{"id":"https://openalex.org/W4310944847","doi":"https://doi.org/10.1002/advs.202201724","title":"Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T\u2010Cell Acute Lymphoblastic Leukemia","display_name":"Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T\u2010Cell Acute Lymphoblastic Leukemia","publication_year":2022,"publication_date":"2022-12-07","ids":{"openalex":"https://openalex.org/W4310944847","doi":"https://doi.org/10.1002/advs.202201724","pmid":"https://pubmed.ncbi.nlm.nih.gov/36478193","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9839875"},"language":"en","primary_location":{"id":"doi:10.1002/advs.202201724","doi":"https://doi.org/10.1002/advs.202201724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202201724","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.202201724","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046555997","display_name":"Ying Zhou","orcid":"https://orcid.org/0000-0001-8276-2735","observed_orcids":["https://orcid.org/0000-0001-8276-2735","https://orcid.org/0000-0002-2319-7024"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhou","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Ji","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024374013","display_name":"Yuan Xia","orcid":"https://orcid.org/0000-0002-7292-8903","observed_orcids":["https://orcid.org/0000-0002-7292-8903"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Xia","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085747771","display_name":"Xiaoyu Han","orcid":"https://orcid.org/0000-0002-8617-8664","observed_orcids":["https://orcid.org/0000-0002-8617-8664"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Han","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109543506","display_name":"Mingying Li","orcid":"https://orcid.org/0000-0001-7419-9655","observed_orcids":["https://orcid.org/0000-0001-7419-9655"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingying Li","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318082","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-9931-5990","observed_orcids":["https://orcid.org/0000-0001-9931-5990"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Sun","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650589","display_name":"Jingru Zhang","orcid":"https://orcid.org/0000-0003-1061-1246","observed_orcids":["https://orcid.org/0000-0003-1061-1246","https://orcid.org/0000-0003-0929-2815","https://orcid.org/0009-0002-6537-2334"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingru Zhang","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087766294","display_name":"Fei Lu","orcid":"https://orcid.org/0000-0001-5086-1157","observed_orcids":["https://orcid.org/0000-0001-5086-1157","https://orcid.org/0009-0007-8572-2465"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Lu","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833104","display_name":"Yanping Sun","orcid":"https://orcid.org/0009-0004-3401-917X","observed_orcids":["https://orcid.org/0009-0004-3401-917X","https://orcid.org/0000-0003-0105-5137"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Sun","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389811","display_name":"Na Liu","orcid":"https://orcid.org/0000-0003-4324-4585","observed_orcids":["https://orcid.org/0000-0003-4324-4585"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Liu","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049507373","display_name":"Jingxin Li","orcid":"https://orcid.org/0000-0001-7370-703X","observed_orcids":["https://orcid.org/0000-0001-7370-703X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxin Li","raw_affiliation_strings":["Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115594649","display_name":"Daoxin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoxin Ma","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101676263","display_name":"Jingjing Ye","orcid":"https://orcid.org/0009-0000-8906-4454","observed_orcids":["https://orcid.org/0009-0000-8906-4454"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingjing Ye","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036274351","display_name":"Chunyan Ji","orcid":"https://orcid.org/0000-0003-4438-1768","observed_orcids":["https://orcid.org/0000-0003-4438-1768"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunyan Ji","raw_affiliation_strings":["Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-4438-1768","affiliations":[{"raw_affiliation_string":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P. R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036274351","https://openalex.org/A5101676263"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":1.4695,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82301906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"e2201724","last_page":"e2201724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.9919999837875366},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/fto-demethylase","display_name":"FTO demethylase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/epitranscriptomics","display_name":"epitranscriptomics","score":0.9079999923706055},{"id":"https://openalex.org/keywords/leukemia-progression","display_name":"leukemia progression","score":0.6949999928474426},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.6666127443313599},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5770026445388794},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4841683506965637},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.46952882409095764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45423123240470886},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4538998007774353},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.4251849353313446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3418455123901367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33932632207870483},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.18400710821151733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15519508719444275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08431252837181091}],"mesh":[{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.202201724","doi":"https://doi.org/10.1002/advs.202201724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202201724","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9839875