{"id":"https://openalex.org/W4310692048","doi":"https://doi.org/10.3389/fphar.2022.1009668","title":"Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches","display_name":"Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches","publication_year":2022,"publication_date":"2022-12-05","ids":{"openalex":"https://openalex.org/W4310692048","doi":"https://doi.org/10.3389/fphar.2022.1009668","pmid":"https://pubmed.ncbi.nlm.nih.gov/36545309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9760683"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.1009668","doi":"https://doi.org/10.3389/fphar.2022.1009668","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1009668","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2022.1009668","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114928969","display_name":"Hongda Liu","orcid":"https://orcid.org/0000-0002-1925-7637","observed_orcids":["https://orcid.org/0000-0002-1925-7637"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongda Liu","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036538817","display_name":"Le Yang","orcid":"https://orcid.org/0009-0007-1381-9903","observed_orcids":["https://orcid.org/0009-0007-1381-9903"]},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Yang","raw_affiliation_strings":["State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004689088","display_name":"Chunlei Wan","orcid":"https://orcid.org/0009-0000-0669-0530","observed_orcids":["https://orcid.org/0009-0000-0669-0530"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlei Wan","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080064097","display_name":"Zhineng Li","orcid":"https://orcid.org/0000-0002-6255-5947","observed_orcids":["https://orcid.org/0000-0002-6255-5947"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhineng Li","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101075651","display_name":"Guangli Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangli Yan","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006627718","display_name":"Ying Han","orcid":"https://orcid.org/0000-0002-1791-6870","observed_orcids":["https://orcid.org/0000-0002-1791-6870"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Han","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105718194","display_name":"Hui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Sun","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100709594","display_name":"Xijun Wang","orcid":"https://orcid.org/0000-0001-9375-8280","observed_orcids":["https://orcid.org/0000-0001-9375-8280"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]},{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN","MO"],"is_corresponding":true,"raw_author_name":"Xijun Wang","raw_affiliation_strings":["National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, China","State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China","institution_ids":["https://openalex.org/I192327786"]},{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]},{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, China","institution_ids":["https://openalex.org/I111950717"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100709594","https://openalex.org/A5105718194"],"corresponding_institution_ids":["https://openalex.org/I111950717","https://openalex.org/I192327786","https://openalex.org/I4210105984"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.217,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84593464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"1009668","last_page":"1009668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/urine-metabolomics","display_name":"urine metabolomics","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6069999933242798},{"id":"https://openalex.org/keywords/n-acetylserotonin","display_name":"N-acetylserotonin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/n-methyltryptamine","display_name":"N-methyltryptamine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/6-hydroxymelatonin","display_name":"6-hydroxymelatonin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/folate-biosynthesis","display_name":"folate biosynthesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/phenylalanine-metabolism","display_name":"phenylalanine metabolism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tyrosine-metabolism","display_name":"tyrosine metabolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7419999837875366},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.6840000152587891},{"id":"https://openalex.org/keywords/ethology","display_name":"ethology","score":0.4350000023841858},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.7608957290649414},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6167455911636353},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6023017168045044},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.5500683188438416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5249671339988708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48428553342819214},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.45667383074760437},{"id":"https://openalex.org/C175909808","wikidata":"https://www.wikidata.org/wiki/Q7155","display_name":"Ethology","level":2,"score":0.4447661340236664},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.4298650026321411},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30076783895492554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24527066946029663},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.17516714334487915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17008444666862488},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06982886791229248},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.06259095668792725},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.1009668","doi":"https://doi.org/10.3389/fphar.2022.1009668","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1009668","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9760683","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9760683/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9760683/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:36545309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36545309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a316b5ca183e4d8ea352f32289fceb1e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a316b5ca183e4d8ea352f32289fceb1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.1009668","doi":"https://doi.org/10.3389/fphar.2022.1009668","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1009668","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3221001373","display_name":null,"funder_award_id":"2018YFC1706103","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6619866614","display_name":null,"funder_award_id":"H2016056","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"}],"funders":[{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4310692048.pdf","grobid_xml":"https://content.openalex.org/works/W4310692048.