{"id":"https://openalex.org/W4310159443","doi":"https://doi.org/10.1182/blood-2022-168478","title":"The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7, is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas","display_name":"The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7, is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310159443","doi":"https://doi.org/10.1182/blood-2022-168478"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-168478","doi":"https://doi.org/10.1182/blood-2022-168478","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-168478","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062777666","display_name":"Kanisha Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanisha Patel","raw_affiliation_strings":["1Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015603734","display_name":"Vincent P. Diego","orcid":"https://orcid.org/0000-0002-0007-2085","observed_orcids":["https://orcid.org/0000-0002-0007-2085"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent P. Diego","raw_affiliation_strings":["2South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, BROWNSVILLE, TX","3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, BROWNSVILLE, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110947473","display_name":"Alberto D. Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto D. Lopez","raw_affiliation_strings":["4Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Edinburg,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Edinburg,","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019772996","display_name":"Marcio Almeida","orcid":"https://orcid.org/0000-0002-8114-3892","observed_orcids":["https://orcid.org/0000-0002-8114-3892"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcio A. Almeida","raw_affiliation_strings":["3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088365248","display_name":"Joanne E. Curran","orcid":"https://orcid.org/0000-0002-6898-155X","observed_orcids":["https://orcid.org/0000-0002-6898-155X"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne E. Curran","raw_affiliation_strings":["3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087701839","display_name":"Miguel Antonio Escobar","orcid":"https://orcid.org/0000-0002-2944-0240","observed_orcids":["https://orcid.org/0000-0002-2944-0240"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Escobar","raw_affiliation_strings":["6McGovern Medical School and Gulf States Hemophilia and Thrombophilia Center, University of Texas Health Science Center, Houston Medical School, Houston, TX","7Gulf States Hemophilia and Thrombophilia Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6McGovern Medical School and Gulf States Hemophilia and Thrombophilia Center, University of Texas Health Science Center, Houston Medical School, Houston, TX","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"7Gulf States Hemophilia and Thrombophilia Center, Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108785086","display_name":"Jerry Sherman Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry S. Powell","raw_affiliation_strings":["8Haplogenics, Brownsville, TX","9Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, The University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Haplogenics, Brownsville, TX","institution_ids":[]},{"raw_affiliation_string":"9Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, The University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023001389","display_name":"Donna M. Lehman","orcid":"https://orcid.org/0000-0001-8547-9927","observed_orcids":["https://orcid.org/0000-0001-8547-9927"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna M. Lehman","raw_affiliation_strings":["10School of Medicine, University of Texas Health Science Center - San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10School of Medicine, University of Texas Health Science Center - San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073917506","display_name":"Ralph Anthony DeFronzo","orcid":"https://orcid.org/0000-0002-8581-6273","observed_orcids":["https://orcid.org/0000-0002-8581-6273"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A DeFronzo","raw_affiliation_strings":["11University of Texas Health Science Center - San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11University of Texas Health Science Center - San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105876643","display_name":"Sarah Williams\u2010Blangero","orcid":"https://orcid.org/0000-0002-4456-222X","observed_orcids":["https://orcid.org/0000-0002-4456-222X"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Williams-Blangero","raw_affiliation_strings":["3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069814838","display_name":"Ravi Duggirala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Duggirala","raw_affiliation_strings":["12Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Edinburg, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Edinburg, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001935511","display_name":"Laura A. Almasy","orcid":"https://orcid.org/0000-0002-9184-8124","observed_orcids":["https://orcid.org/0000-0002-9184-8124"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Almasy","raw_affiliation_strings":["13Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723","observed_orcids":["https://orcid.org/0000-0001-6250-5723"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":["3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"5South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056308632","display_name":"Tom E. Howard","orcid":"https://orcid.org/0000-0002-4550-278X","observed_orcids":["https://orcid.org/0000-0002-4550-278X"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom E. Howard","raw_affiliation_strings":["14Department of Pathology and Laboratory Medicine, VA Valley Coastal Bend Healthcare System, Harlingen, TX","15South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX","3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","8Haplogenics, Brownsville, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Department of Pathology and Laboratory Medicine, VA Valley Coastal Bend Healthcare System, Harlingen, TX","institution_ids":[]},{"raw_affiliation_string":"15South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"3Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"8Haplogenics, Brownsville, TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.1514,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45863663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"2799","last_page":"2800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-synonymous-single-nucleotide-polymorphisms","display_name":"non-synonymous