{"id":"https://openalex.org/W4311260165","doi":"https://doi.org/10.2147/ijn.s384085","title":"In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment","display_name":"In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment","publication_year":2022,"publication_date":"2022-12-01","ids":{"openalex":"https://openalex.org/W4311260165","doi":"https://doi.org/10.2147/ijn.s384085","pmid":"https://pubmed.ncbi.nlm.nih.gov/36531115","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9753765"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s384085","doi":"https://doi.org/10.2147/ijn.s384085","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s384085","pdf_url":"https://www.dovepress.com/getfile.php?fileID=86035","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=86035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033189660","display_name":"Saeedeh Khajeh Ahmadi","orcid":"https://orcid.org/0000-0002-5691-4237","observed_orcids":["https://orcid.org/0000-0002-5691-4237"]},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeedeh Ahmadi","raw_affiliation_strings":["Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020545201","display_name":"Mahmoud Seraj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmoud Seraj","raw_affiliation_strings":["Integrative Research Laboratory, Islamic Azad University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Research Laboratory, Islamic Azad University of Medical Sciences, Tehran, Iran","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052805703","display_name":"Mohsen Chiani","orcid":"https://orcid.org/0000-0001-6413-8752","observed_orcids":["https://orcid.org/0000-0001-6413-8752"]},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohsen Chiani","raw_affiliation_strings":["Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0001-6413-8752","affiliations":[{"raw_affiliation_string":"Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010172158","display_name":"Seyedayin Hosseini","orcid":"https://orcid.org/0000-0003-3221-2270","observed_orcids":["https://orcid.org/0000-0003-3221-2270"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"SeyedAyin Hosseini","raw_affiliation_strings":["School of Medicine, Sh Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0003-3221-2270","affiliations":[{"raw_affiliation_string":"School of Medicine, Sh Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044234986","display_name":"Saba Bazzazan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saba Bazzazan","raw_affiliation_strings":["Core Facility Lab, Pasteur Institute of Iran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility Lab, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019607599","display_name":"Iman Akbarzadeh","orcid":"https://orcid.org/0000-0001-5136-2122","observed_orcids":["https://orcid.org/0000-0001-5136-2122","https://orcid.org/0009-0003-7611-0943"]},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Iman Akbarzadeh","raw_affiliation_strings":["Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111799422","display_name":"Samaneh Saffar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Samaneh Saffar","raw_affiliation_strings":["Core Facility Lab, Pasteur Institute of Iran, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility Lab, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001724302","display_name":"Ebrahim Mostafavi","orcid":"https://orcid.org/0000-0003-3958-5002","observed_orcids":["https://orcid.org/0000-0003-3958-5002"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ebrahim Mostafavi","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0003-3958-5002","affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5001724302"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.082,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87954198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"Volume 17","issue":null,"first_page":"6233","last_page":"6255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":0.9670000076293945},{"id":"https://openalex.org/keywords/niosomes","display_name":"niosomes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7580000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.968999981880188},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mcf-10a-cells","display_name":"MCF10A cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/korsmeyer-peppas-kinetics","display_name":"Korsmeyer-Peppas