{"id":"https://openalex.org/W4310127366","doi":"https://doi.org/10.1182/blood-2022-159615","title":"Comparison of Patients with Newly Diagnosed (ND) Acute Myeloid Leukemia (AML) Treated with Venetoclax and Hypomethylating Agents Vs Other Therapies By TP53 and IDH1/2 Mutation: Results from the AML Real World Evidence (ARC) Initiative","display_name":"Comparison of Patients with Newly Diagnosed (ND) Acute Myeloid Leukemia (AML) Treated with Venetoclax and Hypomethylating Agents Vs Other Therapies By TP53 and IDH1/2 Mutation: Results from the AML Real World Evidence (ARC) Initiative","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310127366","doi":"https://doi.org/10.1182/blood-2022-159615"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-159615","doi":"https://doi.org/10.1182/blood-2022-159615","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159615","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001922074","display_name":"Ofir Wolach","orcid":"https://orcid.org/0000-0002-8662-0707","observed_orcids":["https://orcid.org/0000-0002-8662-0707"]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ofir Wolach","raw_affiliation_strings":["1Rabin Medical Center, Petah Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Rabin Medical Center, Petah Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102705548","display_name":"Jacqueline Suen Garcia","orcid":"https://orcid.org/0000-0003-2118-6302","observed_orcids":["https://orcid.org/0000-0003-2118-6302","https://orcid.org/0000-0002-2599-7308"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline S. Garcia","raw_affiliation_strings":["2Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076552127","display_name":"Pinkal M. Desai","orcid":"https://orcid.org/0000-0002-9816-7284","observed_orcids":["https://orcid.org/0000-0002-9816-7284"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pinkal Desai","raw_affiliation_strings":["3Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038004259","display_name":"Pankit J. Vachhani","orcid":"https://orcid.org/0000-0001-9779-6217","observed_orcids":["https://orcid.org/0000-0001-9779-6217"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039376","display_name":"O'Neal Comprehensive Cancer Center","ror":"https://ror.org/03j18km61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250","https://openalex.org/I4390039376"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankit Vachhani","raw_affiliation_strings":["4O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040303721","display_name":"Joshua F. Zeidner","orcid":"https://orcid.org/0000-0002-9014-1514","observed_orcids":["https://orcid.org/0000-0002-9014-1514"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua F. Zeidner","raw_affiliation_strings":["5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024732914","display_name":"Sameem M. Abedin","orcid":"https://orcid.org/0000-0003-1165-4766","observed_orcids":["https://orcid.org/0000-0003-1165-4766"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameem Abedin","raw_affiliation_strings":["6Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057933586","display_name":"Kendra Lynn Sweet","orcid":"https://orcid.org/0000-0001-6248-3317","observed_orcids":["https://orcid.org/0000-0001-6248-3317"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra Sweet","raw_affiliation_strings":["7Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Lai","raw_affiliation_strings":["8University of Pennsylvania Perelman Center for Advanced Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8University of Pennsylvania Perelman Center for Advanced Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077836212","display_name":"Yakir Moshe","orcid":"https://orcid.org/0009-0003-3810-0218","observed_orcids":["https://orcid.org/0009-0003-3810-0218"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yakir Moshe","raw_affiliation_strings":["9Tel Aviv (Sourasky) Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Tel Aviv (Sourasky) Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032549755","display_name":"Daniel Aaron Pollyea","orcid":"https://orcid.org/0000-0001-6519-4860","observed_orcids":["https://orcid.org/0000-0001-6519-4860"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Pollyea","raw_affiliation_strings":["10University of Colorado School of Medicine, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113969008","display_name":"Marin Feldman Xavier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146979","display_name":"Scripps MD Anderson Cancer Center","ror":"https://ror.org/0509zzg37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marin Xavier","raw_affiliation_strings":["11Scripps-MD Anderson, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Scripps-MD Anderson, San Diego, CA","institution_ids":["https://openalex.org/I4210146979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023585815","display_name":"Boaz