{"id":"https://openalex.org/W4311797484","doi":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","title":"Adaptive immune response in pathogenesis and treatment of head and neck squamous cell carcinoma: the influence of immunosuppression factors and gender","display_name":"Adaptive immune response in pathogenesis and treatment of head and neck squamous cell carcinoma: the influence of immunosuppression factors and gender","publication_year":2022,"publication_date":"2022-10-14","ids":{"openalex":"https://openalex.org/W4311797484","doi":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126"},"language":"en","primary_location":{"id":"doi:10.17650/2222-1468-2022-12-3-114-126","doi":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","pdf_url":"https://ogsh.abvpress.ru/jour/article/download/820/547","source":{"id":"https://openalex.org/S2738175511","display_name":"Head and neck tumors (HNT)","issn_l":"2222-1468","issn":["2222-1468","2411-4634"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head and neck tumors (HNT)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ogsh.abvpress.ru/jour/article/download/820/547","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081086608","display_name":"\u0410. I. Stukan","orcid":"https://orcid.org/0000-0002-0698-7710","observed_orcids":["https://orcid.org/0000-0002-0698-7710","https://orcid.org/0009-0005-6153-3059"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. I. Stukan","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","Kuban State Medical University, Ministry of Health of Russia","Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0698-7710","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]},{"raw_affiliation_string":"Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065954156","display_name":"R. A. Murashko","orcid":"https://orcid.org/0000-0001-8084-8770","observed_orcids":["https://orcid.org/0000-0001-8084-8770"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R.\u200a A. Murashko","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","Kuban State Medical University, Ministry of Health of Russia","Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-8084-8770","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]},{"raw_affiliation_string":"Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091794680","display_name":"N. A. Tsygan","orcid":"https://orcid.org/0000-0002-9783-6423","observed_orcids":["https://orcid.org/0000-0002-9783-6423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. A. Tsygan","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory"],"raw_orcid":"https://orcid.org/0000-0002-9783-6423","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082375361","display_name":"\u0410. Yu. Goryainova","orcid":"https://orcid.org/0000-0001-7127-7945","observed_orcids":["https://orcid.org/0000-0001-7127-7945"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Yu. Goryainova","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","Kuban State Medical University, Ministry of Health of Russia","Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-7127-7945","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]},{"raw_affiliation_string":"Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049350961","display_name":"O. N. Nefedov","orcid":"https://orcid.org/0000-0002-0325-0932","observed_orcids":["https://orcid.org/0000-0002-0325-0932"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. N. Nefedov","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","Kuban State Medical University, Ministry of Health of Russia","Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0325-0932","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]},{"raw_affiliation_string":"Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082422514","display_name":"Vladimir Alekseyevich Porkhanov","orcid":"https://orcid.org/0000-0003-0572-1395","observed_orcids":["https://orcid.org/0000-0003-0572-1395"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. A. Porkhanov","raw_affiliation_strings":["Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","Kuban State Medical University, Ministry of Health of Russia","S.V. Ochapovsky Research Institute \u2013 Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Territory","Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia; S.V. Ochapovsky Research Institute \u2013 Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Territory"],"raw_orcid":"https://orcid.org/0000-0003-0572-1395","affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory","institution_ids":[]},{"raw_affiliation_string":"Kuban State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"S.V. Ochapovsky Research Institute \u2013 Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Territory","institution_ids":["https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar Territory; Kuban State Medical University, Ministry of Health of Russia; S.V. Ochapovsky Research Institute \u2013 Regional Clinical Hospital No. 1, Ministry of Health of Krasnodar Territory","institution_ids":["https://openalex.org/I168528297","https://openalex.org/I4210117042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7021,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64260694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":"3","first_page":"114","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7990000247955322},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5569999814033508},{"id":"https://openalex.org/keywords/alcohol-abuse","display_name":"alcohol abuse","score":0.8360000252723694},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.6700000166893005},{"id":"https://openalex.org/keywords/age-related-immune-senescence","display_name":"age-related immune senescence","score":0.6930000185966492},{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.8479999899864197},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.871999979019165},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7548819780349731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6965847611427307},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6658832430839539},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6381218433380127},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5486418604850769},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5240336060523987},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5125086307525635},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44985589385032654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44213753938674927},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41336938738822937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4126776158809662},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.410925030708313}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17650/2222-1468-2022-12-3-114-126","doi":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","pdf_url":"https://ogsh.abvpress.ru/jour/article/download/820/547","source":{"id":"https://openalex.org/S2738175511","display_name":"Head and neck tumors (HNT)","issn_l":"2222-1468","issn":["2222-1468","2411-4634"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head and neck tumors (HNT)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2ce3c2f3a3fc4a1d80af1f92824a25f3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2ce3c2f3a3fc4a1d80af1f92824a25f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041e\u043f\u0443\u0445\u043e\u043b\u0438 \u0433\u043e\u043b\u043e\u0432\u044b \u0438 \u0448\u0435\u0438, Vol 12, Iss 3, Pp 114-126 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17650/2222-1468-2022-12-3-114-126","doi":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2222-1468-2022-12-3-114-126","pdf_url":"https://ogsh.abvpress.ru/jour/article/download/820/547","source":{"id":"https://openalex.org/S2738175511","display_name":"Head and neck tumors (HNT)","issn_l":"2222-1468","issn":["2222-1468","2411-4634"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head and neck tumors (HNT)","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311797484.pdf","grobid_xml":"https://content.openalex.org/works/W4311797484.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1645587630","https://openalex.org/W1972587517","https://openalex.org/W1975241511","https://openalex.org/W1975881159","https://openalex.org/W1975992327","https://openalex.org/W1976125614","https://openalex.org/W2005120878","https://openalex.org/W2005182767","https://openalex.org/W2009486245","https://openalex.org/W2031472841","https://openalex.org/W2038976306","https://openalex.org/W2062551567","https://openalex.org/W2110945993","https://openalex.org/W2112498628","https://openalex.org/W2112994594","https://openalex.org/W2121071871","https://openalex.org/W2126339385","https://openalex.org/W2127505226","https://openalex.org/W2147638016","https://openalex.org/W2148344434","https://openalex.org/W2180600242","https://openalex.org/W2211122879","https://openalex.org/W2225731386","https://openalex.org/W2339375057","https://openalex.org/W2401455386","https://openalex.org/W2419439766","https://openalex.org/W2468155864","https://openalex.org/W2521696249","https://openalex.org/W2529484692","https://openalex.org/W2561926137","https://openalex.org/W2587975409","https://openalex.org/W2622195638","https://openalex.org/W2735904407","https://openalex.org/W2739276243","https://openalex.org/W2