{"id":"https://openalex.org/W4312088221","doi":"https://doi.org/10.1002/alz.060772","title":"Higher CSF Ab38 levels protect against cognitive decline in high\u2010functioning individuals","display_name":"Higher CSF Ab38 levels protect against cognitive decline in high\u2010functioning individuals","publication_year":2022,"publication_date":"2022-12-01","ids":{"openalex":"https://openalex.org/W4312088221","doi":"https://doi.org/10.1002/alz.060772"},"language":"en","primary_location":{"id":"doi:10.1002/alz.060772","doi":"https://doi.org/10.1002/alz.060772","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alz.060772","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066440154","display_name":"Davide Bruno","orcid":"https://orcid.org/0000-0003-1943-9905","observed_orcids":["https://orcid.org/0000-0003-1943-9905"]},"institutions":[{"id":"https://openalex.org/I63098007","display_name":"Liverpool John Moores University","ror":"https://ror.org/04zfme737","country_code":"GB","type":"education","lineage":["https://openalex.org/I63098007"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Davide Bruno","raw_affiliation_strings":["Liverpool John Moores University, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liverpool John Moores University, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I63098007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048616578","display_name":"Chelsea Reichert Plaska","orcid":"https://orcid.org/0000-0001-9662-6179","observed_orcids":["https://orcid.org/0000-0001-9662-6179"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea Reichert","raw_affiliation_strings":["Nathan Kline Institute, Orangeburg, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079766290","display_name":"Henrik Zetterberg","orcid":"https://orcid.org/0000-0003-3930-4354","observed_orcids":["https://orcid.org/0000-0003-3930-4354","https://orcid.org/0000-0002-4671-6763"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Henrik Zetterberg","raw_affiliation_strings":["Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong","The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden","UCL Queen Square Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong","institution_ids":[]},{"raw_affiliation_string":"The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"UCL Queen Square Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025313057","display_name":"Kaj Blennow","orcid":"https://orcid.org/0000-0002-1890-4193","observed_orcids":["https://orcid.org/0000-0002-1890-4193"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kaj Blennow","raw_affiliation_strings":["Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037802542","display_name":"Nunzio Pomara","orcid":"https://orcid.org/0000-0002-8075-4253","observed_orcids":["https://orcid.org/0000-0002-8075-4253","https://orcid.org/0000-0003-2204-0102"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nunzio Pomara","raw_affiliation_strings":["Nathan Kline Institute, Orangeburg, NY, USA","New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]},{"raw_affiliation_string":"New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5066440154"],"corresponding_institution_ids":["https://openalex.org/I63098007"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.1592,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48794725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"18","issue":"S5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1793999969959259,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6445675492286682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5943029522895813},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5826826095581055},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.572944700717926},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.5662471652030945},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5651616454124451},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5449416637420654},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.49676328897476196},{"id":"https://openalex.org/C2781357127","wikidata":"https://www.wikidata.org/wiki/Q438896","display_name":"Late life