{"id":"https://openalex.org/W4310905282","doi":"https://doi.org/10.21203/rs.3.rs-2340823/v1","title":"Determining Mortality Likelihood of Opioid Drug Combinations using Decision Tree Analysis","display_name":"Determining Mortality Likelihood of Opioid Drug Combinations using Decision Tree Analysis","publication_year":2022,"publication_date":"2022-12-08","ids":{"openalex":"https://openalex.org/W4310905282","doi":"https://doi.org/10.21203/rs.3.rs-2340823/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2340823/v1","doi":"https://doi.org/10.21203/rs.3.rs-2340823/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2340823/v1","pdf_url":"https://www.researchsquare.com/article/rs-2340823/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2340823/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012328389","display_name":"Robert P. Schumaker","orcid":"https://orcid.org/0000-0003-2977-1856","observed_orcids":["https://orcid.org/0000-0003-2977-1856"]},"institutions":[{"id":"https://openalex.org/I221716585","display_name":"The University of Texas at Tyler","ror":"https://ror.org/01azfw069","country_code":"US","type":"education","lineage":["https://openalex.org/I221716585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Schumaker","raw_affiliation_strings":["The University of Texas at Tyler","Department of Computer Science, The University of Texas at Tyler"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Tyler","institution_ids":["https://openalex.org/I221716585"]},{"raw_affiliation_string":"Department of Computer Science, The University of Texas at Tyler","institution_ids":["https://openalex.org/I221716585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183699","display_name":"Michael A. Veronin","orcid":"https://orcid.org/0000-0002-0226-7791","observed_orcids":["https://orcid.org/0000-0002-0226-7791"]},"institutions":[{"id":"https://openalex.org/I221716585","display_name":"The University of Texas at Tyler","ror":"https://ror.org/01azfw069","country_code":"US","type":"education","lineage":["https://openalex.org/I221716585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Veronin","raw_affiliation_strings":["The University of Texas at Tyler","Department of Pharmaceutical Sciences, The University of Texas at Tyler"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Tyler","institution_ids":["https://openalex.org/I221716585"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, The University of Texas at Tyler","institution_ids":["https://openalex.org/I221716585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071248790","display_name":"Rohit R. Dixit","orcid":"https://orcid.org/0000-0002-9888-6633","observed_orcids":["https://orcid.org/0000-0002-9888-6633"]},"institutions":[{"id":"https://openalex.org/I221716585","display_name":"The University of Texas at Tyler","ror":"https://ror.org/01azfw069","country_code":"US","type":"education","lineage":["https://openalex.org/I221716585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohit R. Dixit","raw_affiliation_strings":["Department of Computer Science, The University of Texas at Tyler"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Texas at Tyler","institution_ids":["https://openalex.org/I221716585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I221716585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-combination","display_name":"opioid combination","score":0.7829999923706055},{"id":"https://openalex.org/keywords/heroin","display_name":"heroin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/opioid-overdose-deaths","display_name":"opioid overdose deaths","score":0.7929999828338623},{"id":"https://openalex.org/keywords/opioid-resistance","display_name":"opioid resistance","score":0.6399999856948853},{"id":"https://openalex.org/keywords/opioid-crisis","display_name":"opioid epidemic","score":0.5320000052452087},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.42500001192092896},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/patient-survival-prediction","display_name":"patient survival prediction","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.9701719880104065},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.8634157180786133},{"id":"https://openalex.org/C2778903686","wikidata":"https://www.wikidata.org/wiki/Q60168","display_name":"Heroin","level":3,"score":0.8131780028343201},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6716234683990479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6348413825035095},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49197742342948914},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4408937990665436},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.37843263149261475},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3730405867099762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25363996624946594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20436516404151917},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2340823/v1","doi":"https://doi.org/10.21203/rs.3.rs-2340823/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2340823/v1","pdf_url":"https://www.researchsquare.com/article/rs-2340823/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2340823/v1","doi":"https://doi.org/10.21203/rs.3.rs-2340823/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2340823/v1","pdf_url":"https://www.researchsquare.com/article/rs-2340823/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4310905282.pdf","grobid_xml":"https://content.openalex.org/works/W4310905282.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1764750372","https://openalex.org/W1965840806","https://openalex.org/W1993178542","https://openalex.org/W2000127653","https://openalex.org/W2024150610","https://openalex.org/W2113514677","https://openalex.org/W2154653591","https://openalex.org/W2210972404","https://openalex.org/W2234741790","https://openalex.org/W2282002114","https://openalex.org/W2329316201","https://openalex.org/W2553715008","https://openalex.org/W2620083467","https://openalex.org/W2735867837","https://openalex.org/W2799758428","https://openalex.org/W2892170611","https://openalex.org/W2982451723"],"related_works":["https://openalex.org/W2895784304","https://openalex.org/W4382371731","https://openalex.org/W2907699537","https://openalex.org/W2748858088","https://openalex.org/W2377786642","https://openalex.org/W4225293048","https://openalex.org/W4412785048","https://openalex.org/W6958161933","https://openalex.org/W2368765456","https://openalex.org/W4417333473"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"opioid":[2],"epidemic":[3],"is":[4],"taxing":[5],"medical":[6],"infrastructure":[7],"in":[8,42],"terms":[9],"of":[10,69,134],"patient":[11,26,52,70,80],"care":[12,19],"and":[13,28,64,75,113,124],"costs.":[14,30],"Being":[15],"able":[16],"to":[17,38,49,51,57,67,83,88,103,107,120],"prioritize":[18],"based":[20],"on":[21],"expected":[22],"outcomes":[23],"could":[24],"improve":[25],"safety":[27],"reduce":[29],"To":[31],"investigate,":[32],"we":[33],"constructed":[34],"a":[35,101],"decision":[36],"tree":[37],"examine":[39],"what":[40],"opioids":[41,104],"conjunction":[43],"with":[44,131],"heroin":[45,63,74,112],"were":[46,117],"most":[47],"likely":[48,119],"lead":[50],"death":[53],"versus":[54,85],"their":[55],"ability":[56],"survive.":[58,109],"Our":[59],"model":[60],"demonstrated":[61],"that":[62,94],"fentanyl":[65,76,114],"contributed":[66],"77.60%":[68],"deaths,":[71],"however,":[72],"when":[73],"combinations":[77],"included":[78],"oxycodone,":[79],"deaths":[81],"decreased":[82,130],"34.78%":[84],"an":[86],"increase":[87],"81.94%":[89],"without":[90,115],"oxycodone.":[91,135],"We":[92],"speculate":[93],"patients":[95],"already":[96],"taking":[97,111],"oxycodone":[98,116],"have":[99],"built":[100],"resistance":[102],"allowing":[105],"them":[106],"better":[108],"Patients":[110],"more":[118],"experience":[121],"cardiac,":[122],"toxicity":[123],"respiratory":[125],"symptoms":[126,129],"whereas":[127],"these":[128],"the":[132],"addition":[133]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":16}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-12-20T00:00:00"}