758800803","https://openalex.org/W2762087959","https://openalex.org/W2777662145","https://openalex.org/W2781906226","https://openalex.org/W2782685575","https://openalex.org/W2785374083","https://openalex.org/W2788371883","https://openalex.org/W2791868377","https://openalex.org/W2792388782","https://openalex.org/W2797675217","https://openalex.org/W2797780288","https://openalex.org/W2797995753","https://openalex.org/W2799372507","https://openalex.org/W2799568166","https://openalex.org/W2804772768","https://openalex.org/W2808755202","https://openalex.org/W2883414633","https://openalex.org/W2894101188","https://openalex.org/W2900031363","https://openalex.org/W2901145902","https://openalex.org/W2903090366","https://openalex.org/W2906776850","https://openalex.org/W2910439966","https://openalex.org/W2932481641","https://openalex.org/W2944288745","https://openalex.org/W2946644285","https://openalex.org/W2949319488","https://openalex.org/W2980659545","https://openalex.org/W2981789682","https://openalex.org/W2995384138","https://openalex.org/W2995456522","https://openalex.org/W2999449437","https://openalex.org/W3007779298","https://openalex.org/W3008317427","https://openalex.org/W3010733920","https://openalex.org/W3045379462","https://openalex.org/W3168058619","https://openalex.org/W3209624761","https://openalex.org/W3212734681","https://openalex.org/W4224862576"],"related_works":["https://openalex.org/W2343237855","https://openalex.org/W7126579414","https://openalex.org/W7217990969","https://openalex.org/W3018170433","https://openalex.org/W7096777000","https://openalex.org/W2995456522","https://openalex.org/W2062257317","https://openalex.org/W7135918825","https://openalex.org/W2400859047","https://openalex.org/W1974760995"],"abstract_inverted_index":{"An":[0,70],"obvious":[1],"trend":[2],"of":[3,18,21,33,41,64,78,101,123,143,161,167,173,186,203,234,241,252,278],"the":[4,19,34,37,65,107,120,141,171,184,201,232,242,249,273,279],"last":[5],"decade":[6],"in":[7,36,48,56,72,84,106,153,170,194,198,206,213,217,231,246,248],"head":[8,49,91,131],"and":[9,39,50,67,75,86,92,97,113,132,148,157,200,244,255],"neck":[10,51,93,133],"squamous":[11,52,94,134],"cell":[12,53,95,135],"carcinoma":[13,54,136],"pathogenesis":[14],"evaluation":[15],"is":[16,137,176,191,210,260],"awareness":[17],"impact":[20],"immune":[22,174,187],"response":[23,47,175,188],"disorders":[24],"on":[25,272],"disease":[26],"manifestation.":[27],"The":[28,165],"review":[29],"presents":[30],"an":[31,245],"analysis":[32],"differences":[35,169],"type":[38,172],"degree":[40],"immunosuppression,":[42],"as":[43,45,265,267,281,283],"well":[44,266,282],"treatment":[46,268],"patients":[55,89,124],"accordance":[57],"with":[58,90,125,208],"influencing":[59,274],"carcinogenic":[60],"factor,":[61,275],"gender,":[62,276],"age":[63,277],"patient":[66],"concomitant":[68],"diseases.":[69],"increase":[71],"CD8+":[73,102],"T-lymphocytes":[74,103,236],"a":[76,98,158,229],"decrease":[77,230],"memory":[79,253],"T-cells":[80],"has":[81,180],"been":[82,181],"evaluated":[83],"smoking":[85],"alcohol":[87],"abusing":[88],"carcinoma,":[96],"smaller":[99],"number":[100,233,251],"were":[104,226],"detected":[105],"tumor":[108],"microenvironment":[109],"compared":[110],"to":[111,140,238],"non-smoking":[112],"non-drinking":[114],"patients.":[115],"Studies":[116],"have":[117],"shown":[118,182],"that":[119,183,262],"improved":[121],"prognosis":[122],"human":[126],"papillomavirus":[127],"(Hpv)":[128],"\u2013":[129],"associated":[130],"largely":[138],"due":[139,237],"presence":[142],"antibodies":[144],"against":[145],"Hpv":[146],"E6":[147],"E7,":[149],"E7-specific":[150],"CD8+T":[151],"lymphocytes":[152],"periphe":[154],"ral":[155],"blood":[156],"high":[159],"level":[160],"tumor-infiltrating":[162],"T":[163],"lymphocytes.":[164],"issue":[166],"gender":[168],"widely":[177],"discussed.":[178],"It":[179],"use":[185,202],"checkpoint":[189],"inhibitors":[190],"more":[192,211],"effective":[193,212],"improving":[195],"survival":[196],"rates":[197],"men,":[199],"these":[204],"drugs":[205],"combination":[207],"chemotherapy":[209],"women.":[214],"In":[215],"addition,":[216],"elderly":[218],"cancer":[219],"patients,":[220],"numerous":[221],"age-associated":[222],"T-lymphocyte\u2019s":[223],"function":[224],"changes":[225],"revealed,":[227],"including":[228],"naive":[235],"age-related":[239],"involution":[240],"thymus":[243],"crease":[247],"relative":[250],"cells":[254],"effector":[256],"cells.":[257],"Thus,":[258],"it":[259],"clear":[261],"immunosuppression":[263],"type,":[264],"response,":[269],"differ":[270],"depending":[271],"patient,":[280],"comorbidities.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-12-28T00:00:00"}