Nachmias","orcid":"https://orcid.org/0000-0002-7341-2167","observed_orcids":["https://orcid.org/0000-0002-7341-2167"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Boaz Nachmias","raw_affiliation_strings":["12Hadassah-Hebrew University Medical Centre, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Hadassah-Hebrew University Medical Centre, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011180142","display_name":"Tsila Zuckerman","orcid":"https://orcid.org/0000-0002-6204-977X","observed_orcids":["https://orcid.org/0000-0002-6204-977X"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tsila Zuckerman","raw_affiliation_strings":["13Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319638","display_name":"Sangmin Lee","orcid":"https://orcid.org/0000-0003-3136-9292","observed_orcids":["https://orcid.org/0000-0003-3136-9292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sangmin Lee","raw_affiliation_strings":["14Janssen Research and Development, New Brunswick, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Janssen Research and Development, New Brunswick, NJ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049531005","display_name":"Evan Chris Chen","orcid":"https://orcid.org/0000-0002-9218-215X","observed_orcids":["https://orcid.org/0000-0002-9218-215X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan C. Chen","raw_affiliation_strings":["2Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010236874","display_name":"Srilakshmi Bathini","orcid":"https://orcid.org/0000-0001-8519-1333","observed_orcids":["https://orcid.org/0000-0001-8519-1333"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039376","display_name":"O'Neal Comprehensive Cancer Center","ror":"https://ror.org/03j18km61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250","https://openalex.org/I4390039376"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srilakshmi Bathini","raw_affiliation_strings":["4O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049340614","display_name":"Wesleigh F. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146979","display_name":"Scripps MD Anderson Cancer Center","ror":"https://ror.org/0509zzg37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesleigh Edwards","raw_affiliation_strings":["11Scripps-MD Anderson, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Scripps-MD Anderson, San Diego, CA","institution_ids":["https://openalex.org/I4210146979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112340531","display_name":"Cat N. Bui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cat N. Bui","raw_affiliation_strings":["15AbbVie Inc, North Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15AbbVie Inc, North Chicago, IL","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109366387","display_name":"Wei\u2010Han Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Han Cheng","raw_affiliation_strings":["16AbbVie, Inc., North Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16AbbVie, Inc., North Chicago, IL","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079342456","display_name":"Catherine L. Miller","orcid":"https://orcid.org/0000-0002-2488-4758","observed_orcids":["https://orcid.org/0000-0002-2488-4758"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Miller","raw_affiliation_strings":["17AbbVie Inc., North Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17AbbVie Inc., North Chicago, IL","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109107770","display_name":"Annie Gu\u00e9rin","orcid":"https://orcid.org/0000-0002-9333-0812","observed_orcids":["https://orcid.org/0000-0002-9333-0812"]},"institutions":[{"id":"https://openalex.org/I60158472","display_name":"Concordia University","ror":"https://ror.org/0420zvk78","country_code":"CA","type":"education","lineage":["https://openalex.org/I60158472"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Annie Guerin","raw_affiliation_strings":["18Analysis Group Inc, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Analysis Group Inc, Montreal, Canada","institution_ids":["https://openalex.org/I60158472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005258531","display_name":"Jessica Maitland","orcid":"https://orcid.org/0009-0002-6804-319X","observed_orcids":["https://orcid.org/0009-0002-6804-319X"]},"institutions":[{"id":"https://openalex.org/I60158472","display_name":"Concordia University","ror":"https://ror.org/0420zvk78","country_code":"CA","type":"education","lineage":["https://openalex.org/I60158472"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jessica Maitland","raw_affiliation_strings":["18Analysis Group Inc, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Analysis Group Inc, Montreal, Canada","institution_ids":["https://openalex.org/I60158472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109896728","display_name":"Esprit Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esprit Ma","raw_affiliation_strings":["19Genentech, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19Genentech, South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710013","display_name":"Melissa