{"id":"https://openalex.org/W4310249064","doi":"https://doi.org/10.1177/10668969221137514","title":"A Case Report of HER2 -Amplification in the Breast Without Histological Abnormality","display_name":"A Case Report of HER2 -Amplification in the Breast Without Histological Abnormality","publication_year":2022,"publication_date":"2022-11-27","ids":{"openalex":"https://openalex.org/W4310249064","doi":"https://doi.org/10.1177/10668969221137514","pmid":"https://pubmed.ncbi.nlm.nih.gov/36437641"},"language":"en","primary_location":{"id":"doi:10.1177/10668969221137514","doi":"https://doi.org/10.1177/10668969221137514","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10668969221137514","pdf_url":null,"source":{"id":"https://openalex.org/S121892090","display_name":"International Journal of Surgical Pathology","issn_l":"1066-8969","issn":["1066-8969","1940-2465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101558965","display_name":"Miseon Lee","orcid":"https://orcid.org/0000-0002-6385-7621","observed_orcids":["https://orcid.org/0000-0002-6385-7621","https://orcid.org/0009-0004-5377-2845"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Miseon Lee","raw_affiliation_strings":["Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6385-7621","affiliations":[{"raw_affiliation_string":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351736","display_name":"Jieun Lee","orcid":"https://orcid.org/0000-0002-2656-0650","observed_orcids":["https://orcid.org/0000-0002-2656-0650","https://orcid.org/0000-0001-8074-9561"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jieun Lee","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102891232","display_name":"Ahwon Lee","orcid":"https://orcid.org/0000-0002-2523-9531","observed_orcids":["https://orcid.org/0000-0002-2523-9531"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ahwon Lee","raw_affiliation_strings":["Cancer Research Institute, The Catholic University of Korea, Seoul, Korea","Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I87111246"]},{"raw_affiliation_string":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079682715","display_name":"Jun Kyu Kang","orcid":"https://orcid.org/0000-0002-7967-0917","observed_orcids":["https://orcid.org/0000-0002-7967-0917"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jun Kang","raw_affiliation_strings":["Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079682715"],"corresponding_institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.1122,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35208842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"31","issue":"5","first_page":"801","last_page":"804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.21719999611377716,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.996999979019165},{"id":"https://openalex.org/keywords/atypical-ductal-hyperplasia","display_name":"atypical ductal hyperplasia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/terminal-duct-lobular-units","display_name":"terminal duct lobular units","score":0.8989999890327454},{"id":"https://openalex.org/keywords/microcalcifications","display_name":"microcalcifications","score":0.7239999771118164},{"id":"https://openalex.org/keywords/breast-cancer-precursor-lesions","display_name":"breast cancer precursor lesions","score":0.718999981880188},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/wide-local-excision","display_name":"wide local excision","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7435615062713623},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.6883108615875244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6618767380714417},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6582898497581482},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.5628646016120911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5486689805984497},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.49277833104133606},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.43544620275497437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3847202658653259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23527029156684875},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/10668969221137514","doi":"https://doi.org/10.1177/10668969221137514","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10668969221137514","pdf_url":null,"source":{"id":"https://openalex.org/S121892090","display_name":"International