{"id":"https://openalex.org/W4311580279","doi":"https://doi.org/10.1038/s41419-022-05490-5","title":"Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein","display_name":"Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein","publication_year":2022,"publication_date":"2022-12-12","ids":{"openalex":"https://openalex.org/W4311580279","doi":"https://doi.org/10.1038/s41419-022-05490-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36509750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9744908"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-022-05490-5","doi":"https://doi.org/10.1038/s41419-022-05490-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05490-5","pdf_url":"https://www.nature.com/articles/s41419-022-05490-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-022-05490-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100386054","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0001-8988-1649","observed_orcids":["https://orcid.org/0000-0001-8988-1649"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323718","display_name":"Wei Wei","orcid":"https://orcid.org/0000-0002-4297-6357","observed_orcids":["https://orcid.org/0000-0002-4297-6357"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wei","raw_affiliation_strings":["Center for Experimental Medicine, School of Public Health, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Medicine, School of Public Health, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102916222","display_name":"Changying Li","orcid":"https://orcid.org/0000-0002-3944-2207","observed_orcids":["https://orcid.org/0000-0002-3944-2207"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changying Li","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China. changlinli@mail.nankai.edu.cn","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. changlinli@mail.nankai.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China. changlinli@mail.nankai.edu.cn","institution_ids":["https://openalex.org/I51185872"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. changlinli@mail.nankai.edu.cn","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406266","display_name":"Shanshan Wang","orcid":"https://orcid.org/0000-0002-9416-0050","observed_orcids":["https://orcid.org/0000-0002-9416-0050"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Yan","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406266","display_name":"Shanshan Wang","orcid":"https://orcid.org/0000-0002-9416-0050","observed_orcids":["https://orcid.org/0000-0002-9416-0050"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Wang","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105039024","display_name":"Shudong Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shudong Xiao","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chenchen He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenchen He","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital, Xi'An Jiaotong University School of Medicine, 710061, Xi'An, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital, Xi'An Jiaotong University School of Medicine, 710061, Xi'An, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108578280","display_name":"Zhi Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, Nankai University, 300071, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, Nankai University, 300071, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108578280","display_name":"Zhi Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Qi","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, Nankai University, 300071, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, Nankai University, 300071, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084681260","display_name":"Benyi Li","orcid":"https://orcid.org/0000-0001-6242-5117","observed_orcids":["https://orcid.org/0000-0001-6242-5117"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benyi Li","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS, 66160, USA"],"raw_orcid":"https://orcid.org/0000-0001-6242-5117","affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030667042","display_name":"Kuo Yang","orcid":"https://orcid.org/0000-0001-6192-8804","observed_orcids":["https://orcid.org/0000-0001-6192-8804"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kuo Yang","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. ykuoster@126.com","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0001-6192-8804","affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. ykuoster@126.com","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100700188","display_name":"Changlin Li","orcid":"https://orcid.org/0000-0001-5872-6443","observed_orcids":["https://orcid.org/0000-0001-5872-6443"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changlin Li","raw_affiliation_strings":["Institute of Precision Medicine, Jining Medical University, 272067, Jining, China. changlinli@mail.nankai.edu.cn","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. changlinli@mail.nankai.edu.cn","Institute of Precision Medicine, Jining Medical University, 272067, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China. changlinli@mail.nankai.edu.cn","institution_ids":["https://openalex.org/I51185872"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, 300211, Tianjin, China. changlinli@mail.nankai.edu.cn","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Institute of Precision Medicine, Jining Medical University, 272067, Jining, China","institution_ids":["https://openalex.org/I51185872"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5030667042","https://openalex.org/A5100700188","https://openalex.org/A5102916222"],"corresponding_institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I51185872","https://openalex.org/I5740404"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":0.806,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72920802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"13","issue":"12","first_page":"1034","last_page":"1034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idarubicin","display_name":"idarubicin","score":1.0},{"id":"https://openalex.org/keywords/abiraterone-resistance","display_name":"abiraterone resistance","score":0.9649999737739563},{"id":"https://openalex.org/keywords/enzalutamide-resistance","display_name":"enzalutamide resistance","score":1.0},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8809999823570251},{"id":"https://openalex.org/keywords/crispr-cas9-knockout-screen","display_name":"CRISPR-Cas9 knockout screen","score":0.828000009059906},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.6380000114440918},{"id":"https://openalex.org/keywords/dna-damaging-agents","display_name":"DNA-damaging