{"id":"https://openalex.org/W4311290989","doi":"https://doi.org/10.1007/s13402-022-00762-w","title":"YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m6A-mediated YWHAZ stability","display_name":"YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m6A-mediated YWHAZ stability","publication_year":2022,"publication_date":"2022-12-13","ids":{"openalex":"https://openalex.org/W4311290989","doi":"https://doi.org/10.1007/s13402-022-00762-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/36512307","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12974669"},"language":"en","primary_location":{"id":"doi:10.1007/s13402-022-00762-w","doi":"https://doi.org/10.1007/s13402-022-00762-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00762-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s13402-022-00762-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029983714","display_name":"Jihua Chai","orcid":"https://orcid.org/0009-0005-6637-3672","observed_orcids":["https://orcid.org/0009-0005-6637-3672"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihua Chai","raw_affiliation_strings":["The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774658","display_name":"Qifan Wang","orcid":"https://orcid.org/0000-0002-1676-9530","observed_orcids":["https://orcid.org/0000-0002-1676-9530"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qifan Wang","raw_affiliation_strings":["Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China","The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082538818","display_name":"Qiang Qiu","orcid":"https://orcid.org/0000-0002-7400-5950","observed_orcids":["https://orcid.org/0000-0002-7400-5950"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Qiu","raw_affiliation_strings":["State Key Laboratory of Biotherapy, West China Hospital & Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy, West China Hospital & Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100964128","display_name":"Guoqiang Han","orcid":"https://orcid.org/0009-0000-2477-0593","observed_orcids":["https://orcid.org/0009-0000-2477-0593"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqiang Han","raw_affiliation_strings":["Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393638","display_name":"Yilin Chen","orcid":"https://orcid.org/0009-0000-9552-5990","observed_orcids":["https://orcid.org/0009-0000-9552-5990"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Chen","raw_affiliation_strings":["Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695255","display_name":"Wei\u2010Ming Li","orcid":"https://orcid.org/0000-0001-6155-0696","observed_orcids":["https://orcid.org/0000-0001-6155-0696"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Li","raw_affiliation_strings":["Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102000141","display_name":"Haojian Zhang","orcid":"https://orcid.org/0000-0003-2371-843X","observed_orcids":["https://orcid.org/0000-0003-2371-843X"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haojian Zhang","raw_affiliation_strings":["Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China. haojian_zhang@whu.edu.cn","The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China. haojian_zhang@whu.edu.cn","Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China. haojian_zhang@whu.edu.cn","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, No.185, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, People's Republic of China. haojian_zhang@whu.edu.cn","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102000141"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.6952,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.91186568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"2","first_page":"451","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yb-1","display_name":"YB-1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/14-3-3","display_name":"14-3-3\u03b6","score":0.9750000238418579},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/igf2bp","display_name":"IGF2BP","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.7670000195503235},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.6539999842643738},{"id":"https://openalex.org/keywords/stem-cell-survival","display_name":"stem cell survival","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6552608609199524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6236607432365417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6081834435462952},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5546838641166687},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5477614998817444},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47931304574012756},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32467204332351685}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s13402-022-00762-w","doi":"https://doi.org/10.1007/s13402-022-00762-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00762-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12974669","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12974669/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12974669/pdf/13402_2022_Article_762.