{"id":"https://openalex.org/W4311292693","doi":null,"title":"Molecular subtypes of cuproptosis regulators and their correlation with clinical prognosis and immune response in glioma.","display_name":"Molecular subtypes of cuproptosis regulators and their correlation with clinical prognosis and immune response in glioma.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4311292693","pmid":"https://pubmed.ncbi.nlm.nih.gov/36505293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9730092"},"language":"en","primary_location":{"id":"pmid:36505293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36505293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9730092/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100456169","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0001-9254-5144","observed_orcids":["https://orcid.org/0000-0001-9254-5144"]},"institutions":[{"id":"https://openalex.org/I4210113254","display_name":"Second Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/026bqfq17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113254"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of Pathology, The Second Affiliated Hospital of Zhengzhou University Zhengzhou, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Second Affiliated Hospital of Zhengzhou University Zhengzhou, Henan Province, China","institution_ids":["https://openalex.org/I4210113254"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuehui Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuehui Dai","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan Province, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072985182","display_name":"Zhanzhan Li","orcid":"https://orcid.org/0000-0001-9256-728X","observed_orcids":["https://orcid.org/0000-0001-9256-728X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanzhan Li","raw_affiliation_strings":["Department of Oncology, Xiangya Hospital, Central South University Changsha, Hunan Province, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University Changsha, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangya Hospital, Central South University Changsha, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University Changsha, Hunan Province, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2616,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.3823811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"11","first_page":"8085","last_page":"8102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cuproptosis","display_name":"cuproptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8980000019073486},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.9100000262260437},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.8040000200271606},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8560000061988831},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.7789999842643738},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8155982494354248},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.733002245426178},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.713051438331604},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.6418527960777283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5077515840530396},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.49630314111709595},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4107184410095215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4105342626571655},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4059474766254425},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3536533713340759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33960771560668945},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33695143461227417},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28324535489082336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1015973687171936},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:36505293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36505293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9730092","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9730092/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9730092","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9730092/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1767508090","https://openalex.org/W2008757142","https://openalex.org/W2095242372","https://openalex.org/W2114161561","https://openalex.org/W2159675211","https://openalex.org/W2159707944","https://openalex.org/W2214074259","https://openalex.org/W2220553089","https://openalex.org/W2518001395","https://openalex.org/W2558713142","https://openalex.org/W2578528809","https://openalex.org/W2592264367","https://openalex.org/W2770097243","https://openalex.org/W2906664418","https://openalex.org/W2953247538","https://openalex.org/W2979398595","https://openalex.org/W2986962832","https://openalex.org/W3003215804","https://openalex.org/W3005468192","https://openalex.org/W3015123349","https://openalex.org/W3016541254","https://openalex.org/W3033869535","https://openalex.org/W3080951954","https://openalex.org/W3092298447","https://openalex.org/W3092309646","https://openalex.org/W3112754342","https://openalex.org/W3119959867","https://openalex.org/W3129792315","https://openalex.org/W3143999558","https://openalex.org/W3161233656","https://openalex.org/W3161919037","https://openalex.org/W3168339232","https://openalex.org/W3183845470","https://openalex.org/W3202746761","https://openalex.org/W3216052998","https://openalex.org/W4211105004","https://openalex.org/W4212947398","https://openalex.org/W4214877324","https://openalex.org/W4221115671","https://openalex.org/W4226086188"],"related_works":["https://openalex.org/W4382796773","https://openalex.org/W4404492447","https://openalex.org/W4301398533","https://openalex.org/W4385377490","https://openalex.org/W4290613806","https://openalex.org/W4400238224","https://openalex.org/W4321601039","https://openalex.org/W4321193719","https://openalex.org/W4291377822","https://openalex.org/W4307370694"],"abstract_inverted_index":{"Cuproptosis":[0],"is":[1,11,194],"a":[2,69,83,89],"newly":[3],"described":[4],"form":[5],"of":[6,16,26,78,96,169],"cell":[7,36,61,108],"death.":[8],"However,":[9],"nothing":[10],"known":[12],"about":[13],"the":[14,24,75,93,97,163,167,188,206],"roles":[15],"cuproptosis":[17,27,48,98,102,164,178],"regulators":[18,179],"in":[19,39,182,191,226],"glioma.":[20,40,192,227],"First,":[21],"we":[22,45,65,125],"explored":[23],"characteristics":[25,58],"molecular":[28,150],"subtypes":[29,49],"and":[30,50,59,67,116,142,145,159,186,223],"relevant":[31],"tumor":[32,111],"microenvironment":[33],"(TME)":[34],"immune":[35,107,184,211],"infiltration":[37,62,109,185],"patterns":[38],"Using":[41],"unsupervised":[42],"clustering":[43],"analysis,":[44],"identified":[46,126],"two":[47],"three":[51],"gene":[52,114],"clusters":[53],"that":[54,152,162,177],"exhibited":[55],"different":[56,201,207],"clinical":[57,94,189,197],"TME":[60,183],"patterns.":[63],"Then,":[64],"developed":[66],"validated":[68],"cuproptosis-related":[70],"prognostic":[71],"model":[72],"for":[73,196,219],"predicting":[74],"overall":[76,122],"survival":[77],"glioma":[79],"patients.":[80],"We":[81],"established":[82],"risk":[84,103],"score":[85,104,165],"tool":[86],"based":[87,134],"on":[88,135],"nomogram":[90],"to":[91,199,205],"assess":[92],"applicability":[95],"model.":[99],"A":[100],"high":[101,106],"with":[105,210],"level,":[110],"mutation":[112],"burden,":[113],"alterations,":[115],"immunity":[117],"activation":[118],"had":[119],"an":[120],"unfavorable":[121],"survival.":[123],"Next,":[124],"possible":[127],"competing":[128],"endogenous":[129],"ribonucleic":[130],"acid":[131],"regulatory":[132],"networks":[133],"significantly":[136],"differentially":[137],"expressed":[138],"genes":[139],"between":[140],"high-risk":[141],"low-risk":[143],"groups":[144],"screened":[146],"several":[147],"candidate":[148],"small":[149],"compounds":[151],"may":[153],"improve":[154],"chemotherapy.":[155],"Data":[156],"from":[157],"IMvigor":[158],"GSE78200":[160],"showed":[161],"affected":[166],"prognosis":[168,190],"patients":[170],"who":[171],"received":[172],"immunotherapy.":[173],"Our":[174],"study":[175],"indicated":[176],"are":[180],"involved":[181],"impact":[187],"It":[193],"necessary":[195],"practice":[198],"develop":[200],"therapeutic":[202],"strategies":[203,222],"according":[204],"phenotypes":[208],"associated":[209],"response.":[212],"The":[213],"present":[214],"findings":[215],"provide":[216],"new":[217],"insight":[218],"improving":[220],"immunotherapy":[221],"individualized":[224],"treatment":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-12-25T00:00:00"}
