{"id":"https://openalex.org/W4311588014","doi":"https://doi.org/10.1371/journal.pgen.1010274","title":"Activation of ChvG-ChvI regulon by cell wall stress confers resistance to \u03b2-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens","display_name":"Activation of ChvG-ChvI regulon by cell wall stress confers resistance to \u03b2-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens","publication_year":2022,"publication_date":"2022-12-08","ids":{"openalex":"https://openalex.org/W4311588014","doi":"https://doi.org/10.1371/journal.pgen.1010274","pmid":"https://pubmed.ncbi.nlm.nih.gov/36480495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9731437"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1010274","doi":"https://doi.org/10.1371/journal.pgen.1010274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1010274","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010274&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010274&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michelle A. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Williams","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065760462","display_name":"Jacob M. Bouchier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob M. Bouchier","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amara K. Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amara K. Mason","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033625597","display_name":"Pamela Brown","orcid":"https://orcid.org/0000-0002-7558-7155","observed_orcids":["https://orcid.org/0000-0002-7558-7155"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pamela J.B. Brown","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7558-7155","affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033625597"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6591,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83943937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"e1010274","last_page":"e1010274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-wall-stress","display_name":"cell wall stress","score":0.8169999718666077},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/agrobacterium-tumefaciens","display_name":"Agrobacterium tumefaciens","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pbp1a","display_name":"PBP1a","score":0.8330000042915344},{"id":"https://openalex.org/keywords/penicillin-binding-proteins","display_name":"penicillin-binding proteins","score":0.8840000033378601},{"id":"https://openalex.org/keywords/microcolony-formation","display_name":"microcolony formation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/surface-spreading","display_name":"surface spreading","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cefsulodin","display_name":"cefsulodin","score":0.843999981880188},{"id":"https://openalex.org/keywords/alphaproteobacteria","display_name":"Alphaproteobacteria","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.8299157619476318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6819626092910767},{"id":"https://openalex.org/C2776162087","wikidata":"https://www.wikidata.org/wiki/Q131472","display_name":"Agrobacterium tumefaciens","level":4,"score":0.6321810483932495},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.4943718910217285},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4579419791698456},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4368259012699127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3907691538333893},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3526216149330139},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32157212495803833},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016960","descriptor_name":"Agrobacterium tumefaciens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pgen.1010274","doi":"https://doi.org/10.1371/journal.pgen.1010274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1010274","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010274&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/2022.05.26.493563","doi":"https://doi.org/10.1101/2022.05.26.493563","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.05.26.493563","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/02/2022.05.26.493563.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9731437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9731437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:36480495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36480495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0b6fdbbcb52146d6a80e8071a1457e07","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0b6fdbbcb52146d6a80e8071a1457e07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 18, Iss 12, p e1010274 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7a7b550214c14df2b9d3f7c2cd5d9282","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7a7b550214c14df2b9d3f7c2cd5d9282","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 18, Iss 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1010274","doi":"https://doi.org/10.1371/journal.pgen.1010274","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1010274","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010274&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1592088611","display_name":"Mechanism of Asymmetric Growth of the Bacterial Plant Pathogen Agrobacterium tumefaciens","funder_award_id":"1557806","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G498123872","display_name":"MARC at the University of Missouri-Columbia","funder_award_id":"T34GM136493","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8760597890","display_name":null,"funder_award_id":"R01-GM129325","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G9000342017","display_name":null,"funder_award_id":"IOS1557806","funder_id":"https://openalex.org/F4320337399","funder_display_name":"Division of Integrative Organismal Systems"},{"id":"https://openalex.org/G9000909391","display_name":"ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling","funder_award_id":"R01GM129325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337399","display_name":"Division of Integrative Organismal Systems","ror":"https://ror.org/01rvays47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311588014.pdf","grobid_xml":"https://content.openalex.org/works/W4311588014.