{"id":"https://openalex.org/W4312032016","doi":"https://doi.org/10.1101/2022.12.19.521127","title":"Adenoviral-Based Vaccine Elicits Robust Systemic and Mucosal Cross-Reactive Responses in African Green Monkeys and Reduces Shedding after SARS-CoV-2 Challenge","display_name":"Adenoviral-Based Vaccine Elicits Robust Systemic and Mucosal Cross-Reactive Responses in African Green Monkeys and Reduces Shedding after SARS-CoV-2 Challenge","publication_year":2022,"publication_date":"2022-12-20","ids":{"openalex":"https://openalex.org/W4312032016","doi":"https://doi.org/10.1101/2022.12.19.521127"},"language":"en","primary_location":{"id":"doi:10.1101/2022.12.19.521127","doi":"https://doi.org/10.1101/2022.12.19.521127","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.19.521127","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/20/2022.12.19.521127.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/20/2022.12.19.521127.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020129863","display_name":"Sarah N. Tedjakusuma","orcid":"https://orcid.org/0000-0002-0933-6737","observed_orcids":["https://orcid.org/0000-0002-0933-6737"]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah N. Tedjakusuma","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087295376","display_name":"Colin A. Lester","orcid":"https://orcid.org/0009-0001-2639-5990","observed_orcids":["https://orcid.org/0009-0001-2639-5990"]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin A. Lester","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052696653","display_name":"Elena D. Neuhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena D. Neuhaus","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072741174","display_name":"Emery G. Dora","orcid":"https://orcid.org/0000-0002-0587-2751","observed_orcids":["https://orcid.org/0000-0002-0587-2751"]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emery G. Dora","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018857037","display_name":"Sean N. Tucker","orcid":"https://orcid.org/0000-0002-6233-225X","observed_orcids":["https://orcid.org/0000-0002-6233-225X"]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean N. Tucker","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004337160","display_name":"Becca A. Flitter","orcid":"https://orcid.org/0000-0002-3478-8751","observed_orcids":["https://orcid.org/0000-0002-3478-8751"]},"institutions":[{"id":"https://openalex.org/I4210129257","display_name":"Vaxart (United States)","ror":"https://ror.org/03qecha53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129257"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Becca A. Flitter","raw_affiliation_strings":["Vaxart, Inc. South San Francisco CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxart, Inc. South San Francisco CA 94080","institution_ids":["https://openalex.org/I4210129257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004337160"],"corresponding_institution_ids":["https://openalex.org/I4210129257"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/adenovirus-vectored-vaccine","display_name":"adenovirus vector vaccine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/rad5","display_name":"Rad5","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mucosal-immunization","display_name":"mucosal immunization","score":0.9459999799728394},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.7960000038146973},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cross-reactive-neutralizing-antibodies","display_name":"cross-reactive neutralizing antibodies","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mucosal-iga","display_name":"mucosal IgA","score":0.8500000238418579},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"viral shedding","score":0.6729999780654907},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.6539999842643738},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.8500000238418579},{"id":"https://openalex.org/keywords/vervet-monkey","display_name":"vervet monkey","score":0.6909999847412109},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/molecular-adjuvant","display_name":"molecular adjuvant","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.7370487451553345},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7217500805854797},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6386059522628784},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6379004716873169},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6339336037635803},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5777594447135925},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5590775012969971},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5581564903259277},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49901771545410156},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.48562970757484436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45381420850753784},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.45343321561813354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43140825629234314},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4268144965171814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4225555956363678},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.42137253284454346}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.12.19.521127","doi":"https://doi.org/10.1101/2022.12.19.521127","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.19.521127","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/20/2022.12.19.521127.