{"id":"https://openalex.org/W4311237372","doi":"https://doi.org/10.3389/fcell.2022.1023413","title":"The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice","display_name":"The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice","publication_year":2022,"publication_date":"2022-12-13","ids":{"openalex":"https://openalex.org/W4311237372","doi":"https://doi.org/10.3389/fcell.2022.1023413","pmid":"https://pubmed.ncbi.nlm.nih.gov/36582470"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2022.1023413","doi":"https://doi.org/10.3389/fcell.2022.1023413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.1023413","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2022.1023413/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2022.1023413/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028727007","display_name":"Adekunle Akeem Bakare","orcid":"https://orcid.org/0000-0001-9829-1587","observed_orcids":["https://orcid.org/0000-0001-9829-1587"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Adekunle A. Bakare","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003665005","display_name":"Victoria Y. Moses","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Victoria Y. Moses","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026660317","display_name":"Charles T. Beckely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Charles T. Beckely","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034075506","display_name":"Toluwani I. Oluyemi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Toluwani I. Oluyemi","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003160522","display_name":"Gift O. Ogunfeitimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Gift O. Ogunfeitimi","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041859981","display_name":"Aduragbemi A. Adelaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Aduragbemi A. Adelaja","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073182085","display_name":"Glory T. Ayorinde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Glory T. Ayorinde","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036534333","display_name":"Adeyinka M. Gbadebo","orcid":"https://orcid.org/0000-0001-7543-6368","observed_orcids":["https://orcid.org/0000-0001-7543-6368"]},"institutions":[{"id":"https://openalex.org/I4405253191","display_name":"Chrisland University","ror":"https://ror.org/00d1mx684","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405253191"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Adeyinka M. Gbadebo","raw_affiliation_strings":["Department of Biological Science, Chrisland University, Abeokuta, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Chrisland University, Abeokuta, Nigeria","institution_ids":["https://openalex.org/I4405253191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025776880","display_name":"Olukunle Silas Fagbenro","orcid":"https://orcid.org/0000-0001-9362-8304","observed_orcids":["https://orcid.org/0000-0001-9362-8304"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olukunle S. Fagbenro","raw_affiliation_strings":["Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022314279","display_name":"Olusegun I. Ogunsuyi","orcid":"https://orcid.org/0000-0001-9075-1446","observed_orcids":["https://orcid.org/0000-0001-9075-1446"]},"institutions":[{"id":"https://openalex.org/I197610006","display_name":"University of Lagos","ror":"https://ror.org/05rk03822","country_code":"NG","type":"education","lineage":["https://openalex.org/I197610006"]},{"id":"https://openalex.org/I4210092144","display_name":"Mountain Top University","ror":"https://ror.org/00effsg46","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210092144"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olusegun I. Ogunsuyi","raw_affiliation_strings":["Department of Biological Sciences, College of Basic and Applied Sciences, Mountain Top University, Ibafo, Ogun State, Nigeria","Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, College of Basic and Applied Sciences, Mountain Top University, Ibafo, Ogun State, Nigeria","institution_ids":["https://openalex.org/I4210092144"]},{"raw_affiliation_string":"Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos State, Nigeria","institution_ids":["https://openalex.org/I197610006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075878421","display_name":"Opeoluwa M. Ogunsuyi","orcid":"https://orcid.org/0000-0001-6685-6029","observed_orcids":["https://orcid.org/0000-0001-6685-6029"]},"institutions":[{"id":"https://openalex.org/I197610006","display_name":"University of