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1549831375","https://openalex.org/W1560409804","https://openalex.org/W1645742762","https://openalex.org/W1803102843","https://openalex.org/W1887365968","https://openalex.org/W1929180688","https://openalex.org/W1933350383","https://openalex.org/W1936606969","https://openalex.org/W1945783633","https://openalex.org/W1965190594","https://openalex.org/W1970707135","https://openalex.org/W1973568443","https://openalex.org/W1982666531","https://openalex.org/W1989472957","https://openalex.org/W1989950116","https://openalex.org/W1990453950","https://openalex.org/W1993234114","https://openalex.org/W1994901531","https://openalex.org/W2001751957","https://openalex.org/W2003136752","https://openalex.org/W2006591980","https://openalex.org/W2013375955","https://openalex.org/W2036897871","https://openalex.org/W2039072473","https://openalex.org/W2042166463","https://openalex.org/W2042367878","https://openalex.org/W2050000908","https://openalex.org/W2053712815","https://openalex.org/W2070607600","https://openalex.org/W2081895739","https://openalex.org/W2082535576","https://openalex.org/W2084469839","https://openalex.org/W2096525273","https://openalex.org/W2101158504","https://openalex.org/W2103202276","https://openalex.org/W2105698604","https://openalex.org/W2106024571","https://openalex.org/W2109613442","https://openalex.org/W2117921160","https://openalex.org/W2120772351","https://openalex.org/W2122630531","https://openalex.org/W2132926880","https://openalex.org/W2136170412","https://openalex.org/W2146341019","https://openalex.org/W2170551349","https://openalex.org/W2179438025","https://openalex.org/W2266044792","https://openalex.org/W2332027069","https://openalex.org/W2416324531","https://openalex.org/W2467964007","https://openalex.org/W2469808342","https://openalex.org/W2688864166","https://openalex.org/W2755432955","https://openalex.org/W2769614577","https://openalex.org/W2769773184","https://openalex.org/W2799524357","https://openalex.org/W2803189605","https://openalex.org/W2877927674","https://openalex.org/W2886136878","https://openalex.org/W2889996632","https://openalex.org/W2900629010","https://openalex.org/W2924530200","https://openalex.org/W2945336205","https://openalex.org/W2949298436","https://openalex.org/W2949458212","https://openalex.org/W2986347027","https://openalex.org/W3023276116","https://openalex.org/W3028082238","https://openalex.org/W3038412226","https://openalex.org/W3083406432","https://openalex.org/W3095583226","https://openalex.org/W3112376646","https://openalex.org/W3177828909","https://openalex.org/W3184658964","https://openalex.org/W3195607325","https://openalex.org/W3198993868","https://openalex.org/W3199145516","https://openalex.org/W3202105508","https://openalex.org/W3204027584","https://openalex.org/W4200520163","https://openalex.org/W4205440119","https://openalex.org/W4289274885","https://openalex.org/W4311577309","https://openalex.org/W7000755285"],"related_works":["https://openalex.org/W4405307852","https://openalex.org/W4410397884","https://openalex.org/W6927354827","https://openalex.org/W2203933710","https://openalex.org/W2115317294","https://openalex.org/W2271441102","https://openalex.org/W4312209436","https://openalex.org/W2034306538","https://openalex.org/W3023276116","https://openalex.org/W4295281063"],"abstract_inverted_index":{"A":[0],"core":[1],"component":[2],"of":[3,58,86,97,106,116,121,130,142,151,158,172,240],"nearly":[4],"all":[5],"bacteria,":[6],"the":[7,35,59,70,117,149,159,200,235,241],"cell":[8,30,48,154,213,231],"wall":[9,31,49,214,232],"is":[10,238],"an":[11,102],"ideal":[12],"target":[13],"for":[14,88,123],"broad":[15],"spectrum":[16],"antibiotics.":[17],"Many":[18],"bacteria":[19,39],"have":[20],"evolved":[21],"strategies":[22],"to":[23,27,185,193,210,230],"sense":[24],"and":[25,55,68,101,110,134,156,174,180],"respond":[26],"antibiotics":[28,211],"targeting":[29,212],"synthesis,":[32],"especially":[33],"in":[34,76,92,95,104,127,145,191,208,227],"soil":[36],"where":[37],"antibiotic-producing":[38],"compete":[40],"with":[41,168,195],"one":[42],"another.":[43],"Here":[44],"we":[45,82,175,217],"show":[46,83],"that":[47,84,178,199,220,237],"stress":[50,138,233],"caused":[51],"by":[52],"both":[53],"chemical":[54],"genetic":[56],"inhibition":[57],"essential,":[60],"bifunctional":[61],"penicillin-binding":[62],"protein":[63],"PBP1a":[64,87,122,173],"prevents":[65],"microcolony":[66,165],"formation":[67],"activates":[69],"canonical":[71],"host-invasion":[72],"two-component":[73],"system":[74],"ChvG-ChvI":[75,118,201,221,242],"Agrobacterium":[77],"tumefaciens":[78],".":[79],"Using":[80],"RNA-seq,":[81],"depletion":[85,171],"6":[89],"hours":[90],"results":[91,126],"a":[93,114,137,205,224],"downregulation":[94],"transcription":[96,105],"flagellum-dependent":[98],"motility":[99],"genes":[100,133],"upregulation":[103],"type":[107],"VI":[108],"secretion":[109],"succinoglycan":[111,152,160],"biosynthesis":[112,161],"genes,":[113],"hallmark":[115],"regulon.":[119],"Depletion":[120],"16":[124],"hours,":[125],"differential":[128],"expression":[129],"many":[131],"additional":[132],"may":[135,203],"promote":[136],"response,":[139],"resembling":[140],"those":[141],"sigma":[143],"factors":[144],"other":[146],"bacteria.":[147],"Remarkably,":[148],"overproduction":[150],"causes":[153],"spreading":[155],"deletion":[157],"gene":[162],"exoA":[163],"restores":[164],"formation.":[166],"Treatment":[167],"cefsulodin":[169],"phenocopies":[170],"correspondingly":[176],"find":[177],"chvG":[179],"chvI":[181],"mutants":[182],"are":[183],"hypersensitive":[184],"cefsulodin.":[186],"This":[187],"hypersensitivity":[188],"only":[189],"occurs":[190],"response":[192],"treatment":[194],"\u03b2-lactam":[196],"antibiotics,":[197],"suggesting":[198],"pathway":[202],"play":[204],"key":[206],"role":[207,226],"resistance":[209,229],"synthesis.":[215],"Finally,":[216],"provide":[218],"evidence":[219],"likely":[222],"has":[223],"conserved":[225],"conferring":[228],"within":[234],"Alphaproteobacteria":[236],"independent":[239],"repressor":[243],"ExoR.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-12-27T00:00:00"}
