{"id":"https://openalex.org/W4312129696","doi":"https://doi.org/10.1016/j.theriogenology.2022.12.024","title":"KSOM-R supports both mouse and rat preimplantation embryo development in vitro","display_name":"KSOM-R supports both mouse and rat preimplantation embryo development in vitro","publication_year":2022,"publication_date":"2022-12-17","ids":{"openalex":"https://openalex.org/W4312129696","doi":"https://doi.org/10.1016/j.theriogenology.2022.12.024","pmid":"https://pubmed.ncbi.nlm.nih.gov/36563630","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9870949"},"language":"en","primary_location":{"id":"doi:10.1016/j.theriogenology.2022.12.024","doi":"https://doi.org/10.1016/j.theriogenology.2022.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2022.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0093691X22005465/pdf","source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0093691X22005465/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014458921","display_name":"Hongsheng Men","orcid":"https://orcid.org/0000-0002-8101-4644","observed_orcids":["https://orcid.org/0000-0002-8101-4644"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongsheng Men","raw_affiliation_strings":["Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA. Electronic address: menho@missouri.edu","Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Mutant Mouse Resource and Research Center, USA","Rat Resource and Research Center, USA"],"raw_orcid":"https://orcid.org/0000-0002-8101-4644","affiliations":[{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA. Electronic address: menho@missouri.edu","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA","institution_ids":[]},{"raw_affiliation_string":"Rat Resource and Research Center, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024191783","display_name":"James M Amos-Landgraf","orcid":"https://orcid.org/0000-0003-2535-7746","observed_orcids":["https://orcid.org/0000-0003-2535-7746"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Amos-Landgraf","raw_affiliation_strings":["Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Mutant Mouse Resource and Research Center, USA","Rat Resource and Research Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA","institution_ids":[]},{"raw_affiliation_string":"Rat Resource and Research Center, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089417787","display_name":"Elizabeth C. Bryda","orcid":"https://orcid.org/0000-0002-9936-3607","observed_orcids":["https://orcid.org/0000-0002-9936-3607"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C. Bryda","raw_affiliation_strings":["Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Mutant Mouse Resource and Research Center, USA","Rat Resource and Research Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA","institution_ids":[]},{"raw_affiliation_string":"Rat Resource and Research Center, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012586926","display_name":"Craig L. Franklin","orcid":"https://orcid.org/0000-0002-9198-867X","observed_orcids":["https://orcid.org/0000-0002-9198-867X"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig L. Franklin","raw_affiliation_strings":["Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","Mutant Mouse Resource and Research Center, USA","Rat Resource and Research Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA; Rat Resource and Research Center, USA; Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Pathobiology, University of Missouri-Columbia, 4011 Discovery Drive, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Mutant Mouse Resource and Research Center, USA","institution_ids":[]},{"raw_affiliation_string":"Rat Resource and Research Center, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014458921"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":{"value":3740,"currency":"USD","value_usd":3740},"fwci":0.8828,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7296345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"198","issue":null,"first_page":"69","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preimplantation-embryo-culture","display_name":"preimplantation embryo culture","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mouse-embryonic-development","display_name":"mouse embryo development","score":0.6949999928474426},{"id":"https://openalex.org/keywords/rat-embryo-development","display_name":"rat embryo development","score":0.996999979019165},{"id":"https://openalex.org/keywords/amino-acid-supplementation","display_name":"amino acid supplementation","score":0.609000027179718},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cleavage","display_name":"cleavage","score":0.5239999890327454},{"id":"https://openalex.org/keywords/embryo-hatching","display_name":"embryo hatching","score":0.7409999966621399},{"id":"https://openalex.org/keywords/surgical-embryo-transfer","display_name":"surgical embryo transfer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/live-birth","display_name":"live birth","score":0.4359999895095825},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8303040266036987},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8148961067199707},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.788641095161438},{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.731147825717926},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6656709909439087},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.622105598449707},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.5975186824798584},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.14928606152534485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1345161497592926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015053","descriptor_name":"Zygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.theriogenology.2022.12.024","doi":"https://doi.org/10.1016/j.theriogenology.2022.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2022.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0093691X22005465/pdf","source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},{"id":"pmid:36563630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36563630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9870949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9870949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Theriogenology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.theriogenology.2022.12.024","doi":"https://doi.org/10.1016/j.theriogenology.2022.