depression","level":3,"score":0.48796766996383667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43716731667518616},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.42235201597213745},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4133700728416443},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3757147490978241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3698806166648865},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33646857738494873},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3024264872074127},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.28940466046333313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26978322863578796},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24831604957580566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13615107536315918},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.060772","doi":"https://doi.org/10.1002/alz.060772","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alz.060772","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200144098","https://openalex.org/W2074017019","https://openalex.org/W4390194780","https://openalex.org/W4406874640","https://openalex.org/W3020923599","https://openalex.org/W2612535028","https://openalex.org/W2004620798","https://openalex.org/W2300591501","https://openalex.org/W2075275965","https://openalex.org/W2062135776"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,96,230],"amyloid":[3],"cascade":[4],"hypothesis":[5],"proposes":[6],"that":[7,37,69,233],"Alzheimer\u2019s":[8],"disease":[9],"(AD)":[10],"pathology":[11],"starts":[12],"with":[13,53,55,79,195,246,260,286,318,334],"accumulation":[14],"of":[15,75,92,98,177,257,271,281,308,326],"b\u2010amyloid":[16],"(Ab)":[17],"peptides,":[18],"leading":[19],"to":[20,94,102,202,299],"plaque":[21],"deposition.":[22],"In":[23],"this":[24,99],"context,":[25],"the":[26,83,142,234,244,255,258,269,272,306,313,324],"spotlight":[27],"has":[28,67],"been":[29],"pointed":[30],"firmly":[31],"onto":[32],"Ab42,":[33,209],"but":[34],"evidence":[35,248],"suggests":[36],"shorter":[38,328],"isoforms":[39,330],"may":[40],"also":[41,108,331],"play":[42],"an":[43,174],"important":[44],"role":[45],"in":[46,111,114,133,197,289,332],"modulating":[47],"AD":[48],"pathophysiology.":[49],"A":[50],"recent":[51],"report":[52],"individuals":[54,124,163,333],"mild":[56],"cognitive":[57,61,336,340],"impairment":[58,337],"or":[59,179,338],"subjective":[60,339],"decline":[62,81,288],"(Cullen":[63],"et":[64],"al.,":[65],"2021)":[66],"shown":[68],"higher":[70,180,278,293],"cerebrospinal":[71],"fluid":[72],"(CSF)":[73],"levels":[74,107,280,296],"Ab38":[76,106,238,283],"were":[77,120,151,164,170,284,297],"associated":[78,285],"less":[80,287],"on":[82,136],"mini\u2010mental":[84],"state":[85],"exam":[86],"(MMSE)":[87],"score":[88,176,199],"and":[89,146,168,210,217,224,239,266],"reduced":[90],"risk":[91],"conversion":[93],"AD.":[95],"aim":[97],"study":[100,135],"was":[101,243,310,316],"test":[103,184],"whether":[104],"CSF":[105,206,208,211,237,240,282],"predicted":[109],"change":[110,196],"MMSE":[112,175,198,290],"scores":[113],"cognitively":[115],"intact":[116],"individuals.":[117],"Method":[118],"Data":[119,150],"obtained":[121],"from":[122,200],"40":[123],"(age":[125],"=":[126,250,264,276],"67.3,":[127],"6.3),":[128],"who":[129],"had":[130,173],"taken":[131],"part":[132],"a":[134,190],"late\u2010life":[137],"major":[138],"depressive":[139],"disorder":[140],"at":[141,166,181],"Nathan":[143],"Kline":[144],"Institute":[145],"New":[147],"York":[148],"University.":[149],"available":[152],"for":[153,219],"baseline":[154,201,279],"examination":[155],"as":[156,158,204,215],"well":[157],"three\u2010year":[159],"follow":[160],"up.":[161],"Twenty\u2010three":[162],"depressed":[165,304],"baseline,":[167],"17":[169],"controls;":[171],"all":[172,261],"28":[178],"baseline.":[182],"To":[183],"our":[185],"hypothesis,":[186],"we":[187],"carried":[188],"out":[189],"Bayesian":[191],"linear":[192],"regression":[193],"analysis":[194],"follow\u2010up":[203],"outcome;":[205],"Ab38,":[207],"phosphorylated":[212],"(p)":[213],"tau":[214,242,295],"predictors;":[216],"controlling":[218],"age,":[220],"sex,":[221],"APOE":[222],"e4\u2010status":[223],"depression":[225],"diagnosis":[226],"(null":[227],"model).":[228],"Result":[229],"results":[231,309],"showed":[232],"model":[235,259,274,315],"combining":[236],"p":[241,294],"strongest,":[245],"moderate":[247],"(BFm":[249],"4),":[251],"carrying":[252],"nearly":[253],"double":[254],"odds":[256,270],"predictors":[262],"(BF10":[263,275],"0.539),":[265],"4.6":[267],"times":[268],"null":[273,314],"0.219):":[277],"score,":[291],"while":[292,312],"linked":[298],"more":[300],"decline.":[301,341],"When":[302],"isolating":[303],"individuals,":[305],"pattern":[307],"unchanged,":[311],"strongest":[317],"controls.":[319],"Conclusion":[320],"These":[321],"findings":[322],"confirm":[323],"importance":[325],"examining":[327],"Ab":[329],"no":[335]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-04T00:00:00"}