{"id":"https://openalex.org/W4310125449","doi":"https://doi.org/10.1182/blood-2022-157273","title":"Ruxolitinib Versus Best Available Therapy for PV Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial","display_name":"Ruxolitinib Versus Best Available Therapy for PV Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310125449","doi":"https://doi.org/10.1182/blood-2022-157273"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-157273","doi":"https://doi.org/10.1182/blood-2022-157273","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-157273","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046827092","display_name":"Claire N. Harrison","orcid":"https://orcid.org/0000-0002-3212-920X","observed_orcids":["https://orcid.org/0000-0002-3212-920X"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Harrison","raw_affiliation_strings":["1Dept. of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dept. of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087775013","display_name":"Jyoti Nangalia","orcid":"https://orcid.org/0000-0001-7122-4608","observed_orcids":["https://orcid.org/0000-0001-7122-4608"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jyoti Nangalia","raw_affiliation_strings":["2Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom","3Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom","4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"3Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080315299","display_name":"Rebecca H. Boucher","orcid":"https://orcid.org/0000-0002-6739-4193","observed_orcids":["https://orcid.org/0000-0002-6739-4193"]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca H. Boucher","raw_affiliation_strings":["5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016267427","display_name":"Aimee E. Jackson","orcid":"https://orcid.org/0000-0002-9324-9635","observed_orcids":["https://orcid.org/0000-0002-9324-9635"]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aimee Jackson","raw_affiliation_strings":["5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028677250","display_name":"Christina Yap","orcid":"https://orcid.org/0000-0002-6715-2514","observed_orcids":["https://orcid.org/0000-0002-6715-2514"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christina Yap","raw_affiliation_strings":["5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","6Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"raw_affiliation_string":"6Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003941928","display_name":"Jennifer O\u2019Sullivan","orcid":"https://orcid.org/0000-0003-0502-7133","observed_orcids":["https://orcid.org/0000-0003-0502-7133"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer O'Sullivan","raw_affiliation_strings":["7Guy's and St Thomas NHS Foundation Trust, London, United Kingdom","8Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Guy's and St Thomas NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]},{"raw_affiliation_string":"8Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114005762","display_name":"Sonia Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sonia Fox","raw_affiliation_strings":["9Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045229290","display_name":"Isaak Ailts","orcid":"https://orcid.org/0000-0001-6998-2274","observed_orcids":["https://orcid.org/0000-0001-6998-2274"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaak Ailts","raw_affiliation_strings":["10Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090009905","display_name":"Amylou Constance Dueck","orcid":"https://orcid.org/0000-0002-9912-1085","observed_orcids":["https://orcid.org/0000-0002-9912-1085"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amylou C Dueck","raw_affiliation_strings":["11Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060196258","display_name":"Holly Lynn Geyer","orcid":"https://orcid.org/0000-0002-3963-2350","observed_orcids":["https://orcid.org/0000-0002-3963-2350"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly L. Geyer","raw_affiliation_strings":["10Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039057642","display_name":"Ruben A. Mesa","orcid":"https://orcid.org/0000-0001-5880-7972","observed_orcids":["https://orcid.org/0000-0001-5880-7972"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Mesa","raw_affiliation_strings":["12Mays Cancer Center at UT Health San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Mays Cancer Center at UT Health San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044382545","display_name":"William G. Dunn","orcid":"https://orcid.org/0000-0001-7246-5198","observed_orcids":["https://orcid.org/0000-0001-7246-5198"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Dunn","raw_affiliation_strings":["4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004923811","display_name":"Eugene Nadezhdin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eugene Nadezhdin","raw_affiliation_strings":["3Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036577994","display_name":"Natalia Curto\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0003-1437-4583","observed_orcids":["https://orcid.org/0000-0003-1437-4583"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalia Curto-Garcia","raw_affiliation_strings":["13Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052912270","display_name":"Anna C. Green","orcid":"https://orcid.org/0000-0002-1241-4230","observed_orcids":["https://orcid.org/0000-0002-1241-4230"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Green","raw_affiliation_strings":["14Department of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Department of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109989165","display_name":"Bridget S. Wilkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bridget Wilkins","raw_affiliation_strings":["15Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056954410","display_name":"Jason Coppell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801242002","display_name":"Royal Devon and Exeter Hospital","ror":"https://ror.org/03jrh3t05","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801242002"]},{"id":"https://openalex.org/I4210154447","display_name":"Exeter Hospital","ror":"https://ror.org/05a5dkj17","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210154447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason Coppell","raw_affiliation_strings":["16Royal Devon and Exeter Hospital, Exeter, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Royal Devon and Exeter Hospital, Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2801242002","https://openalex.org/I4210154447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070567455","display_name":"John Laurie","orcid":"https://orcid.org/0009-0005-2499-6994","observed_orcids":["https://orcid.org/0009-0005-2499-6994"]},"institutions":[{"id":"https://openalex.org/I2800540624","display_name":"Worthing Hospital","ror":"https://ror.org/00yn4km03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800540624","https://openalex.org/I4210151332"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Laurie","raw_affiliation_strings":["17Worthing Hospital, Worthing, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Worthing Hospital, Worthing, United Kingdom","institution_ids":["https://openalex.org/I2800540624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033344593","display_name":"Mamta Krishnan Garg","orcid":"https://orcid.org/0000-0002-3560-0132","observed_orcids":["https://orcid.org/0000-0002-3560-0132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mamta Garg","raw_affiliation_strings":["18University Hospital of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18University Hospital of Leicester, Leicester, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109979724","display_name":"Joanne