{"id":"https://openalex.org/W4310191248","doi":"https://doi.org/10.3390/cancers14235865","title":"Radiotherapy with Helium Ions Has the Potential to Improve Both Endocrine and Neurocognitive Outcome in Pediatric Patients with Ependymoma","display_name":"Radiotherapy with Helium Ions Has the Potential to Improve Both Endocrine and Neurocognitive Outcome in Pediatric Patients with Ependymoma","publication_year":2022,"publication_date":"2022-11-28","ids":{"openalex":"https://openalex.org/W4310191248","doi":"https://doi.org/10.3390/cancers14235865","pmid":"https://pubmed.ncbi.nlm.nih.gov/36497348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9736041"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14235865","doi":"https://doi.org/10.3390/cancers14235865","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14235865","pdf_url":"https://www.mdpi.com/2072-6694/14/23/5865/pdf?version=1669797689","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/23/5865/pdf?version=1669797689","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086128204","display_name":"Ricarda Wickert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ricarda Wickert","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039168411","display_name":"Thomas Tessonnier","orcid":"https://orcid.org/0000-0002-8919-4299","observed_orcids":["https://orcid.org/0000-0002-8919-4299"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Tessonnier","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010687963","display_name":"Maximilian Y. Deng","orcid":"https://orcid.org/0000-0003-4925-7600","observed_orcids":["https://orcid.org/0000-0003-4925-7600"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Deng","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076635156","display_name":"Sebastian Adeberg","orcid":"https://orcid.org/0000-0001-8463-514X","observed_orcids":["https://orcid.org/0000-0001-8463-514X"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Adeberg","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8463-514X","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033830737","display_name":"Katharina Seidensaal","orcid":"https://orcid.org/0000-0001-5969-6426","observed_orcids":["https://orcid.org/0000-0001-5969-6426"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Seidensaal","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034449120","display_name":"Line Hoeltgen","orcid":"https://orcid.org/0000-0002-3433-2455","observed_orcids":["https://orcid.org/0000-0002-3433-2455"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Line Hoeltgen","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003238","display_name":"J\u00fcrgen Debus","orcid":"https://orcid.org/0000-0002-6411-4811","observed_orcids":["https://orcid.org/0000-0002-6411-4811"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Debus","raw_affiliation_strings":["Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","German Cancer Consortium (DKTK), 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070621357","display_name":"Klaus K Herfarth","orcid":"https://orcid.org/0000-0002-6325-4193","observed_orcids":["https://orcid.org/0000-0002-6325-4193"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Herfarth","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000073064","display_name":"Semi Harrabi","orcid":"https://orcid.org/0000-0003-1195-7150","observed_orcids":["https://orcid.org/0000-0003-1195-7150","https://orcid.org/0000-0002-0348-8609"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210100820","display_name":"Heidelberger Institut f\u00fcr Radioonkologie","ror":"https://ror.org/015wgw417","country_code":"DE","type":"other","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210100820"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Semi B. Harrabi","raw_affiliation_strings":["Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210100820"]},{"raw_affiliation_string":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000073064"],"corresponding_institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I4210100820","https://openalex.org/I4210111460"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":1464,"currency":"EUR","value_usd":1578},"fwci":1.6133,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.84772055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"14","issue":"23","first_page":"5865","last_page":"5865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.996999979019165},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/intensity-modulated-radiotherapy","display_name":"intensity-modulated radiotherapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/normal-tissue-complication-probability","display_name":"normal tissue complication probability","score":0.9240000247955322},{"id":"https://openalex.org/keywords/organs-at-risk-sparing","display_name":"organs at risk sparing","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neuropsychological-outcomes","display_name":"neuropsychological outcomes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/endocrine-outcomes","display_name":"endocrine outcomes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dose-distribution","display_name":"dose distribution","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.7011446356773376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.637764573097229},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.5559857487678528},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5258617401123047},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.4892897307872772},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.45923930406570435},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.43993836641311646},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3810942769050598},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.28405845165252686},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.22532838582992554},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18117815256118774},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.07399028539657593},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers14235865","doi":"https://doi.org/10.3390/cancers14235865","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14235865","pdf_url":"https://www.mdpi.com/2072-6694/14/23/5865/pdf?version=1669797689","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9736041","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9736041","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:36497348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36497348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bf2cd89c0fbd43868f9e66a90a820729","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bf2cd89c0fbd43868f9e66a90a820729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 