{"id":"https://openalex.org/W4310696554","doi":"https://doi.org/10.1073/pnas.2215333119","title":"A structural mechanism of nuclear receptor biased agonism","display_name":"A structural mechanism of nuclear receptor biased agonism","publication_year":2022,"publication_date":"2022-12-05","ids":{"openalex":"https://openalex.org/W4310696554","doi":"https://doi.org/10.1073/pnas.2215333119","pmid":"https://pubmed.ncbi.nlm.nih.gov/36469765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9897460"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2215333119","doi":"https://doi.org/10.1073/pnas.2215333119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2215333119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2215333119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005431448","display_name":"Michelle D. Nemetchek","orcid":"https://orcid.org/0000-0003-3524-952X","observed_orcids":["https://orcid.org/0000-0003-3524-952X"]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle D. Nemetchek","raw_affiliation_strings":["Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]},{"raw_affiliation_string":"Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021037920","display_name":"Ian M. Chrisman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian M. Chrisman","raw_affiliation_strings":["Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]},{"raw_affiliation_string":"Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016974166","display_name":"Mariah L. Rayl","orcid":"https://orcid.org/0000-0003-0248-9754","observed_orcids":["https://orcid.org/0000-0003-0248-9754"]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariah L. Rayl","raw_affiliation_strings":["Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812"],"raw_orcid":"https://orcid.org/0000-0003-0248-9754","affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]},{"raw_affiliation_string":"Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090478523","display_name":"Andrew H. Voss","orcid":"https://orcid.org/0000-0003-4446-2568","observed_orcids":["https://orcid.org/0000-0003-4446-2568"]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew H. Voss","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula 59812"],"raw_orcid":"https://orcid.org/0000-0003-4446-2568","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007950856","display_name":"Tudor Hughes","orcid":"https://orcid.org/0000-0002-5764-5884","observed_orcids":["https://orcid.org/0000-0002-5764-5884"]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Travis S. Hughes","raw_affiliation_strings":["Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812","Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula 59812"],"raw_orcid":"https://orcid.org/0000-0002-5764-5884","affiliations":[{"raw_affiliation_string":"Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]},{"raw_affiliation_string":"Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]},{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula 59812","institution_ids":["https://openalex.org/I6750721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007950856"],"corresponding_institution_ids":["https://openalex.org/I6750721"],"apc_list":null,"apc_paid":null,"fwci":1.7634,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86163288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"119","issue":"50","first_page":"e2215333119","last_page":"e2215333119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/coactivator-peptide","display_name":"coactivator peptide","score":0.8050000071525574},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.843999981880188},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.9449999928474426},{"id":"https://openalex.org/keywords/coactivator-binding","display_name":"coactivator binding","score":0.6200000047683716},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C14527384","wikidata":"https://www.wikidata.org/wiki/Q4693403","display_name":"Agonism","level":3,"score":0.9564779996871948},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7414760589599609},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3472270965576172},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2064323127269745},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.14782321453094482},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2215333119","doi":"https://doi.org/10.1073/pnas.2215333119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2215333119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9897460","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9897460/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9897460/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:36469765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36469765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umt.edu:etd-13169","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umt.edu/etd/12054","pdf_url":null,"source":{"id":"https://openalex.org/S190740074","display_name":"The Mathematics Enthusiast","issn_l":"1551-3440","issn":["1551-3440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Student Theses, Dissertations, & Professional Papers","raw_type":"dissertation"}],"best_oa_location":{"id":"doi:10.1073/pnas.2215333119","doi":"https://doi.org/10.1073/pnas.2215333119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2215333119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1332342009","display_name":"Connecting the functional effects of drugs to how they change PPAR gamma","funder_award_id":"R00DK103116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2108262220","display_name":null,"funder_award_id":"R00DK103116","funder_id":"https://openalex.org/F4320338422","funder_display_name":"Division of Diabetes, Endocrinology, and Metabolic Diseases"},{"id":"https://openalex.org/G5369120653","display_name":null,"funder_award_id":"R01DK129646","funder_id":"https://openalex.org/F4320338422","funder_display_name":"Division of Diabetes, Endocrinology, and Metabolic Diseases"},{"id":"https://openalex.org/G8793229545","display_name":"Biomolecular Structure and Dynamics","funder_award_id":"P20GM103546","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000875854","display_name":"Structural definition of biased agonism in the nuclear receptor PPAR gamma.","funder_award_id":"R01DK129646","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320310589","display_name":"University of Montana","ror":"https://ror.org/0078xmk34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338422","display_name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4310696554.pdf","grobid_xml":"https://content.openalex.org/works/W4310696554.