{"id":"https://openalex.org/W4310244375","doi":"https://doi.org/10.2174/0929867330666221125105253","title":"Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease using Conjugates of Serotonin with Sesquiterpene Lactones","display_name":"Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease using Conjugates of Serotonin with Sesquiterpene Lactones","publication_year":2022,"publication_date":"2022-11-28","ids":{"openalex":"https://openalex.org/W4310244375","doi":"https://doi.org/10.2174/0929867330666221125105253","pmid":"https://pubmed.ncbi.nlm.nih.gov/36437724"},"language":"en","primary_location":{"id":"doi:10.2174/0929867330666221125105253","doi":"https://doi.org/10.2174/0929867330666221125105253","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0929867330666221125105253","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045070576","display_name":"\u041c\u0430\u0440\u0433\u0430\u0440\u0438\u0442\u0430 \u0415. \u041d\u0435\u0433\u0430\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-9346-5920","observed_orcids":["https://orcid.org/0000-0001-9346-5920"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["CN","RU"],"is_corresponding":false,"raw_author_name":"Margarita Neganova","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China","Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0001-9346-5920","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682138","display_name":"Junqi Liu","orcid":"https://orcid.org/0000-0002-6015-1033","observed_orcids":["https://orcid.org/0000-0002-6015-1033","https://orcid.org/0000-0001-6309-951X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junqi Liu","raw_affiliation_strings":["Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-6015-1033","affiliations":[{"raw_affiliation_string":"Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033413678","display_name":"Yulia R. Aleksandrova","orcid":"https://orcid.org/0000-0002-5370-3370","observed_orcids":["https://orcid.org/0000-0002-5370-3370"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia Aleksandrova","raw_affiliation_strings":["Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5370-3370","affiliations":[{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108296535","display_name":"Natalia Vasilieva","orcid":"https://orcid.org/0000-0002-2173-6135","observed_orcids":["https://orcid.org/0000-0002-2173-6135"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia Vasilieva","raw_affiliation_strings":["Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0002-2173-6135","affiliations":[{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067878943","display_name":"\u0410. \u0412. \u0421\u0435\u043c\u0430\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-6434-8976","observed_orcids":["https://orcid.org/0000-0002-6434-8976"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Semakov","raw_affiliation_strings":["Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6434-8976","affiliations":[{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031094499","display_name":"Ekaterina Yu. Yandulova","orcid":"https://orcid.org/0000-0002-8712-8941","observed_orcids":["https://orcid.org/0000-0002-8712-8941"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Yandulova","raw_affiliation_strings":["Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0002-8712-8941","affiliations":[{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056967574","display_name":"Olga A. Sukocheva","orcid":"https://orcid.org/0000-0003-1041-3311","observed_orcids":["https://orcid.org/0000-0003-1041-3311"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Olga Sukocheva","raw_affiliation_strings":["Discipline of Health Sciences, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1041-3311","affiliations":[{"raw_affiliation_string":"Discipline of Health Sciences, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004971694","display_name":"Konstantin V. Balakin","orcid":"https://orcid.org/0000-0001-7611-0802","observed_orcids":["https://orcid.org/0000-0001-7611-0802"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin Balakin","raw_affiliation_strings":["Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Russia"],"raw_orcid":"https://orcid.org/0000-0001-7611-0802","affiliations":[{"raw_affiliation_string":"Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078225383","display_name":"Sergey G. Klochkov","orcid":"https://orcid.org/0000-0002-0299-9183","observed_orcids":["https://orcid.org/0000-0002-0299-9183"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210162996","display_name":"Institute of Physiologically Active Compounds","ror":"https://ror.org/05xw3yj26","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210162996"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey Klochkov","raw_affiliation_strings":["Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0299-9183","affiliations":[{"raw_affiliation_string":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210162996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015333922","display_name":"Ruitai Fan","orcid":"https://orcid.org/0000-0003-3401-4315","observed_orcids":["https://orcid.org/0000-0003-3401-4315","https://orcid.org/0000-0002-1371-8930","https://orcid.org/0000-0003-1870-0745"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruitai Fan","raw_affiliation_strings":["Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-1371-8930","affiliations":[{"raw_affiliation_string":"Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015333922","https://openalex.org/A5056967574"],"corresponding_institution_ids":["https://openalex.org/I169541294","https://openalex.org/I4210156804"],"apc_list":null,"apc_paid":null,"fwci":0.8554,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65981442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"5","first_page":"529","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.2896000146865845,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.871999979019165},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/sesquiterpene-lactones","display_name":"sesquiterpene lactones","score":1.0},{"id":"https://openalex.org/keywords/isoalantolactone","display_name":"isoalantolactone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/michael-addition","display_name":"Michael