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1553571663","https://openalex.org/W1971729817","https://openalex.org/W2032899687","https://openalex.org/W2063573554","https://openalex.org/W2072098211","https://openalex.org/W2107457791","https://openalex.org/W2121836743","https://openalex.org/W2129402932","https://openalex.org/W2135190897","https://openalex.org/W2145846115","https://openalex.org/W2168403212","https://openalex.org/W2286636876","https://openalex.org/W2301024847","https://openalex.org/W2321747493","https://openalex.org/W2466199133","https://openalex.org/W2474889045","https://openalex.org/W2513649498","https://openalex.org/W2539494034","https://openalex.org/W2582214045","https://openalex.org/W2598364092","https://openalex.org/W2605052861","https://openalex.org/W2743825815","https://openalex.org/W2783789109","https://openalex.org/W2810237918","https://openalex.org/W2898826086","https://openalex.org/W2907062905","https://openalex.org/W2913532466","https://openalex.org/W2916376502","https://openalex.org/W2950194569","https://openalex.org/W2954184358","https://openalex.org/W2981095443","https://openalex.org/W2985450025","https://openalex.org/W2995209959","https://openalex.org/W3004932650","https://openalex.org/W3028113015","https://openalex.org/W3085158981","https://openalex.org/W3093102145","https://openalex.org/W3104369805","https://openalex.org/W3110999929","https://openalex.org/W3117432541","https://openalex.org/W3141294635","https://openalex.org/W3170371610","https://openalex.org/W3190151470","https://openalex.org/W3197619374","https://openalex.org/W3200166422","https://openalex.org/W4205307688","https://openalex.org/W4205549211","https://openalex.org/W4206765783","https://openalex.org/W4225733743","https://openalex.org/W4231896431","https://openalex.org/W4293548511"],"related_works":["https://openalex.org/W4293548511","https://openalex.org/W4297168743","https://openalex.org/W2601334638","https://openalex.org/W2351747364","https://openalex.org/W4213387550","https://openalex.org/W4280607977","https://openalex.org/W3008650759","https://openalex.org/W4221067488","https://openalex.org/W2943795668","https://openalex.org/W4387046423"],"abstract_inverted_index":{"radix":[0],"et":[1],"rhizoma].":[2],"Besides,":[3],"CWT":[4,48,95,120,139,158,197,242],"is":[5,15,239],"included":[6,211],"in":[7,18,49,70,78,221,254,265,286],"the":[8,19,44,71,92,114,123,149,167,199,218,255,266,272],"2020":[9],"edition":[10],"of":[11,21,47,68,73,94,111,129,151,169,174,201,268,274],"Chinese":[12],"Pharmacopoeia":[13],"and":[14,34,57,65,84,118,126,131,144,147,155,165,194,215,234,250,278,283],"widely":[16],"used":[17],"treatment":[20,72,267],"insomnia.":[22,97],"It":[23],"mainly":[24],"contains":[25],"eleutheroside":[26,28,31],"B,":[27],"E,":[29],"isofraxidin,":[30],"C,":[32],"ciwujiatone,":[33],"chlorogenic":[35],"acid,":[36],"as":[37,39,190,227],"well":[38],"other":[40,251],"chemical":[41],"components.":[42],"Although":[43],"clinical":[45],"efficacy":[46],"treating":[50],"insomnia":[51,74,269],"has":[52,259],"been":[53,62,260],"confirmed,":[54],"its":[55,66,133],"functions":[56],"pharmacological":[58,134],"effects":[59],"have":[60],"not":[61],"systematically":[63,90],"evaluated":[64],"mechanism":[67],"action":[69],"remains":[75],"unclear.":[76],"Therefore,":[77],"this":[79],"study,":[80],"behavioral,":[81],"energy":[82],"metabolism,":[83,229,233,245,249],"metabonomics":[85,100],"methods":[86],"were":[87,104,223],"applied":[88],"to":[89,106,177,205,262,280],"evaluate":[91],"effect":[93],"on":[96,102],"Additionally,":[98,217],"urine":[99,181],"based":[101],"UPLC-Q-TOF-MS/MS":[103],"utilized":[105],"identify":[107],"potential":[108,127,186],"endogenous":[109,187],"biomarkers":[110,203],"insomnia,":[112],"detect":[113],"various":[115],"changes":[116],"before":[117],"after":[119],"treatment,":[121,198],"explore":[122],"metabolic":[124,172,219,252],"pathway":[125],"target":[128],"CWT,":[130],"reveal":[132],"mechanism.":[135],"Results":[136],"revealed":[137],"that":[138,241],"increased":[140],"inhibitory":[141],"neurotransmitter":[142],"(5-HT":[143],"GABA)":[145],"content":[146,150,200,273],"reduced":[148],"excitatory":[152],"neurotransmitters":[153],"(DA":[154],"NE).":[156],"Moreover,":[157],"enhanced":[159],"autonomous":[160],"behavioral":[161],"activity,":[162],"stabilized":[163],"emotions,":[164],"promoted":[166],"return":[168],"daily":[170],"basic":[171],"indexes":[173],"insomniac":[175],"rats":[176,222],"normal":[178,206,284],"levels.":[179,207],"The":[180,208],"metabolomics":[182],"experiment":[183],"identified":[184],"28":[185],"biomarkers,":[188],"such":[189,226],"allysine,":[191],"7,8-dihydroneopterin,":[192],"5-phosphonooxy-L-lysine,":[193],"N-acetylserotonin.":[195],"After":[196],"22":[202],"returned":[204],"representative":[209],"markers":[210],"N-acetylserotonin,":[212,277],"serotonin,":[213,275],"N-methyltryptamine,":[214],"6-hydroxymelatonin.":[216],"pathways":[220],"significantly":[224],"reversed,":[225],"tryptophan":[228,244,287],"folate":[230,246],"biosynthesis,":[231,247],"phenylalanine":[232,248],"tyrosine":[235],"metabolism.":[236,288],"Ultimately,":[237],"it":[238],"concluded":[240],"regulated":[243],"levels":[253],"body.":[256],"This":[257],"drug":[258],"confirmed":[261],"be":[263],"effective":[264],"by":[270],"regulating":[271],"6-hydroxymelatonin,":[276],"N-methyltryptamine":[279],"a":[281],"stable":[282],"level":[285]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-12-15T00:00:00"}
