{"id":"https://openalex.org/W4310108994","doi":"https://doi.org/10.1182/blood-2022-164798","title":"Therapy-Related AML: Clinical/Biological Features and Long-Term Outcome in a Cohort of 1133 Adult AML Patients","display_name":"Therapy-Related AML: Clinical/Biological Features and Long-Term Outcome in a Cohort of 1133 Adult AML Patients","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310108994","doi":"https://doi.org/10.1182/blood-2022-164798"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-164798","doi":"https://doi.org/10.1182/blood-2022-164798","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-164798","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sophia Gross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophia Gross","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046816531","display_name":"Jana Ihlow","orcid":"https://orcid.org/0000-0001-5484-1321","observed_orcids":["https://orcid.org/0000-0001-5484-1321"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Ihlow","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054746266","display_name":"Leonie Marie Busack","orcid":"https://orcid.org/0000-0001-5466-1793","observed_orcids":["https://orcid.org/0000-0001-5466-1793"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leonie Busack","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012038062","display_name":"Kacper Adamiak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kacper Adamiak","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075021493","display_name":"Jens Schrezenmeier","orcid":"https://orcid.org/0000-0001-5239-4513","observed_orcids":["https://orcid.org/0000-0001-5239-4513"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens F. Schrezenmeier","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059330586","display_name":"Julia Jesse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Jesse","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108285763","display_name":"Michaela Schwarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michaela Schwarz","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014059649","display_name":"Anne Floercken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Floercken","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085192155","display_name":"Kathrin Rieger","orcid":"https://orcid.org/0000-0002-2754-8581","observed_orcids":["https://orcid.org/0000-0002-2754-8581"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Rieger","raw_affiliation_strings":["3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027030420","display_name":"Jan Kr\u00f6nke","orcid":"https://orcid.org/0000-0002-4649-0506","observed_orcids":["https://orcid.org/0000-0002-4649-0506"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Kr\u00f6nke","raw_affiliation_strings":["3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038582279","display_name":"Philipp le Coutre","orcid":"https://orcid.org/0000-0003-4532-1097","observed_orcids":["https://orcid.org/0000-0003-4532-1097"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp le Coutre","raw_affiliation_strings":["4Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9 Campus Mitte, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9 Campus Mitte, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039911844","display_name":"Vivien Boldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vivien Boldt","raw_affiliation_strings":["5Department of Tumor Cytogenetics, Labor Berlin - Charit\u00e9 Vivantes GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Tumor Cytogenetics, Labor Berlin - Charit\u00e9 Vivantes GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048784176","display_name":"Ann\u2010Christin von Br\u00fcnneck","orcid":"https://orcid.org/0000-0003-4371-4292","observed_orcids":["https://orcid.org/0000-0003-4371-4292"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Christin von Bruenneck","raw_affiliation_strings":["2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494503","display_name":"David A. Horst","orcid":"https://orcid.org/0000-0003-4755-5743","observed_orcids":["https://orcid.org/0000-0003-4755-5743"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Horst","raw_affiliation_strings":["2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029065407","display_name":"Thomas Burmeister","orcid":"https://orcid.org/0000-0003-4843-2876","observed_orcids":["https://orcid.org/0000-0003-4843-2876"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Burmeister","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060295441","display_name":"Igor Wolfgang Blau","orcid":"https://orcid.org/0000-0003-1416-819X","observed_orcids":["https://orcid.org/0000-0003-1416-819X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Wolfgang Blau","raw_affiliation_strings":["6Department of BMT, Clinic of Hematology, Oncology and Tumorimmunology, University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of BMT, Clinic of Hematology, Oncology and Tumorimmunology, University