193806089","https://openalex.org/W2335212817","https://openalex.org/W2465917013","https://openalex.org/W2511963020","https://openalex.org/W2530928249","https://openalex.org/W2548887475","https://openalex.org/W2555626725","https://openalex.org/W2556548281","https://openalex.org/W2573812177","https://openalex.org/W2616922646","https://openalex.org/W2763010484","https://openalex.org/W2783441930","https://openalex.org/W2784600881","https://openalex.org/W2789551841","https://openalex.org/W2794991451","https://openalex.org/W2804488057","https://openalex.org/W2807228974","https://openalex.org/W2894687190","https://openalex.org/W2899478022","https://openalex.org/W2901006884","https://openalex.org/W2911685613","https://openalex.org/W2916020270","https://openalex.org/W2941319520","https://openalex.org/W2947808148","https://openalex.org/W2949177718","https://openalex.org/W2951068818","https://openalex.org/W2951158909","https://openalex.org/W2951911538","https://openalex.org/W2970127500","https://openalex.org/W2971227980","https://openalex.org/W2974638051","https://openalex.org/W2984472267","https://openalex.org/W2992151131","https://openalex.org/W3000639815","https://openalex.org/W3003280117","https://openalex.org/W3007935255","https://openalex.org/W3023019126","https://openalex.org/W3028249176","https://openalex.org/W3038763010","https://openalex.org/W3042896257","https://openalex.org/W3048152017","https://openalex.org/W3093329358","https://openalex.org/W3100967665","https://openalex.org/W3111084394","https://openalex.org/W3132661792","https://openalex.org/W3133589067","https://openalex.org/W3162580982","https://openalex.org/W3163962193","https://openalex.org/W3164692211","https://openalex.org/W3183266614","https://openalex.org/W3190202966","https://openalex.org/W4200395225","https://openalex.org/W4206742719","https://openalex.org/W4225259023","https://openalex.org/W4254687493","https://openalex.org/W6647607493","https://openalex.org/W6668139878","https://openalex.org/W6931353560","https://openalex.org/W7034024092","https://openalex.org/W7073723595"],"related_works":["https://openalex.org/W2556548281","https://openalex.org/W2947808148","https://openalex.org/W4386416792","https://openalex.org/W2996171578","https://openalex.org/W2118600633","https://openalex.org/W7212277321","https://openalex.org/W3120533356","https://openalex.org/W1987079301","https://openalex.org/W2911685613","https://openalex.org/W4283591478"],"abstract_inverted_index":{"Heart":[0],"development":[1,35],"is":[2],"a":[3],"continuous":[4],"process":[5],"involving":[6],"significant":[7],"remodeling":[8],"during":[9],"embryogenesis":[10,66],"and":[11,91,100,126,133,139],"neonatal":[12,69,92,107,131],"stages.":[13,38,70],"To":[14],"date,":[15],"several":[16,79],"groups":[17],"have":[18,114,141],"used":[19],"single-cell":[20],"sequencing":[21],"to":[22,29,67],"characterize":[23],"the":[24,31,45,57,61,98],"heart":[25,34,63,111,143,159],"transcriptomes":[26],"but":[27],"failed":[28],"capture":[30],"progression":[32],"of":[33,47,60,74,135,146,154,158],"at":[36,88,106,130],"most":[37],"This":[39],"has":[40],"left":[41,99],"gaps":[42],"in":[43,97],"understanding":[44],"contribution":[46],"each":[48],"cell":[49,95,115,128],"type":[50],"across":[51],"cardiac":[52],"development.":[53,160],"Here,":[54],"we":[55,77],"report":[56],"transcriptional":[58,80],"profile":[59],"murine":[62],"from":[64],"early":[65,89],"late":[68],"Through":[71],"further":[72],"analysis":[73],"this":[75,147],"dataset,":[76],"identify":[78,83],"features.":[81],"We":[82],"gene":[84],"expression":[85],"modules":[86],"enriched":[87],"embryonic":[90],"stages;":[93,108,132],"multiple":[94],"types":[96,129],"right":[101],"atriums":[102],"are":[103,121],"transcriptionally":[104],"distinct":[105],"many":[109],"congenital":[110],"defect-associated":[112],"genes":[113,137],"type-specific":[116],"expression;":[117],"stage-unique":[118],"ligand-receptor":[119],"interactions":[120],"mostly":[122],"between":[123],"epicardial":[124],"cells":[125],"other":[127],"mutants":[134],"epicardium-expressed":[136],"Wt1":[138],"Tbx18":[140],"different":[142],"defects.":[144],"Assessment":[145],"dataset":[148],"serves":[149],"as":[150],"an":[151],"invaluable":[152],"source":[153],"information":[155],"for":[156],"studies":[157]},"counts_by_year":[{"year":2026,"cited_by_count":36},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-04T00:00:00"}
