{"id":"https://openalex.org/W4310125540","doi":"https://doi.org/10.1182/blood-2022-167119","title":"Analysis of the Platelet Proteome Reveals Insights into the Pro-Inflammatory and Pro-Thrombotic State Associated with the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms","display_name":"Analysis of the Platelet Proteome Reveals Insights into the Pro-Inflammatory and Pro-Thrombotic State Associated with the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310125540","doi":"https://doi.org/10.1182/blood-2022-167119"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-167119","doi":"https://doi.org/10.1182/blood-2022-167119","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-167119","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087671934","display_name":"Sarah Kelliher","orcid":"https://orcid.org/0000-0002-3867-1585","observed_orcids":["https://orcid.org/0000-0002-3867-1585"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sarah Kelliher","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062217593","display_name":"Fionnuala N\u00ed \u00c1inle","orcid":"https://orcid.org/0000-0003-0163-792X","observed_orcids":["https://orcid.org/0000-0003-0163-792X"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Fionnuala N\u00ed \u00c1inle","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","4Rotunda Hospital, Dublin, Ireland","5Irish Network for Venous Thromboembolism Research (INViTE), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]},{"raw_affiliation_string":"4Rotunda Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2799298456"]},{"raw_affiliation_string":"5Irish Network for Venous Thromboembolism Research (INViTE), Dublin, Ireland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061479278","display_name":"Luisa Wei\u00df","orcid":"https://orcid.org/0000-0002-7018-5325","observed_orcids":["https://orcid.org/0000-0002-7018-5325"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Luisa Weiss","raw_affiliation_strings":["2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007470946","display_name":"Sara Gamba","orcid":"https://orcid.org/0000-0002-6150-7521","observed_orcids":["https://orcid.org/0000-0002-6150-7521"]},"institutions":[{"id":"https://openalex.org/I4210106645","display_name":"Ospedale Papa Giovanni XXIII","ror":"https://ror.org/01savtv33","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210106645"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Gamba","raw_affiliation_strings":["7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy","institution_ids":["https://openalex.org/I4210106645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024136567","display_name":"E. Fouhy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ella Fouhy","raw_affiliation_strings":["2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058851458","display_name":"Marina Marchetti","orcid":"https://orcid.org/0000-0001-9036-960X","observed_orcids":["https://orcid.org/0000-0001-9036-960X"]},"institutions":[{"id":"https://openalex.org/I4210106645","display_name":"Ospedale Papa Giovanni XXIII","ror":"https://ror.org/01savtv33","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210106645"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Marchetti","raw_affiliation_strings":["7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy","institution_ids":["https://openalex.org/I4210106645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068459860","display_name":"Francesca Schieppati","orcid":"https://orcid.org/0000-0003-0338-2000","observed_orcids":["https://orcid.org/0000-0003-0338-2000"]},"institutions":[{"id":"https://openalex.org/I4210106645","display_name":"Ospedale Papa Giovanni XXIII","ror":"https://ror.org/01savtv33","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210106645"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Schieppati","raw_affiliation_strings":["7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy","institution_ids":["https://openalex.org/I4210106645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070904404","display_name":"Hayley Macleod","orcid":"https://orcid.org/0000-0002-9532-8820","observed_orcids":["https://orcid.org/0000-0002-9532-8820"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hayley Macleod","raw_affiliation_strings":["2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015600063","display_name":"Kathleen Bennett","orcid":"https://orcid.org/0000-0002-2861-7665","observed_orcids":["https://orcid.org/0000-0002-2861-7665"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kathleen Bennett","raw_affiliation_strings":["8RCSI School of Population Health, RCSI University of Medicine and Health Science, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8RCSI School of Population Health, RCSI University