Montez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Montez","raw_affiliation_strings":["19Genentech, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19Genentech, South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086382795","display_name":"Moshe Grunspan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moshe Grunspan","raw_affiliation_strings":["20AbbVie Inc., Hod-Hasharon, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"20AbbVie Inc., Hod-Hasharon, Israel","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059283771","display_name":"Aaron D. Goldberg","orcid":"https://orcid.org/0000-0002-2892-2643","observed_orcids":["https://orcid.org/0000-0002-2892-2643"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron D Goldberg","raw_affiliation_strings":["21Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"21Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.3594,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54241308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"11026","last_page":"11028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.8690000176429749},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/newly-diagnosed-aml","display_name":"newly diagnosed AML","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9879999756813049},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":1.0},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/idh1-2-mutation","display_name":"IDH1/2 mutation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.699999988079071},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7409999966621399},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8769999742507935},{"id":"https://openalex.org/keywords/transfusion-independence","display_name":"transfusion independence","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7809014320373535},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.6842749118804932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.655086100101471},{"id":"https://openalex.org/C9583187","wikidata":"https://www.wikidata.org/wiki/Q7919510","display_name":"Ven","level":2,"score":0.6079234480857849},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5039147734642029},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.4660395681858063},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46421054005622864},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.4554445743560791},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.3131309151649475},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3022492825984955},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.11648359894752502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-159615","doi":"https://doi.org/10.1182/blood-2022-159615","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-159615","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3097349395","https://openalex.org/W3217612228","https://openalex.org/W3211710841","https://openalex.org/W3129717088","https://openalex.org/W4389246668","https://openalex.org/W3212823054","https://openalex.org/W4291818824","https://openalex.org/W4391750128","https://openalex.org/W2987113244","https://openalex.org/W7171667188"],"abstract_inverted_index":{"Introduction:":[0],"Venetoclax":[1],"(VEN;":[2],"a":[3,367,400],"BCL-2":[4],"inhibitor)":[5],"is":[6,135],"approved":[7],"in":[8,57,226,304,324,357,406,414,459,469,493,526,542,553,567,580,593,604,620,631,658,677,686,695,734,743],"combination":[9],"with":[10,21,52,70,83,87,190,214,245,330,366,399,436,452,612,641,667,718,727],"hypomethylating":[11],"agents":[12],"(HMA)":[13],"or":[14,32,69,147,157,189,257,279,492],"low":[15],"dose":[16],"cytarabine":[17],"for":[18,24,444,524,664,740],"ND":[19,84,642],"adults":[20],"AML":[22,85,643],"ineligible":[23],"intensive":[25],"chemotherapy":[26],"(IC)":[27],"(i.e.,":[28],"\u226575":[29,66,186,297],"years":[30,67,187,298],"old":[31,68,188,299],"comorbidities":[33],"that":[34],"preclude":[35],"use":[36],"of":[37,48,183,193,231,263,284,293,310,312,335,340,361,371,376,384,389,404,412,423,428,479,507,512,615,650,673,684],"IC).":[38],"This":[39],"study":[40,77],"describes":[41],"the":[42,58,174,197,271,305,325,358,396,407,415,445,470,486,494,527,543,554,568,581,594,605,610,621,632,659,687,696,711,738],"real-world":[43],"characteristics":[44],"and":[45,62,122,167,177,200,210,216,235,261,282,302,338,346,348,374,382,387,410,421,426,447,468,488,502,510,523,540,545,549,551,564,570,575,577,591,596,600,602,618,623,627,629,666,671,679,693],"clinical":[46,708],"outcomes":[47,709],"patients":[49],"(pts)":[50],"treated":[51,86],"VEN-HMA":[53,645],"vs.":[54,465,474],"non-VEN-based":[55,109,656],"regimens":[56,110,657],"ARC":[59],"Initiative,":[60],"overall":[61,160,446,460,491,522,660,688,712],"specifically":[63],"among":[64,212],"pts":[65,82,106,185,204,213,234,238,252,265,275,286,294,314,329,337,342,365,373,378,386,391,405,413,425,430,435,451,498,509,514,611,654,685,700,717],"comorbidities.":[71],"Methods:":[72],"A":[73