{"id":"https://openalex.org/W4310270218","doi":"https://doi.org/10.1016/j.celrep.2022.111739","title":"Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism","display_name":"Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4310270218","doi":"https://doi.org/10.1016/j.celrep.2022.111739","pmid":"https://pubmed.ncbi.nlm.nih.gov/36450261"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2022.111739","doi":"https://doi.org/10.1016/j.celrep.2022.111739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2022.111739","pdf_url":"http://www.cell.com/article/S2211124722016175/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124722016175/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034023658","display_name":"Reut Dudkevich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Reut Dudkevich","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059171690","display_name":"Jhee Hong Koh","orcid":"https://orcid.org/0000-0002-4154-8369","observed_orcids":["https://orcid.org/0000-0002-4154-8369"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jhee Hong Koh","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051586718","display_name":"Caroline Beaudoin\u2010Chabot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Caroline Beaudoin-Chabot","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019242876","display_name":"Cenk Celik","orcid":"https://orcid.org/0000-0001-8301-0172","observed_orcids":["https://orcid.org/0000-0001-8301-0172"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cenk Celik","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004444211","display_name":"Ilana Lebenthal-Loinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ilana Lebenthal-Loinger","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084528625","display_name":"Sarit Karako\u2010Lampert","orcid":"https://orcid.org/0000-0002-1569-2105","observed_orcids":["https://orcid.org/0000-0002-1569-2105"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sarit Karako-Lampert","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056290755","display_name":"Syed Ahmad-Albukhari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Syed Ahmad-Albukhari","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022705111","display_name":"Guillaume Thibault","orcid":"https://orcid.org/0000-0002-7926-4812","observed_orcids":["https://orcid.org/0000-0002-7926-4812"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Guillaume Thibault","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore; Institute of Molecular and Cell Biology, A(\u2217)STAR, Singapore 138673, Singapore","Institute of Molecular and Cell Biology, A\u2217STAR, Singapore 138673, Singapore","Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore","School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore; Institute of Molecular and Cell Biology, A(\u2217)STAR, Singapore 138673, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4405277086","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, A\u2217STAR, Singapore 138673, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078955564","display_name":"Sivan Henis\u2010Korenblit","orcid":"https://orcid.org/0000-0001-8023-6336","observed_orcids":["https://orcid.org/0000-0001-8023-6336"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Sivan Henis-Korenblit","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. Electronic address: sivan.korenblit@biu.ac.il","The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"],"raw_orcid":"https://orcid.org/0000-0001-8023-6336","affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. Electronic address: sivan.korenblit@biu.ac.il","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078955564"],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":1.1635,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73733108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"41","issue":"9","first_page":"111739","last_page":"111739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ire1","display_name":"IRE1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/cold-stress-response","display_name":"cold stress response","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fat-metabolism","display_name":"fat metabolism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/neuronal-signaling","display_name":"neuronal signaling","score":0.722000002861023},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuropeptide-signaling","display_name":"neuropeptide signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/lipid-saturation","display_name":"lipid saturation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cold-tolerance","display_name":"cold tolerance","score":0.4779999852180481},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7691284418106079},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.687025785446167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6292743682861328},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6001656651496887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5968900918960571},{"id":"https://openalex.org/C2780118905","wikidata":"https://www.wikidata.org/wiki/Q16949811","display_name":"Cold