{"id":"https://openalex.org/W4311728958","doi":"https://doi.org/10.12688/f1000research.127138.2","title":"An open label, single arm, pilot study to evaluate the safety, tolerability, and efficacy of daily fluconazole 150 mg in subjects suffering from Tinea cruris and Tinea corporis","display_name":"An open label, single arm, pilot study to evaluate the safety, tolerability, and efficacy of daily fluconazole 150 mg in subjects suffering from Tinea cruris and Tinea corporis","publication_year":2022,"publication_date":"2022-12-07","ids":{"openalex":"https://openalex.org/W4311728958","doi":"https://doi.org/10.12688/f1000research.127138.2"},"language":"en","primary_location":{"id":"doi:10.12688/f1000research.127138.2","doi":"https://doi.org/10.12688/f1000research.127138.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.127138.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12688/f1000research.127138.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113532002","display_name":"D G Saple","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dattatray Gopal Saple","raw_affiliation_strings":["La\u2019Mer Clinic, Mumbai, Maharashtra, 400014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La\u2019Mer Clinic, Mumbai, Maharashtra, 400014, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087573859","display_name":"Sushrut Save","orcid":"https://orcid.org/0000-0001-7182-4443","observed_orcids":["https://orcid.org/0000-0001-7182-4443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sushrut Save","raw_affiliation_strings":["La\u2019Mer Clinic, Mumbai, Maharashtra, 400014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La\u2019Mer Clinic, Mumbai, Maharashtra, 400014, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Devesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devesh Kumar","raw_affiliation_strings":["Innovate Research, Noida, Uttar Pradesh, 201301, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovate Research, Noida, Uttar Pradesh, 201301, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065767415","display_name":"S Sood","orcid":"https://orcid.org/0000-0003-1125-1721","observed_orcids":["https://orcid.org/0000-0003-1125-1721"]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Suneet Sood","raw_affiliation_strings":["Department of Surgery, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-1125-1721","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065767415"],"corresponding_institution_ids":["https://openalex.org/I62370553"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":null,"first_page":"1446","last_page":"1446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11253","display_name":"Nail Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11253","display_name":"Nail Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tinea-cruris","display_name":"tinea cruris","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tinea-corporis","display_name":"tinea corporis","score":1.0},{"id":"https://openalex.org/keywords/dermatophytosis","display_name":"dermatophytosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5730000138282776},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mycological-cure","display_name":"mycological cure","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.5929999947547913},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.8270000219345093},{"id":"https://openalex.org/keywords/terbinafine","display_name":"terbinafine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cost-comparison","display_name":"cost comparison","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.8396419286727905},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8359943628311157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8229749202728271},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.8114610910415649},{"id":"https://openalex.org/C2778217265","wikidata":"https://www.wikidata.org/wiki/Q650766","display_name":"Tinea capitis","level":2,"score":0.6067783832550049},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.5581533908843994},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.5087617039680481},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4567407965660095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2169194519519806},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.1569201946258545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07284045219421387},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.12688/f1000research.127138.2","doi":"https://doi.org/10.12688/f1000research.127138.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.127138.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},{"id":"doi:10.12688/f1000research.127138.1","doi":"https://doi.org/10.12688/f1000research.127138.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.127138.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12688/f1000research.127138.2","doi":"https://doi.org/10.12688/f1000research.127138.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.127138.