5865, p 5865 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers14235865","doi":"https://doi.org/10.3390/cancers14235865","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14235865","pdf_url":"https://www.mdpi.com/2072-6694/14/23/5865/pdf?version=1669797689","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8925489155","display_name":null,"funder_award_id":"1DH1811398","funder_id":"https://openalex.org/F4320323528","funder_display_name":"Dietmar Hopp Stiftung"}],"funders":[{"id":"https://openalex.org/F4320323528","display_name":"Dietmar Hopp Stiftung","ror":"https://ror.org/02t2ah669"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4310191248.pdf","grobid_xml":"https://content.openalex.org/works/W4310191248.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1978825072","https://openalex.org/W1999351639","https://openalex.org/W2025909970","https://openalex.org/W2033456044","https://openalex.org/W2035833991","https://openalex.org/W2054850180","https://openalex.org/W2062879918","https://openalex.org/W2092467531","https://openalex.org/W2095379644","https://openalex.org/W2110083750","https://openalex.org/W2119449786","https://openalex.org/W2132327237","https://openalex.org/W2136716437","https://openalex.org/W2162695324","https://openalex.org/W2290159425","https://openalex.org/W2329522359","https://openalex.org/W2401426593","https://openalex.org/W2408109442","https://openalex.org/W2479753880","https://openalex.org/W2483701019","https://openalex.org/W2592975196","https://openalex.org/W2646751502","https://openalex.org/W2741256553","https://openalex.org/W2782647223","https://openalex.org/W2806764617","https://openalex.org/W2887682196","https://openalex.org/W2921906463","https://openalex.org/W2975917903","https://openalex.org/W2991588978","https://openalex.org/W3097075064","https://openalex.org/W3166521908","https://openalex.org/W3170737052","https://openalex.org/W3213908560","https://openalex.org/W4206467252","https://openalex.org/W4213444068","https://openalex.org/W4223578060","https://openalex.org/W4281790289"],"related_works":["https://openalex.org/W4281761749","https://openalex.org/W2782647223","https://openalex.org/W2157931080","https://openalex.org/W2015865721","https://openalex.org/W1996887521","https://openalex.org/W2071155486","https://openalex.org/W2078332269","https://openalex.org/W6939605729","https://openalex.org/W2757839364","https://openalex.org/W4220720201"],"abstract_inverted_index":{"Ependymomas":[0],"are":[1],"the":[2,12,96,106,113,137,199,212,230,242,252,258,264],"third":[3],"most-frequent":[4],"pediatric":[5,63,224],"brain":[6,143,227],"tumors.":[7,228],"To":[8,111],"prevent":[9],"local":[10],"recurrence,":[11],"resection":[13],"site":[14],"should":[15],"be":[16,146],"irradiated.":[17],"Compared":[18],"to":[19,36,94,105,153,159,172,192,198,260],"photon":[20],"radiation":[21],"treatment,":[22],"proton":[23,193],"therapy":[24,103,194],"often":[25],"achieves":[26],"even":[27,261],"better":[28,48],"results":[29,243],"regarding":[30],"target":[31,55],"coverage":[32,128],"and":[33,87,195],"organ-sparing.":[34],"Due":[35],"their":[37],"physical":[38],"properties,":[39],"helium":[40,85,118,179,185,255],"ions":[41,186,256],"could":[42,145,208],"further":[43,262],"reduce":[44,263],"side":[45],"effects,":[46],"providing":[47],"protection":[49],"of":[50,100,117,170,184,202,215,233,244,254],"healthy":[51,142],"tissue":[52,121,144],"despite":[53],"similar":[54],"coverage.":[56],"In":[57,204],"our":[58,245],"in":[59,131],"silico":[60],"study,":[61],"15":[62],"ependymoma":[64],"patients":[65,69,225],"were":[66,92,125,175],"considered.":[67],"All":[68],"underwent":[70],"adjuvant":[71],"radiotherapeutic":[72],"treatment":[73,267],"with":[74,149,226,239],"active-scanned":[75],"protons":[76,150,216],"at":[77,236],"Heidelberg":[78],"Ion":[79],"Beam":[80],"Therapy":[81],"Center":[82],"(HIT).":[83],"Both":[84],"ion":[86,101],"highly":[88],"conformal":[89],"IMRT":[90,196],"plans":[91],"calculated":[93],"evaluate":[95],"potential":[97,114,259],"dosimetric":[98,213],"advantage":[99,214],"beam":[102],"compared":[104,158,191],"current":[107],"state-of-the-art":[108],"photon-based":[109],"treatments.":[110],"estimate":[112],"clinical":[115,221],"benefit":[116,222],"ions,":[119],"normal":[120],"complication":[122],"probabilities":[123],"(NTCP)":[124],"calculated.":[126],"Target":[127],"was":[129],"comparable":[130],"all":[132],"three":[133],"modalities.":[134],"As":[135],"expected,":[136],"integral":[138],"dose":[139,164,182],"absorbed":[140],"by":[141,151],"significantly":[147,188],"reduced":[148],"up":[152,171],"-48%":[154],"vs.":[155],"IMRT.":[156],"Even":[157],"actively":[160],"scanned":[161],"protons,":[162],"relative":[163],"reductions":[165],"for":[166,223,266],"critical":[167,234],"neuronal":[168],"structures":[169],"another":[173],"-39%":[174],"achieved":[176],"when":[177,190],"using":[178],"ions.":[180],"The":[181],"distribution":[183],"is":[187],"superior":[189],"due":[197],"improved":[200],"sparing":[201],"OAR.":[203],"fact,":[205],"previous":[206],"studies":[207],"clearly":[209],"demonstrate":[210],"that":[211,251],"translates":[217],"into":[218],"a":[219,248],"measurable":[220],"Given":[229],"dose-response":[231],"relationship":[232],"organs":[235],"risk":[237,265],"combined":[238],"NTCP":[240],"calculation,":[241],"study":[246],"provide":[247],"strong":[249],"rationale":[250],"use":[253],"has":[257],"related":[268],"sequelae.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-11-30T00:00:00"}