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9839875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:36478193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36478193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/advs.202201724","doi":"https://doi.org/10.1002/advs.202201724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202201724","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2675689107","display_name":null,"funder_award_id":"ZR2020MH118","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G5457925468","display_name":"\u9aa8\u9ad3\u8102\u80aa\u7ec6\u80de\u5f02\u5e38\u5206\u5316\u5728\u6025\u6027T\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u5fae\u5c0f\u6b8b\u7559\u75c5\u4e2d\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"81770159","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5623439796","display_name":null,"funder_award_id":"ZR2020KH016","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G6189131065","display_name":"METTL3\u901a\u8fc7m6A\u7532\u57fa\u5316\u8c03\u63a7\u7ec6\u80de\u5f52\u5de2\u4ecb\u5bfc\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u5316\u7597\u8010\u836f\u53ca\u5176\u673a\u5236\u7814\u7a76","funder_award_id":"82070160","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6548565841","display_name":null,"funder_award_id":"ZR2020MH119","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G7659405602","display_name":null,"funder_award_id":"82100176","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1559637642","https://openalex.org/W1709431973","https://openalex.org/W1977380325","https://openalex.org/W1981629946","https://openalex.org/W1986988560","https://openalex.org/W1991807334","https://openalex.org/W2000259453","https://openalex.org/W2000589976","https://openalex.org/W2007240193","https://openalex.org/W2008568428","https://openalex.org/W2014889002","https://openalex.org/W2019913536","https://openalex.org/W2021028235","https://openalex.org/W2022770379","https://openalex.org/W2030539252","https://openalex.org/W2037918348","https://openalex.org/W2065847836","https://openalex.org/W2071930821","https://openalex.org/W2074342156","https://openalex.org/W2074433596","https://openalex.org/W2078964320","https://openalex.org/W2081308460","https://openalex.org/W2091235283","https://openalex.org/W2091724447","https://openalex.org/W2093489226","https://openalex.org/W2112016025","https://openalex.org/W2112180572","https://openalex.org/W2116634909","https://openalex.org/W2117409731","https://openalex.org/W2129247811","https://openalex.org/W2130044217","https://openalex.org/W2136669853","https://openalex.org/W2142296404","https://openalex.org/W2142324556","https://openalex.org/W2147640266","https://openalex.org/W2165547003","https://openalex.org/W2167969891","https://openalex.org/W2563912688","https://openalex.org/W2589225545","https://openalex.org/W2594926959","https://openalex.org/W2604637348","https://openalex.org/W2753673852","https://openalex.org/W2754499625","https://openalex.org/W2769630486","https://openalex.org/W2769675217","https://openalex.org/W2793785833","https://openalex.org/W2800471491","https://openalex.org/W2895593282","https://openalex.org/W2907354996","https://openalex.org/W2931058147","https://openalex.org/W2936790196","https://openalex.org/W2947993870","https://openalex.org/W2992958546","https://openalex.org/W3000112755","https://openalex.org/W3025785250","https://openalex.org/W3150071815","https://openalex.org/W3172877770","https://openalex.org/W4310944847"],"related_works":["https://openalex.org/W4410809531","https://openalex.org/W2123416522","https://openalex.org/W4360609254","https://openalex.org/W7127711575","https://openalex.org/W3089021149","https://openalex.org/W2893163849","https://openalex.org/W4410805885","https://openalex.org/W2117409731","https://openalex.org/W2553011900","https://openalex.org/W3132755604"],"abstract_inverted_index":{"T-cell":[0],"acute":[1],"lymphoblastic":[2],"leukemia":[3,34],"(T-ALL)":[4],"is":[5,24,47,61,65,74,121,149],"an":[6,118],"aggressive":[7],"hematological":[8,53],"malignancy":[9],"with":[10,79],"a":[11,25,48,152],"poor":[12],"prognosis,":[13],"urging":[14],"for":[15,52,123],"novel":[16],"therapeutic":[17],"targets":[18],"and":[19,99,114,138,169,192,200],"treatment":[20],"strategies.":[21],"N6-methyladenosine":[22],"(m6A)":[23],"crucial":[26,49],"methylation":[27],"modification":[28],"that":[29],"affects":[30],"the":[31,37,86,97,106,146,164,171,183,188,197],"pathogenesis":[32,184],"of":[33,39,72,82,88,94,101,133,154,158,166,173,185,190,203],"by":[35,104,176],"regulating":[36],"mRNA":[38,140],"key":[40],"genes.":[41],"Interferon":[42],"regulatory":[43],"factor":[44,51],"8":[45],"(IRF8)":[46],"transcription":[50],"lineage":[54],"commitment,":[55],"but":[56],"its":[57],"role":[58],"in":[59,77,91,129],"T-ALL":[60,90,102,174,186],"unclear.":[62],"Here,":[63],"IRF8":[64,73,95,134,178],"shown":[66],"to":[67,126],"suppress":[68],"T-ALL.":[69,80,204],"The":[70,111],"expression":[71],"abnormally":[75],"silenced":[76],"patients":[78],"Knockout":[81],"Irf8":[83],"significantly":[84],"hastens":[85],"progression":[87],"Notch1-induced":[89],"vivo.":[92],"Overexpression":[93],"suppresses":[96],"proliferation":[98,165],"invasion":[100],"cells":[103,168],"inhibiting":[105],"phosphatidylinositol":[107],"3-kinase/AKT":[108],"signaling":[109],"pathway.":[110],"fat":[112],"mass-":[113],"obesity-associated":[115],"protein":[116],"(FTO),":[117],"m6A":[119,127,143],"demethylase,":[120],"responsible":[122],"directly":[124],"binding":[125],"sites":[128],"3'":[130],"untranslated":[131],"region":[132],"messenger":[135],"RNA":[136],"(mRNA)":[137],"inducing":[139],"degradation":[141],"via":[142],"modification.":[144],"Targeting":[145],"FTO-IRF8":[147],"axis":[148],"used":[150],"as":[151],"proof":[153],"concept":[155],"therapy;":[156],"inhibition":[157],"FTO's":[159],"demethylase":[160],"activity":[161],"drastically":[162],"alleviates":[163],"leukemic":[167],"prolongs":[170],"survival":[172],"mice":[175],"restoring":[177],"expression.":[179],"This":[180],"study":[181],"elucidates":[182],"from":[187],"perspective":[189],"epitranscriptomics":[191],"provides":[193],"new":[194],"insight":[195],"into":[196],"genetic":[198],"mechanisms":[199],"targeted":[201],"therapy":[202]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-12-21T00:00:00"}
