{"id":"https://openalex.org/W4311020146","doi":"https://doi.org/10.1093/oncolo/oyac248","title":"Clinical Implications and Treatment Strategies for ESR1 Fusions in Hormone Receptor-Positive Metastatic Breast Cancer: A Case Series","display_name":"Clinical Implications and Treatment Strategies for ESR1 Fusions in Hormone Receptor-Positive Metastatic Breast Cancer: A Case Series","publication_year":2022,"publication_date":"2022-12-09","ids":{"openalex":"https://openalex.org/W4311020146","doi":"https://doi.org/10.1093/oncolo/oyac248","pmid":"https://pubmed.ncbi.nlm.nih.gov/36493359","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9907034"},"language":"en","primary_location":{"id":"doi:10.1093/oncolo/oyac248","doi":"https://doi.org/10.1093/oncolo/oyac248","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac248","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/oncolo/oyac248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076798199","display_name":"Jamie O. Brett","orcid":"https://orcid.org/0000-0003-3112-5204","observed_orcids":["https://orcid.org/0000-0003-3112-5204"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie O Brett","raw_affiliation_strings":["Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA"],"raw_orcid":"https://orcid.org/0000-0003-3112-5204","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070257501","display_name":"Lauren L. Ritterhouse","orcid":"https://orcid.org/0000-0002-7655-630X","observed_orcids":["https://orcid.org/0000-0002-7655-630X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren L Ritterhouse","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072420523","display_name":"Erik T. Newman","orcid":"https://orcid.org/0000-0003-4941-4039","observed_orcids":["https://orcid.org/0000-0003-4941-4039"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik T Newman","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Orthopedic Surgery, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Orthopedic Surgery, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065932145","display_name":"Kelly Edwards Irwin","orcid":"https://orcid.org/0000-0002-4591-9876","observed_orcids":["https://orcid.org/0000-0002-4591-9876"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E Irwin","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Psychiatry, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Psychiatry, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Megan Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Dawson","raw_affiliation_strings":["Massachusetts General Hospital Department of Psychiatry, Harvard Medical School , Boston, MA , USA","University of Michigan Department of Psychiatry, University of Michigan Medical School , Ann Arbor, MI , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Department of Psychiatry, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"University of Michigan Department of Psychiatry, University of Michigan Medical School , Ann Arbor, MI , USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043140897","display_name":"Lianne Y. Ryan","orcid":"https://orcid.org/0009-0009-1898-550X","observed_orcids":["https://orcid.org/0009-0009-1898-550X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lianne Y Ryan","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018738915","display_name":"Laura M. Spring","orcid":"https://orcid.org/0000-0001-8904-3514","observed_orcids":["https://orcid.org/0000-0001-8904-3514"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M Spring","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033765545","display_name":"Miguel N. Rivera","orcid":"https://orcid.org/0000-0002-3636-2113","observed_orcids":["https://orcid.org/0000-0002-3636-2113"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel N Rivera","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067299042","display_name":"Jochen K. Lennerz","orcid":"https://orcid.org/0000-0003-2434-4978","observed_orcids":["https://orcid.org/0000-0003-2434-4978"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jochen K Lennerz","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA"],"raw_orcid":"https://orcid.org/0000-0003-2434-4978","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006018613","display_name":"Dora C. Dias-Santagata","orcid":"https://orcid.org/0000-0002-1174-3972","observed_orcids":["https://orcid.org/0000-0002-1174-3972"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dora Dias-Santagata","raw_affiliation_strings":["Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA"],"raw_orcid":"https://orcid.org/0000-0002-1174-3972","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Department of Pathology, Center for Integrated Diagnostics, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052735318","display_name":"Leif William Ellisen","orcid":"https://orcid.org/0000-0003-0444-7910","observed_orcids":["https://orcid.org/0000-0003-0444-7910"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif W Ellisen","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA"],"raw_orcid":"https://orcid.org/0000-0003-4885-1157","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025351031","display_name":"Seth Andrew Wander","orcid":"https://orcid.org/0000-0002-4127-4708","observed_orcids":["https://orcid.org/0000-0002-4127-4708"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seth A Wander","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Department of Medicine, Harvard Medical School , Boston, MA , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025351031"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3494,"currency":"USD","value_usd":3494},"apc_paid":{"value":3494,"currency":"USD","value_usd":3494},"fwci":1.2895,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80939216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"28","issue":"2","first_page":"172","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-receptor-positive-metastatic-breast-cancer","display_name":"hormone receptor-positive metastatic breast cancer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8690000176429749},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.8930000066757202},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.6650000214576721},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8642531037330627},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6853299140930176},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5803320407867432},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.5763726830482483},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.5594350695610046},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4987373352050781},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48012280464172363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43443435430526733},{"id":"https://openalex.org/C2910080358","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Oestrogen receptor","level":4,"score":0.4147886633872986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37518075108528137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3537263870239258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08153706789016724},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oncolo/oyac248","doi":"https://doi.org/10.1093/oncolo/oyac248","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac248","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9907034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9907034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologist","raw_type":"Text"},{"id":"pmid:36493359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36493359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/oncolo/oyac248","doi":"https://doi.org/10.1093/oncolo/oyac248","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac248","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G9000897310","display_name":"Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology","funder_award_id":"K12CA087723","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320314458","display_name":"National Comprehensive Cancer Network","ror":"https://ror.org/0465x5x63"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2025784247","https://openalex.org/W2042337609","https://openalex.org/W2062291041","https://openalex.org/W2124358769","https://openalex.org/W2694134812","https://openalex.org/W2743649404","https://openalex.org/W2773461708","https://openalex.org/W2794280643","https://openalex.org/W2796292093","https://openalex.org/W2887861528","https://openalex.org/W2897779677","https://openalex.org/W2917288175","https://openalex.org/W3015634062","https://openalex.org/W3037364446","https://openalex.org/W3048242943","https://openalex.org/W3108385842","https://openalex.org/W3135893428","https://openalex.org/W3169471863","https://openalex.org/W3190199458","https://openalex.org/W3193378962","https://openalex.org/W3211255002","https://openalex.org/W3214538404","https://openalex.org/W4205612598","https://openalex.org/W4221007135","https://openalex.org/W4229067692"],"related_works":["https://openalex.org/W2897779677","https://openalex.org/W4313584691","https://openalex.org/W4282979406","https://openalex.org/W2887208641","https://openalex.org/W2887861528","https://openalex.org/W4397006953","https://openalex.org/W2949733807","https://openalex.org/W2944598790","https://openalex.org/W4403537539","https://openalex.org/W7130681161"],"abstract_inverted_index":{"In":[0],"hormone":[1],"receptor-positive":[2],"metastatic":[3],"breast":[4],"cancer":[5],"(HR+":[6],"MBC),":[7],"endocrine":[8],"resistance":[9,32],"is":[10,42],"commonly":[11],"due":[12],"to":[13,33],"genetic":[14],"alterations":[15],"of":[16,51,69,101,113],"ESR1,":[17],"the":[18,45,67,70,80,99],"gene":[19],"encoding":[20],"estrogen":[21],"receptor":[22],"alpha":[23],"(ER\u03b1).":[24],"While":[25],"ESR1":[26,52],"point":[27],"mutations":[28],"(ESR1-MUT)":[29],"cause":[30],"acquired":[31],"aromatase":[34],"inhibition":[35,84],"(AI)":[36],"through":[37],"constitutive":[38],"activation,":[39],"far":[40],"less":[41],"known":[43],"about":[44],"molecular":[46],"functions":[47],"and":[48,78],"clinical":[49],"consequences":[50],"fusions":[53],"(ESR1-FUS).":[54],"This":[55],"case":[56],"series":[57],"discusses":[58],"4":[59],"patients":[60,106],"with":[61,64,91,107],"HR+":[62,108],"MBC":[63,109],"ESR1-FUS":[65,72,90,104],"in":[66,105],"context":[68],"existing":[71],"literature.":[73],"We":[74],"consider":[75],"therapeutic":[76],"strategies":[77],"raise":[79],"hypothesis":[81],"that":[82],"CDK4/6":[83],"(CDK4/6i)":[85],"may":[86],"be":[87],"effective":[88],"against":[89],"functional":[92],"ligand-binding":[93],"domain":[94],"swaps.":[95],"These":[96],"cases":[97],"highlight":[98],"importance":[100],"screening":[102],"for":[103,116],"while":[110],"continuing":[111],"investigation":[112],"precision":[114],"treatments":[115],"these":[117],"genomic":[118],"rearrangements.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-12-22T00:00:00"}