addition","score":0.699999988079071},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mitoprotection","display_name":"mitoprotection","score":0.7850000262260437},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7580000162124634},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8165016770362854},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.7220470309257507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6172231435775757},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6135384440422058},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5098909139633179},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.4888765215873718},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.47693318128585815},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.4768967628479004},{"id":"https://openalex.org/C2779046751","wikidata":"https://www.wikidata.org/wiki/Q421076","display_name":"Tacrine","level":4,"score":0.4676622450351715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44480568170547485},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41836899518966675},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.24202856421470642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22074559330940247},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.20324012637138367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20140519738197327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1799861490726471},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10984116792678833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08269369602203369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08148843050003052},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07255831360816956},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/0929867330666221125105253","doi":"https://doi.org/10.2174/0929867330666221125105253","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0929867330666221125105253","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:36437724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36437724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3320503951","display_name":null,"funder_award_id":"22-23-00995","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G3415524783","display_name":null,"funder_award_id":"State Assignment 0090-2019-0006","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G4363223337","display_name":null,"funder_award_id":"075-15-2021-684","funder_id":"https://openalex.org/F4320330091","funder_display_name":"Moscow Institute of Physics and Technology"},{"id":"https://openalex.org/G6869623954","display_name":null,"funder_award_id":"0090-2019-0006","funder_id":"https://openalex.org/F4320334801","funder_display_name":"Russian Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320330091","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322"},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1506043065","https://openalex.org/W1515525840","https://openalex.org/W1521776891","https://openalex.org/W1552916016","https://openalex.org/W1903912475","https://openalex.org/W1947475203","https://openalex.org/W1970881583","https://openalex.org/W1996838919","https://openalex.org/W2008935907","https://openalex.org/W2016370157","https://openalex.org/W2027783468","https://openalex.org/W2055775253","https://openalex.org/W2077152493","https://openalex.org/W2082841638","https://openalex.org/W2086004720","https://openalex.org/W2089940631","https://openalex.org/W2090495748","https://openalex.org/W2093491661","https://openalex.org/W2133432707","https://openalex.org/W2141282621","https://openalex.org/W2148641357","https://openalex.org/W2157434148","https://openalex.org/W2162507994","https://openalex.org/W2169473035","https://openalex.org/W2170644095","https://openalex.org/W2175835252","https://openalex.org/W2210020869","https://openalex.org/W2277468569","https://openalex.org/W2342501741","https://openalex.org/W2463653768","https://openalex.org/W2469299248","https://openalex.org/W2558319372","https://openalex.org/W2570047468","https://openalex.org/W2605070482","https://openalex.org/W2611412318","https://openalex.org/W2751493662","https://openalex.org/W2753434084","https://openalex.org/W2793027389","https://openalex.org/W2794056114","https://openalex.org/W2884982789","https://openalex.org/W2885706121","https://openalex.org/W2890363323","https://openalex.org/W2890705624","https://openalex.org/W2904244708","https://openalex.org/W2904361233","https://openalex.org/W2913440408","https://openalex.org/W2914696138","https://openalex.org/W2917445235","https://openalex.org/W2934233926","https://openalex.org/W2937074474","https://openalex.org/W2972368830","https://openalex.org/W2985538915","https://openalex.org/W3004363853","https://openalex.org/W3008202901","https://openalex.org/W3015905428","https://openalex.org/W3094538783","https://openalex.org/W3095990125","https://openalex.org/W3096384055","https://openalex.org/W3097434651","https://openalex.org/W3193110435","https://openalex.org/W3210587964","https://openalex.org/W3212222702","https://openalex.org/W4205876365","https://openalex.org/W4211016192"],"related_works":["https://openalex.org/W2224830186","https://openalex.org/W4293206611","https://openalex.org/W2909729743","https://openalex.org/W4390710995","https://openalex.org/W7125976526","https://openalex.org/W4390658808","https://openalex.org/W3087370001","https://openalex.org/W4390777595","https://openalex.org/W4313367294","https://openalex.org/W2597520033"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sesquiterpene":[1],"lactones":[2,168],"are":[3,49,169],"secondary":[4],"plant":[5],"metabolites":[6],"with":[7,74,96,178],"a":[8,135],"wide":[9],"variety":[10],"of":[11,16,28,43,50,57,71,80,139,175],"biological":[12,113],"activities.":[13,121,131],"The":[14,78,115],"process":[15],"lactone":[17],"conjugation":[18],"to":[19,85,124,166],"other":[20],"pharmacophores":[21],"can":[22,65],"increase":[23],"the":[24,29,69,107,144,159,173],"efficacy":[25],"and":[26,110,129,151,154],"specificity":[27],"conjugated":[30,95,123,145],"agent":[31,146],"effect":[32],"on":[33],"molecular":[34],"targets":[35],"in":[36,68],"various":[37],"diseases,":[38],"including":[39,46],"brain":[40],"pathologies.":[41],"Derivatives":[42],"biogenic":[44],"indoles,":[45],"neurotransmitter":[47],"serotonin,":[48],"considerable":[51],"interest":[52],"as":[53],"potential":[54,87],"pharmacophores.":[55],"Most":[56],"these":[58],"compounds":[59,103],"have":[60],"neurotropic":[61],"activity":[62],"and,":[63],"therefore,":[64],"be":[66],"used":[67,111],"synthesis":[70,83],"new":[72],"drugs":[73],"neuroprotective":[75,120],"properties.":[76],"AIM:":[77],"aim":[79],"this":[81],"experimental":[82],"was":[84],"generate":[86],"treatment":[88,174],"agents":[89,171],"for":[90,112,172],"Alzheimer's":[91,140,179],"disease":[92,141],"using":[93],"serotonin":[94,164],"natural":[97],"sesquiterpene":[98,167],"lactones.":[99],"METHODS:":[100],"Three":[101],"novel":[102],"were":[104],"obtained":[105,116,160],"via":[106],"Michael":[108],"reaction":[109],"testing.":[114],"conjugates":[117,165],"demonstrated":[118],"complex":[119],"Serotonin":[122],"isoalantolactone":[125],"exhibited":[126],"strong":[127],"antioxidant":[128],"mitoprotective":[130],"RESULTS:":[132],".":[133],"In":[134,157],"transgenic":[136],"animal":[137],"model":[138],"(5xFAD":[142],"line),":[143],"restored":[147],"declined":[148],"cognitive":[149],"functions":[150],"improved":[152],"learning":[153],"memory.":[155],"CONCLUSION:":[156],"conclusion,":[158],"results":[161],"indicate":[162],"that":[163],"promising":[170],"symptoms":[176],"associated":[177],"disease.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-11-30T00:00:00"}