Medicine Berlin, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028510513","display_name":"Ulrich Bernd Keller","orcid":"https://orcid.org/0000-0002-8485-1958","observed_orcids":["https://orcid.org/0000-0002-8485-1958"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Keller","raw_affiliation_strings":["3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040956966","display_name":"Lars Bullinger","orcid":"https://orcid.org/0000-0002-5890-5510","observed_orcids":["https://orcid.org/0000-0002-5890-5510"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Bullinger","raw_affiliation_strings":["7Department of Hematology, Oncology, and Tumor Immunology, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Hematology, Oncology, and Tumor Immunology, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073388713","display_name":"Joerg Westermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joerg Westermann","raw_affiliation_strings":["1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology, Oncology and Tumor Immunology, Campus Virchow-Clinic, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24647602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"1291","last_page":"1292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapy-related-acute-myeloid-leukemia","display_name":"therapy-related acute myeloid leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/de-novo-acute-myeloid-leukemia","display_name":"de novo acute myeloid leukemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.7639999985694885},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/monosomal-karyotype","display_name":"monosomal karyotype","score":0.7540000081062317},{"id":"https://openalex.org/keywords/complex-karyotype","display_name":"complex karyotype","score":0.8529999852180481},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.6990000009536743},{"id":"https://openalex.org/keywords/risk-of-relapse","display_name":"relapse risk","score":0.9459999799728394},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7669002413749695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7634062767028809},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5857471227645874},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5785114169120789},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5398115515708923},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5382018089294434},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5255215167999268},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.4113207757472992},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4039117097854614},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1080460250377655}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-164798","doi":"https://doi.org/10.1182/blood-2022-164798","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-164798","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3213778696","https://openalex.org/W2035482751","https://openalex.org/W2375707865","https://openalex.org/W2994686985","https://openalex.org/W4281722959","https://openalex.org/W2000069119","https://openalex.org/W2418647453","https://openalex.org/W2364114640","https://openalex.org/W2920898438","https://openalex.org/W1990078544"],"abstract_inverted_index":{"Introduction:":[0],"Therapy-related":[1],"acute":[2],"myeloid":[3],"leukemia":[4],"(t-AML)":[5],"affects":[6],"approximately":[7],"7%":[8,240,253],"of":[9,38,55,71,92,134,144,177,198,304,374,562,609,620,630],"AML":[10,66,72,285,316,356,377,442,556,599,639],"patients":[11,41,56,77,94,162,199,270,297,320,345,415,600],"and":[12,44,52,59,87,101,142,173,207,261,384,427,439,455,495,530,566,611],"exhibits":[13],"adverse":[14,178,514,563],"genetic":[15,179,360,564,603],"features":[16],"that":[17,546,582],"are":[18,624],"assumably":[19],"caused":[20,393],"by":[21,149,394],"increased":[22,171],"DNA":[23],"damage":[24],"after":[25,485,498],"antecedent":[26],"radiation/chemotherapy.":[27],"There":[28],"is":[29],"an":[30,464,560],"ongoing":[31],"medical":[32],"need":[33],"for":[34,349,468,589],"a":[35,68,90,174,301,325,369,633,643],"better":[36,328],"understanding":[37],"differences":[39,109,396],"between":[40,82,113,258,397,436],"with":[42,57,63,95,218,300,353,500,593,627],"t-AML":[43,58,76,161,262,269,307,350,437,460,550,572,586,631],"de":[45,64,96,158,283,314,331,354,375,440,554,597],"novo":[46,65,97,159,284,315,332,355,376,441,555,598],"AML.":[47,98],"Here,":[48],"we":[49],"assess":[50,108],"clinical":[51],"biological":[53],"characteristics":[54,112],"compare":[60],"long-term":[61],"survival":[62,123],"in":[67,110,196,221,225,230,239,244,252,282,291,306,313,330,344,372,476,540,549,585,596,606,625],"large":[69],"cohort":[70,91],"patients.":[73,479],"Methods:":[74],"225":[75],"who":[78,416],"were":[79,84,105,147,163],"newly":[80],"diagnosed":[81,195],"1995-2018":[83],"retrospectively":[85],"analyzed":[86],"compared":[88,156,278,310,489,552],"to":[89,107,120,129,157,190,279,296,311,490,553],"908":[