{"id":"https://openalex.org/W4310108080","doi":"https://doi.org/10.1182/blood-2022-170315","title":"Pediatric Age at Hematopoietic Stem Cell Transplant: Associations with Non-Malignant Genetic Disease and Race","display_name":"Pediatric Age at Hematopoietic Stem Cell Transplant: Associations with Non-Malignant Genetic Disease and Race","publication_year":2022,"publication_date":"2022-11-15","ids":{"openalex":"https://openalex.org/W4310108080","doi":"https://doi.org/10.1182/blood-2022-170315"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2022-170315","doi":"https://doi.org/10.1182/blood-2022-170315","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-170315","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085912121","display_name":"Mitchell K. Higashi","orcid":"https://orcid.org/0000-0002-1047-0263","observed_orcids":["https://orcid.org/0000-0002-1047-0263"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell K. Higashi","raw_affiliation_strings":["1Sema4, Stamford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sema4, Stamford, CT","institution_ids":["https://openalex.org/I4210110193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087687382","display_name":"Paul S. Kruszka","orcid":"https://orcid.org/0000-0003-4949-0875","observed_orcids":["https://orcid.org/0000-0003-4949-0875"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Kruszka","raw_affiliation_strings":["2Medical, Sema4, Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical, Sema4, Gaithersburg, MD","institution_ids":["https://openalex.org/I4210110193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046021066","display_name":"Marra S. Francis","orcid":"https://orcid.org/0000-0003-1844-5633","observed_orcids":["https://orcid.org/0000-0003-1844-5633"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marra S. Francis","raw_affiliation_strings":["3Medical, Sema4, Stamford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical, Sema4, Stamford, CT","institution_ids":["https://openalex.org/I4210110193"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly K. Parsons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kelly K. Parsons","raw_affiliation_strings":["4Research, Sema4, Stamford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Research, Sema4, Stamford, CT","institution_ids":["https://openalex.org/I4210110193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078027978","display_name":"William K. Oh","orcid":"https://orcid.org/0000-0001-5113-8147","observed_orcids":["https://orcid.org/0000-0001-5113-8147"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William K. Oh","raw_affiliation_strings":["5medical, Sema4, Stamford, CT","6Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5medical, Sema4, Stamford, CT","institution_ids":["https://openalex.org/I4210110193"]},{"raw_affiliation_string":"6Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074288964","display_name":"Kenan Onel","orcid":"https://orcid.org/0000-0002-2021-6250","observed_orcids":["https://orcid.org/0000-0002-2021-6250"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenan Onel","raw_affiliation_strings":["1Sema4, Stamford, CT","6Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sema4, Stamford, CT","institution_ids":["https://openalex.org/I4210110193"]},{"raw_affiliation_string":"6Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046021066","https://openalex.org/A5085912121","https://openalex.org/A5087687382"],"corresponding_institution_ids":["https://openalex.org/I4210110193"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24358409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"Supplement 1","first_page":"7973","last_page":"7974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5870000123977661},{"id":"https://openalex.org/keywords/age-at-transplantation","display_name":"age at transplantation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7480000257492065},{"id":"https://openalex.org/keywords/diagnostic-odyssey","display_name":"diagnostic