{"id":"https://openalex.org/W4310162573","doi":"https://doi.org/10.1182/blood-2022-159867","title":"Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia","display_name":"Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310162573","doi":"https://doi.org/10.1182/blood-2022-159867"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-159867","doi":"https://doi.org/10.1182/blood-2022-159867","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159867","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028049853","display_name":"Richard B. Lock","orcid":"https://orcid.org/0000-0002-3436-9071","observed_orcids":["https://orcid.org/0000-0002-3436-9071"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard B Lock","raw_affiliation_strings":["1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102933279","display_name":"Kathryn Evans","orcid":"https://orcid.org/0000-0001-8737-6358","observed_orcids":["https://orcid.org/0000-0001-8737-6358"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Evans","raw_affiliation_strings":["1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066608974","display_name":"Joanna Randall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Joanna Randall","raw_affiliation_strings":["1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090752952","display_name":"Stephen W. Erickson","orcid":"https://orcid.org/0000-0001-7602-1770","observed_orcids":["https://orcid.org/0000-0001-7602-1770"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen W Erickson","raw_affiliation_strings":["2RTI International, Research Triangle Park, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2RTI International, Research Triangle Park, NC","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008815542","display_name":"Eric J. Earley","orcid":"https://orcid.org/0000-0001-6576-1319","observed_orcids":["https://orcid.org/0000-0001-6576-1319"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J Earley","raw_affiliation_strings":["2RTI International, Research Triangle Park, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2RTI International, Research Triangle Park, NC","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090619305","display_name":"Steven B. Neuhauser","orcid":"https://orcid.org/0000-0002-2993-9324","observed_orcids":["https://orcid.org/0000-0002-2993-9324"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Neuhauser","raw_affiliation_strings":["3The Jackson Laboratory, Bar Harbor, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Jackson Laboratory, Bar Harbor, ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019180679","display_name":"Timothy M. Stearns","orcid":"https://orcid.org/0000-0002-5533-6076","observed_orcids":["https://orcid.org/0000-0002-5533-6076"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Stearns","raw_affiliation_strings":["3The Jackson Laboratory, Bar Harbor, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Jackson Laboratory, Bar Harbor, ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043034121","display_name":"Vivek M. Philip","orcid":"https://orcid.org/0000-0001-5126-707X","observed_orcids":["https://orcid.org/0000-0001-5126-707X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Philip","raw_affiliation_strings":["3The Jackson Laboratory, Bar Harbor, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Jackson Laboratory, Bar Harbor, ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040137655","display_name":"Beverly A. Teicher","orcid":"https://orcid.org/0000-0003-1535-7304","observed_orcids":["https://orcid.org/0000-0003-1535-7304"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly A Teicher","raw_affiliation_strings":["4National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085737520","display_name":"Krystal Watkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096123","display_name":"ImmunoGen (United States)","ror":"https://ror.org/00scb2f23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystal Watkins","raw_affiliation_strings":["5ImmunoGen, Inc., Waltham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5ImmunoGen, Inc., Waltham, MA","institution_ids":["https://openalex.org/I4210096123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089572805","display_name":"Callum Mortimer Sloss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096123","display_name":"ImmunoGen (United States)","ror":"https://ror.org/00scb2f23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callum M Sloss","raw_affiliation_strings":["5ImmunoGen, Inc., Waltham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5ImmunoGen, Inc., Waltham, MA","institution_ids":["https://openalex.org/I4210096123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006250220","display_name":"Patrick A. Zweidler\u2010McKay","orcid":"https://orcid.org/0000-0001-6621-523X","observed_orcids":["https://orcid.org/0000-0001-6621-523X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick A Zweidler-McKay","raw_affiliation_strings":["6ImmunoGen, Inc., Lincoln, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6ImmunoGen, Inc., Lincoln, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046943976","display_name":"Malcolm