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Oncol (Dordr)","raw_type":"Text"},{"id":"pmid:36512307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36512307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular oncology (Dordrecht, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13402-022-00762-w","doi":"https://doi.org/10.1007/s13402-022-00762-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-022-00762-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G358344697","display_name":null,"funder_award_id":"82230007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8442203157","display_name":null,"funder_award_id":"2042021kf0225","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322271","display_name":"Science Fund for Creative Research Groups","ror":null},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311290989.pdf","grobid_xml":"https://content.openalex.org/works/W4311290989.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1970154345","https://openalex.org/W1982401508","https://openalex.org/W1986988560","https://openalex.org/W1987239635","https://openalex.org/W2003118255","https://openalex.org/W2008188428","https://openalex.org/W2008494886","https://openalex.org/W2017728128","https://openalex.org/W2024290860","https://openalex.org/W2029979788","https://openalex.org/W2065684068","https://openalex.org/W2068574812","https://openalex.org/W2073889874","https://openalex.org/W2075542228","https://openalex.org/W2085106808","https://openalex.org/W2091242855","https://openalex.org/W2096003848","https://openalex.org/W2107268345","https://openalex.org/W2111336104","https://openalex.org/W2115219499","https://openalex.org/W2127328679","https://openalex.org/W2152171710","https://openalex.org/W2165120623","https://openalex.org/W2167100625","https://openalex.org/W2530576721","https://openalex.org/W2614253029","https://openalex.org/W2751668414","https://openalex.org/W2754499625","https://openalex.org/W2755975022","https://openalex.org/W2769630486","https://openalex.org/W2776540408","https://openalex.org/W2785329615","https://openalex.org/W2809295169","https://openalex.org/W2885965305","https://openalex.org/W2917612467","https://openalex.org/W2937042206","https://openalex.org/W2941333182","https://openalex.org/W2942816224","https://openalex.org/W3024244355","https://openalex.org/W3024994706","https://openalex.org/W3137919635","https://openalex.org/W3158161932","https://openalex.org/W3198529911","https://openalex.org/W3205043031","https://openalex.org/W4256613750"],"related_works":["https://openalex.org/W3137919635","https://openalex.org/W4389833260","https://openalex.org/W2008494886","https://openalex.org/W170664412","https://openalex.org/W3148782807","https://openalex.org/W4248214638","https://openalex.org/W4285381093","https://openalex.org/W4200201700","https://openalex.org/W3198529911","https://openalex.org/W2560023695"],"abstract_inverted_index":{"Chronic":[0],"myeloid":[1],"leukemia":[2,22],"(CML)":[3],"is":[4,139,149],"a":[5,228,241],"myeloproliferative":[6],"disease":[7,41],"derived":[8],"from":[9],"hematopoietic":[10],"stem":[11,23],"cells":[12,24],"(HSCs)":[13],"that":[14,120,136,147,176],"harbor":[15],"Philadelphia":[16],"chromosome":[17],"(Ph":[18],"chromosome).":[19],"In":[20],"clinic,":[21],"(LSCs)":[25],"in":[26,70,128,142,197,233,246],"CML":[27,53,59,75,132,143,163,223,237,247],"are":[28,38],"insensitive":[29],"to":[30,64,88,193],"the":[31,44,66,72,160,219],"treatment":[32],"with":[33,186],"tyrosine":[34],"kinase":[35],"inhibitors,":[36],"and":[37,57,80,82,114,145,168,203],"responsible":[39],"for":[40,47,151,243],"relapse.":[42],"However,":[43],"molecular":[45],"mechanisms":[46],"maintaining":[48,152,234],"LSCs":[49,99],"survival":[50,73,100,130,153,235],"remain":[51],"elusive.":[52],"patient-derived":[54],"cell":[55,166],"lines":[56],"BCR-ABL-induced":[58],"mouse":[60],"model":[61],"were":[62,86,101],"used":[63,87],"explore":[65],"role":[67,127,230],"of":[68,74,95,131,154,157,162,171,180,205,215,221,231,236],"YBX1":[69,97,123,137,148,158,177,184,206,232,245],"regulating":[71,129],"LSCs.":[76,133,155,172],"Bone":[77],"marrow":[78],"transduction":[79],"transplantation,":[81],"colony-forming":[83],"unit":[84],"assay":[85],"investigate":[89],"LSC":[90],"function.":[91],"The":[92],"underlying":[93],"mechanism":[94],"how":[96],"regulates":[98,178],"assessed":[102],"using":[103],"flow":[104],"cytometry,":[105],"RNA":[106,110,115,187],"sequencing,":[107],"western":[108],"blot,":[109],"decay":[111],"assay,":[112],"co-immunoprecipitation":[113],"immunoprecipitation.":[116],"Here":[117],"we":[118,174],"show":[119],"RNA-binding":[121],"protein":[122],"plays":[124],"an":[125,198],"important":[126],"We":[134],"find":[135,175],"expression":[138,179,209],"significantly":[140],"increased":[141],"cells,":[144],"confirm":[146],"required":[150],"Deletion":[156],"impairs":[159],"propagation":[161],"through":[164],"blocking":[165],"proliferation":[167],"inducing":[169],"apoptosis":[170],"Mechanistically,":[173],"apoptotic":[181],"associated":[182],"genes.":[183],"cooperates":[185],"m":[188,199],"6":[189,200],"A":[190],"reader":[191],"IGF2BPs":[192],"stabilize":[194],"YWHAZ":[195,208,216],"transcript":[196],"A-dependent":[201],"manner,":[202],"loss":[204],"decreases":[207],"by":[210],"accelerating":[211],"mRNA":[212],"decay.":[213],"Restoration":[214],"efficiently":[217],"rescues":[218],"defects":[220],"YBX1-deficient":[222],"cells.":[224],"Our":[225],"findings":[226],"reveal":[227],"critical":[229],"LSCs,":[238],"which":[239],"provides":[240],"rationale":[242],"targeting":[244],"treatment.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-12-25T00:00:00"}