Lagos","ror":"https://ror.org/05rk03822","country_code":"NG","type":"education","lineage":["https://openalex.org/I197610006"]},{"id":"https://openalex.org/I4210092144","display_name":"Mountain Top University","ror":"https://ror.org/00effsg46","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210092144"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Opeoluwa M. Ogunsuyi","raw_affiliation_strings":["Department of Biological Sciences, College of Basic and Applied Sciences, Mountain Top University, Ibafo, Ogun State, Nigeria","Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, College of Basic and Applied Sciences, Mountain Top University, Ibafo, Ogun State, Nigeria","institution_ids":["https://openalex.org/I4210092144"]},{"raw_affiliation_string":"Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos State, Nigeria","institution_ids":["https://openalex.org/I197610006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112858668","display_name":"Olusoji Mayowa Ige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olusoji Mayowa Ige","raw_affiliation_strings":["Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028727007"],"corresponding_institution_ids":["https://openalex.org/I181631907"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.5405,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82051914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"1023413","last_page":"1023413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.3212999999523163,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/first-line-antituberculosis-drugs","display_name":"first-line antituberculosis drugs","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sperm-morphology","display_name":"sperm morphology","score":0.7170000076293945},{"id":"https://openalex.org/keywords/testicular-histopathology","display_name":"testicular histopathology","score":0.824999988079071},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":1.0},{"id":"https://openalex.org/keywords/ethambutol","display_name":"ethambutol","score":1.0},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":1.0},{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5899999737739563},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5408225059509277},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5359652042388916},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4533613622188568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4474600553512573},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39558786153793335},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38732704520225525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33382976055145264},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11631578207015991}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fcell.2022.1023413","doi":"https://doi.org/10.3389/fcell.2022.1023413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.1023413","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2022.1023413/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:36582470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36582470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9793334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9793334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:27d11f8e20564598bdbca6f003d033cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/27d11f8e20564598bdbca6f003d033cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 10 (2022)","raw_type":"article"},{"id":"doi:10.60692/c4wva-zwe37","doi":"https://doi.org/10.60692/c4wva-zwe37","is_oa":true,"landing_page_url":"https://doi.org/10.60692/c4wva-zwe37","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/kq2nf-sc868","doi":"https://doi.org/10.60692/kq2nf-sc868","is_oa":true,"landing_page_url":"https://doi.org/10.60692/kq2nf-sc868","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3389/fcell.2022.1023413","doi":"https://doi.org/10.3389/fcell.2022.1023413","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2022.1023413","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2022.1023413/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311237372.pdf","grobid_xml":"https://content.openalex.org/works/W4311237372.