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2022.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0093691X22005465/pdf","source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1447899690","display_name":"Mutant Mouse Resource and Research Center","funder_award_id":"U42RR014821","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000866593","display_name":"Rat Resource and Research Center","funder_award_id":"P40OD011062","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000910673","display_name":"The Mutant Mouse Resource and Research Center at the University of Missouri","funder_award_id":"U42OD010918","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332179","display_name":"Office of the Director","ror":"https://ror.org/04nseet23"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312129696.pdf","grobid_xml":"https://content.openalex.org/works/W4312129696.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W39364543","https://openalex.org/W39426010","https://openalex.org/W1847316829","https://openalex.org/W1968487093","https://openalex.org/W1973107120","https://openalex.org/W1980813479","https://openalex.org/W1985139261","https://openalex.org/W1993834457","https://openalex.org/W2002783281","https://openalex.org/W2012099407","https://openalex.org/W2015632173","https://openalex.org/W2016106800","https://openalex.org/W2016738037","https://openalex.org/W2032002636","https://openalex.org/W2040846074","https://openalex.org/W2064745146","https://openalex.org/W2075672155","https://openalex.org/W2078826636","https://openalex.org/W2106521012","https://openalex.org/W2121230264","https://openalex.org/W2125552957","https://openalex.org/W2126966500","https://openalex.org/W2155436742","https://openalex.org/W2158014022","https://openalex.org/W2162480880","https://openalex.org/W2166672007","https://openalex.org/W2467665811","https://openalex.org/W2550578458","https://openalex.org/W2952044912","https://openalex.org/W2952928961","https://openalex.org/W3010868308","https://openalex.org/W3109615835","https://openalex.org/W3199297491"],"related_works":["https://openalex.org/W2467665811","https://openalex.org/W2064745146","https://openalex.org/W2059270395","https://openalex.org/W2380848504","https://openalex.org/W3010868308","https://openalex.org/W2389307313","https://openalex.org/W2409923105","https://openalex.org/W3130402179","https://openalex.org/W2387697514","https://openalex.org/W2135776691"],"abstract_inverted_index":{"A":[0],"modified":[1],"KSOM":[2,83,86,188,238],"for":[3,64,264,329],"rat":[4,18,127,314,359],"embryo":[5,19,50,218,304,315],"culture":[6,239,355],"(KSOM-R),":[7],"which":[8],"has":[9],"enriched":[10],"taurine,":[11],"glycine,":[12],"glutamic":[13],"acid,":[14],"and":[15,25,52,85,115,123,141,162,196,230,253,274,313,321,358,361],"alanine,":[16],"promoted":[17],"development":[20,51,89,119,170,316],"in":[21,32,91,94,138,172,190,204,208,223,250,258,271,282,317],"vitro.":[22,318],"Since":[23],"mice":[24],"rats":[26],"share":[27],"similar":[28],"amino":[29],"acid":[30],"profiles":[31],"their":[33],"female":[34],"reproductive":[35],"tracts,":[36],"this":[37],"study":[38,339],"explored":[39],"whether":[40],"KSOM-R":[41,54,80],"would":[42],"also":[43,200],"have":[44],"a":[45],"positive":[46],"effect":[47,103],"on":[48,87,117,302],"mouse":[49,122,303,312,357],"if":[53],"modifications":[55],"could":[56],"extend":[57],"its":[58],"shelf":[59,106,366],"time":[60],"at":[61,76,110,158,176,185,227,235,261,268,288,326,330],"2-8":[62,77,111,159,186,228,236,262,289,327],"\u00b0C":[63,263,328],"consistency.":[65],"We":[66,99],"first":[67],"examined":[68],"the":[69,88,102,118,148,169,213,347],"effects":[70,299],"of":[71,90,104,113,120,144,156,171,192],"newly":[72,181,231,283],"made":[73,151,182,232,284,370],"(\u22641":[74,183,233,286],"month":[75,184,234,287],"\u00b0C)":[78,112,187,229,237],"antibiotics-free":[79,82],"(mKSOM-R),":[81],"(mKSOM)":[84],"vivo":[92,173],"or":[93],"vitro":[95],"derived":[96],"C57BL/6NJ":[97,121,145,174,220],"zygotes.":[98],"then":[100],"investigated":[101],"extended":[105,365],"life":[107,367],"(6":[108,225],"months":[109,155,226,266,333],"mKSOM-R":[114,161,224,259,285,306,320,353],"mKOSM":[116],"Sprague":[124],"Dawley":[125],"(SD)":[126],"embryos.":[128],"The":[129,291],"results":[130],"showed":[131,293],"that":[132,341],"there":[133],"were":[134,164,199,300],"no":[135,201,247,296],"significant":[136,202,297],"differences":[137,203],"cleavage,":[139,193,272],"blastocyst,":[140],"hatching":[142,275],"rates":[143,178,270,276],"embryos":[146],"among":[147,212],"three":[149,214],"freshly":[150],"media.":[152],"After":[153,216],"6":[154,265,332],"storage":[157],"\u00b0C,":[160],"mKSOM":[163,322],"still":[165],"able":[166,308],"to":[167,279,309,345,354],"support":[168,310],"zygotes":[175,256],"comparable":[177,269],"seen":[179],"with":[180,364],"(control)":[189],"terms":[191],"blastocyst":[194,273],"formation":[195],"hatching.":[197],"There":[198],"total":[205],"cell":[206],"numbers":[207],"day":[209],"4":[210],"blastocysts":[211,221],"groups.":[215],"surgical":[217],"transfers,":[219],"cultured":[222,257,281],"developed":[240,267],"into":[241],"live":[242],"pups.":[243],"These":[244],"pups":[245],"had":[246],"gross":[248],"abnormalities":[249],"animal":[251],"morphology":[252],"growth.":[254],"SD":[255],"stored":[260,325],"when":[277],"compared":[278],"those":[280],"\u00b0C).":[290],"data":[292],"that,":[294],"although":[295],"beneficial":[298],"observed":[301],"development,":[305],"was":[307],"both":[311,356],"Additionally,":[319],"can":[323,368],"be":[324,369],"least":[331],"without":[334],"significantly":[335],"compromising":[336],"quality.":[337],"This":[338],"suggests":[340],"it":[342],"is":[343],"possible":[344],"reduce":[346],"media":[348,363],"inventory":[349],"by":[350],"using":[351],"only":[352],"embryos,":[360],"quality":[362],"through":[371],"modifications.":[372]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-01-04T00:00:00"}
