{"id":"https://openalex.org/W4310160030","doi":"https://doi.org/10.1182/blood-2022-168924","title":"Bitopertin, a Selective Glycine Transporter 1 Inhibitor, Reduced Protoporphyrin IX (PPIX) Level and Improved Liver Fibrosis in a Mouse Model of Erythropoietic Protoporphyria (EPP)","display_name":"Bitopertin, a Selective Glycine Transporter 1 Inhibitor, Reduced Protoporphyrin IX (PPIX) Level and Improved Liver Fibrosis in a Mouse Model of Erythropoietic Protoporphyria (EPP)","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310160030","doi":"https://doi.org/10.1182/blood-2022-168924"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-168924","doi":"https://doi.org/10.1182/blood-2022-168924","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-168924","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103744331","display_name":"Min Wu","orcid":"https://orcid.org/0000-0001-6204-4103","observed_orcids":["https://orcid.org/0000-0001-6204-4103"]},"institutions":[{"id":"https://openalex.org/I4405266992","display_name":"Disc Medicine, Inc. (United States)","ror":"https://ror.org/00pccsa50","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Wu","raw_affiliation_strings":["1Disc Medicine, Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Disc Medicine, Watertown, MA","institution_ids":["https://openalex.org/I4405266992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025896775","display_name":"Sarah Ducamp","orcid":"https://orcid.org/0009-0005-4731-0772","observed_orcids":["https://orcid.org/0009-0005-4731-0772"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ducamp","raw_affiliation_strings":["2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101188250","display_name":"Xiang Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266992","display_name":"Disc Medicine, Inc. (United States)","ror":"https://ror.org/00pccsa50","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Xiang","raw_affiliation_strings":["1Disc Medicine, Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Disc Medicine, Watertown, MA","institution_ids":["https://openalex.org/I4405266992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054158194","display_name":"Juan Putra","orcid":"https://orcid.org/0000-0002-3487-4641","observed_orcids":["https://orcid.org/0000-0002-3487-4641"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Putra","raw_affiliation_strings":["2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051427859","display_name":"Mark D. Fleming","orcid":"https://orcid.org/0000-0003-0948-4024","observed_orcids":["https://orcid.org/0000-0003-0948-4024"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D. Fleming","raw_affiliation_strings":["2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266992","display_name":"Disc Medicine, Inc. (United States)","ror":"https://ror.org/00pccsa50","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian MacDonald","raw_affiliation_strings":["1Disc Medicine, Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Disc Medicine, Watertown, MA","institution_ids":["https://openalex.org/I4405266992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103080083","display_name":"Paul Joseph Schmidt","orcid":"https://orcid.org/0000-0001-6978-0656","observed_orcids":["https://orcid.org/0000-0001-6978-0656"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J Schmidt","raw_affiliation_strings":["2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.4412,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.51336208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"8192","last_page":"8193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitopertin","display_name":"bitopertin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glycine-transporter-1-inhibitor","display_name":"glycine transporter 1 inhibitor","score":0.8420000076293945},{"id":"https://openalex.org/keywords/erythropoietic-protoporphyria","display_name":"erythropoietic protoporphyria","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/porphyria","display_name":"porphyria","score":0.5019999742507935},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2777799353","wikidata":"https://www.wikidata.org/wiki/Q1759600","display_name":"Erythropoietic protoporphyria","level":4,"score":0.9759264588356018},{"id":"https://openalex.org/C2778417259","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin","level":3,"score":0.7337878346443176},{"id":"https://openalex.org/C2781149050","wikidata":"https://www.wikidata.org/wiki/Q408712","display_name":"Ferrochelatase","level":4,"score":0.5641524195671082},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5580750703811646},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5277194380760193},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.5216262936592102},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4520804286003113},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43533363938331604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4122184216976166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40172770619392395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3302610516548157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30605292320251465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.263480007648468},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.19586610794067383},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.09731563925743103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09092935919761658},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08869224786758423},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07851317524909973},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-168924","doi":"https://doi.org/10.1182/blood-2022-168924","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-168924","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412430226","https://openalex.org/W4405096189","https://openalex.org/W4414195929","https://openalex.org/W4310112192","https://openalex.org/W4405034859","https://openalex.org/W4389243118","https://openalex.org/W4386101560","https://openalex.org/W4385830366","https://openalex.org/W4402696303","https://openalex.org/W4402696249"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}