{"id":"https://openalex.org/W4312104147","doi":"https://doi.org/10.1093/geroni/igac059.1558","title":"LIPIDOMIC ANALYSIS OF GAIT SPEED IN THE LONG LIFE FAMILY STUDY","display_name":"LIPIDOMIC ANALYSIS OF GAIT SPEED IN THE LONG LIFE FAMILY STUDY","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4312104147","doi":"https://doi.org/10.1093/geroni/igac059.1558"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igac059.1558","doi":"https://doi.org/10.1093/geroni/igac059.1558","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.1558","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/396/48308753/igac059.1558.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/396/48308753/igac059.1558.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043967551","display_name":"Adam J. Santanasto","orcid":"https://orcid.org/0000-0002-6912-2909","observed_orcids":["https://orcid.org/0000-0002-6912-2909"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Santanasto","raw_affiliation_strings":["School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057385227","display_name":"Mary Fiestosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Fiestosa","raw_affiliation_strings":["Washington University School of Medicine in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060180450","display_name":"Michael S. Lustgarten","orcid":"https://orcid.org/0000-0003-1262-784X","observed_orcids":["https://orcid.org/0000-0003-1262-784X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Lustgarten","raw_affiliation_strings":["Tufts University , Boston, Massachusetts , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University , Boston, Massachusetts , United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019626205","display_name":"Kaare Christensen","orcid":"https://orcid.org/0000-0002-5429-5292","observed_orcids":["https://orcid.org/0000-0002-5429-5292"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kaare Christensen","raw_affiliation_strings":["Southern Denmark University , Odense, Syddanmark , Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Denmark University , Odense, Syddanmark , Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027513211","display_name":"Gary J. Patti","orcid":"https://orcid.org/0000-0002-3748-6193","observed_orcids":["https://orcid.org/0000-0002-3748-6193"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Patti","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056009082","display_name":"Joseph M. Zmuda","orcid":"https://orcid.org/0000-0001-7237-3162","observed_orcids":["https://orcid.org/0000-0001-7237-3162"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Zmuda","raw_affiliation_strings":["School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043871483","display_name":"Ryan Cvejkus","orcid":"https://orcid.org/0000-0001-5287-5341","observed_orcids":["https://orcid.org/0000-0001-5287-5341"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Cvejkus","raw_affiliation_strings":["School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Pittsburgh , Oakmont, Pennsylvania , United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031200792","display_name":"Mary K. Wojczynski","orcid":"https://orcid.org/0000-0002-2420-162X","observed_orcids":["https://orcid.org/0000-0002-2420-162X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Wojczynski","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_1","first_page":"396","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":1.0},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/lipid-metabolites","display_name":"lipid metabolites","score":0.8379999995231628},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8809999823570251},{"id":"https://openalex.org/keywords/acylcarnitines","display_name":"acylcarnitines","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sphingosine","display_name":"sphingosine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mitochondrial-fatty-acid-beta-oxidation","display_name":"mitochondrial beta-oxidation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/long-life-family-study","display_name":"Long Life Family Study","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C11940443","wikidata":"https://www.wikidata.org/wiki/Q16965645","display_name":"Slowness","level":2,"score":0.8697839975357056},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.6577778458595276},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.586459219455719},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.5749290585517883},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.541801393032074},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.49572694301605225},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4760596454143524},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.47189244627952576},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.45143088698387146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41123393177986145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3757787346839905},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3746287226676941},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3211447596549988},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30991798639297485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27033665776252747},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2529217302799225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24509841203689575},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.10113808512687683},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06935596466064453},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igac059.1558","doi":"https://doi.org/10.1093/geroni/igac059.1558","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.1558","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/396/48308753/igac059.1558.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9770184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9770184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igac059.1558","doi":"https://doi.org/10.1093/geroni/igac059.1558","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.1558","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/396/48308753/igac059.1558.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312104147.pdf","grobid_xml":"https://content.openalex.org/works/W4312104147.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804501047","https://openalex.org/W2989164174","https://openalex.org/W2733610233","https://openalex.org/W3002832137","https://openalex.org/W7097952868","https://openalex.org/W2144652882","https://openalex.org/W7118094426","https://openalex.org/W1993899575","https://openalex.org/W4410501477","https://openalex.org/W4391583992"],"abstract_inverted_index":{"Abstract":[0],"Gait":[1,53,102],"speed":[2,35,54,103,147],"is":[3],"a":[4,127],"predictor":[5],"of":[6,93,121],"overall":[7],"health":[8],"and":[9,59,75,108,126,141],"mortality":[10],"in":[11,36,148],"older":[12,149],"adults.":[13,150],"Metabolomics":[14],"may":[15],"provide":[16],"insights":[17],"into":[18],"biological":[19],"mechanisms":[20],"underlying":[21],"gait":[22,34,146],"speed.":[23],"Herein,":[24],"we":[25],"examined":[26],"the":[27,81],"association":[28,82],"between":[29,83],"193":[30],"lipid":[31,113],"metabolites":[32,85,114],"with":[33,86,118,138],"1,717":[37],"adults":[38],"(52.1%":[39],"women)":[40],"aged":[41],"82.0":[42],"\u00b1":[43,106],"14.5.":[44],"Lipidomic":[45],"analysis":[46],"was":[47,55,61,95,104],"performed":[48],"using":[49],"liquid":[50],"chromatography-mass":[51],"spectrometry.":[52],"measured":[56],"over":[57],"4-meters":[58],"slowness":[60],"defined":[62],"as":[63],"<0.8m/s.":[64],"Logistic":[65],"regression,":[66],"adjusted":[67],"for":[68,99],"age,":[69],"sex,":[70],"field":[71],"center,":[72],"height,":[73],"fasting-duration":[74],"familial-relatedness,":[76],"were":[77,115],"used":[78],"to":[79,97,145],"examine":[80],"log-transformed":[84],"slowness.":[87,111],"A":[88],"false":[89],"discovery":[90],"rate":[91],"(FDR)":[92],"p<0.05":[94],"employed":[96],"account":[98],"multiple":[100],"comparisons.":[101],"0.83":[105],"0.32":[107],"53.4%":[109],"had":[110],"Three":[112],"significantly":[116],"associated":[117],"lower":[119],"odds":[120],"slowness:":[122],"an":[123],"acylcarnitine,":[124],"sphingomyelin":[125],"ceramide":[128],"non-hydroxy":[129],"fatty":[130],"acid-sphingosine.":[131],"Our":[132],"results":[133],"potentially":[134],"link":[135],"lipids":[136],"involved":[137],"mitochondrial":[139],"beta-oxidation":[140],"nerve":[142],"signal":[143],"transduction":[144]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-01-04T00:00:00"}
