{"id":"https://openalex.org/W4310119306","doi":"https://doi.org/10.1182/blood-2022-163452","title":"Clinical Research in Western Africa: Efficacy and Safety of a Phase II Study of R-CHOP in First-Line DLBCL in Senegal","display_name":"Clinical Research in Western Africa: Efficacy and Safety of a Phase II Study of R-CHOP in First-Line DLBCL in Senegal","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310119306","doi":"https://doi.org/10.1182/blood-2022-163452"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-163452","doi":"https://doi.org/10.1182/blood-2022-163452","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-163452","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040293217","display_name":"Saliou Diop","orcid":"https://orcid.org/0000-0002-2354-3839","observed_orcids":["https://orcid.org/0000-0002-2354-3839"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Saliou Diop","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044070947","display_name":"Charline Moulin","orcid":"https://orcid.org/0000-0003-3696-0655","observed_orcids":["https://orcid.org/0000-0003-3696-0655"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charline Moulin","raw_affiliation_strings":["2Hematology Department, Nancy University Hospital, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Department, Nancy University Hospital, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002693716","display_name":"Sokhna A\u00efssatou Tour\u00e9","orcid":"https://orcid.org/0000-0003-0251-1368","observed_orcids":["https://orcid.org/0000-0003-0251-1368"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Sokhna A\u00efssatou Tour\u00e9","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002894062","display_name":"Serigne Mourtalla Gueye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mourtalla Gueye","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037019150","display_name":"Sabine Deltour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sabine Deltour","raw_affiliation_strings":["3H\u00e9matologie Clinique CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3H\u00e9matologie Clinique CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109277575","display_name":"Yankhoba Diop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148259","display_name":"H\u00f4pital Principal de Dakar","ror":"https://ror.org/046yvwt23","country_code":"SN","type":"healthcare","lineage":["https://openalex.org/I4210148259"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Yankhoba Diop","raw_affiliation_strings":["4Service d'anatomo-pathologie H\u00f4pital Principal de Dakar, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Service d'anatomo-pathologie H\u00f4pital Principal de Dakar, Dakar, Senegal","institution_ids":["https://openalex.org/I4210148259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111430757","display_name":"Fatou Samba Diago Ndiaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Fatou Samba Ndiaye","raw_affiliation_strings":["5Hematology Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Hematology Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112879122","display_name":"Mouhamadou Cherif Dial","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mouhamadou Cherif Dial","raw_affiliation_strings":["6Service d'anatomo-pathologie Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Service d'anatomo-pathologie Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074072891","display_name":"Herv\u00e9 Sartelet","orcid":"https://orcid.org/0000-0002-3183-0125","observed_orcids":["https://orcid.org/0000-0002-3183-0125","https://orcid.org/0000-0002-2568-5312"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Sartelet","raw_affiliation_strings":["7Service d'anatomo-pathologie CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Service d'anatomo-pathologie CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003212322","display_name":"Moussa Seck","orcid":"https://orcid.org/0000-0002-0561-6707","observed_orcids":["https://orcid.org/0000-0002-0561-6707"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Moussa Seck","raw_affiliation_strings":["8Hematology Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Hematology Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103765426","display_name":"Seynabou Fall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Seynabou Fall","raw_affiliation_strings":["8Hematology Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Hematology Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020337284","display_name":"Alioune Badara Senghor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Alioune Badara Senghor","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112334369","display_name":"Awa