odyssey","score":0.871999979019165},{"id":"https://openalex.org/keywords/racial-minorities","display_name":"racial minorities","score":0.6539999842643738},{"id":"https://openalex.org/keywords/payer-status","display_name":"payer status","score":0.4909999966621399},{"id":"https://openalex.org/keywords/urban-rural-differences","display_name":"urban-rural differences","score":0.7310000061988831},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6890000104904175},{"id":"https://openalex.org/keywords/transplant-outcomes","display_name":"transplant outcomes","score":0.6690000295639038},{"id":"https://openalex.org/keywords/kids-inpatient-database","display_name":"Kids' Inpatient Database","score":0.7120000123977661},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/thalassemia","display_name":"thalassemia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7643663883209229},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5507916212081909},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.508887767791748},{"id":"https://openalex.org/C2779195980","wikidata":"https://www.wikidata.org/wiki/Q5691206","display_name":"Healthcare Cost and Utilization Project","level":3,"score":0.4684325158596039},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4683375358581543},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4415043890476227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3561055064201355},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.24596834182739258},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2022-170315","doi":"https://doi.org/10.1182/blood-2022-170315","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2022-170315","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7390999794006348}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2913248429","https://openalex.org/W4322767864","https://openalex.org/W4377697120","https://openalex.org/W4405043913","https://openalex.org/W3034118011","https://openalex.org/W4400650564","https://openalex.org/W4402599468","https://openalex.org/W2324056414","https://openalex.org/W3096424904","https://openalex.org/W2327088383"],"abstract_inverted_index":{"Introduction:":[0],"Increasingly,":[1],"hematopoietic":[2],"stem":[3,175],"cell":[4,227,411],"transplant":[5,365,420],"(HSCT)":[6],"is":[7,26,45,53,118,210,325,483,492],"used":[8,259],"in":[9,214,216,221,229,298,312,478,490,496,505,514],"pediatrics":[10],"to":[11,112,124,200,237,243,260,337,431,485,494],"treat":[12],"both":[13],"malignant":[14,234,275,466],"and":[15,30,90,102,106,147,158,252,279,293,369,376,396,409,430,437,465,472,510,522],"nonmalignant":[16,21],"conditions.":[17],"Many":[18],"of":[19,81,136,172,264,307,401,499,507],"the":[20,37,50,98,115,133,137,144,153,207,217,497],"disorders":[22,44],"for":[23,40,55,62,120,155,170,187,205,233,318,361,407,426,460],"which":[24,83,206],"HSCT":[25,104,162,238,265,297,324,383,443,504,524],"curative":[27],"are":[28,310,343,380,440,476],"genetic,":[29],"it":[31],"has":[32],"long":[33],"been":[34],"recognized":[35],"that":[36,70,475],"diagnostic":[38,51,116,197,241,451],"odyssey":[39,52,117],"patients":[41,57,64,290,309,321,339,379],"with":[42,58,65,87,270,323,340,382,414,442,519],"genetic":[43,59,66,189,203,473,500],"frequently":[46],"quite":[47],"long.":[48],"Notably,":[49],"longer":[54,119],"non-white":[56],"diseases":[60,204,474,501],"than":[61,212,352,391],"white":[63],"diseases.":[67],"We":[68,231,285],"hypothesized":[69],"this":[71,129,488],"disparity":[72],"would":[73],"also":[74],"manifest":[75],"as":[76,463],"older":[77,390,446],"age":[78,263,317],"at":[79,419,444],"time":[80],"HSCT,":[82,338],"could":[84],"be":[85,422,517],"associated":[86,269,413,441,518],"greater":[88,211],"co-morbidities":[89],"worse":[91,523],"outcomes.":[92,525],"While":[93],"previous":[94],"studies":[95],"have":[96],"analyzed":[97],"association":[99],"between