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.12.19.521127","doi":"https://doi.org/10.1101/2022.12.19.521127","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.19.521127","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/20/2022.12.19.521127.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312032016.pdf","grobid_xml":"https://content.openalex.org/works/W4312032016.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1895663386","https://openalex.org/W1965570141","https://openalex.org/W1993150792","https://openalex.org/W1999283861","https://openalex.org/W2016244758","https://openalex.org/W2060566204","https://openalex.org/W2073525950","https://openalex.org/W2097034992","https://openalex.org/W2141064625","https://openalex.org/W2826397905","https://openalex.org/W2907822139","https://openalex.org/W2982755374","https://openalex.org/W3002094328","https://openalex.org/W3014232369","https://openalex.org/W3045724532","https://openalex.org/W3108193091","https://openalex.org/W3112028440","https://openalex.org/W3138437538","https://openalex.org/W3139533040","https://openalex.org/W3172273960","https://openalex.org/W3189985782","https://openalex.org/W3216580572","https://openalex.org/W4200535281","https://openalex.org/W4213440258","https://openalex.org/W4214500638","https://openalex.org/W4226060119","https://openalex.org/W4229036607","https://openalex.org/W4286212735","https://openalex.org/W4288432606","https://openalex.org/W4302009688","https://openalex.org/W4304112065"],"related_works":["https://openalex.org/W4391323301","https://openalex.org/W4311736916","https://openalex.org/W4214500638","https://openalex.org/W4417321373","https://openalex.org/W4321499101","https://openalex.org/W4404997434","https://openalex.org/W4407587728","https://openalex.org/W3049348882","https://openalex.org/W7166297892","https://openalex.org/W3200737820"],"abstract_inverted_index":{"Abstract":[0],"As":[1],"new":[2],"SARS-CoV-2":[3,70,101,218],"variants":[4,127,152],"continue":[5],"to":[6,13,47,179],"emerge":[7],"and":[8,28,53,75,88,121,144,166,175,206,208,212],"impact":[9],"communities":[10],"worldwide,":[11],"efforts":[12],"develop":[14],"next":[15],"generation":[16],"vaccines":[17],"that":[18,189],"enhance":[19],"mucosal":[20,44,133,190],"immunity":[21],"would":[22],"be":[23],"beneficial":[24],"for":[25],"protecting":[26],"individuals":[27],"reducing":[29],"community":[30],"transmission.":[31],"We":[32],"have":[33],"developed":[34],"a":[35,50,54,139,160],"non-replicating":[36],"recombinant":[37],"adenovirus":[38],"vector":[39],"(rAd5)":[40],"vaccine":[41,72,97],"delivered":[42],"by":[43],"administration":[45,141],"engineered":[46],"express":[48],"both":[49,171,203],"protein":[51,103],"antigen":[52,131],"novel":[55],"molecular":[56],"adjuvant":[57],"in":[58,81,106,116,163,170,202],"the":[59,65,172,204],"same":[60],"cell.":[61],"Here":[62],"we":[63],"describe":[64],"immunogenicity":[66],"of":[67,128,142],"three":[68],"unique":[69],"rAd5":[71,96,143,193],"preclinical":[73],"candidates":[74,98],"their":[76],"efficacy":[77],"following":[78,182],"viral":[79,100,109,164,210],"challenge":[80,183,215],"African":[82],"green":[83],"monkeys.":[84],"Animals":[85],"were":[86,136],"prime":[87],"boost":[89],"immunized":[90],"intranasally":[91],"twenty-nine":[92],"days":[93],"apart":[94],"with":[95,108,184,216],"containing":[99],"spike":[102],"alone":[104],"or":[105],"combination":[107],"nucleocapsid.":[110],"Mucosal":[111],"immunization":[112,191],"elicited":[113],"significant":[114,161],"increases":[115],"antigen-specific":[117],"serum":[118],"antibody":[119],"responses":[120,135,201],"functional":[122],"neutralizing":[123,148],"activity":[124],"against":[125,150],"multiple":[126,151,217],"concern.":[129],"Robust":[130],"specific":[132],"IgA":[134],"observed":[137],"after":[138],"single":[140],"generated":[145],"strong":[146],"cross-reactive":[147,199],"antibodies":[149],"including":[153],"delta.":[154],"Importantly,":[155],"all":[156],"vaccinated":[157],"animals":[158],"exhibited":[159],"reduction":[162],"loads":[165,211],"infectious":[167],"particle":[168],"shedding":[169,213],"nasal":[173],"passages":[174],"lower":[176],"airways":[177],"compared":[178],"unvaccinated":[180],"controls":[181],"SARS-CoV-2.":[185],"These":[186],"findings":[187],"demonstrate":[188],"using":[192],"is":[194],"highly":[195],"immunogenic,":[196],"confers":[197],"protective":[198],"humoral":[200],"circulation":[205],"mucosa,":[207],"reduces":[209],"upon":[214],"variants.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-01-04T00:00:00"}