single nucleotide polymorphisms","score":0.8330000042915344},{"id":"https://openalex.org/keywords/factor-vii","display_name":"factor VII","score":0.8989999890327454},{"id":"https://openalex.org/keywords/f7-gene","display_name":"F7 gene","score":0.906000018119812},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.828000009059906},{"id":"https://openalex.org/keywords/mexican-americans","display_name":"Mexican Americans","score":0.8379999995231628},{"id":"https://openalex.org/keywords/south-texas","display_name":"South Texas","score":0.7710000276565552},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4519999921321869},{"id":"https://openalex.org/keywords/cardiovascular-genetics","display_name":"cardiovascular genetics","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7760633826255798},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.653957188129425},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6475437879562378},{"id":"https://openalex.org/C2780930249","wikidata":"https://www.wikidata.org/wiki/Q412850","display_name":"Factor VII","level":3,"score":0.614290714263916},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5555456876754761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44538936018943787},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4039103090763092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3481471836566925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3183744251728058},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2425907552242279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17146939039230347},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.04922771453857422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2022-168478","doi":"https://doi.org/10.1182/blood-2022-168478","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-168478","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:scholarworks.utrgv.edu:som_pub-2346","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.utrgv.edu/som_pub/1348","pdf_url":null,"source":{"id":"https://openalex.org/S4306402611","display_name":"ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802326326","host_organization_name":"The University of Texas Rio Grande Valley","host_organization_lineage":["https://openalex.org/I2802326326"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Medicine Publications and Presentations","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030530325","https://openalex.org/W1910534203","https://openalex.org/W3117923171","https://openalex.org/W2361058145","https://openalex.org/W2385547179","https://openalex.org/W1971731831","https://openalex.org/W2007998398","https://openalex.org/W2315378749","https://openalex.org/W2039342466","https://openalex.org/W2005705743"],"abstract_inverted_index":{"We":[0,230],"performed":[1,69],"an":[2,70],"exome-wide":[3,71,116,131],"scan":[4,72],"of":[5,17,30,49,54,58,65,99,125,194,280,296,316,338,358,385],"known":[6],"genetic":[7,56,247],"variants":[8],"to":[9,75,150,168,199,211,217,252,261,291,301,307],"identify":[10],"any":[11],"potentially":[12],"associated":[13,44,239,273,379],"with":[14,45,181,240,274,343,364,380],"plasma":[15,76],"levels":[16,78,103,196,382],"FVII":[18],"coagulant":[19],"activity":[20],"(FVII:C)":[21],"in":[22,36,62,73,79,91,159,277,312,336],"Mexican":[23,63],"Americans":[24,64],"from":[25,128,202],"South":[26,66],"Texas.":[27],"Recent":[28],"meta-analyses":[29],"the":[31,41,55,107,112,122,126,130,136,152,156,169,182,185,189,203,206,212,218,222,234,250,278,294,297,304,308,319,344],"353":[32,108,170,235,269,374],"R>Q":[33,109,171,236,270,375],"ns-SNP":[34,110,237,376],"(rs6046)":[35],"F7":[37,298,373],"have":[38],"reported":[39],"that":[40,106,147,268,348,372],"Q-allele":[42],"is":[43,133,143,166,238,259,271,300,321,327,341,377],"a":[46,97,176,192,245,256,262,275,313,323,351,355],"decreased":[47],"risk":[48,279,340,360,384],"CHD.":[50,317,386],"In":[51,368],"our":[52,241,332],"study":[53],"determinants":[57],"cardiovascular":[59],"disease":[60,253],"(CVD)":[61],"Texas,":[67],"we":[68,95,266,370],"relation":[74],"FVII:C":[77,102,195,381],"784":[80],"individuals.":[81],"Accounting":[82],"for":[83,101,188,205,221,249],"age,":[84],"sex,":[85],"and":[86,105,154,163,362,383],"their":[87],"interactions":[88],"as":[89,191],"confounders":[90],"linear":[92],"mixed":[93,264],"model,":[94,265],"found":[96,267,371],"heritability":[98],"30%":[100],"(p=1.1E-08),":[104],"was":[111],"only":[113],"variant":[114,299],"showing":[115],"significance":[117],"(p=2.1E-09;":[118],"Figure":[119],"1A).":[120],"Though":[121],"quantile-quantile":[123],"distribution":[124,138],"p-values":[127],"all":[129],"tests":[132],"not":[134,284,287],"shown,":[135],"p-value":[137],"revealed":[139],"that:":[140],"(i)":[141],"there":[142],"no":[144],"systematic":[145],"bias":[146],"may":[148],"act":[149],"skew":[151],"p-values;":[153],"(ii)":[155],"lone":[157],"exception":[158],"agreement":[160],"between":[161],"observed":[162,333],"expected":[164],"quantiles":[165],"due":[167,290],"signal,":[172],"which":[173,258,310],"strongly":[174],"suggests":[175],"truly":[177],"significant":[178],"effect.":[179],"Consistent":[180],"meta-analysis":[183],"reports,":[184],"regression":[186],"coefficient":[187],"polymorphism":[190],"predictor":[193],"showed":[197],"them":[198],"be":[200],"increasing":[201],"homozygous":[204,220],"major":[207],"G-allele":[208],"(G/G:":[209],"Arg/Arg),":[210],"heterozygous":[213],"individuals":[214,219],"(G/A:":[215],"Arg/Gln),":[216],"minor":[223],"A-allele":[224],"(A/A:":[225],"Gln":[226],"/Gln)":[227],"(Figure":[228],"1B).":[229],"also":[231],"investigated":[232],"if":[233],"CHD":[242,281,339,349],"variable.":[243],"Using":[244],"statistical":[246],"model":[248],"liability":[251,305],"conditional":[254],"on":[255],"threshold,":[257],"equivalent":[260],"probit":[263],"significantly":[272],"reduction":[276,320],"(p=0.005)":[282],"(data":[283],"shown).":[285],"Although":[286],"shown":[288],"here,":[289],"space":[292],"limitations,":[293],"effect":[295,334],"upwardly":[302],"displace":[303],"threshold":[306],"right,":[309],"results":[311],"reduced":[314],"prevalence":[315],"While":[318],"indeed":[322],"small":[324,365],"change,":[325],"it":[326],"statistically":[328],"significant,":[329],"nonetheless.":[330],"Moreover,":[331],"size":[335],"terms":[337],"consistent":[342],"widely":[345],"held":[346],"view":[347],"has":[350],"multifactorial":[352],"etiology":[353],"involving":[354],"complex":[356],"combination":[357],"environmental":[359],"factors":[361],"genes":[363],"effects":[366],"sizes.":[367],"conclusion,":[369],"pleiotropically":[378]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-11-30T00:00:00"}