93],"Mann-Whitney":[99],"U-":[100],"Chi":[102],"square":[103],"test":[104],"used":[106,128,595],"baseline":[111],"subgroups.":[114],"Kaplan":[115],"Meier":[116],"procedure":[117],"was":[118,127,194,263,274,324,351,378,390,402,482],"applied":[119,295],"calculate":[121],"overall":[122],"(OS).":[124],"Cox":[125],"regression":[126],"identify":[130],"hazard":[131,152],"ratios":[132],"(HR)":[133],"independent":[135,465,537],"prognostic":[136,538],"risk":[137,143,361,387,410,429,466,516,568,583],"factors.":[138],"Non-relapse":[139],"mortality":[140],"(NRM)":[141],"relapse":[145],"(RR)":[146],"calculated":[148],"the":[150,358,381,407,579,607,615,628,637],"cause-specific":[151],"method.":[153],"Results:":[154],"As":[155],"AML,":[160,333,621],"older":[164],"(61":[165],"vs.":[166],"55":[167],"years,":[168,322],"p<0.001),":[169],"had":[170,203,209,215],"comorbidity":[172],"higher":[175],"frequency":[176],"alterations":[180,565],"(e.g.":[181],"monosomal":[182],"or":[183,247,473],"complex":[184],"karyotypes,":[185],"-5/-5q,":[186],"-7,":[187],"t(v;11)(v;23)).":[188],"Prior":[189],"t-AML,":[191],"solid":[192],"cancer":[193],"61%":[197],"(138/225),":[200],"whereas":[201],"31%":[202,305],"hematologic":[204],"malignancies":[205,214],"(69/225)":[206],"8%":[208],"autoimmune":[210],"diseases":[211],"(18/225).":[212],"Previous":[213],"been":[216],"treated":[217,268,478],"combined":[219],"radiochemotherapy":[220],"33%":[222],"(75/225),":[223],"chemotherapy":[224],"27%":[226],"(60/225),":[227],"radiation":[228],"therapy":[229,234,243,260,348,487],"22%":[231],"(50/225),":[232],"immunosuppressive":[233],"(Cyclophosphamide,":[235],"Mitoxantrone,":[236],"Methotrexate,":[237],"Azathioprine)":[238],"(16/225),":[241],"radio-iodine":[242,486],"4%":[245],"(9/225)":[246],"multiple":[248,501],"preceding":[249],"cytotoxic":[250,259,502],"therapies":[251,503],"(15/225).":[254],"Median":[255],"latency":[256],"period":[257],"5.8":[264],"years.":[265],"In":[266,319,367],"intensively":[267,477],"(172/225),":[271],"median":[272,292],"OS":[273,293,303,329,343,420,469,481,548],"13.7":[275],"months":[276,281],"as":[277,309,450,463,488,536,551,632],"39.4":[280],"(823/908,":[286],"p<0.001).":[287,318],"The":[288],"substantial":[289],"difference":[290,371,405],"particularly":[294,483],"<60":[298],"years":[299],"5-year":[302],"(96/225)":[308],"51%":[312],"(562/908,":[317],"\u226560":[321],"there":[323,401],"tendency":[326],"towards":[327],"however,":[334],"this":[335],"did":[336,432,457],"not":[337,433,458],"reach":[338],"statistical":[339],"significance":[340],"(p=0.066).":[341],"Interestingly,":[342,480],"receiving":[346],"intensive":[347,531,610],"comparable":[352],"within":[357,380,406,636],"favorable":[359,408,484],"groups":[362],"(APL":[363],"p=0.927,":[364],"ELN-favorable":[365],"p=0.714).":[366],"contrast,":[368],"significant":[370],"favor":[373],"observed":[379],"ELN-intermediate":[382],"(p=0.009)":[383],"ELN-adverse":[385],"(p=0.016)":[386],"groups,":[388],"which":[389],"most":[391],"likely":[392],"age":[395,404,422],"these":[398],"groups.":[399],"However,":[400],"no":[403],"ELN":[409,428,452,515],"group":[411,430],"(p=0.878).":[412],"Considering":[413],"only":[414],"received":[417],"non-intensive":[418,612],"therapy,":[419],"(p=0.394),":[421],"(p=0.087),":[423],"ECOG":[424,454,508],"status":[425],"(p=0.123)":[426],"(p=0.098)":[431],"differ":[434],"significantly":[435],"(53/225)":[438],"(85/908).":[443],"Multivariate":[444,505],"analysis":[445,506],"(including":[446,587],"several":[447],"covariates":[448],"such":[449],"age,":[451],"risk,":[453],"CCI)":[456],"confirm":[459],"per":[461],"se":[462],"factor":[467],"(p=0.081),":[470],"RR":[471],"(p=0.982)":[472],"NRM":[474],"(p=0.320)":[475],"other":[491],"treatment":[492,532],"modalities":[493],"(p=0.042)":[494],"highly":[496],"unfavorable":[497],"pretreatment":[499],"(p=0.009).":[504],"revealed":[507],"score":[509],">1":[510],"(HR":[511,517,523,527,533],"2.3,":[512],"p=0.002),":[513],"1.7,":[518],"p=0.003),":[519],"BMI":[520],"<18,5":[521],"kg/m2":[522],"2.7,":[524],"p=0.029),":[525],"diabetes":[526],"2.0,":[528],"p=0.029)":[529],"0.3,":[534],"p<0.001)":[535],"factors":[539,569],"t-AML.":[541],"Conclusion:":[542],"Our":[543],"data":[544,623],"indicate":[545],"inferior":[547],"rather":[557,641],"results":[558],"from":[559,571],"accumulation":[561],"patient-associated":[567],"than":[570,642],"itself.":[573],"Thus,":[574],"our":[575,622],"study":[576],"strongly":[577],"supports":[578],"current":[580],"view":[581],"stratification":[584],"indication":[588],"allo-HSCT)":[590],"should":[591],"align":[592],"strategies":[594],"(based":[601],"on":[602],"features),":[604],"both":[605],"case":[608],"therapy.":[613],"Regarding":[614],"new":[616],"International":[617],"Consensus":[618],"Classification":[619],"accordance":[626],"classification":[629],"\"diagnostic":[634],"qualifier\"":[635],"different":[638],"subgroups":[640],"separate":[644],"subcategory.":[645]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}