":[100],"race":[101,402],"pediatric":[103,188,202,288,320,378],"access":[105],"survival,":[107],"(PMID:32497418;":[108],"35071585;":[109],"34900869)we":[110],"sought":[111],"determine":[113,486],"if":[114,262,487,511],"racial":[121,479],"minorities":[122],"compared":[123],"Caucasians.":[125],"Methods:":[126],"To":[127],"test":[128,261],"hypothesis,":[130],"we":[131],"utilized":[132],"2019":[134,299],"version":[135],"Kids\u2019":[138],"Inpatient":[139],"Database":[140],"(KID),":[141],"developed":[142],"by":[143,152,503],"Healthcare":[145,156],"Cost":[146],"Utilization":[148],"Project":[149],"(HCUP),":[150],"sponsored":[151],"Agency":[154],"Research":[157],"Quality":[159],"(AHRQ).":[160],"The":[161,304,315,399],"sample":[163],"was":[164,192,258,267],"identified":[165,286],"using":[166,194,239],"ICD-10-PCS":[167],"Procedure":[168],"Codes":[169],"transfusion":[171],"hematopoietic/cord":[173],"blood":[174],"cells:":[176],"Allogenic:":[177],"30243X3,":[178],"30243Y3,":[179],"30243X4,":[180],"30233X4,":[181],"30243Y2;":[182],"Autologous:":[183],"30243Y0.":[184],"A":[185],"variable":[186],"disease":[190,235,363],"(PGD)":[191],"generated":[193],"348":[195],"ICD-10-CM":[196,240],"codes":[198,242],"corresponding":[199],"283":[201],"carrier":[208],"frequency":[209],"1":[213],"500":[215],"general":[218],"population":[219],"or":[220,452],"an":[222,445],"at-risk":[223],"subpopulation":[224],"(e.g.,":[225],"sickle":[226,410],"anemia":[228],"AA).":[230],"controlled":[232],"leading":[236],"identify":[244],"lymphomas,":[245],"leukemias,":[246],"myelodysplastic":[247],"syndrome,":[248],"myeloproliferative":[249],"neoplasms,":[250],"neuroblastomas,":[251],"brain":[253],"tumors.":[254],"Multiple":[255],"linear":[256],"regression":[257],"procedure":[266],"significantly":[268],"race,":[271,362],"known":[272,341],"non-malignant":[273,464],"PGD,":[274],"disease,":[276,412],"payer":[277,468],"status,":[278,368,469],"location":[280],"(rural":[281],"vs.":[282,332],"urban).":[283],"Results:":[284],"1,178":[287],"aged":[289],"(age":[291],"20":[292],"younger)":[294],"who":[295],"received":[296],"(Allogenic":[300],"N=618;":[301],"autologous":[302],"N=560).":[303],"clinical":[305],"characteristics":[306],"these":[308,512],"described":[311],"Table":[313],"1.":[314],"average":[316,346,385],"Caucasian":[319,393],"treated":[322,381,502],"6.8":[326],"years":[327,348,387],"(82":[328],"months).":[329],"Comparing":[330],"PGD":[331,342],"all":[333],"other":[334],"diagnoses":[335],"related":[336],"transplanted":[344],"on":[345,384],"1.9":[347],"(22":[349],"months)":[350,389],"earlier":[351],"matched":[353,392],"controls":[354,394],"(P<0.001).":[355],"This":[356,455],"difference":[357],"persists":[358,403,457],"after":[359,405,458],"controlling":[360,406,459],"severity,":[364],"type,":[366],"Medicaid":[367],"rural":[370,470],"health":[371,428],"system":[372],"location.":[373],"African":[374,435],"American":[375,436],"Asian":[377,438],"1.6":[386],"(18":[388],"(P=0.003":[395],"0.032,":[397],"respectively).":[398],"effect":[400,456],"even":[404],"thalassemias":[408],"non-European":[415],"ancestry.":[416],"Conclusions:":[417],"Age":[418],"may":[421,516],"a":[423,449],"useful":[424],"surrogate":[425],"ongoing":[427],"disparities":[429],"inform":[432],"real-world":[433],"research.":[434],"ancestries":[439],"age,":[447],"suggesting":[448],"prolonged":[450],"therapeutic":[453],"odyssey.":[454],"factors":[461],"such":[462],"conditions,":[467],"location,":[471],"over-represented":[477],"groups.":[480],"More":[481],"work":[482],"required":[484],"delay":[489],"treatment":[491],"due":[493],"differences":[495],"spectrum":[498],"children":[506],"different":[508],"ancestries,":[509],"delays":[513],"therapy":[515],"increased":[520],"comorbidities":[521],"Figure":[526],"1View":[527,530],"largeDownload":[528,531],"PPTFigure":[529],"PPT":[532],"Close":[533],"modal":[534]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-11-30T00:00:00"}