{"id":"https://openalex.org/W4311282811","doi":"https://doi.org/10.1111/pde.15198","title":"Early initiation of treatment with oral propranolol for infantile hemangioma improves success rate","display_name":"Early initiation of treatment with oral propranolol for infantile hemangioma improves success rate","publication_year":2022,"publication_date":"2022-12-13","ids":{"openalex":"https://openalex.org/W4311282811","doi":"https://doi.org/10.1111/pde.15198","pmid":"https://pubmed.ncbi.nlm.nih.gov/36511888"},"language":"en","primary_location":{"id":"doi:10.1111/pde.15198","doi":"https://doi.org/10.1111/pde.15198","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pde.15198","pdf_url":null,"source":{"id":"https://openalex.org/S3992287","display_name":"Pediatric Dermatology","issn_l":"0736-8046","issn":["0736-8046","1525-1470"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091128634","display_name":"Christine L\u00e9aut\u00e9-Labr\u00e8ze","orcid":"https://orcid.org/0000-0002-4110-2607","observed_orcids":["https://orcid.org/0000-0002-4110-2607"]},"institutions":[{"id":"https://openalex.org/I4210112727","display_name":"H\u00f4pital Pellegrin","ror":"https://ror.org/02x581406","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine L\u00e9aut\u00e9\u2010Labr\u00e8ze","raw_affiliation_strings":["Department of Dermatology Pellegrin Children's Hospital  Bordeaux France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology Pellegrin Children's Hospital  Bordeaux France","institution_ids":["https://openalex.org/I4210112727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041484982","display_name":"Ilona J. Frieden","orcid":"https://orcid.org/0000-0001-7305-5940","observed_orcids":["https://orcid.org/0000-0001-7305-5940"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilona Frieden","raw_affiliation_strings":["Department of Dermatology University of California San Francisco  California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology University of California San Francisco  California USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108829930","display_name":"Alain Delarue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alain Delarue","raw_affiliation_strings":["Medical Affairs Pierre Fabre Dermatologie Pierre Fabre  Lavaur France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Pierre Fabre Dermatologie Pierre Fabre  Lavaur France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108829930"],"corresponding_institution_ids":[],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":4.8976,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.96601042,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"40","issue":"2","first_page":"261","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infantile-hemangioma","display_name":"infantile hemangioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-propranolol","display_name":"oral propranolol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-initiation-timing","display_name":"treatment initiation timing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/age-at-treatment-initiation","display_name":"age at treatment initiation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/treatment-success-rate","display_name":"treatment success rate","score":0.902999997138977},{"id":"https://openalex.org/keywords/early-referral","display_name":"early referral","score":0.5590000152587891},{"id":"https://openalex.org/keywords/generalized-additive-models","display_name":"generalized additive models","score":0.4560000002384186},{"id":"https://openalex.org/keywords/pediatric-vascular-tumors","display_name":"pediatric vascular tumors","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.9330920577049255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8953808546066284},{"id":"https://openalex.org/C3019900241","wikidata":"https://www.wikidata.org/wiki/Q52771370","display_name":"Infantile hemangioma","level":3,"score":0.849318265914917},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5765414834022522},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5349971055984497},{"id":"https://openalex.org/C2780191036","wikidata":"https://www.wikidata.org/wiki/Q861028","display_name":"Hemangioma","level":2,"score":0.467529296875},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4324294328689575},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4296822249889374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3085952401161194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27929356694221497}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006391","descriptor_name":"Hemangioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018324","descriptor_name":"Hemangioma, Capillary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/pde.15198","doi":"https://doi.org/10.1111/pde.15198","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pde.15198","pdf_url":null,"source":{"id":"https://openalex.org/S3992287","display_name":"Pediatric Dermatology","issn_l":"0736-8046","issn":["0736-8046","1525-1470"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Dermatology","raw_type":"journal-article"},{"id":"pmid:36511888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36511888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric dermatology","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314128","display_name":"Les Laboratories Pierre Fabre","ror":"https://ror.org/04hdhz511"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1912409832","https://openalex.org/W2009051424","https://openalex.org/W2100584705","https://openalex.org/W2101325544","https://openalex.org/W2178183219","https://openalex.org/W2192238129","https://openalex.org/W2266549651","https://openalex.org/W2886345720","https://openalex.org/W2906007348","https://openalex.org/W3011680325","https://openalex.org/W3048022707","https://openalex.org/W4236322841"],"related_works":["https://openalex.org/W4414461959","https://openalex.org/W2961914393","https://openalex.org/W3014033795","https://openalex.org/W2323154507","https://openalex.org/W2013177106","https://openalex.org/W2886345720","https://openalex.org/W1987931242","https://openalex.org/W2778651811","https://openalex.org/W4312154276","https://openalex.org/W3003525149"],"abstract_inverted_index":{"BACKGROUND/OBJECTIVES:":[0],"Early":[1],"referral":[2],"and":[3,199],"treatment":[4,14,29,46,180,191],"of":[5,21,35,69,98,100,111,118,135,142,162,170,179],"infantile":[6],"hemangioma":[7],"(IH)":[8],"is":[9,18],"a":[10,19,24,50,87,95,139,175],"major":[11],"challenge":[12],"for":[13,27,150],"success.":[15],"However,":[16],"there":[17],"lack":[20],"data":[22,61],"supporting":[23],"specific":[25],"threshold":[26],"initiating":[28],"with":[30,54,81,174,182,188],"oral":[31,55,70,128,183],"propranolol.":[32],"The":[33],"aim":[34],"this":[36],"analysis":[37],"was":[38,172],"to":[39,49,91,195],"find":[40],"factors,":[41],"such":[42],"as":[43,201,203],"age":[44,134,171],"at":[45,115],"initiation,":[47],"leading":[48],"higher":[51,144,177],"success":[52,105,140,148,181],"rate":[53,141,149,178],"propranolol":[56,71,129,184],"treatment.":[57],"METHODS:":[58],"Based":[59],"on":[60],"from":[62],"the":[63,101,112,133,146,155],"pivotal":[64],"phase":[65],"2-3":[66],"clinical":[67],"trial":[68],"in":[72],"IH,":[73],"we":[74],"used":[75],"Generalized":[76,82],"Additive":[77],"Model":[78],"(GAM)":[79],"charts":[80],"Linear":[83],"Models":[84],"(GLM),":[85],"then":[86],"rule":[88],"discovery":[89],"algorithm,":[90],"identify":[92],"sub-groups":[93],"presenting":[94],"high":[96],"probability":[97],"occurrence":[99],"predefined":[102],"outcome":[103],"(i.e.,":[104],"[complete":[106],"or":[107],"nearly":[108],"complete":[109],"resolution":[110],"target":[113],"hemangioma]":[114],"6":[116],"months":[117],"treatment).":[119],"RESULTS:":[120],"Our":[121],"analyses":[122],"identified":[123],"that":[124,153],"patients":[125,152],"who":[126],"started":[127],"3":[130,185],"mg/kg/day":[131],"before":[132,167],"10":[136,160,168],"weeks":[137,161,169],"had":[138],"86%,":[143],"than":[145],"60%":[147],"all":[151],"received":[154],"same":[156],"regimen":[157],"commencing":[158],"after":[159],"age.":[163],"CONCLUSIONS:":[164],"Treatment":[165],"initiation":[166],"associated":[173],"significantly":[176],"mg/kg/day.":[186],"Infants":[187],"IH":[189],"requiring":[190],"should":[192],"be":[193],"referred":[194],"an":[196],"expert":[197],"center":[198],"treated":[200],"soon":[202],"possible.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-12-25T00:00:00"}