kinetics","score":0.7730000019073486},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.9245308637619019},{"id":"https://openalex.org/C2778812593","wikidata":"https://www.wikidata.org/wiki/Q194974","display_name":"Letrozole","level":5,"score":0.7486612796783447},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.6622625589370728},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5958805084228516},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4890356957912445},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.43014198541641235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4300629496574402},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4053384065628052},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.375986784696579},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.347952663898468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30144578218460083},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2735774517059326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23707881569862366},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.1633332073688507},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.13276270031929016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1230187714099884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s384085","doi":"https://doi.org/10.2147/ijn.s384085","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s384085","pdf_url":"https://www.dovepress.com/getfile.php?fileID=86035","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:36531115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36531115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9753765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9753765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fdd32cb80d794a3fb1a2f1355c062ff1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fdd32cb80d794a3fb1a2f1355c062ff1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 17, Pp 6233-6255 (2022)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/80238","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/in-vitro-development-of-controlled-release-nanoniosomes-for-improved-d-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s384085","doi":"https://doi.org/10.2147/ijn.s384085","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s384085","pdf_url":"https://www.dovepress.com/getfile.php?fileID=86035","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000874781","display_name":"Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford","funder_award_id":"T32EB009035","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320326567","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311260165.pdf","grobid_xml":"https://content.openalex.org/works/W4311260165.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W44078951","https://openalex.org/W1529868160","https://openalex.org/W1843214647","https://openalex.org/W1934173384","https://openalex.org/W1966121642","https://openalex.org/W1974598896","https://openalex.org/W1975970944","https://openalex.org/W1977072597","https://openalex.org/W1987147125","https://openalex.org/W1988400258","https://openalex.org/W2002936090","https://openalex.org/W2008028087","https://openalex.org/W2015312618","https://openalex.org/W2017638629","https://openalex.org/W2026438690","https://openalex.org/W2028254240","https://openalex.org/W2033547005","https://openalex.org/W2041606511","https://openalex.org/W2041610629","https://openalex.org/W2049565394","https://openalex.org/W2059621790","https://openalex.org/W2062767906","https://openalex.org/W2063669247","https://openalex.org/W2069727083","https://openalex.org/W2073802516","https://openalex.org/W2089013013","https://openalex.org/W2089448176","https://openalex.org/W2134236073","https://openalex.org/W2174264563","https://openalex.org/W2275975470","https://openalex.org/W2301504437","https://openalex.org/W2338056010","https://openalex.org/W2344543596","https://openalex.org/W2530451418","https://openalex.org/W2571192017","https://openalex.org/W2586473844","https://openalex.org/W2599112769","https://openalex.org/W2737358633","https://openalex.org/W2767458831","https://openalex.org/W2782690276","https://openalex.org/W2805943635","https://openalex.org/W2884131579","https://openalex.org/W2889646458","https://openalex.org/W2890873629","https://openalex.org/W2893037183","https://openalex.org/W2909619884","https://openalex.org/W2945773881","https://openalex.org/W2945880173","https://openalex.org/W2963810530","https://openalex.org/W2964582591","https://openalex.org/W2979256511","https://openalex.org/W2991989248","https://openalex.org/W2998705080","https://openalex.org/W2999074588","https://openalex.org/W3004227146","https://openalex.org/W3009123370","https://openalex.org/W3016013889","https://openalex.org/W3023879699","https://openalex.org/W3053711707","https://openalex.org/W3081465