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1520571203","https://openalex.org/W1522667540","https://openalex.org/W1966561514","https://openalex.org/W1993894665","https://openalex.org/W2024329483","https://openalex.org/W2062105666","https://openalex.org/W2081066719","https://openalex.org/W2115067071","https://openalex.org/W2121237805","https://openalex.org/W2151225364","https://openalex.org/W2154348187","https://openalex.org/W2154671988","https://openalex.org/W2290811366","https://openalex.org/W2291064259","https://openalex.org/W2318488489","https://openalex.org/W2331159921","https://openalex.org/W2602035973","https://openalex.org/W2606000026","https://openalex.org/W2612645239","https://openalex.org/W2724560428","https://openalex.org/W2760140754","https://openalex.org/W2761013707","https://openalex.org/W2883897465","https://openalex.org/W2884016956","https://openalex.org/W2910753668","https://openalex.org/W2915987393","https://openalex.org/W2955420445","https://openalex.org/W2963118445","https://openalex.org/W2993008912","https://openalex.org/W3003409359","https://openalex.org/W4200286236","https://openalex.org/W4286433576","https://openalex.org/W4398626231"],"related_works":["https://openalex.org/W2024329483","https://openalex.org/W7217755483","https://openalex.org/W2060751851","https://openalex.org/W1480501406","https://openalex.org/W4300052858","https://openalex.org/W4283752108","https://openalex.org/W4283728104","https://openalex.org/W2042237030","https://openalex.org/W1997759463","https://openalex.org/W3034084223"],"abstract_inverted_index":{"Background":[0],"Dermatophytes":[1],"are":[2,11,27,39],"the":[3,50,73,118,143,203,271,299],"most":[4],"common":[5],"superficial":[6],"fungal":[7],"infections":[8],"worldwide":[9],"and":[10,18,32,65,96,112,123,132,151,170,173,183,191,213,250,268],"treated":[12],"with":[13,21,62,82,255,279],"prescribed":[14],"regimens":[15,38],"of":[16,24,52,89,120,159,185],"terbinafine":[17,267],"itraconazole,":[19],"or":[20,266],"weekly":[22],"doses":[23],"fluconazole.":[25],"Dermatologists":[26],"increasingly":[28],"encountering":[29],"treatment":[30,37],"failures,":[31],"experts":[33],"suggest":[34,234],"that":[35,235],"standard":[36],"not":[40,221],"applicable":[41],"anymore.":[42],"We":[43,78],"planned":[44],"an":[45],"open-label":[46],"study":[47],"to":[48,99,148,210],"evaluate":[49],"results":[51,233],"fluconazole":[53,236],"150":[54,237],"mg":[55,238],"daily":[56,239],"for":[57,240,298],"8":[58],"weeks":[59,242],"in":[60,142,164,168,175,253],"patients":[61,186,254],"tinea":[63,66],"cruris":[64],"corporis.":[67],"Methods":[68],"Patients":[69,105],"were":[70,102,106,139,146,229],"enrolled":[71],"from":[72,208],"La\u2019Mer":[74],"Clinic,":[75],"Mumbai,":[76],"India.":[77],"included":[79,141],"adult":[80],"subjects":[81,136],"uncomplicated":[83],"dermatophytosis":[84],"confirmed":[85],"by":[86],"microscopic":[87],"examination":[88],"skin":[90],"scrapings.":[91],"Pregnancy,":[92],"poor":[93],"renal":[94],"function,":[95],"recent":[97],"exposure":[98],"anti-fungal":[100],"therapy":[101],"exclusion":[103],"criteria.":[104],"reviewed":[107],"on":[108,125,288],"days":[109],"14,":[110],"28":[111],"56.":[113],"The":[114,157,275],"treating":[115],"doctor":[116],"scored":[117],"severity":[119],"erythema,":[121,190],"scaling,":[122,189],"pruritus":[124],"a":[126,216],"four-point":[127],"scale:":[128],"absent,":[129],"mild,":[130],"moderate,":[131],"severe.":[133],"Of":[134],"107":[135],"screened,":[137],"100":[138],"finally":[140],"study.":[144,300],"Eleven":[145],"lost":[147],"follow":[149],"up":[150],"one":[152,201],"subject":[153],"withdrew":[154],"consent.":[155],"Results":[156],"site":[158],"disease":[160],"was":[161,277],"body":[162,172],"alone":[163,167],"29,":[165],"groin":[166,174],"7,":[169],"both":[171],"64":[176],"cases.":[177],"At":[178],"5":[179],"weeks,":[180],"98%,":[181],"100%,":[182],"97%":[184],"had":[187],"no":[188],"pruritus,":[192],"respectively.":[193],"Skin":[194],"scrapings":[195],"showed":[196],"100%":[197],"mycological":[198],"cure.":[199],"In":[200],"patient":[202],"alanine":[204],"transaminase":[205],"level":[206],"rose":[207],"54.9":[209],"100.2":[211],"U/L,":[212],"qualified":[214],"as":[215],"grade":[217],"1":[218],"adverse":[219,227],"event":[220],"requiring":[222],"intervention.":[223],"No":[224],"other":[225],"significant":[226],"events":[228],"noted.":[230],"Conclusions":[231],"Our":[232],"eight":[241,260],"effectively":[243],"treats":[244],"dermatophytosis.":[245],"This":[246],"regimen":[247],"is":[248,258],"safe":[249],"well-tolerated":[251],"even":[252],"co-morbidities.":[256],"Fluconazole":[257],"about":[259],"times":[261],"less":[262],"expensive":[263],"than":[264],"itraconazole":[265],"may":[269],"be":[270],"preferred":[272],"therapy.":[273],"Registration":[274],"trial":[276],"registered":[278],"Clinical":[280],"Trials":[281],"Registry,":[282],"India":[283],"(Registration":[284],"number":[285],"CTRI/2020/06/026110":[286],")":[287],"24":[289],"June":[290],"2020.":[291],"FDC":[292],"Company,":[293],"India,":[294],"provided":[295],"financial":[296],"support":[297]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-12-28T00:00:00"}