Anders Smith","orcid":"https://orcid.org/0000-0001-9880-9876","observed_orcids":["https://orcid.org/0000-0001-9880-9876"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm A Smith","raw_affiliation_strings":["4National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.2113,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52263761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"8983","last_page":"8984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9520000219345093},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9319999814033508},{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.8320000171661377},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.5799999833106995},{"id":"https://openalex.org/keywords/early-t-cell-precursor-all","display_name":"early T-cell precursor ALL","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7179940342903137},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.5700667500495911},{"id":"https://openalex.org/C2994543053","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical testing","level":2,"score":0.5059036612510681},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.4982738494873047},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4933888018131256},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4475376307964325},{"id":"https://openalex.org/C2908731994","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Hematologic Neoplasms","level":3,"score":0.42713603377342224},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41286349296569824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39180833101272583},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.39030176401138306},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3580610454082489},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32653480768203735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3141682744026184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2890850901603699},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.27229151129722595},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.15826907753944397},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.1430986523628235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-159867","doi":"https://doi.org/10.1182/blood-2022-159867","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159867","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4239493347","https://openalex.org/W3166093931","https://openalex.org/W4283314311","https://openalex.org/W4406491310","https://openalex.org/W2904579561","https://openalex.org/W2989366933","https://openalex.org/W4210730341","https://openalex.org/W2898159047","https://openalex.org/W3031623257","https://openalex.org/W4200413422"],"abstract_inverted_index":{"Introduction:":[0],"Cure":[1],"rates":[2],"for":[3,17,118,187,214,382,477,509],"children":[4],"with":[5,48,104,173,310,371,421,492,513,578,613],"acute":[6],"lymphoblastic":[7],"leukemia":[8],"(ALL)":[9],"are":[10],"close":[11],"to":[12,125,326,362,415,485,525,646],"90%,":[13],"however":[14],"the":[15,23,27,68,75,119,127,233,243,249,264,286,360,379,392,399,425,474,478,499,510,514,526,533,544,551,555,560,647,653,662],"outcome":[16],"high-risk":[18],"subtypes":[19,50,157],"remains":[20],"poor.":[21],"CD123,":[22],"alpha":[24],"subunit":[25],"of":[26,67,106,116,131,138,235,394,620,665],"IL-3":[28],"receptor,":[29],"is":[30,39,46,60,81,86],"overexpressed":[31],"in":[32,89,94,102,128,224,242,359,397,447,559,593,606,635,649,667],"many":[33],"hematological":[34,96],"malignancies,":[35],"including":[36],"ALL.":[37,140,670],"CD123":[38,142,159,175,435,480,488,493,615,636],"primarily":[40],"expressed":[41,446],"on":[42,150],"B-ALL":[43,654],"blasts":[44],"and":[45,74,101,191,227,253,296,318,338,442,487,529,548,589,640,655,677],"associated":[47],"aggressive":[49],"(Angelova":[51],"et":[52,344],"al,":[53,345],"104:":[54],"749-755,":[55],"2019).":[56],"IMGN632":[57,85,132,273,299,428,502,603,650,666],"(pivekimab":[58],"sunirine)":[59],"a":[61,99,188,215,269,293,357,372],"CD123-targeting":[62],"antibody-drug":[63],"conjugate":[64],"(ADC)":[65],"comprised":[66],"novel":[69],"high-affinity":[70],"anti-CD123":[71],"antibody":[72],"G4723A,":[73],"DNA":[76],"alkylating":[77],"payload":[78],"DGN549,":[79],"which":[80,398],"an":[82,311,418],"indolindobenzodiazepine":[83],"pseudodimer.":[84],"being":[87],"studied":[88],"Phase":[90],"I/II":[91],"clinical":[92,663],"trials":[93],"CD123-positive":[95],"malignancies":[97],"as":[98,257,356,378,627,629],"monotherapy":[100],"combination":[103],"standard":[105],"care":[107],"drugs":[108],"(ClinicalTrials.gov":[109],"Identifiers":[110],"NCT03386513,":[111],"NCT04086264).":[112],"Therefore,":[113],"it":[114],"was":[115,146,164,229,290,331,354,429,443,590],"interest":[117],"Pediatric":[120],"Preclinical":[121],"Testing":[122],"Consortium":[123],"(PPTC)":[124],"test":[126],"vivo":[129,607],"activity":[130,608,651],"against