agents","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9790210723876953},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8274641036987305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5667380094528198},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5247309803962708},{"id":"https://openalex.org/C2776421732","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone","level":5,"score":0.5211072564125061},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46853891015052795},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4159695506095886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36731240153312683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28466224670410156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27704834938049316},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.05534055829048157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.051929354667663574}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015255","descriptor_name":"Idarubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051760","descriptor_name":"Xeroderma Pigmentosum Group A Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41419-022-05490-5","doi":"https://doi.org/10.1038/s41419-022-05490-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05490-5","pdf_url":"https://www.nature.com/articles/s41419-022-05490-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9744908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9744908","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:36509750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36509750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6ac3d9b24a9341f2900ef87f581a1cc8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6ac3d9b24a9341f2900ef87f581a1cc8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-022-05490-5","doi":"https://doi.org/10.1038/s41419-022-05490-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05490-5","pdf_url":"https://www.nature.com/articles/s41419-022-05490-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2738549467","display_name":null,"funder_award_id":"2017ZDSYS12","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3692824515","display_name":null,"funder_award_id":"2017ZDSYS12","funder_id":"https://openalex.org/F4320326234","funder_display_name":"Tianjin Medical University"},{"id":"https://openalex.org/G5195850981","display_name":null,"funder_award_id":"ZR2016HL25","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320325426","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54"},{"id":"https://openalex.org/F4320326234","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89"},{"id":"https://openalex.org/F4320329532","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311580279.pdf","grobid_xml":"https://content.openalex.org/works/W4311580279.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1578291413","https://openalex.org/W1634543743","https://openalex.org/W1836530450","https://openalex.org/W1969769040","https://openalex.org/W1976215621","https://openalex.org/W1982597025","https://openalex.org/W1992129085","https://openalex.org/W1992738774","https://openalex.org/W1995904672","https://openalex.org/W2012355926","https://openalex.org/W2017289276","https://openalex.org/W2031211461","https://openalex.org/W2045926255","https://openalex.org/W2051025382","https://openalex.org/W2055346449","https://openalex.org/W2061606253","https://openalex.org/W2062406434","https://openalex.org/W2084217728","https://openalex.org/W2097449851","https://openalex.org/W2107633226","https://openalex.org/W2110194568","https://openalex.org/W2110534364","https://openalex.org/W2118498123","https://openalex.org/W2148643283","https://openalex.org/W2148990963","https://openalex.org/W2156391988","https://openalex.org/W2156923287","https://openalex.org/W2164742545","https://openalex.org/W2168108459","https://openalex.org/W2325110871","https://openalex.org/W2325314411","https://openalex.org/W2396720856","https://openalex.org/W2412161958","https://openalex.org/W2587831721","https://openalex.org/W2592847372","https://openalex.org/W2731880601","https://openalex.org/W2789900707","https://openalex.org/W2792582775","https://openalex.org/W2794022179","https://openalex.org/W2806421431","https://openalex.org/W2884876277","https://openalex.org/W2887371472","https://openalex.org/W2893952234","https://openalex.org/W2903150647","https://openalex.org/W2911986456","https://openalex.org/W2942813814","https://openalex.org/W2944403040","https://openalex.org/W2949193973","https://openalex.org/W2964040556","https://openalex.org/W2974582594","https://openalex.org/W2980925374","https://openalex.org/W2990651874","https://openalex.org/W3000707742","https://openalex.org/W3012328701","https://openalex.org/W3014833643","https://openalex.org/W3023616492","https://openalex.org/W3087480931","https://openalex.org/W3133920567","https://openalex.org/W3136835288","https://openalex.org/W3138241693","https://openalex.org/W3184537515","https://openalex.org/W4230151904","https://openalex.org/W4247126447","https://openalex.org/W4280520375"],"related_works":["https://openalex.org/W7027448666","https://openalex.org/W3138241693","https://openalex.org/W2778786812","https://openalex.org/W3027418027","https://openalex.org/W4286511915","https://openalex.org/W2883836317","https://openalex.org/W1745328274","https://openalex.org/W1634543743","https://openalex.org/W2775443029","https://openalex.org/W1969202480"],"abstract_inverted_index":{"Although":[0],"second-generation":[1],"therapies":[2],"like":[3],"abiraterone":[4,70,99,107],"(ABI)":[5],"and":[6,35,48,71,100,108],"enzalutamide":[7,72,101,109],"(ENZ)":[8],"benefit":[9],"patients":[10],"with":[11],"castration-resistant":[12],"prostate":[13,75,95,117],"cancer":[14,76,96],"(CRPC),":[15],"drug":[16,33],"resistance":[17,47,73,110],"frequently":[18],"occurs,":[19],"eventually":[20],"resulting":[21],"in":[22,56,74,87,116],"therapy":[23],"failure.":[24],"In":[25,103],"this":[26],"study,":[27],"we":[28],"used":[29],"two":[30],"libraries,":[31],"FDA-approved":[32],"library":[34,39],"CRISP/Cas9":[36],"knockout":[37,93],"(GeCKO)":[38],"to":[40,49,98],"screen":[41],"for":[42],"drugs":[43],"that":[44,63],"overcome":[45],"treatment":[46,57,79],"identify":[50],"the":[51,64,81],"potential":[52],"drug-resistant":[53],"genes":[54],"involved":[55],"resistance.":[58],"Our":[59],"screening":[60],"results":[61],"showed":[62],"DNA-damaging":[65],"agent":[66],"idarubicin":[67],"(IDA)":[68],"overcame":[69],"cells.":[77],"IDA":[78,105],"inhibited":[80],"DNA":[82],"repair":[83],"protein":[84,114],"XPA":[85,92,113],"expression":[86],"a":[88],"transcription-independent":[89],"manner.":[90],"Consistently,":[91],"sensitized":[94],"cells":[97],"treatment.":[102],"conclusion,":[104],"combats":[106],"by":[111],"reducing":[112],"level":[115],"cancer.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-12-27T00:00:00"}