{"id":"https://openalex.org/W4310161352","doi":"https://doi.org/10.1182/blood-2022-171164","title":"Single-Cell Multiomics for Residual Disease Detection in Acute Myelogenous Leukemia after Allogeneic Hematopoietic Cell Transplantation","display_name":"Single-Cell Multiomics for Residual Disease Detection in Acute Myelogenous Leukemia after Allogeneic Hematopoietic Cell Transplantation","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310161352","doi":"https://doi.org/10.1182/blood-2022-171164"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-171164","doi":"https://doi.org/10.1182/blood-2022-171164","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-171164","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041324758","display_name":"Melinda Ann Biernacki","orcid":"https://orcid.org/0000-0002-9527-0905","observed_orcids":["https://orcid.org/0000-0002-9527-0905"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Ann Biernacki","raw_affiliation_strings":["1Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085085692","display_name":"Olivia G. Waltner","orcid":"https://orcid.org/0000-0001-7021-0431","observed_orcids":["https://orcid.org/0000-0001-7021-0431"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Waltner","raw_affiliation_strings":["2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066228657","display_name":"Sami B. Kanaan","orcid":"https://orcid.org/0000-0002-4608-0953","observed_orcids":["https://orcid.org/0000-0002-4608-0953"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami B Kanaan","raw_affiliation_strings":["3Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044129051","display_name":"Rula Green Gladden","orcid":"https://orcid.org/0000-0001-5779-8525","observed_orcids":["https://orcid.org/0000-0001-5779-8525"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rula Green Gladden","raw_affiliation_strings":["1Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075617788","display_name":"Shruti S. Bhise","orcid":"https://orcid.org/0009-0002-7826-8704","observed_orcids":["https://orcid.org/0009-0002-7826-8704"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Bhise","raw_affiliation_strings":["4Fred Hutchinson Cancer Center, Seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fred Hutchinson Cancer Center, Seattle,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038841996","display_name":"Todd M. Cooper","orcid":"https://orcid.org/0000-0002-1203-2371","observed_orcids":["https://orcid.org/0000-0002-1203-2371"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd M. Cooper","raw_affiliation_strings":["5Seattle Children's Hospital, Cancer and Blood Disorders Center, Seattle, WA","6Seattle Children's Cancer and Blood Disorders Center, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Seattle Children's Hospital, Cancer and Blood Disorders Center, Seattle, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"6Seattle Children's Cancer and Blood Disorders Center, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010225613","display_name":"Monica S. Thakar","orcid":"https://orcid.org/0000-0001-5801-5457","observed_orcids":["https://orcid.org/0000-0001-5801-5457"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Thakar","raw_affiliation_strings":["2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049490094","display_name":"Soheil Meshinchi","orcid":"https://orcid.org/0000-0002-6276-4423","observed_orcids":["https://orcid.org/0000-0002-6276-4423"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soheil Meshinchi","raw_affiliation_strings":["7Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011647056","display_name":"Marie Bleakley","orcid":"https://orcid.org/0000-0002-7018-8702","observed_orcids":["https://orcid.org/0000-0002-7018-8702"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie Bleakley","raw_affiliation_strings":["1Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630223","display_name":"Xueyan Chen","orcid":"https://orcid.org/0000-0002-3073-7180","observed_orcids":["https://orcid.org/0000-0002-3073-7180","https://orcid.org/0009-0001-7892-3417"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyan Chen","raw_affiliation_strings":["8Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020829925","display_name":"Scott