Oumar Tour\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Awa Oumar Tour\u00e9","raw_affiliation_strings":["8Hematology Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Hematology Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056874745","display_name":"Blaise F\u00e9lix Faye","orcid":"https://orcid.org/0000-0001-7066-7984","observed_orcids":["https://orcid.org/0000-0001-7066-7984"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Blaise Felix Faye","raw_affiliation_strings":["9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022887045","display_name":"Elimane Seydi Bousso","orcid":"https://orcid.org/0009-0007-3148-4289","observed_orcids":["https://orcid.org/0009-0007-3148-4289"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Elimane Seydi Bousso","raw_affiliation_strings":["9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alioune Badara Diallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Alioune Badara Diallo","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Keita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mohamed Keita","raw_affiliation_strings":["9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, SEN","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007157556","display_name":"Elhadji Daouda Niang","orcid":"https://orcid.org/0000-0002-5113-6480","observed_orcids":["https://orcid.org/0000-0002-5113-6480"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Elhadji Daouda Niang","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113817408","display_name":"Nata Dieng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Nata Dieng","raw_affiliation_strings":["1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Service d'H\u00e9matologie clinique Universit\u00e9 Cheikh Anta Diop, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032861655","display_name":"Elsa Aboud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elsa Aboud","raw_affiliation_strings":["7Service d'anatomo-pathologie CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Service d'anatomo-pathologie CHRU Nancy, Universit\u00e9 de Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033073385","display_name":"Catherine Thi\u00e9blemont","orcid":"https://orcid.org/0000-0002-9941-2448","observed_orcids":["https://orcid.org/0000-0002-9941-2448","https://orcid.org/0000-0002-7109-6949"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Thieblemont","raw_affiliation_strings":["10Hemato-oncology Department, Universit\u00e9 de Paris Cit\u00e9/Saint-Louis University Hospital/AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Hemato-oncology Department, Universit\u00e9 de Paris Cit\u00e9/Saint-Louis University Hospital/AP-HP, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057098654","display_name":"Vincent L\u00e9vy","orcid":"https://orcid.org/0000-0003-0423-1255","observed_orcids":["https://orcid.org/0000-0003-0423-1255"]},"institutions":[{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent L\u00e9vy","raw_affiliation_strings":["11Department of Clinical Research, APHP, H\u00f4pital Avicenne, Bobigny, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Department of Clinical Research, APHP, H\u00f4pital Avicenne, Bobigny, France","institution_ids":["https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068303471","display_name":"Marie C. B\u00e9n\u00e9","orcid":"https://orcid.org/0000-0002-6569-7414","observed_orcids":["https://orcid.org/0000-0002-6569-7414"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie C B\u00e9n\u00e9","raw_affiliation_strings":["12Biology Department, Nantes University Hospital, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Biology Department, Nantes University Hospital, Nantes, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009900487","display_name":"Julien Bros\u00e9us","orcid":"https://orcid.org/0000-0002-6689-4006","observed_orcids":["https://orcid.org/0000-0002-6689-4006"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Bros\u00e9us","raw_affiliation_strings":["13Haematology Laboratory Department, University Hospital of Nancy, VANDOEUVRE, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Haematology Laboratory Department, University Hospital of Nancy, VANDOEUVRE, France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047962328","display_name":"Martine Rapha\u00ebl","orcid":"https://orcid.org/0000-0002-1196-5022","observed_orcids":["https://orcid.org/0000-0002-1196-5022"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine Raphael","raw_affiliation_strings":["14Institut Curie, Alliance Mondiale Contre le Cancer, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Institut Curie, Alliance