Journal of Surgical Pathology","issn_l":"1066-8969","issn":["1066-8969","1940-2465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:36437641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36437641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of surgical pathology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1497322432","https://openalex.org/W1570331788","https://openalex.org/W1887832750","https://openalex.org/W1956871134","https://openalex.org/W1979258814","https://openalex.org/W1992826811","https://openalex.org/W2047034979","https://openalex.org/W2057559260","https://openalex.org/W2063605987","https://openalex.org/W2066051514","https://openalex.org/W2073440691","https://openalex.org/W2079841170","https://openalex.org/W2125401785","https://openalex.org/W2126816979","https://openalex.org/W2149858388","https://openalex.org/W2197045356","https://openalex.org/W2885069342","https://openalex.org/W2897064819","https://openalex.org/W2981552021","https://openalex.org/W3020114628","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W2617861064","https://openalex.org/W2031755079","https://openalex.org/W2066051514","https://openalex.org/W2087516271","https://openalex.org/W4391076964","https://openalex.org/W1980058966","https://openalex.org/W2401170370","https://openalex.org/W3108968478","https://openalex.org/W2314458267","https://openalex.org/W2050307563"],"abstract_inverted_index":{"Atypical":[0],"ductal":[1,5],"hyperplasia":[2],"and":[3,77,97,130,143,183,224],"low-grade":[4],"carcinoma":[6],"in":[7,46,134,154,160,167,170,179,194,204,216],"situ":[8,171],"(DCIS)":[9],"are":[10],"regarded":[11],"as":[12,190],"precursor":[13,29,236],"lesions":[14],"of":[15,43,62,85,207,238,246],"estrogen":[16],"receptor":[17,95],"(ER)-positive":[18],"invasive":[19,25],"breast":[20,26,48,180,218,240],"cancer.":[21],"In":[22],"HER2":[23,98,115,158,162,168,173,184,214],"-amplified":[24],"cancer,":[27,241],"a":[28,41,57,78,83],"lesion":[30,237],"before":[31],"DCIS":[32,81,129],"has":[33],"not":[34],"yet":[35],"been":[36,199],"described.":[37],"Here":[38],"we":[39],"introduce":[40],"case":[42],"HER2-positive":[44,120,137,226,239],"lobules":[45,121,138,227],"the":[47,127,149,217,225,235,243],"without":[49,219],"histological":[50,220],"abnormality.":[51],"A":[52],"39-year-old":[53],"premenopausal":[54],"woman":[55],"visited":[56],"hospital":[58],"due":[59],"to":[60,156,188],"identification":[61],"microcalcifications":[63],"on":[64,100,117],"screening":[65],"mammography.":[66],"The":[67,90],"subsequent":[68],"biopsy":[69],"confirmed":[70],"high-grade":[71,80,128],"DCIS.":[72],"She":[73],"underwent":[74],"wide":[75],"excision,":[76],"residual":[79],"with":[82,148],"size":[84],"1.4":[86],"cm":[87],"was":[88,131,164],"found.":[89],"tumor":[91],"cells":[92],"were":[93,107,122],"hormone":[94],"positive":[96],"negative":[99],"immunohistochemical":[101],"(IHC)":[102],"staining.":[103],"Around":[104],"DCIS,":[105],"there":[106],"terminal":[108],"duct":[109],"lobular":[110],"units":[111],"(TDLUs)":[112],"showing":[113,157],"strong":[114],"positivity":[116],"IHC.":[118],"These":[119,136,210],"7":[123],"mm":[124,133],"away":[125],"from":[126],"1.1":[132],"size.":[135],"showed":[139],"no":[140,145],"histologic":[141],"abnormality":[142,221],"had":[144],"difference":[146],"compared":[147],"surrounding":[150],"normal":[151,205],"TDLUs.":[152],"Nevertheless,":[153],"addition":[155],"overexpression":[159],"IHC,":[161],"amplification":[163,174,185,215],"also":[165],"identified":[166],"silver":[169],"hybridization.":[172],"plays":[175],"an":[176,191],"important":[177],"role":[178],"cancer":[181,195],"development,":[182],"is":[186,249],"known":[187],"occur":[189],"early":[192],"event":[193],"development.":[196],"There":[197],"have":[198],"studies":[200],"identifying":[201],"driver":[202],"mutations":[203],"tissues":[206],"other":[208],"organs.":[209],"findings":[211,248],"suggest":[212],"that":[213],"could":[222,228],"occur,":[223],"be":[229],"\u201cat":[230],"risk\u201d":[231],"for":[232],"transformation":[233],"into":[234],"although":[242],"biological":[244],"significance":[245],"these":[247],"unclear.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-30T00:00:00"}