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1487815846","https://openalex.org/W1538625101","https://openalex.org/W1580718844","https://openalex.org/W1600414925","https://openalex.org/W1621466036","https://openalex.org/W1967955049","https://openalex.org/W1986714794","https://openalex.org/W1987926210","https://openalex.org/W1989219811","https://openalex.org/W2002171375","https://openalex.org/W2003268107","https://openalex.org/W2005528905","https://openalex.org/W2011742915","https://openalex.org/W2018289835","https://openalex.org/W2018437991","https://openalex.org/W2023453201","https://openalex.org/W2035393104","https://openalex.org/W2040420065","https://openalex.org/W2044171486","https://openalex.org/W2072356850","https://openalex.org/W2072721264","https://openalex.org/W2080842877","https://openalex.org/W2083103296","https://openalex.org/W2083144797","https://openalex.org/W2095055513","https://openalex.org/W2099230832","https://openalex.org/W2124345456","https://openalex.org/W2124956392","https://openalex.org/W2125593063","https://openalex.org/W2133731158","https://openalex.org/W2139789446","https://openalex.org/W2145034282","https://openalex.org/W2151804384","https://openalex.org/W2164365729","https://openalex.org/W2166822423","https://openalex.org/W2184997810","https://openalex.org/W2231999257","https://openalex.org/W2473801712","https://openalex.org/W2483214427","https://openalex.org/W2517504903","https://openalex.org/W2552041992","https://openalex.org/W2555035115","https://openalex.org/W2772700680","https://openalex.org/W2948535403","https://openalex.org/W3042218145","https://openalex.org/W3088915744","https://openalex.org/W3152434232","https://openalex.org/W3176325656","https://openalex.org/W4213222986","https://openalex.org/W4239111392"],"related_works":["https://openalex.org/W2009261355","https://openalex.org/W2399181824","https://openalex.org/W2056763346","https://openalex.org/W2926418838","https://openalex.org/W1984230762","https://openalex.org/W2047695780","https://openalex.org/W2024683308","https://openalex.org/W2286578414","https://openalex.org/W4323286707","https://openalex.org/W2070214996"],"abstract_inverted_index":{"Rifampicin":[0],"(RIF),":[1],"Isoniazid":[2],"(INH),":[3],"Ethambutol":[4],"(EMB),":[5],"Pyrazinamide":[6],"(PZA),":[7],"and/or":[8],"their":[9,64],"fixed-dose":[10],"combination":[11],"(FDC)":[12],"are":[13,31],"extensively":[14],"prescribed":[15],"in":[16,180,196,229,251],"the":[17,26,40,44,55,67,75,100,163,170,181,197,205,216,220,224,230,236,242,245],"cure":[18],"of":[19,25,33,43,58,74,77,99,107,115,124,133,142,152,162,187,199,204,208,219],"Tuberculosis":[20],"(TB)":[21],"globally.":[22],"In":[23,167],"spite":[24],"beneficial":[27],"effect,":[28],"these":[29],"drugs":[30,47,102,222],"capable":[32],"inducing":[34],"cellular":[35],"toxicity.":[36],"Existing":[37],"information":[38],"on":[39],"genotoxic":[41],"effects":[42],"first-line":[45,238],"anti-TB":[46,101,221,239],"is":[48],"limited":[49],"and":[50,63,111,120,129,138,144,148,160,184,211],"contentious.":[51],"Herein,":[52],"we":[53],"evaluated":[54],"reproductive":[56],"genotoxicity":[57],"RIF,":[59],"INH,":[60],"EMB,":[61],"PZA,":[62],"FDC":[65,153,225,243],"utilizing":[66],"mouse":[68],"sperm":[69],"morphology":[70],"assay.":[71],"Histological":[72],"examination":[73],"testes":[76],"exposed":[78,92,188],"mice":[79,86],"was":[80,176,191],"also":[81],"performed.":[82],"Male":[83],"Swiss":[84],"albino":[85],"(11\u201313":[87],"weeks":[88],"old)":[89],"were":[90],"intraperitoneally":[91],"for":[93],"5":[94],"consecutive":[95],"days":[96],"to":[97,156,247],"each":[98,209],"at":[103,202],"four":[104],"different":[105],"doses":[106,207],"6.25,":[108],"12.5,":[109],"25,":[110],"50":[112],"mg/kg":[113,122,131,140,150],"bw":[114,123,132,141,151],"PZA;":[116],"2.5,":[117,127],"5.0,":[118],"10,":[119],"20":[121],"RIF;":[125],"1.25,":[126],"5.0":[128],"10":[130],"INH;":[134],"3.75,":[135],"7.5,":[136],"15":[137],"30":[139],"EMB;":[143],"7,":[145],"14,":[146],"28":[147],"56":[149],"corresponding":[154],"respectively":[155],"\u00d70.25,":[157],"\u00d70.5,":[158],"\u00d71":[159],"\u00d72.0":[161],"standard":[164],"daily":[165],"dose.":[166],"comparison":[168],"with":[169,215],"negative":[171],"control":[172],"(normal":[173],"saline),":[174],"there":[175],"no":[177],"significant":[178],"difference":[179],"testicular":[182,249],"weight":[183],"organo-somatic":[185],"index":[186],"mice.":[189,253],"There":[190],"an":[192],"increase":[193],"(p>":[194],"0.05)":[195],"frequency":[198],"abnormal":[200],"spermatozoa":[201],"most":[203],"tested":[206],"drug":[210,240],"a":[212],"dose-dependent":[213],"decrease":[214],"FDC.":[217],"Each":[218],"except":[223],"induced":[226],"pathological":[227],"lesions":[228],"testes.":[231],"These":[232],"findings":[233],"suggest":[234],"that":[235],"individual":[237],"unlike":[241],"has":[244],"potential":[246],"provoke":[248],"anomalies":[250],"male":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