N. Furlan","orcid":"https://orcid.org/0000-0003-3007-9840","observed_orcids":["https://orcid.org/0000-0003-3007-9840"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott N Furlan","raw_affiliation_strings":["1Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.1823,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54030338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"10215","last_page":"10216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.16210000216960907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/post-transplant-recurrence","display_name":"post-transplant relapse","score":0.7639999985694885},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cell-surface-proteomics","display_name":"cell surface proteomics","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5740000009536743},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6679999828338623},{"id":"https://openalex.org/keywords/multiparameter-flow-cytometry","display_name":"multiparameter flow cytometry","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hybridization-capture-sequencing","display_name":"hybridization capture sequencing","score":0.6420000195503235},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6638970971107483},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.6357137560844421},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.6057898998260498},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5709484219551086},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5545774102210999},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5086196660995483},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.4864606559276581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4782753884792328},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47271937131881714},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4408620595932007},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43136781454086304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36474621295928955},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35310986638069153},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23969608545303345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1983875036239624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1094096302986145}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-171164","doi":"https://doi.org/10.1182/blood-2022-171164","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-171164","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3212941255","https://openalex.org/W4405054885","https://openalex.org/W4310112971","https://openalex.org/W4405037690","https://openalex.org/W4386282264","https://openalex.org/W4389248510","https://openalex.org/W4402022489","https://openalex.org/W4386102437","https://openalex.org/W4386023931","https://openalex.org/W7007887584"],"abstract_inverted_index":{"Management":[0],"of":[1,16,59,65,144,231,273,307,326,356,367,379,479,501],"acute":[2],"myeloid":[3,71,283],"leukemia":[4],"(AML)":[5],"early":[6,82,286],"after":[7,178],"allogeneic":[8],"hematopoietic":[9,280],"cell":[10,190,205,360],"transplantation":[11],"(alloHCT)":[12],"requires":[13],"regular":[14],"assessments":[15],"measurable":[17],"residual":[18],"disease":[19,109,380],"(MRD).":[20],"Current":[21],"assays":[22,28,44,102],"for":[23,252,410,419,494],"MRD":[24,43,95,438,477,480],"detection":[25,453,478],"include":[26],"molecular":[27],"such":[29,45],"as":[30,46,146],"quantitative":[31],"PCR,":[32],"which":[33,235,260],"are":[34,51,262],"sensitive":[35,476],"and":[36,61,73,103,198,208,285,442,471,475,497],"specific":[37],"but":[38,290],"not":[39,451],"broadly":[40,53],"applicable.":[41,54],"Single-cell":[42],"multiparametric":[47],"flow":[48],"cytometry":[49],"(MFC)":[50],"more":[52],"Still,":[55],"the":[56,62,142,189,324,358,376,484],"phenotypic":[57],"heterogeneity":[58],"AML":[60,173,271,310,414,482,502],"large":[63],"percentage":[64,325,366],"surface":[66,191,304],"markers":[67],"shared":[68],"between":[69],"malignant":[70],"blasts":[72,272,311,327,368,387],"healthy":[74,229],"progenitors":[75],"make":[76],"MFC":[77,320,345,370],"challenging":[78],"to":[79,111,140,160,183,203,249,257,279,315,436,455,489],"interpret,":[80],"especially":