":[133,609],"patient-derived":[134],"xenograft":[135],"(PDX)":[136],"models":[137],"pediatric":[139,610,669],"Methods:":[141],"(IL3RA)":[143],"mRNA":[144,436,489],"expression":[145,176,437,490,616,637],"determined":[147],"by":[148,166,231,333,431,521,672],"RNA-seq":[149],"90":[151],"ALL":[152,171,193,449,611,642],"PDXs":[153,172,194,220,450,463,475,558,580,595,599,612],"representing":[154],"six":[155],"broad":[156],"(http://pedcbioportal.kidsfirstdrc.org).":[158],"specific":[160],"antibody-binding":[161],"capacity":[162],"(sABC)":[163],"quantified":[165],"flow":[167],"cytometry.":[168],"Two":[169],"B-lineage":[170,448,594,668],"moderate":[174],"(one":[177],"B-cell":[178],"precursor,":[179,210],"BCP;":[180],"one":[181],"mixed-lineage":[182],"leukemia-rearranged,":[183],"MLLr)":[184],"were":[185,212,221,255,308,412],"selected":[186,213,476],"dose-response":[189,265,500],"study,":[190,266],"40":[192],"(13":[195],"BCP,":[196,567],"3":[197,203,385,507],"Ph+,":[198,452,569],"8":[199],"Ph-like,":[200,453,571],"9":[201],"MLLr,":[202,573],"T-cell":[204,209],"ALL,":[205],"T-ALL;":[206],"4":[207],"early":[208],"ETP-ALL)":[211],"single":[216,294],"mouse":[217,238,295,334,518],"trial":[218],"(SMT).":[219],"grown":[222],"orthotopically":[223],"NSG":[225],"mice":[226,267,297,307],"engraftment":[228],"evaluated":[230],"enumerating":[232],"proportion":[234],"human":[236],"versus":[237],"CD45+":[239],"cells":[240],"(%huCD45+)":[241],"peripheral":[244],"blood.":[245],"Treatment":[246],"commenced":[247],"when":[248],"%huCD45+":[250,361,380,400],"reached":[251],"\u22651%,":[252],"events":[254],"defined":[256,355],"huCD45+":[258],"\u226525%":[259],"or":[260,272,278],"leukemia-related":[261],"morbidity.":[262],"For":[263,285],"received":[268,298],"control":[270,527],"ADC":[271,327],"(60":[274],"\u00b5g/kg,":[275,277],"120":[276],"240":[279],"\u00b5g/kg":[280,301],"IV":[281,302],"weekly":[282,303],"x":[283,304],"3).":[284,305],"SMT,":[287,479,561],"each":[288],"PDX":[289,539],"inoculated":[291],"into":[292],"(240":[300],"All":[306],"treated":[309],"Fc":[312],"receptor":[313],"blocker":[314],"(400":[315],"mg/kg,":[316,323],"IP)":[317,324],"platelet-activating":[319],"factor":[320],"inhibitor":[321],"(5":[322],"prior":[325],"treatment.":[328,395],"Drug":[329],"efficacy":[330],"assessed":[332],"event-free":[335],"survival":[336],"(EFS)":[337],"stringent":[339],"objective":[340,352,419,564],"response":[341,353],"measures":[342],"(Houghton":[343],"Pediatr":[346],"Blood":[347],"Cancer":[348],"49:928-40,":[349],"2007).":[350],"An":[351],"decrease":[358],"below":[363,404],"1%":[364,405],"at":[365,383,388,406,505,532,543,550,625],"any":[366,389,407],"point":[367,390,408],"after":[368,391,409],"treatment":[369,410],"initiation,":[370],"Maintained":[373],"Complete":[374],"Response":[375],"(MCR)":[376],"indicated":[377],"<1%":[381],"least":[384],"consecutive":[386],"weeks":[387],"completion":[393],"Mice":[396],"did":[401],"not":[402,413],"drop":[403],"initiation":[411],"considered":[414],"have":[416,644],"achieved":[417],"response,":[420],"Progressive":[422],"Disease":[423],"(PD)":[424],"worst":[426],"response.":[427],"provided":[430],"ImmunoGen,":[432],"Inc.":[433],"Results:":[434],"ranged":[438,482,585],"from":[439,483,586],"0.09-51.4":[440],"FPKM":[441],"more":[444],"highly":[445],"(BCP,":[451],"MLLr;":[454],"median":[455,466,519],"9.1,":[456],"range":[457,468],"0.93-51.4":[458],"FPKM;":[459,470],"n=65)":[460],"than":[461,597],"T-lineage":[462,598,641],"(T-ALL;":[464],"ETP;":[465],"0.49,":[467],"0.09-13.0":[469],"n=25,":[471],"p<0.0001).":[472,601],"From":[473],"sABC":[481,494],"0":[484],"3,032":[486],"correlated":[491],"(n=30,":[495],"p=0.0023,":[496],"r=0.536).":[497],"In":[498],"study":[501],"elicited":[503],"MCRs":[504,542],"all":[506],"doses":[508,626],"MLLr-ALL":[511],"PDX,":[512],"high":[515],"dose":[516,535],"extending":[517],"EFS":[520,584],"362":[522],"days":[523,531,588],"compared":[524],"(p=0.0004),":[528],"233":[530],"lowest":[534,552],"(p=0.0002).":[536],"The":[537,632],"BCP-ALL":[538],"also":[540],"scored":[541,563],"two":[545],"highest":[546],"doses,":[547],"PD":[549],"dose.":[553],"Of":[554],"37":[556],"evaluable":[557],"29":[562],"responses":[565],"(11/12":[566],"2/3":[568],"8/8":[570],"6/7":[572],"0/3":[574],"T-ALL,":[575],"2/4":[576],"ETP),":[577],"26":[579],"attaining":[581],"MCRs.":[582],"Mouse":[583],"6.8-379":[587],"significantly":[591],"greater":[592],"(n=30)":[596],"(n=7;":[600],"Conclusions:":[602],"exerted":[604],"profound":[605],"varying":[614],"levels,":[617],"particularly":[618],"those":[619],"B-lineage,":[621],"inducing":[622],"prolonged":[623],"remissions":[624],"low":[628],"60":[630],"\u00b5g/kg.":[631],"significant":[633],"difference":[634,648],"between":[638,652],"B-":[639],"could":[643],"contributed":[645],"T-ALL":[656],"models.":[657],"These":[658],"data":[659],"strongly":[660],"support":[661],"evaluation":[664],"(Supported":[671],"NCI":[673],"Grants":[674],"CA199000,":[675],"CA199222":[676],"CA263963)":[678]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}