942","https://openalex.org/W3082073468","https://openalex.org/W3119314593","https://openalex.org/W3127416942","https://openalex.org/W3135062507","https://openalex.org/W3170001170","https://openalex.org/W3173294803","https://openalex.org/W3185991901","https://openalex.org/W3187457788","https://openalex.org/W3189861073","https://openalex.org/W3209707828","https://openalex.org/W4200037495","https://openalex.org/W4200562242","https://openalex.org/W4213229770","https://openalex.org/W4214684184","https://openalex.org/W4220803146","https://openalex.org/W4224233348","https://openalex.org/W4224256308","https://openalex.org/W4229076259","https://openalex.org/W4281729410","https://openalex.org/W4283582788","https://openalex.org/W4284898326","https://openalex.org/W4288808033","https://openalex.org/W4290466172","https://openalex.org/W4309765825","https://openalex.org/W4309928118"],"related_works":["https://openalex.org/W4200136421","https://openalex.org/W3083092498","https://openalex.org/W4396520578","https://openalex.org/W4200170237","https://openalex.org/W4321384475","https://openalex.org/W4392867151","https://openalex.org/W4281710577","https://openalex.org/W4396787012","https://openalex.org/W3053711707","https://openalex.org/W4309043935"],"abstract_inverted_index":{"Introduction:":[0],"Breast":[1],"cancer":[2,43,173,186,222,294],"is":[3,204],"among":[4,208],"the":[5,14,30,92,131,166,172,205,215,219,227,235,253,265,288],"most":[6],"prevalent":[7],"mortal":[8],"cancers":[9],"in":[10,35,36,62,157,171,218,256],"women":[11],"worldwide.":[12],"In":[13],"present":[15],"study,":[16],"an":[17],"optimum":[18,109],"formulation":[19,79,110,193],"of":[20,52,64,80,108,130,141,168,191,194,229,237,290],"letrozole,":[21,302],"letrozole-loaded":[22,197,268],"niosome,":[23,301],"and":[24,29,40,47,60,75,91,102,125,139,239,259,273],"empty":[25],"niosome":[26,198,269],"was":[27,33,82,111,156],"developed,":[28],"anticancer":[31,306],"effect":[32],"assessed":[34,95],"vitro":[37],"MCF-7,":[38],"MCF10A":[39],"MDA-MB-231":[41,260],"breast":[42,185,221,293,299],"cell":[44,223,261],"lines.":[45],"Materials":[46],"Methods:":[48],"Various":[49],"niosomal":[50,78],"formulations":[51],"letrozole":[53,81,120,195,266,291],"were":[54,94],"fabricated":[55],"through":[56],"thin-film":[57],"hydration":[58],"method":[59],"characterized":[61],"terms":[63],"size,":[65,137],"polydispersity":[66],"index":[67],"(PDI),":[68],"morphology,":[69],"entrapment":[70],"efficiency":[71],"(EE%),":[72],"release":[73,153],"kinetics,":[74],"stability.":[76],"Optimized":[77],"achieved":[83],"by":[84,96,113,225],"response":[85],"surface":[86],"methodology":[87],"(RSM).":[88],"Antiproliferative":[89],"activity":[90],"mechanism":[93],"MTT":[97,175],"assay,":[98],"quantitative":[99],"real-time":[100],"PCR,":[101],"flow":[103,243],"cytometry.":[104],"Furthermore,":[105],"cellular":[106],"uptake":[107],"evaluated":[112],"confocal":[114],"electron":[115],"microscopy.":[116],"Results:":[117],"The":[118,136,151,188,242],"formulated":[119],"had":[121],"a":[122,127,283],"spherical":[123],"shape":[124],"showed":[126,143],"slow-release":[128],"profile":[129],"drug":[132,152,285,303],"after":[133],"72":[134],"h.":[135],"PDI,":[138],"eEE%":[140],"nanoparticles":[142],"higher":[144],"stability":[145],"at":[146],"4\u00b0C":[147],"compared":[148,263],"with":[149,159,196,264],"25\u00b0C.":[150],"from":[154],"niosomes":[155,170,280],"accordance":[158],"Korsmeyer\u2013Peppa\u2019s":[160],"kinetic":[161],"model.":[162],"Confocal":[163],"microscopy":[164],"revealed":[165,177,246],"localization":[167],"drug-loaded":[169],"cells.":[174,187,295],"assay":[176],"that":[178,247,279],"all":[179,209],"samples":[180],"exhibited":[181],"dose-dependent":[182],"cytotoxicity":[183],"against":[184],"IC":[189],"50":[190],"mixed":[192],"(L":[199,270],"+":[200,249],"L":[201,248,250],"3":[202,213,251,271],")":[203],"lowest":[206],"value":[207],"prepared":[210],"formulations.":[211],"L+L":[212],"influenced":[214],"gene":[216,232],"expression":[217,228,236],"tested":[220],"lines":[224,262],"down-regulating":[226],"Bcl":[230],"2":[231],"while":[233],"up-regulating":[234],"p53":[238],"Bax":[240],"genes.":[241],"cytometry":[244],"results":[245],"enhanced":[252],"apoptosis":[254],"rate":[255],"both":[257],"MCF-7":[258],"(L),":[267],"),":[272],"control":[274],"sample.":[275],"Conclusion:":[276],"Results":[277],"indicated":[278],"could":[281],"be":[282],"promising":[284],"carrier":[286],"for":[287],"delivery":[289,304],"to":[292],"Graphical":[296],"Abstract:":[297],"Keywords:":[298],"cancer,":[300],"system,":[305]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-12-25T00:00:00"}