Mondiale Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065987951","display_name":"Pierre Feugier","orcid":"https://orcid.org/0000-0003-2190-3527","observed_orcids":["https://orcid.org/0000-0003-2190-3527"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Feugier","raw_affiliation_strings":["15Hematology Department, University Hospital of Nancy, Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Hematology Department, University Hospital of Nancy, Vandoeuvre, France","institution_ids":["https://openalex.org/I4210100260"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"9489","last_page":"9490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/r-chop","display_name":"R-CHOP","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.8429999947547913},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.8429999947547913},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.5049999952316284},{"id":"https://openalex.org/keywords/senegal","display_name":"Senegal","score":0.4020000100135803},{"id":"https://openalex.org/keywords/west-africa","display_name":"West Africa","score":0.628000020980835},{"id":"https://openalex.org/keywords/access-to-cancer-care","display_name":"access to cancer care","score":0.5979999899864197},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.4569999873638153},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hiv-negative-patients","display_name":"HIV-negative patients","score":0.36899998784065247},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7268022298812866},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.6913715600967407},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.6080628037452698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5781511664390564},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.5481855273246765},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5449879765510559},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.4823541045188904},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4692891538143158},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4328269362449646},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.4178905487060547},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18334731459617615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-163452","doi":"https://doi.org/10.1182/blood-2022-163452","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-163452","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3160104303","https://openalex.org/W4413113234","https://openalex.org/W4365460065","https://openalex.org/W2557431015","https://openalex.org/W2552475722","https://openalex.org/W2907275469","https://openalex.org/W4308730717","https://openalex.org/W2979544122","https://openalex.org/W3136380637","https://openalex.org/W3130564240"],"abstract_inverted_index":{"Background:":[0],"Diffuse":[1],"large":[2],"B":[3],"cell":[4],"lymphoma":[5,68,398,513],"(DLBCL)":[6],"is":[7,55,543,551],"the":[8,63,162,172,323,379,417,488,496,586,596],"most":[9],"frequent":[10],"adult":[11],"Non":[12],"Hodgkin":[13],"Lymphoma":[14],"(NHL)":[15],"subtype.":[16],"DLBCL":[17,71,130,201,358,406],"gold":[18],"standard":[19,175],"treatment":[20,340,345,477,491,587],"associates":[21],"CHOP":[22,549],"(cyclophosphamide,":[23],"doxorubicin,":[24],"vincristine":[25,282],"and":[26,28,48,116,152,156,166,197,245,281,288,332,386,515,528,535,553],"prednisone)":[27],"Rituximab":[29,272],"for":[30,62,127,301,310,410,483,495],"a":[31,79,145,187,393,451,521],"total":[32],"of":[33,42,46,66,99,102,106,110,118,154,164,174,235,238,247,257,261,325,337,344,371,397,412,453,490,501,524,588],"6":[34,302,335,454,509],"to":[35,39,78,95,124,253,295,314,512,517,562,576,579,584],"8":[36],"cycles":[37,336],"leading":[38,561],"an":[40,233,255,374],"ORR":[41,179,256,321,486],"83%":[43],"(including":[44,121],"75%":[45],"CR":[47,262,331,502],"uCR,":[49],"(Coiffier":[50],"B,":[51],"et":[52,88,138,205],"al).":[53,89,139,206],"Little":[54],"known":[56],"about":[57],"NHL":[58],"in":[59,69,72,180,189,199,416,446,545,555,559,567,582],"Africa,":[60],"except":[61],"high":[64],"incidence":[65],"Burkitt":[67],"children.":[70],"adults":[73,226],"have":[74],"also":[75],"been":[76],"related":[77],"close":[80],"association":[81],"with":[82,129,184,230,392,401],"various":[83],"infectious":[84],"agents":[85],"(Naresh":[86],"K,":[87],"Yet,":[90],"difficulties":[91],"including":[92,112,259,499],"low":[93],"access":[94,578],"health":[96,574,580],"care,":[97],"use":[98],"cytopuncture":[100],"instead":[101],"nodal":[103,354],"biopsy,":[104,405],"non-respect":[105],"dose":[107],"intensity,":[108],"cost":[109],"drugs":[111],"CD20":[113],"monoclonal":[114],"antibodies":[115],"absence":[117,237,246],"