sensitivity","level":4,"score":0.5958389043807983},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.507028341293335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48222219944000244},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.4793706238269806},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46142250299453735},{"id":"https://openalex.org/C2992529232","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Cold stress","level":3,"score":0.45484718680381775},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.44751712679862976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29316946864128113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23126408457756042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20081254839897156},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.13357603549957275}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058639","descriptor_name":"Cold-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.celrep.2022.111739","doi":"https://doi.org/10.1016/j.celrep.2022.111739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2022.111739","pdf_url":"http://www.cell.com/article/S2211124722016175/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:36450261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36450261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05770378v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05770378","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, 2022, 41 (9), pp.111739. ⟨10.1016/j.celrep.2022.111739⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/164688","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/164688","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/224704","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10356/224704","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2022.111739","doi":"https://doi.org/10.1016/j.celrep.2022.111739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2022.111739","pdf_url":"http://www.cell.com/article/S2211124722016175/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1424089229","display_name":null,"funder_award_id":"MOH-000566","funder_id":"https://openalex.org/F4320320697","funder_display_name":"Ministry of Health -Singapore"},{"id":"https://openalex.org/G2402200405","display_name":null,"funder_award_id":"C663S","funder_id":"https://openalex.org/F4320309622","funder_display_name":"Harvard University"},{"id":"https://openalex.org/G377185661","display_name":null,"funder_award_id":"689/19","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G4006337942","display_name":null,"funder_award_id":"JCSTF18118","funder_id":"https://openalex.org/F4320320119","funder_display_name":"Company of Biologists"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5794973017","display_name":null,"funder_award_id":"MOE-MOET32020-0001","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320320119","display_name":"Company of Biologists","ror":"https://ror.org/0033z1132"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320697","display_name":"Ministry of Health -Singapore","ror":"https://ror.org/00mrhvv69"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320323346","display_name":"B\u1ed9 Gi\u00e1o d\u1ee5c v\u00e0 \u00d0\u00e0o t\u1ea1o","ror":"https://ror.org/00drv3378"},{"id":"https://openalex.org/F4320323944","display_name":"Ministry of Health, State of Israel","ror":"https://ror.org/016n0q862"},{"id":"https://openalex.org/F4320326410","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4310270218.pdf","grobid_xml":"https://content.openalex.org/works/W4310270218.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W238972648","https://openalex.org/W1537017855","https://openalex.org/W1546139069","https://openalex.org/W1649543050","https://openalex.org/W1944127002","https://openalex.org/W1963731318","https://openalex.org/W1965843055","https://openalex.org/W1966141254","https://openalex.org/W1969601520","https://openalex.org/W1970432631","https://openalex.org/W1972120731","https://openalex.org/W1976674039","https://openalex.org/W1980216636","https://openalex.org/W1981823396","https://openalex.org/W1984160651","https://openalex.org/W1986737010","https://openalex.org/W1989103500","https://openalex.org/W1989512833","https://openalex.org/W1990400035","https://openalex.org/W1997016486","https://openalex.org/W2001399725","https://openalex.org/W2007609864","https://openalex.org/W2011277283","https://openalex.org/W2013690402","https://openalex.org/W2017957177","https://openalex.org/W2027291842","https://openalex.org/W2031837514","https://openalex.org/W2035310767","https://openalex.org/W2037911961","https://openalex.org/W2038018821","https://openalex.org