{"id":"https://openalex.org/W4312102769","doi":"https://doi.org/10.1093/geroni/igac059.956","title":"FOXO3-MEDIATED PROTECTION AGAINST VASCULAR DEMENTIA RISK IN A CASE-CONTROL STUDY OF ASIAN AMERICAN MEN","display_name":"FOXO3-MEDIATED PROTECTION AGAINST VASCULAR DEMENTIA RISK IN A CASE-CONTROL STUDY OF ASIAN AMERICAN MEN","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4312102769","doi":"https://doi.org/10.1093/geroni/igac059.956"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igac059.956","doi":"https://doi.org/10.1093/geroni/igac059.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.956","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/241/48312040/igac059.956.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/241/48312040/igac059.956.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069643898","display_name":"Philip M. C. Davy","orcid":"https://orcid.org/0000-0001-9806-4747","observed_orcids":["https://orcid.org/0000-0001-9806-4747"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Davy","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068589340","display_name":"Kalpana J. Kallianpur","orcid":"https://orcid.org/0000-0002-9978-097X","observed_orcids":["https://orcid.org/0000-0002-9978-097X"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalpana Kallianpur","raw_affiliation_strings":["Kuakini Medical Center, Honolulu, Hawaii , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center, Honolulu, Hawaii , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080086834","display_name":"Randi Chen","orcid":"https://orcid.org/0000-0003-3747-7964","observed_orcids":["https://orcid.org/0000-0003-3747-7964"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randi Chen","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071896879","display_name":"Timothy A. Donlon","orcid":"https://orcid.org/0000-0001-6545-6533","observed_orcids":["https://orcid.org/0000-0001-6545-6533"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Donlon","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022264359","display_name":"Brian J. Morris","orcid":"https://orcid.org/0000-0003-2468-3566","observed_orcids":["https://orcid.org/0000-0003-2468-3566"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Morris","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111802321","display_name":"Richard Allsopp","orcid":"https://orcid.org/0000-0001-7565-5325","observed_orcids":["https://orcid.org/0000-0001-7565-5325"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Allsopp","raw_affiliation_strings":["University of Hawaii , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawaii , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036308409","display_name":"Bradley J. Willcox","orcid":"https://orcid.org/0000-0001-9890-3520","observed_orcids":["https://orcid.org/0000-0001-9890-3520"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley Willcox","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108327705","display_name":"Kamal Masaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamal Masaki","raw_affiliation_strings":["Kuakini Medical Center , Honolulu, Hawaii , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center , Honolulu, Hawaii , United States","institution_ids":["https://openalex.org/I1312008915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_1","first_page":"241","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/japanese-american-men","display_name":"Japanese-American men","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7120000123977661},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8949999809265137},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.800000011920929},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C168003608","wikidata":"https://www.wikidata.org/wiki/Q21101484","display_name":"FOXO3","level":4,"score":0.7585368156433105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6059181094169617},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.5580880641937256},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5315530300140381},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5127478837966919},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.512383759021759},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41833579540252686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37129491567611694},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3300737738609314},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27591902017593384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17020002007484436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15772205591201782},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igac059.956","doi":"https://doi.org/10.1093/geroni/igac059.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.956","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/241/48312040/igac059.956.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9765641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9765641","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igac059.956","doi":"https://doi.org/10.1093/geroni/igac059.956","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igac059.956","pdf_url":"https://academic.oup.com/innovateage/article-pdf/6/Supplement_1/241/48312040/igac059.956.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312102769.pdf","grobid_xml":"https://content.openalex.org/works/W4312102769.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387517776","https://openalex.org/W4390083144","https://openalex.org/W4390191880","https://openalex.org/W2524997705","https://openalex.org/W4384695236","https://openalex.org/W3180401472","https://openalex.org/W7118080205","https://openalex.org/W4404080428","https://openalex.org/W4312088238","https://openalex.org/W7137058340"],"abstract_inverted_index":{"Abstract":[0],"The":[1,195],"longevity-associated":[2,176,222],"allele":[3,177],"of":[4,58,83,103,111,148,172],"FOXO3":[5,36,59,74,84,106,151,175,221],"is":[6],"associated":[7],"with":[8,29,105,150],"a":[9,90,109,166,209,215],"significant":[10,167],"reduction":[11],"in":[12,17,89,108,208,232],"cardiovascular":[13],"disease":[14],"(CVD)":[15],"risk":[16,27,88,132,162,184,204],"older":[18],"adults.":[19],"We":[20,164],"hypothesized":[21],"that":[22,67],"dementia,":[23],"which":[24],"shares":[25],"several":[26],"factors":[28,133,205],"CVD,":[30],"might":[31],"also":[32],"be":[33],"related":[34],"to":[35,54,61,73,99,129,144],"genotype,":[37],"particularly":[38],"vascular":[39,161,225],"dementia":[40,62,104],"(VaD).":[41],"Therefore,":[42,76],"we":[43,77],"utilized":[44,128],"the":[45,56,70,101,121,146,173,220],"Kuakini":[46],"Honolulu":[47],"Heart":[48],"Program/Honolulu":[49],"Asia":[50],"Aging":[51],"Study":[52],"dataset":[53],"assess":[55,100,145],"relation":[57,72],"genotype":[60,85,107,152,223],"risk.":[63],"Preliminary":[64],"analyses":[65],"suggested":[66],"VaD":[68,87,131,135,149,183,207],"had":[69],"strongest":[71],"genotype.":[75],"performed":[78],"larger,":[79],"more":[80],"detailed":[81],"study":[82,115],"and":[86,137,159],"9-year":[91],"nest":[92],"case-control":[93],"study.":[94],"Chi-Square":[95],"test":[96],"was":[97,127,142],"used":[98,143],"association":[102,147,169,197],"sample":[110],"1504":[112],"Japanese-American":[113],"male":[114],"participants,":[116],"aged":[117],"71-93":[118],"years,":[119],"at":[120],"baseline":[122],"exam.":[123],"General":[124],"Linear":[125],"Model":[126],"compare":[130],"between":[134],"cases":[136],"controls.":[138],"Multivariate":[139],"Logistic":[140],"Regression":[141],"adjusting":[153],"for":[154,170,202,206,219],"birth":[155],"year,":[156],"education,":[157],"APOE4":[158],"other":[160,233],"factors.":[163],"found":[165],"protective":[168,196],"carriers":[171],"principal":[174],"(SNP":[178],"rs2802292":[179],"G":[180],"allele-carriers)":[181],"against":[182,224],"(OR":[185],"=":[186,190,193],"0.66,":[187],"95%":[188],"CI":[189],"0.44-0.98,":[191],"p":[192],"0.0388).":[194],"retained":[198],"significance":[199],"when":[200],"controlling":[201],"common":[203],"multivariate":[210],"model.":[211],"These":[212],"data":[213],"indicate":[214],"potential":[216],"neuroprotective":[217],"role":[218],"dementia.":[226],"This":[227],"finding":[228],"merits":[229],"validation":[230],"studies":[231],"cohort":[234],"studies.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-01-04T00:00:00"}