C Ewing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne Ewing","raw_affiliation_strings":["19University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I1308923049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001370766","display_name":"Steven Knapper","orcid":"https://orcid.org/0000-0002-6405-4441","observed_orcids":["https://orcid.org/0000-0002-6405-4441"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve Knapper","raw_affiliation_strings":["20Cardiff University School of Medicine, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"20Cardiff University School of Medicine, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084340492","display_name":"Josephine Crowe","orcid":"https://orcid.org/0009-0008-4217-0602","observed_orcids":["https://orcid.org/0009-0008-4217-0602"]},"institutions":[{"id":"https://openalex.org/I2800549715","display_name":"Royal United Hospital","ror":"https://ror.org/00a858n67","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800549715","https://openalex.org/I4210161895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Josephine Crowe","raw_affiliation_strings":["21Royal United Hospital, Bath, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"21Royal United Hospital, Bath, United Kingdom","institution_ids":["https://openalex.org/I2800549715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066772129","display_name":"Ioannis Koutsavlis","orcid":"https://orcid.org/0000-0002-6379-1298","observed_orcids":["https://orcid.org/0000-0002-6379-1298"]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ioannis Koutsavlis","raw_affiliation_strings":["22Lothian Health Board, Western General Hospital, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"22Lothian Health Board, Western General Hospital, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026534937","display_name":"Anna L. Godfrey","orcid":"https://orcid.org/0000-0003-1955-9499","observed_orcids":["https://orcid.org/0000-0003-1955-9499"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna L Godfrey","raw_affiliation_strings":["23Department of Clinical Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23Department of Clinical Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024556674","display_name":"Siamak Arami","orcid":"https://orcid.org/0000-0001-5232-8241","observed_orcids":["https://orcid.org/0000-0001-5232-8241"]},"institutions":[{"id":"https://openalex.org/I2800484787","display_name":"London North West Healthcare NHS Trust","ror":"https://ror.org/04cntmc13","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Siamak Arami","raw_affiliation_strings":["24London North West University Healthcare NHS Trust, Harrow, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"24London North West University Healthcare NHS Trust, Harrow, GBR","institution_ids":["https://openalex.org/I2800484787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112197328","display_name":"Mark W. Drummond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373718","display_name":"Beatson West of Scotland Cancer Centre","ror":"https://ror.org/03pp86w19","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800373718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark W. Drummond","raw_affiliation_strings":["25The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"25The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I2800373718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075026758","display_name":"Jenny Byrne","orcid":"https://orcid.org/0000-0002-9381-1851","observed_orcids":["https://orcid.org/0000-0002-9381-1851"]},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Byrne","raw_affiliation_strings":["26Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"26Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I1334287468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112221659","display_name":"Fiona J. Clark","orcid":"https://orcid.org/0000-0002-0630-0077","observed_orcids":["https://orcid.org/0000-0002-0630-0077"]},"institutions":[{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fiona J Clark","raw_affiliation_strings":["27Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"27Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035746810","display_name":"Carolyn Mead\u2010Harvey","orcid":"https://orcid.org/0000-0001-6887-0430","observed_orcids":["https://orcid.org/0000-0001-6887-0430"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Mead-Harvey","raw_affiliation_strings":["11Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046985332","display_name":"E. Joanna Baxter","orcid":"https://orcid.org/0000-0002-5946-5238","observed_orcids":["https://orcid.org/0000-0002-5946-5238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna E Baxter","raw_affiliation_strings":["28Haematology, Cambridge Blood and Stem Cell Biobank NHS-BT Cambridge Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"28Haematology, Cambridge Blood and Stem Cell Biobank NHS-BT Cambridge Centre, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072839097","display_name":"Mary Frances McMullin","orcid":"https://orcid.org/0000-0002-0773-0204","observed_orcids":["https://orcid.org/0000-0002-0773-0204"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary Frances McMullin","raw_affiliation_strings":["29Centre for Medical Education, Queen's University, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"29Centre for Medical Education, Queen's University, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025797543","display_name":"Adam J. Mead","orcid":"https://orcid.org/0000-0001-8522-1002","observed_orcids":["https://orcid.org/0000-0001-8522-1002"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam J Mead","raw_affiliation_strings":["30Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom","8Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"30Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"raw_affiliation_string":"8Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210110594"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":29,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.6211,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65628293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"140","issue":"Supplement 1","first_page":"1781","last_page":"1783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9559999704360962},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/best-available-therapy","display_name":"best available therapy","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2779316324","wikidata":"https://www.wikidata.org/wiki/Q212272","display_name":"Hydroxycarbamide","level":3,"score":0.8046560883522034},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.7761269807815552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6978464126586914},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5136044025421143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4565642774105072},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.3236737847328186},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10211390256881714},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.09041222929954529}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-157273","doi":"https://doi.org/10.1182/blood-2022-157273","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-157273","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4367596117","https://openalex.org/W4405748312","https://openalex.org/W7132194402","https://openalex.org/W3027570503","https://openalex.org/W2788713600","https://openalex.org/W2949352360","https://openalex.org/W2564167895","https://openalex.org/W2897023444","https://openalex.org/W2556415172","https://openalex.org/W2766339110"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}