/W2044052768","https://openalex.org/W2048113433","https://openalex.org/W2048354832","https://openalex.org/W2052321340","https://openalex.org/W2052570011","https://openalex.org/W2055075408","https://openalex.org/W2055355505","https://openalex.org/W2067018477","https://openalex.org/W2068988365","https://openalex.org/W2069649414","https://openalex.org/W2076485183","https://openalex.org/W2076774576","https://openalex.org/W2080389159","https://openalex.org/W2080901528","https://openalex.org/W2081294646","https://openalex.org/W2083545988","https://openalex.org/W2087618734","https://openalex.org/W2089959253","https://openalex.org/W2096579700","https://openalex.org/W2096730624","https://openalex.org/W2113678374","https://openalex.org/W2115205812","https://openalex.org/W2117129841","https://openalex.org/W2121429373","https://openalex.org/W2122569219","https://openalex.org/W2132597164","https://openalex.org/W2137522359","https://openalex.org/W2138009056","https://openalex.org/W2139468443","https://openalex.org/W2150028076","https://openalex.org/W2155147247","https://openalex.org/W2155163967","https://openalex.org/W2155945227","https://openalex.org/W2156100123","https://openalex.org/W2164624443","https://openalex.org/W2165362327","https://openalex.org/W2171174186","https://openalex.org/W2176909443","https://openalex.org/W2184634002","https://openalex.org/W2194388869","https://openalex.org/W2238318177","https://openalex.org/W2313928645","https://openalex.org/W2330803985","https://openalex.org/W2344920687","https://openalex.org/W2403889918","https://openalex.org/W2410496837","https://openalex.org/W2440847565","https://openalex.org/W2508503153","https://openalex.org/W2581993304","https://openalex.org/W2588891882","https://openalex.org/W2598825811","https://openalex.org/W2603633505","https://openalex.org/W2727065253","https://openalex.org/W2769642104","https://openalex.org/W2788866306","https://openalex.org/W2814687763","https://openalex.org/W2885058366","https://openalex.org/W2885346484","https://openalex.org/W2885875075","https://openalex.org/W2941461513","https://openalex.org/W2944281137","https://openalex.org/W2949876687","https://openalex.org/W2951000902","https://openalex.org/W2960480621","https://openalex.org/W2967498399","https://openalex.org/W2973933417","https://openalex.org/W2996767918","https://openalex.org/W2996802429","https://openalex.org/W3001667810","https://openalex.org/W3018410811","https://openalex.org/W3096855091","https://openalex.org/W3113059149","https://openalex.org/W3120762029","https://openalex.org/W3165643729","https://openalex.org/W3196639564","https://openalex.org/W3199266530","https://openalex.org/W3210359172","https://openalex.org/W4211066388","https://openalex.org/W4221092044"],"related_works":["https://openalex.org/W2044277260","https://openalex.org/W3198951121","https://openalex.org/W2044052768","https://openalex.org/W4403430029","https://openalex.org/W2057654841","https://openalex.org/W3005329489","https://openalex.org/W3016949412","https://openalex.org/W3194529712","https://openalex.org/W4293109383","https://openalex.org/W1830033513"],"abstract_inverted_index":{"Cold":[0],"affects":[1],"many":[2],"aspects":[3],"of":[4,95,114,118,128,136],"biology,":[5],"medicine,":[6],"agriculture,":[7],"and":[8,49,60,100,134],"industry.":[9],"Here,":[10],"we":[11],"identify":[12],"a":[13],"conserved":[14,89],"endoplasmic":[15],"reticulum":[16],"(ER)":[17],"stress":[18,39,92,120],"response,":[19,26,93],"distinct":[20],"from":[21],"the":[22,37,68,110,115,125],"canonical":[23],"unfolded":[24],"protein":[25],"that":[27,36],"maintains":[28],"lipid":[29,65,137],"homeostasis":[30],"during":[31],"extreme":[32,47],"cold.":[33],"We":[34],"establish":[35],"ER":[38],"sensor":[40],"IRE-1":[41,56],"is":[42,122,141],"critical":[43],"for":[44,124],"resistance":[45],"to":[46,63,106],"cold":[48,52,91,107,129],"activated":[50],"by":[51,76],"temperature.":[53],"Specifically,":[54],"neuronal":[55,97],"signals":[57],"through":[58],"JNK-1":[59],"neuropeptide":[61],"signaling":[62,101],"regulate":[64],"composition":[66],"within":[67],"animal.":[69],"This":[70],"cold-response":[71],"pathway":[72],"can":[73],"be":[74],"bypassed":[75],"dietary":[77],"supplementation":[78],"with":[79],"unsaturated":[80],"fatty":[81],"acids.":[82],"Altogether,":[83],"our":[84],"findings":[85],"define":[86],"an":[87],"ER-centric":[88],"organism-wide":[90],"consisting":[94],"molecular":[96,116],"sensors,":[98],"effectors,":[99],"moieties,":[102],"which":[103,140],"control":[104],"adaptation":[105],"conditions":[108,130],"in":[109,143],"organism.":[111],"Better":[112],"understanding":[113],"basis":[117],"this":[119],"response":[121],"crucial":[123],"optimal":[126],"use":[127],"on":[131],"live":[132],"organisms":[133],"manipulation":[135],"saturation":[138],"homeostasis,":[139],"perturbed":[142],"human":[144],"pathologies.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-11-30T00:00:00"}