{"id":"https://openalex.org/W4312200039","doi":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","title":"MECHANISMS OF RESISTANCE IN THERAPY WITH ANGIOGENESIS BLOCKERS IN COLORECTAL CANCER","display_name":"MECHANISMS OF RESISTANCE IN THERAPY WITH ANGIOGENESIS BLOCKERS IN COLORECTAL CANCER","publication_year":2022,"publication_date":"2022-11-30","ids":{"openalex":"https://openalex.org/W4312200039","doi":"https://doi.org/10.18137/cardiometry.2022.24.conf.37"},"language":"en","primary_location":{"id":"doi:10.18137/cardiometry.2022.24.conf.37","doi":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","is_oa":true,"landing_page_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","pdf_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","source":{"id":"https://openalex.org/S2737259216","display_name":"Cardiometry","issn_l":"2304-7232","issn":["2304-7232"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312590","host_organization_name":"Russian New University","host_organization_lineage":["https://openalex.org/P4310312590"],"host_organization_lineage_names":["Russian New University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CARDIOMETRY","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024836963","display_name":"Elena Petrovna Golubinskaya","orcid":"https://orcid.org/0000-0003-3917-924X","observed_orcids":["https://orcid.org/0000-0003-3917-924X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Golubinskaya, \u0415.P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079149696","display_name":"B. D. Seferov","orcid":"https://orcid.org/0000-0003-0191-7665","observed_orcids":["https://orcid.org/0000-0003-0191-7665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seferov, B.D.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036816684","display_name":"\u041c.\u0410. Kalfa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalfa, \u041c.\u0410.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008729657","display_name":"\u0418. \u0418. \u0424\u043e\u043c\u043e\u0447\u043a\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0003-3065-5748","observed_orcids":["https://orcid.org/0000-0003-3065-5748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fomochkina, I.I.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050728592","display_name":"V.\u0410. Kubyshkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kubyshkin, V.\u0410.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"24","first_page":"66","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.24210000038146973,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8659999966621399},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6050000190734863},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8180000185966492},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.879141628742218},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8071630597114563},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7700706720352173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6475755572319031},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6335464119911194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6013983488082886},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5925381183624268},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5222440361976624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4978342056274414},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.49717357754707336},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4543142318725586},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.438179612159729},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.4340386390686035},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4253157079219818},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.37804532051086426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37178969383239746},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2799184322357178},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2509443163871765},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22073820233345032}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18137/cardiometry.2022.24.conf.37","doi":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","is_oa":true,"landing_page_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","pdf_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","source":{"id":"https://openalex.org/S2737259216","display_name":"Cardiometry","issn_l":"2304-7232","issn":["2304-7232"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312590","host_organization_name":"Russian New University","host_organization_lineage":["https://openalex.org/P4310312590"],"host_organization_lineage_names":["Russian New University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CARDIOMETRY","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18137/cardiometry.2022.24.conf.37","doi":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","is_oa":true,"landing_page_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","pdf_url":"https://doi.org/10.18137/cardiometry.2022.24.conf.37","source":{"id":"https://openalex.org/S2737259216","display_name":"Cardiometry","issn_l":"2304-7232","issn":["2304-7232"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312590","host_organization_name":"Russian New University","host_organization_lineage":["https://openalex.org/P4310312590"],"host_organization_lineage_names":["Russian New University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CARDIOMETRY","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312200039.pdf","grobid_xml":"https://content.openalex.org/works/W4312200039.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1985928174","https://openalex.org/W1990611397","https://openalex.org/W2012247886","https://openalex.org/W2024263380","https://openalex.org/W2038264590","https://openalex.org/W2047956375","https://openalex.org/W2055721190","https://openalex.org/W2057186073","https://openalex.org/W2070364844","https://openalex.org/W2101666731","https://openalex.org/W2103699631","https://openalex.org/W2112123361","https://openalex.org/W2115124692","https://openalex.org/W2128542677","https://openalex.org/W2132896320","https://openalex.org/W2140872369","https://openalex.org/W2145819332","https://openalex.org/W2149642154","https://openalex.org/W2152004182","https://openalex.org/W2156078931","https://openalex.org/W2163188200","https://openalex.org/W2168143310","https://openalex.org/W2314499730","https://openalex.org/W2516152350","https://openalex.org/W2586265133","https://openalex.org/W2783634552","https://openalex.org/W2801380437","https://openalex.org/W2884984109","https://openalex.org/W2896239573","https://openalex.org/W2898088739","https://openalex.org/W2903068930","https://openalex.org/W2945856748","https://openalex.org/W2972270957","https://openalex.org/W2987284967","https://openalex.org/W2997958114","https://openalex.org/W3029545290","https://openalex.org/W3081609738","https://openalex.org/W3093872008","https://openalex.org/W3096384214","https://openalex.org/W3167902873","https://openalex.org/W3174167446","https://openalex.org/W3189317767","https://openalex.org/W3196627712","https://openalex.org/W3201872204","https://openalex.org/W4207033714","https://openalex.org/W4212813303","https://openalex.org/W4214495295","https://openalex.org/W4230255341","https://openalex.org/W4312200053","https://openalex.org/W4312200063","https://openalex.org/W4312200273","https://openalex.org/W4312200278","https://openalex.org/W4312200365","https://openalex.org/W6628797664"],"related_works":["https://openalex.org/W2037317069","https://openalex.org/W2055253966","https://openalex.org/W2077603264","https://openalex.org/W2901819530","https://openalex.org/W4246645856","https://openalex.org/W2154369198","https://openalex.org/W7098370961","https://openalex.org/W2071028825","https://openalex.org/W2148939957","https://openalex.org/W90477195"],"abstract_inverted_index":{"One":[0],"of":[1,17,36,44,49,63],"the":[2,15,18,32,34,60,73],"fundamental":[3],"events":[4],"that":[5,55],"determine":[6],"carcinogenesis":[7],"and":[8,40,58],"its":[9],"progression":[10],"is":[11],"angiogenesis":[12],"mediated":[13],"by":[14],"activation":[16],"vascular":[19],"endothelial":[20],"growth":[21],"factor":[22],"(VEGF).":[23],"The":[24,47],"angiogenic":[25],"cascade":[26],"provides":[27],"a":[28,37,50,70],"comfortable":[29],"micro-environment":[30],"for":[31,76,83],"tumor,":[33],"creation":[35],"metastatic":[38,42,86],"niche":[39],"subsequent":[41],"dissemination":[43],"neoplastic":[45],"cells.":[46],"development":[48],"recombinant":[51],"hyperchimeric":[52],"monoclonal":[53],"antibody":[54],"selectively":[56],"binds":[57],"inhibits":[59],"biological":[61],"activity":[62],"VEGF":[64],"-":[65],"Bevacizumab,":[66],"has":[67],"led":[68],"to":[69],"change":[71],"in":[72,81,95],"therapeutic":[74],"strategy":[75],"patients":[77,84],"with":[78,85],"cancer":[79,88],"and,":[80],"particular,":[82],"colorectal":[87],"(CRC),":[89],"because":[90],"it":[91],"demonstrated":[92],"an":[93],"increase":[94],"their":[96],"survival":[97],"rate.":[98]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-01-04T00:00:00"}
