{"id":"https://openalex.org/W4311288198","doi":"https://doi.org/10.1038/s41593-022-01208-0","title":"Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus\u2013brainstem pathway","display_name":"Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus\u2013brainstem pathway","publication_year":2022,"publication_date":"2022-12-12","ids":{"openalex":"https://openalex.org/W4311288198","doi":"https://doi.org/10.1038/s41593-022-01208-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/36510113"},"language":"en","primary_location":{"id":"doi:10.1038/s41593-022-01208-0","doi":"https://doi.org/10.1038/s41593-022-01208-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-022-01208-0","pdf_url":"https://www.nature.com/articles/s41593-022-01208-0.pdf","source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41593-022-01208-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058100293","display_name":"Sora Shin","orcid":"https://orcid.org/0000-0002-1047-3384","observed_orcids":["https://orcid.org/0000-0002-1047-3384"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sora Shin","raw_affiliation_strings":["Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. srshin@vtc.vt.edu","FBRI Center for Neurobiology Research, Roanoke, VA, USA. srshin@vtc.vt.edu","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA. srshin@vtc.vt.edu","Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. srshin@vtc.vt.edu","Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","FBRI Center for Neurobiology Research, Roanoke, VA, USA","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1047-3384","affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. srshin@vtc.vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA. srshin@vtc.vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA. srshin@vtc.vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. srshin@vtc.vt.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040227712","display_name":"In\u2010Jee You","orcid":"https://orcid.org/0000-0002-6557-5337","observed_orcids":["https://orcid.org/0000-0002-6557-5337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"In-Jee You","raw_affiliation_strings":["FBRI Center for Neurobiology Research, Roanoke, VA, USA","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027333325","display_name":"Minju Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minju Jeong","raw_affiliation_strings":["Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064503084","display_name":"Yeeun Bae","orcid":"https://orcid.org/0000-0002-0485-5036","observed_orcids":["https://orcid.org/0000-0002-0485-5036"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeeun Bae","raw_affiliation_strings":["Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","FBRI Center for Neurobiology Research, Roanoke, VA, USA","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0485-5036","affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447909","display_name":"Xiaoyun Wang","orcid":"https://orcid.org/0000-0002-3000-6441","observed_orcids":["https://orcid.org/0000-0002-3000-6441","https://orcid.org/0000-0002-7410-0667","https://orcid.org/0009-0000-9774-1179","https://orcid.org/0009-0001-1793-5406"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Yun Wang","raw_affiliation_strings":["Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011830239","display_name":"Mikel L. Cawley","orcid":"https://orcid.org/0000-0002-0229-3471","observed_orcids":["https://orcid.org/0000-0002-0229-3471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikel Leann Cawley","raw_affiliation_strings":["FBRI Center for Neurobiology Research, Roanoke, VA, USA","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abraham Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Han","raw_affiliation_strings":["Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","FBRI Center for Neurobiology Research, Roanoke, VA, USA","Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"FBRI Center for Neurobiology Research, Roanoke, VA, USA","institution_ids":[]},{"raw_affiliation_string":"Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074928756","display_name":"Byung Kook Lim","orcid":"https://orcid.org/0000-0002-3766-5415","observed_orcids":["https://orcid.org/0000-0002-3766-5415"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Byung Kook Lim","raw_affiliation_strings":["Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. bklim@ucsd.edu","Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3766-5415","affiliations":[{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. bklim@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058100293","https://openalex.org/A5074928756"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I859038795"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":{"value":11390,"currency":"USD","value_usd":11390},"fwci":3.3894,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94016054,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"26","issue":"1","first_page":"79","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-life-trauma","display_name":"early trauma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/binge-eating","display_name":"binge