{"id":"https://openalex.org/W4312106931","doi":"https://doi.org/10.1002/anbr.202200128","title":"Bio\u2010Orthogonal Chemistry in Cell Engineering","display_name":"Bio\u2010Orthogonal Chemistry in Cell Engineering","publication_year":2022,"publication_date":"2022-12-21","ids":{"openalex":"https://openalex.org/W4312106931","doi":"https://doi.org/10.1002/anbr.202200128"},"language":"en","primary_location":{"id":"doi:10.1002/anbr.202200128","doi":"https://doi.org/10.1002/anbr.202200128","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anbr.202200128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anbr.202200128","source":{"id":"https://openalex.org/S4210232512","display_name":"Advanced NanoBiomed Research","issn_l":"2699-9307","issn":["2699-9307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced NanoBiomed Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anbr.202200128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100328549","display_name":"Yixin Wang","orcid":"https://orcid.org/0000-0003-4324-2408","observed_orcids":["https://orcid.org/0000-0003-4324-2408"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixin Wang","raw_affiliation_strings":["Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705 USA","Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025104162","display_name":"Quanyin Hu","orcid":"https://orcid.org/0000-0003-2946-1655","observed_orcids":["https://orcid.org/0000-0003-2946-1655"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Quanyin Hu","raw_affiliation_strings":["Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705 USA","Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA"],"raw_orcid":"https://orcid.org/0000-0003-2946-1655","affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 USA","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025104162"],"corresponding_institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.0935,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.87751148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"3","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioorthogonal-chemistry","display_name":"bioorthogonal chemistry","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-engineering","display_name":"cell engineering","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cycloaddition","display_name":"cycloaddition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/disease-diagnosis","display_name":"disease diagnosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/infectious-disease-therapy","display_name":"infectious disease therapy","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5466771721839905},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5155922770500183},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.44807201623916626},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44404110312461853},{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.4349510967731476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42557328939437866},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3986937999725342},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19543102383613586},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17020350694656372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13845929503440857},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.13047343492507935},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/anbr.202200128","doi":"https://doi.org/10.1002/anbr.202200128","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anbr.202200128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anbr.202200128","source":{"id":"https://openalex.org/S4210232512","display_name":"Advanced NanoBiomed Research","issn_l":"2699-9307","issn":["2699-9307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced NanoBiomed Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4bfdaba4d736485e99bc7e7003e4ae12","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4bfdaba4d736485e99bc7e7003e4ae12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced NanoBiomed Research, Vol 3, Iss 3, Pp n/a-n/a (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/anbr.202200128","doi":"https://doi.org/10.1002/anbr.202200128","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anbr.202200128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anbr.202200128","source":{"id":"https://openalex.org/S4210232512","display_name":"Advanced NanoBiomed Research","issn_l":"2699-9307","issn":["2699-9307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced NanoBiomed Research","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312106931.pdf","grobid_xml":"https://content.openalex.org/works/W4312106931.