[81],"post-alloHCT.":[83],"We":[84,117],"hypothesize":[85],"that":[86,132,224,276,400,415,429,444,461],"a":[87,120,129,219,228,336,364,406,468],"droplet-based":[88],"single-cell":[89,124,184,333,401,430,463],"multi-omic":[90,244,361,402,431,445],"sequencing":[91,126,138,432,446,465],"platform":[92,121],"can":[93,416,433],"detect":[94,437],"with":[96,169,218,339,375,412],"greater":[97],"confidence":[98],"than":[99,369],"existing":[100],"clinical":[101,319,344,383,421,456],"provide":[104,490],"crucial":[105],"insight":[106],"into":[107],"recurrent/relapsed":[108],"biology":[110],"inform":[112],"rational,":[113,491],"personalized":[114,408,492],"treatment":[115],"strategies.":[116],"previously":[118],"described":[119],"using":[122,193,227,239,332,343],"droplet-partitioned,":[123],"RNA":[125,185,464],"accompanied":[127],"by":[128,318,382],"computational":[130,216],"pipeline":[131,217],"leverages":[133],"natural":[134],"genetic":[135],"variation":[136],"in":[137,156,329,390,396,439,481,483,504],"data":[139,459],"quantify":[141],"origin":[143,275],"cells":[145,226,261],"either":[147],"donor":[148,288],"or":[149,255,423],"recipient.":[150],"Here,":[151],"we":[152,187,213,236,267],"used":[153],"this":[154],"approach":[155,245,362],"an":[157],"expanded":[158],"cohort":[159,331,392],"study":[161,427],"bone":[162],"marrow":[163],"(BM)":[164],"samples":[165],"from":[166,210],"pediatric":[167],"patients":[168,389,411,418,441,496],"clinically":[170],"suspected":[171],"post-alloHCT":[172,485],"relapse":[174,503],"across":[175,388],"multiple":[176],"timepoints":[177],"myeloablative":[179],"conditioning.":[180],"In":[181,264,353],"addition":[182],"quantification,":[186],"measured":[188],"proteome":[192],"140":[194],"oligo-conjugated":[195],"monoclonal":[196],"antibodies":[197],"their":[199],"isotype":[200],"controls.":[201],"Motivated":[202],"annotate":[204],"types":[206],"rigorously":[207],"efficiently":[209],"our":[211,215,330,391,499],"samples,":[212,357],"augmented":[214],"highly":[220],"performant":[221],"machine-learning":[222],"algorithm":[223],"classifies":[225],"reference":[230],"human":[232],"BM":[233],"cells,":[234,282,289],"have":[237,448],"validated":[238],"publicly":[240],"available":[241],"data.":[242],"Our":[243,458],"further":[246],"lends":[247],"itself":[248],"hybridization":[250],"capture-sequencing":[251],"known":[253],"mutations":[254],"fusions":[256],"orthogonally":[258],"validate":[259],"neoplastic.":[263],"all":[265],"patients,":[266],"could":[268],"identify":[269],"putative":[270,309],"recipient":[274],"showed":[277,312,335,393],"similarities":[278,314,395],"stem":[281],"progenitors,":[284],"erythroid":[287],"had":[291],"clearly":[292],"dissimilar":[293],"gene":[294,397],"expression":[295],"profiles":[296,306],"overall":[297],"(A,":[298,321],"upper":[299],"right,":[300],"orange":[301],"circle).":[302],"Cell":[303],"proteomic":[305],"these":[308],"striking":[313],"those":[316,340],"detected":[317,328,363],"bottom).":[322],"Overall,":[323],"multi-omics":[334],"strong":[337],"correlation":[338],"percentages":[341],"obtained":[342],"(B;":[346],"Pearson":[347],"r":[348],"=":[349],"0.9173,":[350],"R2":[351],"0.8415).":[352],"one":[354],"set":[355],"single":[359],"higher":[365,377],"(B,":[371],"red":[372],"circle),":[373],"consistent":[374],"burden":[378],"suggested":[381],"mutational":[384],"testing.":[385],"Relapsed":[386],"minimal":[394],"expression,":[398],"suggesting":[399],"profiling":[403],"may":[404,447],"be":[405,434,467],"suitable":[407],"diagnostic":[409],"relapsed":[413],"risk-stratify":[417],"subsequent":[420],"trials":[422],"next-line":[424],"therapies.":[425],"This":[426],"demonstrates":[428],"applied":[435],"diverse":[440],"suggests":[443],"comparable":[449],"if":[450],"superior":[452],"capabilities":[454],"MFC.":[457],"imply":[460],"droplet-based,":[462],"will":[466,472],"powerful":[469],"tool":[470],"offer":[473],"confident":[474],"setting,":[486],"enabling":[487],"clinicians":[488],"treatments":[493],"individual":[495],"improve":[498],"understanding":[500],"each":[505],"patient.":[506],"Figure":[507],"1View":[508,511],"largeDownload":[509,512],"PPTFigure":[510],"PPT":[513],"Close":[514],"modal":[515]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-11-30T00:00:00"}