eating","score":0.9319999814033508},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ventrolateral-periaqueductal-gray","display_name":"ventrolateral periaqueductal gray","score":0.9470000267028809},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.5329999923706055},{"id":"https://openalex.org/keywords/maladaptive-eating","display_name":"maladaptive eating","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.7490420341491699},{"id":"https://openalex.org/C2781426410","wikidata":"https://www.wikidata.org/wiki/Q2303219","display_name":"Binge eating","level":3,"score":0.7420310378074646},{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.713184118270874},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.6977187395095825},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6383611559867859},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6266758441925049},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6167951822280884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5739412307739258},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5412679314613342},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4441658854484558},{"id":"https://openalex.org/C2778202721","wikidata":"https://www.wikidata.org/wiki/Q209522","display_name":"Binge-eating disorder","level":4,"score":0.43166419863700867},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.42317283153533936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41101598739624023},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.363446980714798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3439941704273224},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.3163721561431885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30921536684036255},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24305453896522522},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.2405584752559662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19753211736679077},{"id":"https://openalex.org/C2777556793","wikidata":"https://www.wikidata.org/wiki/Q64513386","display_name":"Bulimia nervosa","level":3,"score":0.18701231479644775},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1081395149230957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41593-022-01208-0","doi":"https://doi.org/10.1038/s41593-022-01208-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-022-01208-0","pdf_url":"https://www.nature.com/articles/s41593-022-01208-0.pdf","source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},{"id":"pmid:36510113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36510113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9829538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9829538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Neurosci","raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/112866","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/112866","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.1038/s41593-022-01208-0","doi":"https://doi.org/10.1038/s41593-022-01208-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-022-01208-0","pdf_url":"https://www.nature.com/articles/s41593-022-01208-0.pdf","source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1286372449","display_name":null,"funder_award_id":"KL2TR003016/ULTR003015","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G224135905","display_name":null,"funder_award_id":"R01 DA049787","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2272810715","display_name":null,"funder_award_id":"UL1 TR003015","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2290166629","display_name":null,"funder_award_id":"DA049787","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2536021628","display_name":"A leptin-responsive lateral hypothalamus to ventrolateral periaqueductal gray circuit for palatable food overconsumption","funder_award_id":"5r01dk132566-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2891791864","display_name":null,"funder_award_id":"KL2TR003016/ULTR003015","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3476674934","display_name":null,"funder_award_id":"MH107742","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3825684905","display_name":"Institutional Career Development Core","funder_award_id":"5kl2tr003016-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4103025270","display_name":null,"funder_award_id":"R01 DK132566","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G464710589","display_name":null,"funder_award_id":"KL2TR003016","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G5523330542","display_name":null,"funder_award_id":"MH107742","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6912916513","display_name":null,"funder_award_id":"STAT3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7632786900","display_name":"The Neural Basis of Social Stress-induced