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1501286679","https://openalex.org/W1760991466","https://openalex.org/W1848404107","https://openalex.org/W1974900814","https://openalex.org/W1985361810","https://openalex.org/W1987652896","https://openalex.org/W1994111005","https://openalex.org/W1996127793","https://openalex.org/W2003349141","https://openalex.org/W2013242282","https://openalex.org/W2014644506","https://openalex.org/W2023177623","https://openalex.org/W2030623266","https://openalex.org/W2056211855","https://openalex.org/W2056299816","https://openalex.org/W2058105213","https://openalex.org/W2065283382","https://openalex.org/W2072037699","https://openalex.org/W2073578030","https://openalex.org/W2081276121","https://openalex.org/W2083319939","https://openalex.org/W2087613795","https://openalex.org/W2101460040","https://openalex.org/W2105259330","https://openalex.org/W2108698393","https://openalex.org/W2110046079","https://openalex.org/W2113456624","https://openalex.org/W2116513829","https://openalex.org/W2119199305","https://openalex.org/W2121435438","https://openalex.org/W2123774383","https://openalex.org/W2125786873","https://openalex.org/W2134382958","https://openalex.org/W2135009079","https://openalex.org/W2139472488","https://openalex.org/W2141215651","https://openalex.org/W2141686420","https://openalex.org/W2142442530","https://openalex.org/W2151286904","https://openalex.org/W2159083249","https://openalex.org/W2167029191","https://openalex.org/W2168240189","https://openalex.org/W2332712348","https://openalex.org/W2404280981","https://openalex.org/W2558217333","https://openalex.org/W2570555521","https://openalex.org/W2575110262","https://openalex.org/W2581468399","https://openalex.org/W2752307709","https://openalex.org/W2765683277","https://openalex.org/W2772832167","https://openalex.org/W2801215756","https://openalex.org/W2904001408","https://openalex.org/W2911869066","https://openalex.org/W2952205279","https://openalex.org/W2967977322","https://openalex.org/W2995059468","https://openalex.org/W3007903124","https://openalex.org/W3042507822","https://openalex.org/W3047703793","https://openalex.org/W3048271700","https://openalex.org/W3089424026","https://openalex.org/W3124036045","https://openalex.org/W3177828909","https://openalex.org/W4210780590","https://openalex.org/W4239593002","https://openalex.org/W6601221394"],"related_works":["https://openalex.org/W4403673307","https://openalex.org/W7204495501","https://openalex.org/W2034247645","https://openalex.org/W2914693795","https://openalex.org/W7100203359","https://openalex.org/W2046886830","https://openalex.org/W2129471397","https://openalex.org/W2134469697","https://openalex.org/W2015544639","https://openalex.org/W3152997340"],"abstract_inverted_index":{"Efforts":[0],"to":[1,28,69,101,123,135,176],"decrease":[2],"the":[3,55,88,117],"adverse":[4],"effects":[5,45],"of":[6,22,54,84,106,127,139,143,165],"nuclear":[7],"receptor":[8,59],"(NR)":[9],"drugs":[10,76],"have":[11,25],"yielded":[12],"experimental":[13],"agonists":[14,24,53,95,122],"that":[15,51,92,149],"produce":[16],"better":[17,64],"outcomes":[18,65],"in":[19,66,104,113,188],"mice.":[20],"Some":[21],"these":[23],"been":[26],"shown":[27],"cause":[29],"different,":[30],"not":[31],"just":[32],"less":[33],"intense,":[34],"on-target":[35],"transcriptomic":[36],"effects;":[37],"however,":[38],"a":[39,81,136,161],"structural":[40,163],"explanation":[41],"for":[42,168],"such":[43,150,179],"agonist-specific":[44],"remains":[46],"unknown.":[47],"Here,":[48],"we":[49],"show":[50],"partial":[52],"NR":[56],"peroxisome":[57],"proliferator-associated":[58],"\u03b3":[60],"(PPAR\u03b3),":[61],"which":[62,120],"induce":[63],"mice":[67],"compared":[68],"clinically":[70],"utilized":[71],"type":[72],"II":[73],"diabetes":[74],"PPAR\u03b3-binding":[75],"thiazolidinediones":[77],"(TZDs),":[78],"also":[79,97],"favor":[80,124],"different":[82],"group":[83,126],"coactivator":[85,107,118,128,184],"peptides":[86,129],"than":[87],"TZDs.":[89],"We":[90,110],"find":[91,111],"PPAR\u03b3":[93],"full":[94],"can":[96],"be":[98,174],"biased":[99,166],"relative":[100],"each":[102],"other":[103,157],"terms":[105],"peptide":[108],"binding.":[109],"differences":[112],"coactivator-PPAR\u03b3":[114],"bonding":[115,134,154],"between":[116],"subgroups":[119],"allow":[121],"one":[125],"over":[130],"another,":[131],"including":[132],"differential":[133,151],"C-terminal":[137],"residue":[138],"helix":[140,152],"4.":[141],"Analysis":[142],"all":[144],"available":[145],"NR-coactivator":[146,158],"structures":[147],"indicates":[148],"4":[153],"persists":[155],"across":[156],"complexes,":[159],"providing":[160],"general":[162],"mechanism":[164],"agonism":[167],"many":[169],"NRs.":[170],"Further":[171],"work":[172],"will":[173],"necessary":[175],"determine":[177],"if":[178],"bias":[180],"translates":[181],"into":[182],"altered":[183],"occupancy":[185],"and":[186],"physiology":[187],"cells.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-12-15T00:00:00"}