of Medicine and Health Science, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne Fortune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Anne Fortune","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079670670","display_name":"Su Wai Maung","orcid":"https://orcid.org/0000-0002-2679-8896","observed_orcids":["https://orcid.org/0000-0002-2679-8896"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Su Wai Maung","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Fay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael Fay","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072839097","display_name":"Mary Frances McMullin","orcid":"https://orcid.org/0000-0002-0773-0204","observed_orcids":["https://orcid.org/0000-0002-0773-0204"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary Frances McMullin","raw_affiliation_strings":["9Centre for Medical Education, Queen's University, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Centre for Medical Education, Queen's University, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stuart Macleod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Stuart Macleod","raw_affiliation_strings":["3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073879065","display_name":"Claire Andrews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Claire Andrews","raw_affiliation_strings":["10Department of Haematology, St Vincent's University Hospital, Dublin, Ireland","1School of Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Haematology, St Vincent's University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]},{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082349971","display_name":"Liam Smyth","orcid":"https://orcid.org/0000-0002-2219-5780","observed_orcids":["https://orcid.org/0000-0002-2219-5780"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Liam Smyth","raw_affiliation_strings":["11Haematology, St. Vincent's University Hospital, Dublin, Ireland","1School of Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Haematology, St. Vincent's University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]},{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104154039","display_name":"Karen Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Karen Murphy","raw_affiliation_strings":["10Department of Haematology, St Vincent's University Hospital, Dublin, Ireland","1School of Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Haematology, St Vincent's University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]},{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042951664","display_name":"Eibhlin Conneally","orcid":"https://orcid.org/0000-0002-7874-9359","observed_orcids":["https://orcid.org/0000-0002-7874-9359"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Eibhlin Conneally","raw_affiliation_strings":["12Haematology, St. James' Hospital, Dublin, Ireland","13School of Medicine, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Haematology, St. James' Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]},{"raw_affiliation_string":"13School of Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027950733","display_name":"Patricia B. Maguire","orcid":"https://orcid.org/0000-0002-0362-3778","observed_orcids":["https://orcid.org/0000-0002-0362-3778"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Patricia Maguire","raw_affiliation_strings":["14O'Brien Centre for Science, UCD Institute for Discovery, Dublin, Ireland","2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14O'Brien Centre for Science, UCD Institute for Discovery, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"6School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039927165","display_name":"Anna Falanga","orcid":"https://orcid.org/0000-0002-5007-3457","observed_orcids":["https://orcid.org/0000-0002-5007-3457"]},"institutions":[{"id":"https://openalex.org/I4210106645","display_name":"Ospedale Papa Giovanni XXIII","ror":"https://ror.org/01savtv33","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210106645"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Falanga","raw_affiliation_strings":["15Medicine and Surgery, University of Milano-Bicocca, Milan, Italy","7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Medicine and Surgery, University of Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"7Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy","institution_ids":["https://openalex.org/I4210106645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006193076","display_name":"Barry Kevane","orcid":"https://orcid.org/0000-0003-4119-2718","observed_orcids":["https://orcid.org/0000-0003-4119-2718"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Barry Kevane","raw_affiliation_strings":["1School of Medicine, University