supportive":[119],"care":[120,581],"G-CSF)":[122],"lead":[123],"poor":[125],"prognosis":[126],"patients":[128,182,202,224,269,390,558],"(overall":[131],"response":[132],"rate":[133],"(ORR)":[134],"<30%)":[135],"(S":[136],"Diop":[137],"The":[140,316,438,485],"Senegal":[141],"Government":[142],"has":[143],"built":[144],"national":[146],"anti-cancer":[147],"program,":[148],"focusing":[149],"on":[150],"prevention":[151],"improvement":[153],"diagnosis":[155,359,407],"treatment.":[157],"Our":[158,250],"hypothesis":[159,251],"was":[160,217,252,305,320,360,408,422,442,481,492,593],"that":[161,192],"insurance":[163],"prompt":[165],"accurate":[167],"diagnosis,":[168],"as":[169,171,350,352,367,369,565],"well":[170,351,368],"availability":[173],"treatment,":[176],"would":[177],"improve":[178,585],"Senegalese":[181],"diagnosed":[183],"DLBC.":[185],"Recently,":[186],"phase1/2":[188],"Malawi":[190],"showed":[191],"R-CHOP":[193],"could":[194],"be":[195],"feasible":[196,544],"safe":[198,552],"HIV+":[200],"(Kimani":[203],"S,":[204],"Methods:":[207],"This":[208,590],"prospective":[209],"single":[210],"arm":[211],"non-randomized":[212],"phase":[213],"2":[214,443],"clinical":[215,394,591],"trial":[216,592],"performed":[218,475],"at":[219,285,307,322,402,487,530],"Dakar":[220],"University":[221],"Hospital.":[222],"Eligible":[223,268],"were":[225,330,356,399,430,464,473,510,533],"(18-70":[227],"years":[228,424],"old)":[229],"newly":[231],"DLBCL,":[232],"ECOG-PS":[234],"0-2,":[236],"HIV,":[239],"HCV":[240],"or":[241,263,444,459,503],"HBV":[242],"active":[243],"infection":[244],"CNS":[248],"involvement.":[249],"obtain":[254],"70%":[258],"60%":[260],"Cru":[264],"(Cheson":[265],"criteria":[266],"1999).":[267],"received":[270],"IV":[271],"375":[273],"mg/m\u00b2,":[274,277,280],"cyclophosphamide":[275],"750":[276],"doxorubicin":[278],"50":[279],"1.4":[283],"mg/m\u00b2":[284,292],"Day":[286,296],"1":[287,294],"oral":[289],"prednisone":[290],"60":[291],"(Day":[293],"5)":[297],"every":[298],"21":[299],"days":[300,312],"cycles.":[303,456],"G-CSF":[304],"given":[306],"5":[308],"\u00b5g/kg":[309],"4":[311,460],"(D8":[313],"D11).":[315],"primary":[317],"study":[318,328],"endpoint":[319],"end":[324,489],"treatment;":[326],"secondary":[327],"endpoints":[329],"CRu":[333],"after":[334],"R":[338,548],"CHOP,":[339],"toxicity,":[341],"PFS,":[342],"respect":[343],"intensity.":[346],"Whole":[347],"CT":[348],"scan":[349],"surgical":[353],"biopsy":[355],"mandatory.":[357],"confirmed":[361,409],"by":[362,595],"retrospective":[363],"central":[364],"pathology":[365],"review":[366,370],"biopsies":[372],"via":[373],"international":[375],"telepathology":[376],"platform":[377],"using":[378],"software":[380],"i-Path.":[381],"Findings:":[382],"Between":[383],"July":[384],"2018":[385],"May":[387],"2022,":[388],"69":[389,493],"admitted":[391],"presentation":[395],"suggestive":[396],"investigated":[400],"least":[403],"one":[404,468,516],"30":[411],"them,":[413],"thus":[414],"enrolled":[415],"study.":[418],"Their":[419],"median":[420,452,522],"age":[421],"43":[423],"old":[425],"(range":[426],"18-64),":[427],"14":[428],"(46.6%)":[429],"women,":[431],"17":[432],"(56.6%)":[433],"had":[434],"stage":[435],"III-IV":[436],"DLBCL.":[437],"International":[439],"prognostic":[440],"index":[441],"higher":[445],"23":[447],"(77%).":[448],"Patients":[449],"completed":[450],"therapeutic":[455],"Grade":[457],"3":[458],"hematological":[461],"toxic":[462],"effects":[463],"rare":[465],"(one":[466],"anemia,":[467],"neutropenia)":[469],"but":[470],"blood":[471],"counts":[472],"not":[474],"between":[476],"courses.":[478],"One":[479],"patient":[480],"hospitalized":[482],"gastroenteritis.":[484],"%":[494],"whole":[497],"population":[498],"57%":[500],"uCR.":[504],"Of":[505],"7":[506],"(23%)":[507],"deaths,":[508],"due":[511],"progression":[514],"unknown":[518],"cause.":[519],"With":[520],"follow-up":[523],"19.9":[525],"months,":[526],"OS":[527],"PFS":[529],"24":[531],"months":[532],"79.9%":[534],"73.8%,":[536],"respectively":[537],"(Image":[538],"1).":[539],"Interpretation:":[540],"Clinical":[541],"Research":[542],"Western":[546],"Africa.":[547],"therapy":[550],"efficacious":[554],"HIV":[556],"negative":[557],"Senegal,":[560],"similar":[563],"responses":[564],"observed":[566],"high-income":[568],"countries.":[569],"These":[570],"results":[571],"should":[572],"encourage":[573],"authorities":[575],"increase":[577],"order":[583],"cancer.":[589],"supported":[594],"French":[597],"National":[598],"Institute":[599],"(INCA).":[600],"Figure":[601],"1View":[602,605],"largeDownload":[603,606],"PPTFigure":[604],"PPT":[607],"Close":[608],"modal":[609]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-30T00:00:00"}