Depression","funder_award_id":"5r01mh107742-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7645671581","display_name":null,"funder_award_id":"DK132566","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8069596448","display_name":null,"funder_award_id":"DA049787","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000027836","display_name":null,"funder_award_id":"UL1TR003015","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000039614","display_name":null,"funder_award_id":"DK132566","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000213920","display_name":null,"funder_award_id":"KL2TR003016","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000331321","display_name":null,"funder_award_id":"MH107742","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G903539376","display_name":"Dissecting the role of ventral pallidal circuitry in cocaine seeking after the withdrawal","funder_award_id":"5r01da049787-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G919936140","display_name":null,"funder_award_id":"R01MH107742","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311288198.pdf","grobid_xml":"https://content.openalex.org/works/W4311288198.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1506453366","https://openalex.org/W1656827341","https://openalex.org/W1870304014","https://openalex.org/W1970770411","https://openalex.org/W1975727865","https://openalex.org/W1976544983","https://openalex.org/W1986359756","https://openalex.org/W1986925744","https://openalex.org/W1990692915","https://openalex.org/W1996635305","https://openalex.org/W1996713062","https://openalex.org/W2001980298","https://openalex.org/W2004173167","https://openalex.org/W2004750779","https://openalex.org/W2006280142","https://openalex.org/W2009621055","https://openalex.org/W2010342389","https://openalex.org/W2017246888","https://openalex.org/W2025846514","https://openalex.org/W2027718546","https://openalex.org/W2027898754","https://openalex.org/W2030221131","https://openalex.org/W2031124041","https://openalex.org/W2043447430","https://openalex.org/W2043730876","https://openalex.org/W2045931153","https://openalex.org/W2057250808","https://openalex.org/W2061072142","https://openalex.org/W2066171961","https://openalex.org/W2066665477","https://openalex.org/W2070233031","https://openalex.org/W2080002261","https://openalex.org/W2087949440","https://openalex.org/W2089698459","https://openalex.org/W2102214369","https://openalex.org/W2103270369","https://openalex.org/W2103289203","https://openalex.org/W2112364152","https://openalex.org/W2114570899","https://openalex.org/W2116454997","https://openalex.org/W2137113565","https://openalex.org/W2145223707","https://openalex.org/W2155218627","https://openalex.org/W2168154828","https://openalex.org/W2264430018","https://openalex.org/W2293619782","https://openalex.org/W2318811682","https://openalex.org/W2320837109","https://openalex.org/W2546764300","https://openalex.org/W2550239319","https://openalex.org/W2563082826","https://openalex.org/W2596658472","https://openalex.org/W2724120353","https://openalex.org/W2778371518","https://openalex.org/W2791285983","https://openalex.org/W2797089588","https://openalex.org/W2804691881","https://openalex.org/W2806749833","https://openalex.org/W2890819762","https://openalex.org/W2940958280","https://openalex.org/W2954080332","https://openalex.org/W2960606495","https://openalex.org/W2973420280","https://openalex.org/W3181320512","https://openalex.org/W3187695507","https://openalex.org/W3211215709"],"related_works":["https://openalex.org/W4232691407","https://openalex.org/W1991962474","https://openalex.org/W2111741381","https://openalex.org/W1989226804","https://openalex.org/W2029379901","https://openalex.org/W2027506649","https://openalex.org/W2043629555","https://openalex.org/W2159631876","https://openalex.org/W1978419933","https://openalex.org/W1968583301"],"abstract_inverted_index":{"Abstract":[0],"Early-life":[1],"trauma":[2],"(ELT)":[3],"is":[4,51],"a":[5,127],"risk":[6],"factor":[7],"for":[8,145],"binge":[9,146],"eating":[10,57,81,122,134,147],"and":[11,45,58,135,148],"obesity":[12,59],"later":[13],"in":[14,31,40,53,82],"life,":[15],"yet":[16],"the":[17,36,41,68,92,139],"neural":[18,49],"circuits":[19],"that":[20,33,67,130],"underlie":[21],"this":[22],"association":[23],"have":[24],"not":[25],"been":[26],"addressed.":[27],"Here,":[28],"we":[29],"show":[30],"mice":[32],"downregulation":[34],"of":[35,71,86,100,105,141],"leptin":[37],"receptor":[38],"(Lepr)":[39],"lateral":[42],"hypothalamus":[43],"(LH)":[44],"its":[46],"effect":[47],"on":[48],"activity":[50,70],"crucial":[52],"causing":[54],"ELT-induced":[55,120,132],"binge-like":[56,80],"upon":[60],"high-fat":[61],"diet":[62],"exposure.":[63],"We":[64],"also":[65],"found":[66],"increased":[69],"Lepr-expressing":[72],"LH":[73,87,116],"(LH":[74],"Lepr":[75,88,117],")":[76],"neurons":[77,89],"encodes":[78],"sustained":[79],"ELT":[83,101],"mice.":[84,102],"Inhibition":[85],"projecting":[90],"to":[91,138],"ventrolateral":[93,107],"periaqueductal":[94,108],"gray":[95,109],"normalizes":[96],"these":[97],"behavioral":[98],"features":[99],"Furthermore,":[103],"activation":[104],"proenkephalin-expressing":[106],"neurons,":[110,118],"which":[111],"receive":[112],"inhibitory":[113],"inputs":[114],"from":[115],"rescues":[119],"maladaptive":[121,133],"habits.":[123],"Our":[124],"results":[125],"identify":[126],"circuit":[128],"pathway":[129],"mediates":[131],"may":[136],"lead":[137],"identification":[140],"novel":[142],"therapeutic":[143],"targets":[144],"obesity.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