College Dublin, Dublin, Ireland","2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","5Irish Network for Venous Thromboembolism Research (INViTE), Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"2Conway Sphere Research Group, Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"3Haematology, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]},{"raw_affiliation_string":"5Irish Network for Venous Thromboembolism Research (INViTE), Dublin, Ireland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"2654","last_page":"2655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-myeloproliferative-neoplasms","display_name":"Philadelphia-negative myeloproliferative neoplasms","score":0.9520000219345093},{"id":"https://openalex.org/keywords/platelet-proteome","display_name":"platelet proteome","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thromboinflammation","display_name":"thromboinflammation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9120000004768372},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.7620000243186951},{"id":"https://openalex.org/keywords/pro-inflammatory-proteins","display_name":"pro-inflammatory proteins","score":0.7170000076293945},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.5590000152587891},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.3529999852180481},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.30399999022483826},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5685697197914124},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4628220498561859},{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.43323808908462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4268656075000763},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42594659328460693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4232163727283478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4081161916255951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3525933027267456}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-167119","doi":"https://doi.org/10.1182/blood-2022-167119","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-167119","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387936946","https://openalex.org/W4413151999","https://openalex.org/W4415670498","https://openalex.org/W4416812844","https://openalex.org/W7126287901","https://openalex.org/W4405038366","https://openalex.org/W7223131904","https://openalex.org/W7223136668","https://openalex.org/W7172445053","https://openalex.org/W7223569231"],"abstract_inverted_index":{"Introduction:":[0],"Hypercoagulability,":[1],"thrombosis":[2,438,503],"and":[3,40,68,88,101,125,141,154,174,191,216,277,306,348,352,379,417,434,448,501,506,523,530,594],"microvascular":[4],"dysfunction":[5],"are":[6,58,435],"hallmarks":[7],"of":[8,53,63,73,98,115,249,251,275,282,332,334,345,366,377,395,399,424,451,458,470,482,499,513,520,540,554],"the":[9,27,81,96,99,102,113,155,211,285,386,396,467,493,496,511,551,555,559,565,575],"Philadelphia":[10],"chromosome-negative":[11],"myeloproliferative":[12],"neoplasms":[13],"(MPN).":[14],"Elevated":[15],"peripheral":[16],"blood":[17],"cell":[18],"counts":[19],"appear":[20],"to":[21,23,32,131,225,317,323,411,413,429,584,598],"contribute":[22,412],"thrombotic":[24,104],"risk":[25],"but":[26],"precise":[28],"underlying":[29,495],"mechanisms":[30],"remain":[31],"be":[33,71,318,430,585],"fully":[34],"elucidated.":[35],"The":[36,441,480],"interplay":[37],"between":[38,550],"haemostatic":[39],"pro-inflammatory":[41],"pathway":[42],"activity":[43,75,336],"('thrombo-inflammation')":[44],"has":[45,408,475],"emerged":[46],"in":[47,55,65,76,86,112,119,129,170,180,188,218,246,253,261,321,385,404,420,432,446,472,504,510,569,587,596,607],"recent":[48],"years":[49],"as":[50,60,338,372,374,487],"a":[51,219,226,236,247,271,278,364,393],"source":[52],"hypercoagulability":[54],"MPN.":[56,77,570],"Platelets":[57,162],"recognised":[59],"being":[61],"mediators":[62],"thrombo-inflammation":[64,380],"other":[66],"diseases":[67],"may":[69,507,531],"also":[70,508],"effectors":[72,376],"pro-inflammatory/pro-coagulant":[74],"We":[78],"hypothesized":[79],"that":[80,89],"platelet":[82,116,166,204,299,311,335,415,442,454,521,544,589,609],"proteome":[83,443],"is":[84,444,449,527],"altered":[85,445,568],"MPN":[87,310,387,405,433,447,473,505,541,588,608],"its":[90],"characterisation":[91],"would":[92],"reveal":[93],"insights":[94,491],"into":[95,492],"pathophysiology":[97,494],"disease":[100],"associated":[103,436],"risk.":[105,439],"Aim:":[106],"To":[107,464],"determine":[108],"if":[109],"differences":[110],"exist":[111],"pattern":[114],"protein":[117,262,341,390],"expression":[118,263,331,469],"patients":[120,136],"with":[121,270,437,456,460],"polycythaemia":[122],"vera":