,181,229,308],"multicenter":[74],"chart":[75],"review":[76],"including":[78,139,241],"randomly":[79],"selected":[80],"adult":[81],"VEN":[88,175,184,233,244,251,274,336,372,385,408,424,461,487,508,544,569,595,622,678,699,713,716],"(VEN":[89],"cohort)":[90,115],"after":[91,111],"April":[92],"2016":[93],"from":[94,128],"14":[95],"academic":[96],"sites":[97],"(US:":[98],"10;":[99],"Israel:":[100],"4)":[101],"matched":[102,178,202,247,653],"1:1":[103],"to":[104,710],"control":[105],"who":[107,295,499,701],"received":[108,253,266,276,287],"May":[112,129],"2015":[113],"(CON":[114],"based":[116],"on":[117,196,655],"age":[118],"(<60,":[119],"60-74,":[120],"\u226575)":[121],"ELN":[123,318],"risk.":[124],"Interim":[125],"descriptive":[126],"results":[127,211],"2022":[130],"are":[131,224],"presented;":[132],"data":[133],"collection":[134],"ongoing.":[136],"Clinical":[137],"outcomes,":[138],"composite":[140],"complete":[141],"remission":[142],"(CRc;":[143],"i.e.,":[144],"CR,":[145],"CRh,":[146],"CRi),":[148],"minimal":[149],"residual":[150],"disease":[151],"(MRD;":[152],"assessed":[153],"by":[154],"flow":[155],"cytometry":[156],"molecular":[158,746],"monitoring),":[159],"survival":[161],"(OS),":[162],"hematopoietic":[163],"cell":[164],"transplantation":[165],"(HCT),":[166],"transfusion":[168],"independence":[169],"(TI),":[170],"were":[171,205,219,239,296,315,520,675,702],"compared":[172,726],"between":[173,485],"cohort":[176,409,417,690],"CON":[179,203,237,248,264,285,341,377,390,416,429,463,489,513,546,571,597,624,680,689,728],"cohort.":[180,363],"subset":[182],"\u22651":[191],"comorbidity":[192],"interest":[194],"(based":[195],"Ferrara":[198],"criteria)":[199],"their":[201,246],"analyzed":[206],"separately":[207],"(unfit":[208],"subgroup)":[209],"TP53":[215,344,437,719],"IDH1/2":[217,351,453,525,668],"mutation":[218,720],"also":[220],"reported.":[221],"Results:":[222],"Results":[223],"described":[225],"Table":[227],"1.":[228],"total":[230,309],"176":[232,236],"included,":[240],"116":[242],"unfit":[243,272,306,326,359,397,448,471,495,528,555,582,606,633,663,697,705],"pts.":[249,714],"Overall,":[250],"VEN-azacitidine":[254],"(AZA;":[255],"76.1%)":[256],"VEN-decitabine":[258],"(DEC;":[259],"23.9%)":[260],"65.3%":[262],"high":[267,288],"intensity":[268,289],"regimens.":[269,290],"In":[270,395],"subgroup,":[273,556],"VEN-AZA":[277],"(77.6%)":[278],"VEN-DEC":[280],"(22.4%)":[281],"55.2%":[283],"The":[291,477,559,585],"proportion":[292],"was":[300,322,355,440,456,481,533,538,562,589,732],"34.1%":[301],"50.9%":[303],"subgroup.":[307,327,449,496,698],"64.8%":[311],"all":[313],"classified":[316],"as":[317,704],"adverse":[319],"risk,":[320],"which":[321,354],"67.2%":[323],"Among":[328,364,434,450,609],"genetic":[331],"mutations":[332,345],"tested,":[333],"22.2%":[334],"13.5%":[339],"had":[343,350,503,515,646,706,721],"19.9%":[347],"14.6%":[349],"mutations,":[352,438,454],"respectively,":[353,636],"similar":[356,676,707],"subgroup":[360,398,472,529,583,607,634],"each":[362],"response":[368,401,439,674],"assessment,":[369,402],"65.7%":[370],"53.5%":[375],"achieved":[379,392,418,431,500,637],"CRc":[380,419,455,480,501,651,724],"(p<0.05)":[381,548],"39.6%":[383],"43.4%":[388],"CR":[393,432],"(p=0.53).":[394],"66.1%":[403],"44.6%":[411],"(p<0.01)":[420],"37.5%":[422],"36.0%":[427],"(p=0.91).":[433],"not":[441,482,534],"statistically":[442,483],"different":[443,484],"significantly":[457,647],"higher":[458,648,723],"versus":[462],"(87.9%":[464],"54.2%;":[466],"p<0.01)":[467],"(85.7%":[473],"52.9%;":[475],"p<0.05).":[476],"duration":[478],"cohorts,":[490,572],"For":[497],"MRD":[504],"assessed,":[505],"74.0%":[506],"66.7%":[511],"negative":[516],"MRD.":[517],"Similar":[518],"proportions":[519],"observed":[521],"although":[530],"statistical":[531],"significance":[532],"met.":[535],"HCT":[536],"rate":[537,588],"6.8%":[539],"14.2%":[541],"cohorts":[547,598,625],"6.9%":[550],"12.1%":[552],"respectively":[557,573],"(p=0.26).":[558],"median":[560,730],"OS":[561,587,670,731],"15.8":[563],"13.9":[565],"months":[566,579],"(p=0.20)":[574],"17.1":[576],"12.4":[578],"(p=0.30).":[584],"6-month":[586],"74.3%":[590],"70.1%":[592],"(p=0.30)":[599],"75.6%":[601],"66.2%":[603],"(p=0.10).":[608],"\u226556":[613],"days":[614],"follow-up,":[616],"61.9%":[617],"54.8%":[619],"(p=0.29)":[626],"67.0%":[628],"51.1%":[630],"(p=0.05),":[635],"TI.":[638],"Conclusions:":[639],"Pts":[640],"receiving":[644,691],"rates":[649,725],"than":[652],"population,":[661],"those":[662],"IC,":[665],"mutations.":[669],"durability":[672],"pts,":[681,729],"despite":[682],"65%":[683],"IC":[692],"55%":[694],"considered":[703],"Although":[715],"non-significantly":[722],"poor":[733],"both":[735],"groups":[736],"highlighting":[737],"need":[739],"novel":[741],"approaches":[742],"this":[744],"high-risk":[745],"subset.":[747],"Figure":[748],"1View":[749,752],"largeDownload":[750,753],"PPTFigure":[751],"PPT":[754],"Close":[755],"modal":[756]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-11-30T00:00:00"}