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1135359073","https://openalex.org/W1593322963","https://openalex.org/W1966194999","https://openalex.org/W1975742574","https://openalex.org/W1981659539","https://openalex.org/W1989368359","https://openalex.org/W1997099073","https://openalex.org/W2023985105","https://openalex.org/W2026185209","https://openalex.org/W2028277897","https://openalex.org/W2059725389","https://openalex.org/W2069805392","https://openalex.org/W2077605453","https://openalex.org/W2094226245","https://openalex.org/W2098624753","https://openalex.org/W2106105150","https://openalex.org/W2155827990","https://openalex.org/W2158840473","https://openalex.org/W2167028666","https://openalex.org/W2326520547","https://openalex.org/W2414538442","https://openalex.org/W2421934414","https://openalex.org/W2490299533","https://openalex.org/W2519415256","https://openalex.org/W2551127713","https://openalex.org/W2565071994","https://openalex.org/W2582686270","https://openalex.org/W2588301364","https://openalex.org/W2611663512","https://openalex.org/W2620701730","https://openalex.org/W2731987565","https://openalex.org/W2754964600","https://openalex.org/W2790491347","https://openalex.org/W2802685181","https://openalex.org/W2807453159","https://openalex.org/W2809103633","https://openalex.org/W2809769744","https://openalex.org/W2836754285","https://openalex.org/W2897826078","https://openalex.org/W2902178521","https://openalex.org/W2916814431","https://openalex.org/W2922578062","https://openalex.org/W2931669064","https://openalex.org/W2951141760","https://openalex.org/W2953427423","https://openalex.org/W2968825107","https://openalex.org/W2971403174","https://openalex.org/W2971894344","https://openalex.org/W2984915341","https://openalex.org/W2991079475","https://openalex.org/W2998345757","https://openalex.org/W3000412469","https://openalex.org/W3012517478","https://openalex.org/W3025692948","https://openalex.org/W3044613732","https://openalex.org/W3047874793","https://openalex.org/W3087460446","https://openalex.org/W3093237272","https://openalex.org/W3093316577","https://openalex.org/W3093850074","https://openalex.org/W3096433602","https://openalex.org/W3099531449","https://openalex.org/W3106879179","https://openalex.org/W3107730617","https://openalex.org/W3120452655","https://openalex.org/W3131875657","https://openalex.org/W3138784463","https://openalex.org/W3139248248","https://openalex.org/W3147873776","https://openalex.org/W3151725558","https://openalex.org/W3156009349","https://openalex.org/W3157520262","https://openalex.org/W3159102835","https://openalex.org/W3165885178","https://openalex.org/W3173128102","https://openalex.org/W3175628958","https://openalex.org/W3177299830","https://openalex.org/W3197710384","https://openalex.org/W3203323497","https://openalex.org/W3209799485","https://openalex.org/W3212454452","https://openalex.org/W3215360475","https://openalex.org/W4200034359","https://openalex.org/W4211115069","https://openalex.org/W4213265765","https://openalex.org/W4223612852","https://openalex.org/W4225136816","https://openalex.org/W4229029322","https://openalex.org/W4283791041"],"related_works":["https://openalex.org/W4389855335","https://openalex.org/W4413408765","https://openalex.org/W7168292284","https://openalex.org/W3095793999","https://openalex.org/W4414988939","https://openalex.org/W4313531938","https://openalex.org/W4200141628","https://openalex.org/W4403134382","https://openalex.org/W1513322637","https://openalex.org/W2064616912"],"abstract_inverted_index":{"Cell":[0],"therapy":[1],"holds":[2],"great":[3,68],"promise":[4],"in":[5,137,156],"addressing":[6],"a":[7,131,148],"wide":[8],"range":[9],"of":[10,21,49,61,67,82,89,102,105,111,117,133,140,165],"malignant":[11],"diseases,":[12],"such":[13],"as":[14],"cancers":[15],"and":[16,24,51,80,159,161],"infectious":[17],"diseases.":[18],"The":[19],"convergence":[20],"chemistry,":[22],"engineering,":[23],"material":[25],"sciences":[26],"further":[27,52],"create":[28],"tremendous":[29],"opportunities":[30],"to":[31,70],"upgrade":[32],"their":[33,154],"therapeutic":[34],"potential":[35],"by":[36],"integrating":[37],"them":[38,54],"with":[39,55,147],"different":[40],"functional":[41],"motifs,":[42],"which":[43],"can":[44],"strengthen":[45],"the":[46,62,78,100,103,106,112,134,138,163],"inherent":[47],"features":[48],"cells":[50,90,108],"render":[53],"new":[56],"functionalities.":[57],"A":[58],"rational":[59],"selection":[60],"cell":[63,73,126,145,167],"decoration":[64],"methods":[65],"is":[66],"importance":[69],"ensure":[71],"desired":[72],"modification":[74,88],"while":[75],"maximumly":[76],"preserving":[77],"properties":[79],"biofunctions":[81,104],"cells.":[83],"Bio\u2010orthogonal":[84],"chemistry":[85],"allows":[86],"covalent":[87],"at":[91],"favorable":[92],"reaction":[93],"rates":[94],"under":[95],"mild":[96],"biological":[97],"conditions":[98],"without":[99],"perturbation":[101],"engineered":[107],"or":[109],"disturbance":[110],"biosystem.":[113],"Among":[114],"various":[115],"types":[116],"bio\u2010orthogonal":[118,141],"reactions,":[119,152],"cycloaddition":[120,151],"reactions":[121],"are":[122],"widely":[123],"adopted":[124],"for":[125,144],"engineering.":[127],"This":[128],"review":[129],"presents":[130],"summary":[132],"latest":[135],"progress":[136],"development":[139],"chemistry\u2010based":[142],"strategies":[143],"engineering":[146,168],"focus":[149],"on":[150],"highlights":[153],"applications":[155],"disease":[157],"diagnosis":[158],"therapy,":[160],"discusses":[162],"prospects":[164],"this":[166],"technique.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-01-04T00:00:00"}