[123],"(PV)":[124],"essential":[126],"thrombocythaemia":[127],"(ET)":[128],"contrast":[130],"healthy":[132,143],"donors.":[133],"Methods:":[134],"62":[135],"(ET,":[137],"n=38;":[138],"PV,":[139],"n=24)":[140],"9":[142],"volunteers":[144],"were":[145,163,186,207,233,258,264,292,301,315,382,582,605],"recruited":[146],"at":[147,176,254],"Papa":[148],"Giovanni":[149],"XXIII":[150],"Hospital,":[151],"Bergamo,":[152],"Italy":[153],"Mater":[156],"Misericordiae":[157],"University":[158],"hospital,":[159],"Dublin,":[160],"Ireland.":[161],"isolated":[164],"from":[165,298],"rich":[167],"plasma,":[168],"washed":[169],"Krebs":[171],"Ringer":[172],"buffer":[173,190],"resuspended":[175],"1x":[177],"109":[178],"platelets/mL":[179],"phosphate":[181],"buffered":[182],"saline.":[183],"Whole":[184],"platelets":[185,474],"lysed":[187],"RIPA":[189],"differential":[192],"proteomic":[193,518],"signatures":[194],"established":[195],"using":[196,210,239,266],"label-free":[197],"quantification":[198],"(LFQ)":[199],"mass":[200,222],"spectrometry":[201],"(MS),":[202],"where":[203],"lysate":[205,545],"proteins":[206,244,297,314,371,459,566,581,604],"double":[208],"digested":[209],"commercially":[212],"available":[213],"PreOmics":[214],"kit":[215],"analysed":[217],"Bruker":[220],"TimsTOF":[221],"spectrometer":[223],"connected":[224],"EvoSep":[227],"liquid":[228],"chromatography":[229],"system.":[230],"Identified":[231],"peptides":[232],"searched":[234],"against":[235],"human":[237],"FASTA":[238],"MaxQuant.":[240],"For":[241],"statistical":[242,578],"analysis,":[243],"identified":[245],"minimum":[248],"70%":[250],"samples":[252],"least":[255],"one":[256],"group":[257],"included.":[259],"Differences":[260],"determined":[265],"an":[267,452],"unpaired":[268],"t-test":[269,548],"false":[272],"discovery":[273],"rate":[274],"5%":[276],"minimal":[279],"fold":[280],"change":[281],"0.1":[283],"within":[284],"Perseus":[286],"software;":[287],"p-":[288],"values":[289],"below":[290],"0.05":[291],"considered":[293],"significant.":[294],"Results:":[295],"2,180":[296],"lysates":[300,590,600,610],"quantified":[302],"across":[303],"all":[304],"patient":[305],"control":[307,543,599],"samples.":[308],"In":[309],"lysates,":[312],"49":[313],"found":[316,583],"differentially":[319,483],"expressed":[320,357,484],"comparison":[322,597],"controls":[324],"(p<":[325],"0.05)":[326],"(Figure":[327],"1),":[328],"including":[329],"increased":[330,403,431,586],"markers":[333],"such":[337,486],"vesicle-associated":[339],"membrane":[340],"7":[342],"(VAMP-7;":[343],"regulator":[344],"granule":[346],"exocytosis":[347],"actin":[349],"cytoskeleton":[350],"activity)":[351],"CD109":[353],"(a":[354],"GPI-linked":[355],"glycoprotein":[356],"by":[358],"activated":[359,453],"platelets).":[360],"Bioinformatical":[361],"analysis":[362,519],"revealed":[363],"cohort":[365],"mitochondrial,":[367],"cytoskeletal":[368],"&":[369],"ribosomal":[370],"well":[373],"potential":[375],"thrombopoiesis":[378],"which":[381],"significantly":[383,567],"upregulated":[384],"cohort.":[388],"Strikingly,":[389],"disulfide-isomerase":[391],"(PDI,":[392],"member":[394],"thioredoxin":[397],"superfamily":[398],"redox":[400],"proteins)":[401],"was":[402],"lysates.":[406],"PDI":[407,425,471],"been":[409,427,478],"shown":[410,428],"thrombosis,":[414],"activation":[416],"platelet-neutrophil":[418],"interactions":[419],"vivo;":[421],"plasma":[422,524],"levels":[423],"have":[426],"Conclusion:":[440],"suggestive":[450],"phenotype":[455],"over-expression":[457],"known":[461],"pro-coagulant":[462],"activity.":[463],"our":[465],"knowledge":[466],"over":[468],"not":[476],"previously":[477],"described.":[479],"identification":[481,512],"proteins,":[485],"PDI,":[488],"provides":[489],"mechanistic":[490],"substantial":[497],"burden":[498],"arterial":[500],"venous":[502],"assist":[509],"novel":[514],"therapeutic":[515],"targets.":[516],"Additional":[517],"releasate":[522],"extracellular":[525],"vesicles":[526],"currently":[528],"ongoing":[529],"provide":[532],"additional":[533],"pathophysiological":[534],"insights.":[535],"Figure":[536,612],"1:":[537],"Volcano":[538],"plot":[539],"versus":[542],"proteomes":[546],"(x-axis,":[547],"difference":[549],"mean":[552],"log2":[553],"LFQ":[556],"values;":[557],"y-axis,":[558],"negative":[560],"log":[561],"transformed":[562],"p-value)":[563],"representing":[564],"Black":[571],"hyperbolic":[572],"curves":[573],"show":[574],"threshold":[576],"for":[577],"significance.":[579],"36":[580],"(including":[591],"CD109,":[592],"PDIA4":[593],"VAMP-7)":[595],"(red)":[601],"while":[602],"13":[603],"decreased":[606],"(blue).":[611],"1View":[613,616],"largeDownload":[614,617],"PPTFigure":[615],"PPT":[618],"Close":[619],"modal":[620]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}